SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2MO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 1dgj ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
desulfuricans) 		4 / 8 GLU A 495
ALA A 533
GLU A 432
ALA A 392
 None
2MO  A 910 ( 3.8A)
None
None
 0.89A 1ie4B-1dgjA:
undetectable
1ie4D-1dgjA:
undetectable		 1ie4B-1dgjA:
9.33
1ie4D-1dgjA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 1dgj ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
desulfuricans) 		5 / 12 THR A 422
GLY A 424
HIS A 366
LEU A 434
VAL A 435
 MCN  A 914 (-4.3A)
2MO  A 910 ( 3.5A)
None
None
None
 1.06A 1r30B-1dgjA:
undetectable		 1r30B-1dgjA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_O_CHDO3085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 1dgj ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
desulfuricans) 		5 / 11 ARG A 535
PHE A 423
GLY A 424
GLY A 699
GLN A 657
 MCN  A 914 ( 4.0A)
MCN  A 914 (-3.6A)
2MO  A 910 ( 3.5A)
MCN  A 914 (-4.6A)
MCN  A 914 (-3.7A)
 1.09A 1v54G-1dgjA:
0.0
1v54N-1dgjA:
0.0
1v54O-1dgjA:
0.0		 1v54G-1dgjA:
6.46
1v54N-1dgjA:
20.43
1v54O-1dgjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_O_CHDO3085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 1dgj ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
desulfuricans) 		5 / 11 ARG A 535
PHE A 423
GLY A 424
GLY A 699
GLN A 657
 MCN  A 914 ( 4.0A)
MCN  A 914 (-3.6A)
2MO  A 910 ( 3.5A)
MCN  A 914 (-4.6A)
MCN  A 914 (-3.7A)
 1.10A 1v55G-1dgjA:
0.0
1v55N-1dgjA:
0.0
1v55O-1dgjA:
0.0		 1v55G-1dgjA:
6.46
1v55N-1dgjA:
20.43
1v55O-1dgjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE
(Shewanella
massilia) 		4 / 8 PHE A  16
GLN A 659
TRP A 118
TRP A 198
 None
2MD  A 799 (-3.7A)
2MO  A 801 ( 3.9A)
None
 1.22A 2aoxA-1tmoA:
2.4		 2aoxA-1tmoA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_B_THAB401_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE
(Shewanella
massilia) 		4 / 7 PHE A  16
GLN A 659
TRP A 118
TRP A 198
 None
2MD  A 799 (-3.7A)
2MO  A 801 ( 3.9A)
None
 1.21A 2aoxB-1tmoA:
2.6		 2aoxB-1tmoA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 1dgj ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
desulfuricans) 		5 / 11 ARG A 535
PHE A 423
GLY A 424
GLY A 699
GLN A 657
 MCN  A 914 ( 4.0A)
MCN  A 914 (-3.6A)
2MO  A 910 ( 3.5A)
MCN  A 914 (-4.6A)
MCN  A 914 (-3.7A)
 1.13A 2dyrG-1dgjA:
0.0
2dyrN-1dgjA:
0.0
2dyrO-1dgjA:
0.0		 2dyrG-1dgjA:
6.46
2dyrN-1dgjA:
20.43
2dyrO-1dgjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 1dgj ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
desulfuricans) 		5 / 11 ARG A 535
PHE A 423
GLY A 424
GLY A 699
GLN A 657
 MCN  A 914 ( 4.0A)
MCN  A 914 (-3.6A)
2MO  A 910 ( 3.5A)
MCN  A 914 (-4.6A)
MCN  A 914 (-3.7A)
 1.11A 2eijG-1dgjA:
0.0
2eijN-1dgjA:
0.0
2eijO-1dgjA:
0.0		 2eijG-1dgjA:
6.46
2eijN-1dgjA:
20.43
2eijO-1dgjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 1dgj ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
desulfuricans) 		5 / 11 ARG A 535
PHE A 423
GLY A 424
GLY A 699
GLN A 657
 MCN  A 914 ( 4.0A)
MCN  A 914 (-3.6A)
2MO  A 910 ( 3.5A)
MCN  A 914 (-4.6A)
MCN  A 914 (-3.7A)
 1.13A 2eikG-1dgjA:
0.0
2eikN-1dgjA:
0.0
2eikO-1dgjA:
0.0		 2eikG-1dgjA:
6.46
2eikN-1dgjA:
20.43
2eikO-1dgjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 1dgj ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
desulfuricans) 		5 / 11 ARG A 535
PHE A 423
GLY A 424
GLY A 699
GLN A 657
 MCN  A 914 ( 4.0A)
MCN  A 914 (-3.6A)
2MO  A 910 ( 3.5A)
MCN  A 914 (-4.6A)
MCN  A 914 (-3.7A)
 1.12A 2eilG-1dgjA:
0.0
2eilN-1dgjA:
0.0
2eilO-1dgjA:
0.0		 2eilG-1dgjA:
6.46
2eilN-1dgjA:
20.43
2eilO-1dgjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1dgj ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
desulfuricans) 		5 / 8 TYR A 537
GLU A 495
GLY A 531
ALA A 533
ALA A 532
 None
None
None
2MO  A 910 ( 3.8A)
None
 1.34A 2ej3C-1dgjA:
undetectable		 2ej3C-1dgjA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 1dgj ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
desulfuricans) 		5 / 11 GLY A 699
GLN A 657
ARG A 535
PHE A 423
GLY A 424
 MCN  A 914 (-4.6A)
MCN  A 914 (-3.7A)
MCN  A 914 ( 4.0A)
MCN  A 914 (-3.6A)
2MO  A 910 ( 3.5A)
 1.10A 3ag3A-1dgjA:
0.0
3ag3B-1dgjA:
0.0
3ag3T-1dgjA:
0.0		 3ag3A-1dgjA:
20.43
3ag3B-1dgjA:
13.47
3ag3T-1dgjA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 1dgj ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
desulfuricans) 		5 / 11 ARG A 535
PHE A 423
GLY A 424
GLY A 699
GLN A 657
 MCN  A 914 ( 4.0A)
MCN  A 914 (-3.6A)
2MO  A 910 ( 3.5A)
MCN  A 914 (-4.6A)
MCN  A 914 (-3.7A)
 1.04A 3ag3G-1dgjA:
0.0
3ag3N-1dgjA:
0.0
3ag3O-1dgjA:
0.0		 3ag3G-1dgjA:
6.46
3ag3N-1dgjA:
20.43
3ag3O-1dgjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 1dgj ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
desulfuricans) 		5 / 11 GLY A 699
GLN A 657
ARG A 535
PHE A 423
GLY A 424
 MCN  A 914 (-4.6A)
MCN  A 914 (-3.7A)
MCN  A 914 ( 4.0A)
MCN  A 914 (-3.6A)
2MO  A 910 ( 3.5A)
 1.10A 3asoA-1dgjA:
0.0
3asoB-1dgjA:
0.0
3asoT-1dgjA:
0.0		 3asoA-1dgjA:
20.43
3asoB-1dgjA:
13.47
3asoT-1dgjA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 1dgj ALDEHYDE
OXIDOREDUCTASE
(Desulfovibrio
desulfuricans) 		4 / 5 HIS A 655
GLY A 424
TYR A 425
GLU A 370
 MCN  A 914 (-3.6A)
2MO  A 910 ( 3.5A)
None
None
 1.29A 4ae1B-1dgjA:
0.0		 4ae1B-1dgjA:
21.00