SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2OS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 1t3i PROBABLE CYSTEINE
DESULFURASE
(Synechocystis
sp.) 		5 / 12 SER A 385
PHE A 345
LEU A 321
LEU A 390
LEU A  32
 2OS  A 602 ( 3.9A)
None
None
None
None
 1.40A 1p33C-1t3iA:
2.9		 1p33C-1t3iA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 1t3i PROBABLE CYSTEINE
DESULFURASE
(Synechocystis
sp.) 		3 / 3 ASP A 152
LEU A 151
ARG A 328
 None
2OS  A 602 (-4.9A)
2OS  A 602 (-4.1A)
 0.89A 7dfrA-1t3iA:
undetectable		 7dfrA-1t3iA:
18.98