SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2HD'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 4n5i ESTERASE/LIPASE
(Lactobacillus
rhamnosus) 		5 / 12 GLY X  74
GLY X  75
GLY X  76
SER X 146
HIS X 278
 2HD  X 401 (-3.9A)
2HD  X 401 (-3.5A)
2HD  X 401 (-3.6A)
2HD  X 401 (-1.7A)
2HD  X 401 (-3.5A)
 0.29A 1dx6A-4n5iX:
20.2		 1dx6A-4n5iX:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 4n5i ESTERASE/LIPASE
(Lactobacillus
rhamnosus) 		4 / 8 GLY X  76
TYR X 206
SER X 146
HIS X 278
 2HD  X 401 (-3.6A)
2HD  X 401 ( 3.6A)
2HD  X 401 (-1.7A)
2HD  X 401 (-3.5A)
 0.87A 1maaD-4n5iX:
19.5		 1maaD-4n5iX:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 4n5i ESTERASE/LIPASE
(Lactobacillus
rhamnosus) 		5 / 12 GLY X  74
GLY X  75
GLY X  76
SER X 146
HIS X 278
 2HD  X 401 (-3.9A)
2HD  X 401 (-3.5A)
2HD  X 401 (-3.6A)
2HD  X 401 (-1.7A)
2HD  X 401 (-3.5A)
 0.25A 1qtiA-4n5iX:
19.2		 1qtiA-4n5iX:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4n5i ESTERASE/LIPASE
(Lactobacillus
rhamnosus) 		5 / 12 THR X 143
GLY X  74
GLY X 148
LEU X  84
TYR X  88
 None
2HD  X 401 (-3.9A)
None
None
None
 1.09A 1rjdA-4n5iX:
undetectable		 1rjdA-4n5iX:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4n5i ESTERASE/LIPASE
(Lactobacillus
rhamnosus) 		5 / 12 THR X 143
GLY X  74
GLY X 148
LEU X  84
TYR X  88
 None
2HD  X 401 (-3.9A)
None
None
None
 1.11A 1rjdB-4n5iX:
2.6		 1rjdB-4n5iX:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4n5i ESTERASE/LIPASE
(Lactobacillus
rhamnosus) 		5 / 12 THR X 143
GLY X  74
GLY X 148
LEU X  84
TYR X  88
 None
2HD  X 401 (-3.9A)
None
None
None
 1.10A 1rjdC-4n5iX:
2.5		 1rjdC-4n5iX:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 4n5i ESTERASE/LIPASE
(Lactobacillus
rhamnosus) 		5 / 12 GLY X  74
GLY X  75
GLY X  76
SER X 146
HIS X 278
 2HD  X 401 (-3.9A)
2HD  X 401 (-3.5A)
2HD  X 401 (-3.6A)
2HD  X 401 (-1.7A)
2HD  X 401 (-3.5A)
 0.27A 1w6rA-4n5iX:
20.1		 1w6rA-4n5iX:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 4n5i ESTERASE/LIPASE
(Lactobacillus
rhamnosus) 		5 / 10 GLY X  75
GLY X  76
TYR X 206
SER X 146
HIS X 278
 2HD  X 401 (-3.5A)
2HD  X 401 (-3.6A)
2HD  X 401 ( 3.6A)
2HD  X 401 (-1.7A)
2HD  X 401 (-3.5A)
 1.06A 1w76B-4n5iX:
19.4		 1w76B-4n5iX:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 4n5i ESTERASE/LIPASE
(Lactobacillus
rhamnosus) 		5 / 9 GLY X  74
GLY X  75
SER X 146
ALA X 147
HIS X 278
 2HD  X 401 (-3.9A)
2HD  X 401 (-3.5A)
2HD  X 401 (-1.7A)
2HD  X 401 (-3.4A)
2HD  X 401 (-3.5A)
 0.87A 2aceA-4n5iX:
19.7		 2aceA-4n5iX:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 4n5i ESTERASE/LIPASE
(Lactobacillus
rhamnosus) 		5 / 9 GLY X  75
GLY X  76
SER X 146
ALA X 147
HIS X 278
 2HD  X 401 (-3.5A)
2HD  X 401 (-3.6A)
