SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2KC'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GP0_A_NILA1_1 (MITOGEN-ACTIVATED PROTEIN KINASE 11)	4nfn	TAU-TUBULIN KINASE 1 (Homo sapiens)	6 / 12	ALA A 61 GLU A 77 LEU A 81 HIS A 152 ALA A 161 LEU A 175	2KC A 401 (-2.7A) 2KC A 401 (-1.9A) None None None 2KC A 401 ( 3.9A)	1.21A	3gp0A-4nfnA: 18.8	3gp0A-4nfnA: 25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FFW_B_715B801_1 (DIPEPTIDYL PEPTIDASE 4)	4nfn	TAU-TUBULIN KINASE 1 (Homo sapiens)	5 / 12	ARG A 119 GLU A 231 PHE A 126 SER A 158 TYR A 205	SO4 A 403 (-4.6A) SO4 A 403 ( 4.9A) None 2KC A 401 ( 3.1A) None	1.30A	4ffwB-4nfnA: 3.4	4ffwB-4nfnA: 17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HIE_A_P06A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4nfn	TAU-TUBULIN KINASE 1 (Homo sapiens)	4 / 7	GLY A 41 PHE A 93 ASP A 176 PHE A 177	2KC A 401 ( 3.2A) None 2KC A 401 (-2.7A) None	0.77A	5hieA-4nfnA: 4.6	5hieA-4nfnA: 23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HIE_A_P06A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4nfn	TAU-TUBULIN KINASE 1 (Homo sapiens)	4 / 7	ILE A 40 GLY A 41 PHE A 93 ASP A 176	2KC A 401 ( 3.9A) 2KC A 401 ( 3.2A) None 2KC A 401 (-2.7A)	0.66A	5hieA-4nfnA: 4.6	5hieA-4nfnA: 23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LW1_H_ADNH401_1 (MITOGEN-ACTIVATED PROTEIN KINASE 8)	4nfn	TAU-TUBULIN KINASE 1 (Homo sapiens)	5 / 9	ALA A 61 MET A 107 LEU A 109 ASN A 113 LEU A 175	2KC A 401 (-2.7A) 2KC A 401 (-4.1A) 2KC A 401 ( 4.7A) None 2KC A 401 ( 3.9A)	0.89A	5lw1H-4nfnA: 19.1	5lw1H-4nfnA: 11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LW1_H_ADNH401_1 (MITOGEN-ACTIVATED PROTEIN KINASE 8)	4nfn	TAU-TUBULIN KINASE 1 (Homo sapiens)	5 / 9	GLY A 41 ALA A 61 MET A 107 LEU A 109 LEU A 175	2KC A 401 ( 3.2A) 2KC A 401 (-2.7A) 2KC A 401 (-4.1A) 2KC A 401 ( 4.7A) 2KC A 401 ( 3.9A)	0.99A	5lw1H-4nfnA: 19.1	5lw1H-4nfnA: 11.73

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3GP0_A_NILA1_1","MITOGEN-ACTIVATED PROTEIN KINASE 11","4nfn","TAU-TUBULIN KINASE 1","Homo sapiens",6,"ALA A  61;GLU A  77;LEU A  81;HIS A 152;ALA A 161;LEU A 175","2KC A 401 (-2.7A);2KC A 401 (-1.9A);None;None;None;2KC A 401 ( 3.9A)","1.21A","3gp0A-4nfnA:18.8",null],["4FFW_B_715B801_1","DIPEPTIDYL PEPTIDASE 4","4nfn","TAU-TUBULIN KINASE 1","Homo sapiens",5,"ARG A 119;GLU A 231;PHE A 126;SER A 158;TYR A 205","SO4 A 403 (-4.6A);SO4 A 403 ( 4.9A);None;2KC A 401 ( 3.1A);None","1.30A","4ffwB-4nfnA:3.4","3gp0A-4nfnA:25.82"],["5HIE_A_P06A801_2","SERINE\/THREONINE-PROTEIN KINASE B-RAF","4nfn","TAU-TUBULIN KINASE 1","Homo sapiens",4,"GLY A  41;PHE A  93;ASP A 176;PHE A 177","2KC A 401 ( 3.2A);None;2KC A 401 (-2.7A);None","0.77A","5hieA-4nfnA:4.6","4ffwB-4nfnA:17.71"],["5HIE_A_P06A801_2","SERINE\/THREONINE-PROTEIN KINASE B-RAF","4nfn","TAU-TUBULIN KINASE 1","Homo sapiens",4,"ILE A  40;GLY A  41;PHE A  93;ASP A 176","2KC A 401 ( 3.9A);2KC A 401 ( 3.2A);None;2KC A 401 (-2.7A)","0.66A","5hieA-4nfnA:4.6","5hieA-4nfnA:23.48"],["5LW1_H_ADNH401_1","MITOGEN-ACTIVATED PROTEIN KINASE 8","4nfn","TAU-TUBULIN KINASE 1","Homo sapiens",5,"ALA A  61;MET A 107;LEU A 109;ASN A 113;LEU A 175","2KC A 401 (-2.7A);2KC A 401 (-4.1A);2KC A 401 ( 4.7A);None;2KC A 401 ( 3.9A)","0.89A","5lw1H-4nfnA:19.1","5hieA-4nfnA:23.48"],["5LW1_H_ADNH401_1","MITOGEN-ACTIVATED PROTEIN KINASE 8","4nfn","TAU-TUBULIN KINASE 1","Homo sapiens",5,"GLY A  41;ALA A  61;MET A 107;LEU A 109;LEU A 175","2KC A 401 ( 3.2A);2KC A 401 (-2.7A);2KC A 401 (-4.1A);2KC A 401 ( 4.7A);2KC A 401 ( 3.9A)","0.99A","5lw1H-4nfnA:19.1","5lw1H-4nfnA:11.73"]]