SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2OH'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5it1 PUTATIVE CYTOCHROME
P450

(Streptomyces
peucetius)
5 / 12 GLY A  83
ALA A 181
GLY A 232
ALA A 180
ILE A 236
None
2OH  A 402 (-3.9A)
2OH  A 402 ( 3.8A)
2OH  A 402 ( 3.8A)
None
0.90A 1gtnL-5it1A:
undetectable
1gtnV-5it1A:
undetectable
1gtnL-5it1A:
9.04
1gtnV-5it1A:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5it1 PUTATIVE CYTOCHROME
P450

(Streptomyces
peucetius)
5 / 12 GLY A 232
ALA A 180
ILE A 236
GLY A  83
ALA A 181
2OH  A 402 ( 3.8A)
2OH  A 402 ( 3.8A)
None
None
2OH  A 402 (-3.9A)
0.86A 1utdL-5it1A:
undetectable
1utdM-5it1A:
undetectable
1utdL-5it1A:
9.04
1utdM-5it1A:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5it1 PUTATIVE CYTOCHROME
P450

(Streptomyces
peucetius)
5 / 12 GLY A 232
ALA A 180
ILE A 236
GLY A  83
ALA A 181
2OH  A 402 ( 3.8A)
2OH  A 402 ( 3.8A)
None
None
2OH  A 402 (-3.9A)
0.85A 1utdO-5it1A:
undetectable
1utdP-5it1A:
undetectable
1utdO-5it1A:
9.04
1utdP-5it1A:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5it1 PUTATIVE CYTOCHROME
P450

(Streptomyces
peucetius)
5 / 11 GLY A 232
ALA A 180
ILE A 236
GLY A  83
ALA A 181
2OH  A 402 ( 3.8A)
2OH  A 402 ( 3.8A)
None
None
2OH  A 402 (-3.9A)
0.84A 1utdP-5it1A:
undetectable
1utdQ-5it1A:
undetectable
1utdP-5it1A:
9.04
1utdQ-5it1A:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)
5it1 PUTATIVE CYTOCHROME
P450

(Streptomyces
peucetius)
4 / 8 ILE A 236
GLY A 232
LEU A 193
LEU A 192
None
2OH  A 402 ( 3.8A)
None
None
0.93A 2vctC-5it1A:
undetectable
2vctC-5it1A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)
5it1 PUTATIVE CYTOCHROME
P450

(Streptomyces
peucetius)
5 / 12 LEU A 234
PHE A 155
ALA A 169
GLY A 190
LEU A 189
HEM  A 401 ( 4.4A)
None
None
2OH  A 402 ( 4.6A)
2OH  A 402 ( 4.3A)
1.00A 4j7xB-5it1A:
undetectable
4j7xB-5it1A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)
5it1 PUTATIVE CYTOCHROME
P450

(Streptomyces
peucetius)
5 / 12 GLY A 156
ARG A 161
VAL A 157
GLY A 190
GLY A 191
None
None
None
2OH  A 402 ( 4.6A)
None
1.12A 6brdB-5it1A:
undetectable
6brdB-5it1A:
13.42