SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2OY'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 4nsy LYSYL ENDOPEPTIDASE
(Lysobacter
enzymogenes) 		4 / 7 GLY A 212
ASP A 113
HIS A  57
ALA A  55
 2OY  A 301 (-4.0A)
None
2OY  A 301 (-2.7A)
None
 0.97A 1gxsA-4nsyA:
undetectable
1gxsB-4nsyA:
undetectable		 1gxsA-4nsyA:
23.55
1gxsB-4nsyA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 4nsy LYSYL ENDOPEPTIDASE
(Lysobacter
enzymogenes) 		4 / 6 ASP A 225
GLY A 212
PRO A 191
SER A 194
 2OY  A 301 (-2.2A)
2OY  A 301 (-4.0A)
2OY  A 301 (-3.0A)
2OY  A 301 (-1.4A)
 1.00A 1n4fA-4nsyA:
undetectable		 1n4fA-4nsyA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4nsy LYSYL ENDOPEPTIDASE
(Lysobacter
enzymogenes) 		4 / 5 PHE A 114
TYR A  51
ILE A 198
LEU A 209
 None
None
None
2OY  A 301 ( 4.2A)
 1.20A 3sueC-4nsyA:
11.1		 3sueC-4nsyA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 4nsy LYSYL ENDOPEPTIDASE
(Lysobacter
enzymogenes) 		5 / 9 TRP A 182
THR A 189
LEU A 209
GLY A 195
THR A  37
 None
2OY  A 301 (-3.6A)
2OY  A 301 ( 4.2A)
None
None
 1.49A 4c9kA-4nsyA:
undetectable		 4c9kA-4nsyA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 4nsy LYSYL ENDOPEPTIDASE
(Lysobacter
enzymogenes) 		5 / 9 TRP A 182
THR A 189
LEU A 209
GLY A 195
THR A  37
 None
2OY  A 301 (-3.6A)
2OY  A 301 ( 4.2A)
None
None
 1.48A 4c9kB-4nsyA:
undetectable		 4c9kB-4nsyA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4nsy LYSYL ENDOPEPTIDASE
(Lysobacter
enzymogenes) 		5 / 9 ALA A 146
THR A 145
ALA A 144
GLY A 187
ASP A 225
 None
None
None
None
2OY  A 301 (-2.2A)
 1.10A 5l5zK-4nsyA:
undetectable
5l5zL-4nsyA:
undetectable		 5l5zK-4nsyA:
23.69
5l5zL-4nsyA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4nsy LYSYL ENDOPEPTIDASE
(Lysobacter
enzymogenes) 		5 / 9 ALA A 146
THR A 145
ALA A 144
GLY A 187
ASP A 225
 None
None
None
None
2OY  A 301 (-2.2A)
 1.09A 5l5zY-4nsyA:
undetectable
5l5zZ-4nsyA:
undetectable		 5l5zY-4nsyA:
23.69
5l5zZ-4nsyA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4nsy LYSYL ENDOPEPTIDASE
(Lysobacter
enzymogenes) 		4 / 7 HIS A 148
LEU A 209
VAL A 188
SER A 158
 None
2OY  A 301 ( 4.2A)
None
None
 0.61A 5m8rA-4nsyA:
undetectable		 5m8rA-4nsyA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4nsy LYSYL ENDOPEPTIDASE
(Lysobacter
enzymogenes) 		4 / 8 HIS A 148
LEU A 209
VAL A 188
SER A 158
 None
2OY  A 301 ( 4.2A)
None
None
 0.59A 5m8rB-4nsyA:
undetectable		 5m8rB-4nsyA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4nsy LYSYL ENDOPEPTIDASE
(Lysobacter
enzymogenes) 		4 / 8 HIS A 148
LEU A 209
VAL A 188
SER A 158
 None
2OY  A 301 ( 4.2A)
None
None
 0.59A 5m8rC-4nsyA:
undetectable		 5m8rC-4nsyA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4nsy LYSYL ENDOPEPTIDASE
(Lysobacter
enzymogenes) 		4 / 8 HIS A 148
LEU A 209
VAL A 188
SER A 158
 None
2OY  A 301 ( 4.2A)
None
None
 0.63A 5m8rD-4nsyA:
undetectable		 5m8rD-4nsyA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 4nsy LYSYL ENDOPEPTIDASE
(Lysobacter
enzymogenes) 		4 / 7 GLY A 228
HIS A 177
HIS A  57
ASP A 113
 None
None
2OY  A 301 (-2.7A)
None
 0.84A 5nnwD-4nsyA:
undetectable		 5nnwD-4nsyA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 4nsy LYSYL ENDOPEPTIDASE
(Lysobacter
enzymogenes) 		4 / 7 GLY A 228
HIS A 177
HIS A  57
ASP A 113
 None
None
2OY  A 301 (-2.7A)
None
 0.85A 5no9D-4nsyA:
undetectable		 5no9D-4nsyA:
13.55