SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2OB'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AOF_C_FRDC305_1 (POL POLYPROTEIN PEPTIDE INHIBITOR)	4f2a	CHOLESTERYL ESTER TRANSFER PROTEIN (Homo sapiens)	4 / 5	GLY A 256 PRO A 18 ALA A 19 ILE A 15	None None None 2OB A 605 (-3.8A)	0.87A	2aofA-4f2aA: undetectable	2aofA-4f2aA: 12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y69_C_CHDC1265_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 3)	4f2a	CHOLESTERYL ESTER TRANSFER PROTEIN (Homo sapiens)	4 / 5	PHE A 463 PHE A 461 LEU A 261 PHE A 263	2OB A 605 (-4.6A) 2OB A 605 (-3.9A) 0SF A 610 ( 4.3A) 0SF A 610 ( 4.1A)	1.22A	2y69C-4f2aA: undetectable 2y69J-4f2aA: undetectable	2y69C-4f2aA: 19.43 2y69J-4f2aA: 12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y69_P_CHDP1265_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 3)	4f2a	CHOLESTERYL ESTER TRANSFER PROTEIN (Homo sapiens)	4 / 5	PHE A 463 PHE A 461 LEU A 261 PHE A 263	2OB A 605 (-4.6A) 2OB A 605 (-3.9A) 0SF A 610 ( 4.3A) 0SF A 610 ( 4.1A)	1.29A	2y69P-4f2aA: undetectable 2y69W-4f2aA: undetectable	2y69P-4f2aA: 19.43 2y69W-4f2aA: 12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ABM_C_CHDC271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 3)	4f2a	CHOLESTERYL ESTER TRANSFER PROTEIN (Homo sapiens)	4 / 5	PHE A 463 PHE A 461 LEU A 261 PHE A 263	2OB A 605 (-4.6A) 2OB A 605 (-3.9A) 0SF A 610 ( 4.3A) 0SF A 610 ( 4.1A)	1.24A	3abmC-4f2aA: undetectable 3abmJ-4f2aA: undetectable	3abmC-4f2aA: 19.43 3abmJ-4f2aA: 13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ABM_P_CHDP1271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 3)	4f2a	CHOLESTERYL ESTER TRANSFER PROTEIN (Homo sapiens)	4 / 5	PHE A 463 PHE A 461 LEU A 261 PHE A 263	2OB A 605 (-4.6A) 2OB A 605 (-3.9A) 0SF A 610 ( 4.3A) 0SF A 610 ( 4.1A)	1.25A	3abmP-4f2aA: undetectable 3abmW-4f2aA: undetectable	3abmP-4f2aA: 19.43 3abmW-4f2aA: 13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AG3_C_CHDC271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 3)	4f2a	CHOLESTERYL ESTER TRANSFER PROTEIN (Homo sapiens)	4 / 5	PHE A 463 PHE A 461 LEU A 261 PHE A 263	2OB A 605 (-4.6A) 2OB A 605 (-3.9A) 0SF A 610 ( 4.3A) 0SF A 610 ( 4.1A)	1.25A	3ag3C-4f2aA: undetectable 3ag3J-4f2aA: undetectable	3ag3C-4f2aA: 19.43 3ag3J-4f2aA: 13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NUV_A_ASDA126_1 (STEROID DELTA-ISOMERASE)	4f2a	CHOLESTERYL ESTER TRANSFER PROTEIN (Homo sapiens)	5 / 12	PHE A 429 LEU A 455 PHE A 265 VAL A 269 PHE A 236	2OB A 606 (-3.5A) None PCW A 607 (-4.4A) None PCW A 607 (-4.5A)	1.40A	3nuvA-4f2aA: 1.8	3nuvA-4f2aA: 14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OZU_A_X89A411_1 (FLAVOHEMOPROTEIN)	4f2a	CHOLESTERYL ESTER TRANSFER PROTEIN (Homo sapiens)	5 / 12	ILE A 11 PHE A 263 LEU A 457 ALA A 373 LEU A 380	0SF A 610 (-3.2A) 0SF A 610 ( 4.1A) 2OB A 606 (-4.5A) 2OB A 606 ( 3.8A) None	0.99A	3ozuA-4f2aA: undetectable	3ozuA-4f2aA: 21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3R24_A_SAMA302_0 (2'-O-METHYL TRANSFERASE)	4f2a	CHOLESTERYL ESTER TRANSFER PROTEIN (Homo sapiens)	5 / 12	SER A 226 GLY A 256 LEU A 21 MET A 260 PHE A 461	None None None None 2OB A 605 (-3.9A)	1.43A	3r24A-4f2aA: undetectable	3r24A-4f2aA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_H_ZPCH1318_2 (CYS-LOOP LIGAND-GATED ION CHANNEL)	4f2a	CHOLESTERYL ESTER