SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2MR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5vqh TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN HOMOLOG
(Bombyx
mori) 		5 / 10 ALA A  61
ALA A  72
VAL A 102
GLY A  67
ASP A  98
 None
None
None
None
2MR  A 501 (-2.8A)
 0.95A 2f16K-5vqhA:
undetectable
2f16L-5vqhA:
undetectable		 2f16K-5vqhA:
22.43
2f16L-5vqhA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5vqh TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN HOMOLOG
(Bombyx
mori) 		5 / 10 ALA A  61
ALA A  72
VAL A 102
GLY A  67
ASP A  98
 None
None
None
None
2MR  A 501 (-2.8A)
 0.96A 2f16Y-5vqhA:
undetectable
2f16Z-5vqhA:
undetectable		 2f16Y-5vqhA:
22.43
2f16Z-5vqhA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5vqh TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN HOMOLOG
(Bombyx
mori) 		5 / 11 ALA A  61
ALA A  72
VAL A 102
GLY A  67
ASP A  98
 None
None
None
None
2MR  A 501 (-2.8A)
 0.96A 3mg0K-5vqhA:
undetectable
3mg0L-5vqhA:
undetectable		 3mg0K-5vqhA:
22.43
3mg0L-5vqhA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5vqh TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN HOMOLOG
(Bombyx
mori) 		4 / 8 TRP A  69
TYR A  93
ARG A  68
MET A  35
 None
2MR  A 501 (-3.9A)
2MR  A 501 (-4.4A)
None
 1.38A 3wipB-5vqhA:
undetectable
3wipC-5vqhA:
undetectable		 3wipB-5vqhA:
22.56
3wipC-5vqhA:
22.56