SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2NG'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3SFU_A_RBVA601_1 (RNA POLYMERASE)	4nru	RNA DEPENDENT RNA POLYMERASE (Norwalk virus)	9 / 9	ASP A 247 SER A 300 THR A 305 THR A 306 ASN A 309 TYR A 341 GLY A 342 ASP A 343 ASP A 344	None None None None None 2NG A1101 ( 4.8A) None None MG A1102 (-3.4A)	0.22A	3sfuA-4nruA: 57.2	3sfuA-4nruA: 99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3SFU_B_RBVB601_1 (RNA POLYMERASE)	4nru	RNA DEPENDENT RNA POLYMERASE (Norwalk virus)	8 / 9	ASP A 247 THR A 306 ASN A 309 TYR A 341 GLY A 342 ASP A 343 ASP A 344 LEU A 391	None None None 2NG A1101 ( 4.8A) None None MG A1102 (-3.4A) 2NG A1101 ( 4.1A)	0.27A	3sfuB-4nruA: 56.7	3sfuB-4nruA: 99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3UR0_C_SVRC517_1 (RNA-DEPENDENT RNA POLYMERASE)	4nru	RNA DEPENDENT RNA POLYMERASE (Norwalk virus)	5 / 11	GLN A 66 GLU A 168 LYS A 180 ARG A 245 ARG A 392	None None None None 2NG A1101 (-3.7A)	0.86A	3ur0C-4nruA: 57.1	3ur0C-4nruA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5V1T_A_SAMA605_0 (RADICAL SAM)	4nru	RNA DEPENDENT RNA POLYMERASE (Norwalk virus)	5 / 12	LEU A 94 THR A 97 TYR A 341 THR A 306 GLU A 337	None None 2NG A1101 ( 4.8A) None None	1.27A	5v1tA-4nruA: undetectable	5v1tA-4nruA: 22.90

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3SFU_A_RBVA601_1","RNA POLYMERASE","4nru","RNA DEPENDENT RNA POLYMERASE","Norwalk virus",9,"ASP A 247;SER A 300;THR A 305;THR A 306;ASN A 309;TYR A 341;GLY A 342;ASP A 343;ASP A 344","None;None;None;None;None;2NG A1101 ( 4.8A);None;None; MG A1102 (-3.4A)","0.22A","3sfuA-4nruA:57.2",null],["3SFU_B_RBVB601_1","RNA POLYMERASE","4nru","RNA DEPENDENT RNA POLYMERASE","Norwalk virus",8,"ASP A 247;THR A 306;ASN A 309;TYR A 341;GLY A 342;ASP A 343;ASP A 344;LEU A 391","None;None;None;2NG A1101 ( 4.8A);None;None; MG A1102 (-3.4A);2NG A1101 ( 4.1A)","0.27A","3sfuB-4nruA:56.7","3sfuA-4nruA:99.42"],["3UR0_C_SVRC517_1","RNA-DEPENDENT RNA POLYMERASE","4nru","RNA DEPENDENT RNA POLYMERASE","Norwalk virus",5,"GLN A  66;GLU A 168;LYS A 180;ARG A 245;ARG A 392","None;None;None;None;2NG A1101 (-3.7A)","0.86A","3ur0C-4nruA:57.1","3sfuB-4nruA:99.42"],["5V1T_A_SAMA605_0","RADICAL SAM","4nru","RNA DEPENDENT RNA POLYMERASE","Norwalk virus",5,"LEU A  94;THR A  97;TYR A 341;THR A 306;GLU A 337","None;None;2NG A1101 ( 4.8A);None;None","1.27A","5v1tA-4nruA:undetectable","3ur0C-4nruA:100.00"]]