TRANSFER PROTEIN (Homo sapiens)	4 / 7	ILE A 367 GLU A 365 VAL A 311 PHE A 363	2OB A 606 (-4.7A) None None None	1.07A	4a97H-4f2aA: undetectable	4a97H-4f2aA: 20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FVQ_A_ACTA904_0 (TYROSINE-PROTEIN KINASE JAK2)	4f2a	CHOLESTERYL ESTER TRANSFER PROTEIN (Homo sapiens)	3 / 3	PHE A 348 VAL A 346 GLU A 365	None 2OB A 606 ( 4.9A) None	0.75A	4fvqA-4f2aA: 0.3	4fvqA-4f2aA: 18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WAU_C_CHDC306_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	4f2a	CHOLESTERYL ESTER TRANSFER PROTEIN (Homo sapiens)	4 / 5	PHE A 463 PHE A 461 LEU A 261 PHE A 263	2OB A 605 (-4.6A) 2OB A 605 (-3.9A) 0SF A 610 ( 4.3A) 0SF A 610 ( 4.1A)	1.20A	5wauC-4f2aA: undetectable 5wauJ-4f2aA: undetectable	5wauC-4f2aA: 19.43 5wauJ-4f2aA: 13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WAU_C_CHDC308_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	4f2a	CHOLESTERYL ESTER TRANSFER PROTEIN (Homo sapiens)	4 / 5	PHE A 463 PHE A 461 LEU A 261 PHE A 263	2OB A 605 (-4.6A) 2OB A 605 (-3.9A) 0SF A 610 ( 4.3A) 0SF A 610 ( 4.1A)	1.22A	5wauc-4f2aA: undetectable 5wauj-4f2aA: undetectable	5wauc-4f2aA: 19.43 5wauj-4f2aA: 13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XDQ_C_CHDC308_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	4f2a	CHOLESTERYL ESTER TRANSFER PROTEIN (Homo sapiens)	4 / 5	PHE A 463 PHE A 461 LEU A 261 PHE A 263	2OB A 605 (-4.6A) 2OB A 605 (-3.9A) 0SF A 610 ( 4.3A) 0SF A 610 ( 4.1A)	1.24A	5xdqC-4f2aA: undetectable 5xdqJ-4f2aA: undetectable	5xdqC-4f2aA: 19.43 5xdqJ-4f2aA: 13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XDQ_P_CHDP306_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	4f2a	CHOLESTERYL ESTER TRANSFER PROTEIN (Homo sapiens)	4 / 5	PHE A 463 PHE A 461 LEU A 261 PHE A 263	2OB A 605 (-4.6A) 2OB A 605 (-3.9A) 0SF A 610 ( 4.3A) 0SF A 610 ( 4.1A)	1.25A	5xdqP-4f2aA: undetectable 5xdqW-4f2aA: undetectable	5xdqP-4f2aA: 19.43 5xdqW-4f2aA: 13.91

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2AOF_C_FRDC305_1","POL POLYPROTEIN;PEPTIDE INHIBITOR","4f2a","CHOLESTERYL ESTER TRANSFER PROTEIN","Homo sapiens",4,"GLY A 256;PRO A  18;ALA A  19;ILE A  15","None;None;None;2OB A 605 (-3.8A)","0.87A","2aofA-4f2aA:undetectable",null],["2Y69_C_CHDC1265_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 3","4f2a","CHOLESTERYL ESTER TRANSFER PROTEIN","Homo sapiens",4,"PHE A 463;PHE A 461;LEU A 261;PHE A 263","2OB A 605 (-4.6A);2OB A 605 (-3.9A);0SF A 610 ( 4.3A);0SF A 610 ( 4.1A)","1.22A","2y69C-4f2aA:undetectable;2y69J-4f2aA:undetectable","2aofA-4f2aA:12.99"],["2Y69_P_CHDP1265_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 3","4f2a","CHOLESTERYL ESTER TRANSFER PROTEIN","Homo sapiens",4,"PHE A 463;PHE A 461;LEU A 261;PHE A 263","2OB A 605 (-4.6A);2OB A 605 (-3.9A);0SF A 610 ( 4.3A);0SF A 610 ( 4.1A)","1.29A","2y69P-4f2aA:undetectable;2y69W-4f2aA:undetectable","2y69C-4f2aA:19.43;2y69J-4f2aA:12.89"],["3ABM_C_CHDC271_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 3","4f2a","CHOLESTERYL ESTER TRANSFER PROTEIN","Homo sapiens",4,"PHE A 463;PHE A 461;LEU A 261;PHE A 263","2OB A 605 (-4.6A);2OB A 605 (-3.9A);0SF A 610 ( 4.3A);0SF A 610 ( 4.1A)","1.24A","3abmC-4f2aA:undetectable;3abmJ-4f2aA:undetectable","2y69P-4f2aA:19.43;2y69W-4f2aA:12.89"],["3ABM_P_CHDP1271_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 