2HD  X 401 (-1.7A)
2HD  X 401 (-3.4A)
2HD  X 401 (-3.5A)
 0.45A 2aceA-4n5iX:
19.7		 2aceA-4n5iX:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 4n5i ESTERASE/LIPASE
(Lactobacillus
rhamnosus) 		5 / 8 GLY X  75
GLY X  76
ALA X 147
PHE X 245
HIS X 278
 2HD  X 401 (-3.5A)
2HD  X 401 (-3.6A)
2HD  X 401 (-3.4A)
2HD  X 401 (-4.6A)
2HD  X 401 (-3.5A)
 1.23A 2ha4A-4n5iX:
20.6		 2ha4A-4n5iX:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 4n5i ESTERASE/LIPASE
(Lactobacillus
rhamnosus) 		4 / 7 GLY X  75
GLY X  76
ALA X 147
HIS X 278
 2HD  X 401 (-3.5A)
2HD  X 401 (-3.6A)
2HD  X 401 (-3.4A)
2HD  X 401 (-3.5A)
 0.32A 2ha4B-4n5iX:
20.9		 2ha4B-4n5iX:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4n5i ESTERASE/LIPASE
(Lactobacillus
rhamnosus) 		3 / 3 SER X  94
GLU X  29
ASP X  22
 None
None
2HD  X 401 ( 4.7A)
 0.53A 2zulA-4n5iX:
undetectable		 2zulA-4n5iX:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4n5i ESTERASE/LIPASE
(Lactobacillus
rhamnosus) 		5 / 12 THR X 143
GLY X  74
GLY X 148
LEU X  84
TYR X  88
 None
2HD  X 401 (-3.9A)
None
None
None
 1.10A 2zw9B-4n5iX:
3.0		 2zw9B-4n5iX:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4n5i ESTERASE/LIPASE
(Lactobacillus
rhamnosus) 		3 / 3 SER X  94
GLU X  29
ASP X  22
 None
None
2HD  X 401 ( 4.7A)
 0.54A 3dmhA-4n5iX:
undetectable		 3dmhA-4n5iX:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 4n5i ESTERASE/LIPASE
(Lactobacillus
rhamnosus) 		5 / 7 GLY X  75
GLY X  76
SER X 146
PHE X 245
HIS X 278
 2HD  X 401 (-3.5A)
2HD  X 401 (-3.6A)
2HD  X 401 (-1.7A)
2HD  X 401 (-4.6A)
2HD  X 401 (-3.5A)
 0.87A 3o9mA-4n5iX:
20.5		 3o9mA-4n5iX:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 4n5i ESTERASE/LIPASE
(Lactobacillus
rhamnosus) 		4 / 6 GLY X  75
GLY X  76
SER X 146
HIS X 278
 2HD  X 401 (-3.5A)
2HD  X 401 (-3.6A)
2HD  X 401 (-1.7A)
2HD  X 401 (-3.5A)
 0.57A 3o9mB-4n5iX:
20.6		 3o9mB-4n5iX:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 4n5i ESTERASE/LIPASE
(Lactobacillus
rhamnosus) 		5 / 12 GLY X  74
GLY X  75
GLY X  76
SER X 146
HIS X 278
 2HD  X 401 (-3.9A)
2HD  X 401 (-3.5A)
2HD  X 401 (-3.6A)
2HD  X 401 (-1.7A)
2HD  X 401 (-3.5A)
 0.26A 4ey6A-4n5iX:
20.9		 4ey6A-4n5iX:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 4n5i ESTERASE/LIPASE
(Lactobacillus
rhamnosus) 		5 / 12 GLY X  74
GLY X  75
GLY X  76
SER X 146
HIS X 278
 2HD  X 401 (-3.9A)
2HD  X 401 (-3.5A)
2HD  X 401 (-3.6A)
2HD  X 401 (-1.7A)
2HD  X 401 (-3.5A)
 0.23A 4ey6B-4n5iX:
19.6		 4ey6B-4n5iX:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 4n5i ESTERASE/LIPASE
(Lactobacillus
rhamnosus) 		5 / 11 GLY X 101
TYR X  56
TRP X  37
HIS X  73
GLY X  74
 None
None
None
None
2HD  X 401 (-3.9A)
 1.50A 4ey7B-4n5iX:
20.4		 4ey7B-4n5iX:
22.59