SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2P0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWI_B_115B1_2 (HMG-COA REDUCTASE)	4dpy	MEVALONATE DIPHOSPHATE DECARBOXYLASE (Staphylococcus epidermidis)	4 / 8	SER A 143 SER A 33 ASN A 31 LYS A 21	None 2P0 A 401 ( 4.8A) None 2P0 A 401 (-2.6A)	1.22A	1hwiB-4dpyA: 3.3	1hwiB-4dpyA: 22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWK_A_117A2_1 (HMG-COA REDUCTASE)	4dpy	MEVALONATE DIPHOSPHATE DECARBOXYLASE (Staphylococcus epidermidis)	4 / 8	SER A 143 SER A 33 ASN A 31 LYS A 21	None 2P0 A 401 ( 4.8A) None 2P0 A 401 (-2.6A)	1.22A	1hwkA-4dpyA: undetectable	1hwkA-4dpyA: 22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWK_C_117C4_1 (HMG-COA REDUCTASE)	4dpy	MEVALONATE DIPHOSPHATE DECARBOXYLASE (Staphylococcus epidermidis)	4 / 8	SER A 143 SER A 33 ASN A 31 LYS A 21	None 2P0 A 401 ( 4.8A) None 2P0 A 401 (-2.6A)	1.25A	1hwkC-4dpyA: 3.3	1hwkC-4dpyA: 22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWK_D_117D3_2 (HMG-COA REDUCTASE)	4dpy	MEVALONATE DIPHOSPHATE DECARBOXYLASE (Staphylococcus epidermidis)	4 / 8	SER A 143 SER A 33 ASN A 31 LYS A 21	None 2P0 A 401 ( 4.8A) None 2P0 A 401 (-2.6A)	1.26A	1hwkD-4dpyA: 3.4	1hwkD-4dpyA: 22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ACA_C_DXCC1475_0 (TRANSLATION ELONGATION FACTOR SELB)	4dpy	MEVALONATE DIPHOSPHATE DECARBOXYLASE (Staphylococcus epidermidis)	5 / 8	ILE A 92 ASP A 56 ILE A 73 SER A 141 GLY A 138	None None None 2P0 A 401 (-2.7A) None	1.45A	4acaC-4dpyA: undetectable	4acaC-4dpyA: 22.92

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1HWI_B_115B1_2","HMG-COA REDUCTASE","4dpy","MEVALONATE DIPHOSPHATE DECARBOXYLASE","Staphylococcus epidermidis",4,"SER A 143;SER A  33;ASN A  31;LYS A  21","None;2P0 A 401 ( 4.8A);None;2P0 A 401 (-2.6A)","1.22A","1hwiB-4dpyA:3.3",null],["1HWK_A_117A2_1","HMG-COA REDUCTASE","4dpy","MEVALONATE DIPHOSPHATE DECARBOXYLASE","Staphylococcus epidermidis",4,"SER A 143;SER A  33;ASN A  31;LYS A  21","None;2P0 A 401 ( 4.8A);None;2P0 A 401 (-2.6A)","1.22A","1hwkA-4dpyA:undetectable","1hwiB-4dpyA:22.15"],["1HWK_C_117C4_1","HMG-COA REDUCTASE","4dpy","MEVALONATE DIPHOSPHATE DECARBOXYLASE","Staphylococcus epidermidis",4,"SER A 143;SER A  33;ASN A  31;LYS A  21","None;2P0 A 401 ( 4.8A);None;2P0 A 401 (-2.6A)","1.25A","1hwkC-4dpyA:3.3","1hwkA-4dpyA:22.15"],["1HWK_D_117D3_2","HMG-COA REDUCTASE","4dpy","MEVALONATE DIPHOSPHATE DECARBOXYLASE","Staphylococcus epidermidis",4,"SER A 143;SER A  33;ASN A  31;LYS A  21","None;2P0 A 401 ( 4.8A);None;2P0 A 401 (-2.6A)","1.26A","1hwkD-4dpyA:3.4","1hwkC-4dpyA:22.15"],["4ACA_C_DXCC1475_0","TRANSLATION ELONGATION FACTOR SELB","4dpy","MEVALONATE DIPHOSPHATE DECARBOXYLASE","Staphylococcus epidermidis",5,"ILE A  92;ASP A  56;ILE A  73;SER A 141;GLY A 138","None;None;None;2P0 A 401 (-2.7A);None","1.45A","4acaC-4dpyA:undetectable","1hwkD-4dpyA:22.15"]]