3","4f2a","CHOLESTERYL ESTER TRANSFER PROTEIN","Homo sapiens",4,"PHE A 463;PHE A 461;LEU A 261;PHE A 263","2OB A 605 (-4.6A);2OB A 605 (-3.9A);0SF A 610 ( 4.3A);0SF A 610 ( 4.1A)","1.25A","3abmP-4f2aA:undetectable;3abmW-4f2aA:undetectable","3abmC-4f2aA:19.43;3abmJ-4f2aA:13.91"],["3AG3_C_CHDC271_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 3","4f2a","CHOLESTERYL ESTER TRANSFER PROTEIN","Homo sapiens",4,"PHE A 463;PHE A 461;LEU A 261;PHE A 263","2OB A 605 (-4.6A);2OB A 605 (-3.9A);0SF A 610 ( 4.3A);0SF A 610 ( 4.1A)","1.25A","3ag3C-4f2aA:undetectable;3ag3J-4f2aA:undetectable","3abmP-4f2aA:19.43;3abmW-4f2aA:13.91"],["3NUV_A_ASDA126_1","STEROID DELTA-ISOMERASE","4f2a","CHOLESTERYL ESTER TRANSFER PROTEIN","Homo sapiens",5,"PHE A 429;LEU A 455;PHE A 265;VAL A 269;PHE A 236","2OB A 606 (-3.5A);None;PCW A 607 (-4.4A);None;PCW A 607 (-4.5A)","1.40A","3nuvA-4f2aA:1.8","3ag3C-4f2aA:19.43;3ag3J-4f2aA:13.91"],["3OZU_A_X89A411_1","FLAVOHEMOPROTEIN","4f2a","CHOLESTERYL ESTER TRANSFER PROTEIN","Homo sapiens",5,"ILE A  11;PHE A 263;LEU A 457;ALA A 373;LEU A 380","0SF A 610 (-3.2A);0SF A 610 ( 4.1A);2OB A 606 (-4.5A);2OB A 606 ( 3.8A);None","0.99A","3ozuA-4f2aA:undetectable","3nuvA-4f2aA:14.25"],["3R24_A_SAMA302_0","2'-O-METHYL TRANSFERASE","4f2a","CHOLESTERYL ESTER TRANSFER PROTEIN","Homo sapiens",5,"SER A 226;GLY A 256;LEU A  21;MET A 260;PHE A 461","None;None;None;None;2OB A 605 (-3.9A)","1.43A","3r24A-4f2aA:undetectable","3ozuA-4f2aA:21.78"],["4A97_H_ZPCH1318_2","CYS-LOOP LIGAND-GATED ION CHANNEL","4f2a","CHOLESTERYL ESTER TRANSFER PROTEIN","Homo sapiens",4,"ILE A 367;GLU A 365;VAL A 311;PHE A 363","2OB A 606 (-4.7A);None;None;None","1.07A","4a97H-4f2aA:undetectable","3r24A-4f2aA:undetectable"],["4FVQ_A_ACTA904_0","TYROSINE-PROTEIN KINASE JAK2","4f2a","CHOLESTERYL ESTER TRANSFER PROTEIN","Homo sapiens",3,"PHE A 348;VAL A 346;GLU A 365","None;2OB A 606 ( 4.9A);None","0.75A","4fvqA-4f2aA:0.3","4a97H-4f2aA:20.93"],["5WAU_C_CHDC306_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","4f2a","CHOLESTERYL ESTER TRANSFER PROTEIN","Homo sapiens",4,"PHE A 463;PHE A 461;LEU A 261;PHE A 263","2OB A 605 (-4.6A);2OB A 605 (-3.9A);0SF A 610 ( 4.3A);0SF A 610 ( 4.1A)","1.20A","5wauC-4f2aA:undetectable;5wauJ-4f2aA:undetectable","4fvqA-4f2aA:18.52"],["5WAU_C_CHDC308_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","4f2a","CHOLESTERYL ESTER TRANSFER PROTEIN","Homo sapiens",4,"PHE A 463;PHE A 461;LEU A 261;PHE A 263","2OB A 605 (-4.6A);2OB A 605 (-3.9A);0SF A 610 ( 4.3A);0SF A 610 ( 4.1A)","1.22A","5wauc-4f2aA:undetectable;5wauj-4f2aA:undetectable","5wauC-4f2aA:19.43;5wauJ-4f2aA:13.91"],["5XDQ_C_CHDC308_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","4f2a","CHOLESTERYL ESTER TRANSFER PROTEIN","Homo sapiens",4,"PHE A 463;PHE A 461;LEU A 261;PHE A 263","2OB A 605 (-4.6A);2OB A 605 (-3.9A);0SF A 610 ( 4.3A);0SF A 610 ( 4.1A)","1.24A","5xdqC-4f2aA:undetectable;5xdqJ-4f2aA:undetectable","5wauc-4f2aA:19.43;5wauj-4f2aA:13.91"],["5XDQ_P_CHDP306_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","4f2a","CHOLESTERYL ESTER TRANSFER PROTEIN","Homo sapiens",4,"PHE A 463;PHE A 461;LEU A 261;PHE A 263","2OB A 605 (-4.6A);2OB A 605 (-3.9A);0SF A 610 ( 4.3A);0SF A 610 ( 4.1A)","1.25A","5xdqP-4f2aA:undetectable;5xdqW-4f2aA:undetectable","5xdqC-4f2aA:19.43;5xdqJ-4f2aA:13.91"]]