SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2PG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Geobacillus
stearothermophil
us) 		4 / 5 ASP A 403
HIS A 407
HIS A 445
HIS A 462
 MN  A 601 ( 2.0A)
MN  A 601 ( 3.2A)
2PG  A 801 (-4.4A)
MN  A 601 ( 3.3A)
 0.48A 1ei6A-1o99A:
17.8		 1ei6A-1o99A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Geobacillus
stearothermophil
us) 		5 / 8 ASP A  12
ASP A 403
HIS A 407
HIS A 445
HIS A 462
 2PG  A 801 ( 4.5A)
MN  A 601 ( 2.0A)
MN  A 601 ( 3.2A)
2PG  A 801 (-4.4A)
MN  A 601 ( 3.3A)
 0.62A 1ei6C-1o99A:
17.2		 1ei6C-1o99A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		4 / 5 ARG A  49
SER A 158
ASN A 155
SER A 375
 None
None
None
2PG  A 441 (-2.7A)
 1.38A 1kiaB-1p43A:
undetectable		 1kiaB-1p43A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		5 / 8 GLU A 211
GLY A 398
SER A 372
ASP A 320
ASP A 246
 2PG  A 441 (-2.9A)
None
2PG  A 441 ( 4.1A)
MG  A 438 ( 3.1A)
MG  A 438 ( 2.6A)
 1.50A 1m4iA-1p43A:
undetectable		 1m4iA-1p43A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ND4_A_KANA1300_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)		 4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Staphylococcus
aureus) 		5 / 10 ASP A 192
ARG A 194
ARG A 260
ASP A 259
GLU A 231
 None
None
2PG  A 603 (-3.1A)
2PG  A 603 (-3.4A)
None
 1.23A 1nd4A-4qaxA:
0.0		 1nd4A-4qaxA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ND4_B_KANB2300_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)		 4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Staphylococcus
aureus) 		5 / 9 ASP A 192
ARG A 194
ARG A 260
ASP A 259
GLU A 231
 None
None
2PG  A 603 (-3.1A)
2PG  A 603 (-3.4A)
None
 1.19A 1nd4B-4qaxA:
0.0		 1nd4B-4qaxA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Geobacillus
stearothermophil
us) 		5 / 12 SER A 118
LEU A 116
ASP A 263
HIS A 339
VAL A 122
 None
None
2PG  A 801 ( 4.4A)
2PG  A 801 ( 4.7A)
2PG  A 801 ( 4.9A)
 1.26A 1uobA-1o99A:
undetectable		 1uobA-1o99A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		5 / 12 SER B 131
LEU B 129
ASP B 284
HIS B 360
VAL B 135
 None
None
2PG  B 565 ( 4.5A)
3PG  B 564 ( 4.2A)
2PG  B 565 (-4.6A)
 1.23A 1uobA-3igzB:
undetectable		 1uobA-3igzB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Staphylococcus
aureus) 		5 / 11 ARG A 153
HIS A 401
ASP A 397
HIS A 456
ARG A 257
 2PG  A 603 (-3.8A)
MN  A 601 (-3.4A)
MN  A 601 (-2.4A)
MN  A 601 (-3.6A)
2PG  A 603 (-2.6A)
 1.44A 1uofA-4qaxA:
undetectable		 1uofA-4qaxA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A 263
PHE A 343
ARG A 261
 2PG  A 801 ( 4.4A)
None
2PG  A 801 (-2.9A)
 0.73A 2a3aA-1o99A:
3.0		 2a3aA-1o99A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A 407
GLY A  60
HIS A 462
ASP A 403
ASP A  12
 MN  A 601 ( 3.2A)
None
MN  A 601 ( 3.3A)
MN  A 601 ( 2.0A)
2PG  A 801 ( 4.5A)
 1.09A 2pgrA-1o99A:
undetectable		 2pgrA-1o99A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Geobacillus
stearothermophil
us) 		4 / 8 HIS A 462
HIS A 407
ASP A  12
GLY A  13
 MN  A 601 ( 3.3A)
MN  A 601 ( 3.2A)
2PG  A 801 ( 4.5A)
None
 0.87A 3c0zB-1o99A:
3.5		 3c0zB-1o99A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Geobacillus
stearothermophil
us) 		4 / 7 LYS A 193
ASN A 398
HIS A  66
ALA A  62
 None
None
None
2PG  A 801 (-3.4A)
 1.01A 3frqB-1o99A:
undetectable		 3frqB-1o99A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		4 / 8 ASP B 471
SER B 470
ASP B 425
ASP B 167
 None
None
CO  B 562 (-2.1A)
2PG  B 565 ( 2.4A)
 1.07A 3havA-3igzB:
undetectable		 3havA-3igzB:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A 462
HIS A 407
GLY A 406
ASP A  12
GLY A  13
 MN  A 601 ( 3.3A)
MN  A 601 ( 3.2A)
None
2PG  A 801 ( 4.5A)
None
 1.15A 4bz6C-1o99A:
3.5		 4bz6C-1o99A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 342
LEU A 343
ILE A 383
ILE A 395
LEU A 390
 None
2PG  A 441 (-4.7A)
None
None
None
 1.27A 4j24C-1p43A:
undetectable		 4j24C-1p43A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 342
LEU A 343
ILE A 383
ILE A 395
LEU A 390
 None
2PG  A 441 (-4.7A)
None
None
None
 1.20A 4j26B-1p43A:
undetectable		 4j26B-1p43A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A 462
HIS A 407
GLY A 406
ASP A  12
GLY A  13
 MN  A 601 ( 3.3A)
MN  A 601 ( 3.2A)
None
2PG  A 801 ( 4.5A)
None
 1.16A 4lxzA-1o99A:
3.3		 4lxzA-1o99A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A 462
HIS A 407
GLY A 406
ASP A  12
GLY A  13
 MN  A 601 ( 3.3A)
MN  A 601 ( 3.2A)
None
2PG  A 801 ( 4.5A)
None
 1.15A 4lxzC-1o99A:
2.3		 4lxzC-1o99A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A 462
HIS A 407
GLY A 406
ASP A  12
GLY A  13
 MN  A 601 ( 3.3A)
MN  A 601 ( 3.2A)
None
2PG  A 801 ( 4.5A)
None
 1.21A 4qa0A-1o99A:
3.6		 4qa0A-1o99A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 3qtp ENOLASE 1
(Entamoeba
histolytica) 		4 / 8 GLY A 400
GLU A 208
GLU A 296
ALA A 241
 None
2PG  A 437 (-3.0A)
MG  A 441 (-3.3A)
None
 0.89A 4rjdA-3qtpA:
undetectable
4rjdB-3qtpA:
undetectable		 4rjdA-3qtpA:
11.06
4rjdB-3qtpA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Geobacillus
stearothermophil
us) 		4 / 8 HIS A 462
ASN A  61
ARG A 264
ARG A 261
 MN  A 601 ( 3.3A)
2PG  A 801 (-4.5A)
2PG  A 801 (-4.0A)
2PG  A 801 (-2.9A)
 1.23A 5db5A-1o99A:
3.1
5db5B-1o99A:
undetectable		 5db5A-1o99A:
21.64
5db5B-1o99A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		4 / 5 GLY B 133
ASP B 167
ARG B 202
MET B 315
 None
2PG  B 565 ( 2.4A)
3PG  B 564 ( 2.8A)
None
 1.41A 5gwkA-3igzB:
2.1		 5gwkA-3igzB:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Geobacillus
stearothermophil
us) 		3 / 3 HIS A  66
HIS A 339
ARG A 261
 None
2PG  A 801 ( 4.7A)
2PG  A 801 (-2.9A)
 1.03A 6b58A-1o99A:
undetectable		 6b58A-1o99A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Staphylococcus
aureus) 		3 / 3 ARG A 153
ARG A 197
ARG A 191
 2PG  A 603 (-3.8A)
None
2PG  A 603 (-3.3A)
 1.01A 6bplA-4qaxA:
undetectable
6bplB-4qaxA:
undetectable		 6bplA-4qaxA:
9.59
6bplB-4qaxA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 1p43 ENOLASE 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 406
LEU A 409
GLY A 212
GLY A 376
ARG A 374
 None
None
None
None
2PG  A 441 (-3.9A)
 1.00A 6ce2B-1p43A:
undetectable		 6ce2B-1p43A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 295
ASN A 259
PHE A 260
ASP A 154
GLY A 121
 None
None
None
2PG  A 801 (-2.6A)
None
 1.06A 6dwnA-1o99A:
0.0		 6dwnA-1o99A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Geobacillus
stearothermophil
us) 		4 / 5 ASN A  61
GLY A 115
HIS A 123
ASP A 263
 2PG  A 801 (-4.5A)
None
2PG  A 801 (-4.0A)
2PG  A 801 ( 4.4A)
 1.14A 6gh9A-1o99A:
0.2		 6gh9A-1o99A:
9.00