SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2FP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Bartonella
henselae) 		4 / 5 LYS A 223
GLU A 178
ALA A 261
LEU A  12
 2FP  A 350 (-2.2A)
2FP  A 350 (-2.6A)
None
None
 1.10A 1eta1-3mmtA:
undetectable		 1eta1-3mmtA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Bartonella
henselae) 		4 / 5 LYS A 223
GLU A 178
ALA A 261
LEU A  12
 2FP  A 350 (-2.2A)
2FP  A 350 (-2.6A)
None
None
 1.11A 1eta2-3mmtA:
undetectable		 1eta2-3mmtA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Bartonella
henselae) 		4 / 6 LYS A 223
GLU A 178
ALA A 261
LEU A  12
 2FP  A 350 (-2.2A)
2FP  A 350 (-2.6A)
None
None
 1.10A 1etb1-3mmtA:
undetectable		 1etb1-3mmtA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Bartonella
henselae) 		5 / 11 LYS A 223
GLU A 178
ALA A 261
LEU A  12
THR A 290
 2FP  A 350 (-2.2A)
2FP  A 350 (-2.6A)
None
None
None
 1.04A 1ictA-3mmtA:
undetectable
1ictC-3mmtA:
undetectable		 1ictA-3mmtA:
15.70
1ictC-3mmtA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Bartonella
henselae) 		4 / 6 LYS A 223
ALA A 261
LEU A  12
THR A 290
 2FP  A 350 (-2.2A)
None
None
None
 1.00A 1ictB-3mmtA:
undetectable		 1ictB-3mmtA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		5 / 11 GLU A1187
LEU A1270
ILE A1185
TYR A1213
THR A1205
 2FP  A5001 (-4.3A)
2FP  A5001 ( 3.9A)
None
None
None
 1.19A 1jomA-1fdjA:
undetectable		 1jomA-1fdjA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 8 ASP A 132
ASP A 233
GLU A 347
GLY A 267
 MG  A 403 ( 2.7A)
MG  A 401 (-2.5A)
MG  A 401 ( 4.0A)
2FP  A 400 (-4.4A)
 0.78A 1m4iA-1umgA:
undetectable		 1m4iA-1umgA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Bartonella
henselae) 		4 / 7 PHE A  53
ALA A  22
ILE A  29
GLU A  24
 None
None
None
2FP  A 350 ( 4.9A)
 0.93A 1oniA-3mmtA:
undetectable
1oniB-3mmtA:
undetectable		 1oniA-3mmtA:
19.88
1oniB-3mmtA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Bartonella
henselae) 		4 / 7 PHE A  53
ALA A  22
ILE A  29
GLU A  24
 None
None
None
2FP  A 350 ( 4.9A)
 0.89A 1oniD-3mmtA:
1.4
1oniF-3mmtA:
undetectable		 1oniD-3mmtA:
19.88
1oniF-3mmtA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Bartonella
henselae) 		4 / 7 ILE A  29
GLU A  24
PHE A  53
ALA A  22
 None
2FP  A 350 ( 4.9A)
None
None
 1.00A 1oniD-3mmtA:
undetectable
1oniE-3mmtA:
undetectable		 1oniD-3mmtA:
19.88
1oniE-3mmtA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Bartonella
henselae) 		4 / 7 ILE A  29
GLU A  24
PHE A  53
ALA A  22
 None
2FP  A 350 ( 4.9A)
None
None
 0.98A 1oniG-3mmtA:
undetectable
1oniI-3mmtA:
undetectable		 1oniG-3mmtA:
19.88
1oniI-3mmtA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3mbf FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Encephalitozoon
cuniculi) 		4 / 5 LEU A  72
GLY A  23
ALA A  27
ILE A  71
 None
None
None
2FP  A 345 ( 4.7A)
 0.84A 2aohB-3mbfA:
undetectable		 2aohB-3mbfA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Bartonella
henselae) 		5 / 6 LYS A 223
GLU A 178
ALA A 261
LEU A  12
THR A 290
 2FP  A 350 (-2.2A)
2FP  A 350 (-2.6A)
None
None
None
 1.19A 2roxB-3mmtA:
undetectable		 2roxB-3mmtA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 3mbf FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Encephalitozoon
cuniculi) 		3 / 3 PHE A 136
SER A 292
LEU A  25
 None
2FP  A 345 (-4.4A)
None
 0.69A 2w1bA-3mbfA:
undetectable		 2w1bA-3mbfA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Bartonella
henselae) 		3 / 3 PHE A 134
SER A 292
LEU A  20
 None
2FP  A 350 ( 4.7A)
None
 0.72A 2w1bA-3mmtA:
undetectable		 2w1bA-3mmtA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Bartonella
henselae) 		4 / 7 LYS A 223
ALA A 261
LEU A  12
THR A 290
 2FP  A 350 (-2.2A)
None
None
None
 0.94A 3cfqA-3mmtA:
undetectable
3cfqB-3mmtA:
undetectable		 3cfqA-3mmtA:
15.70
3cfqB-3mmtA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Bartonella
henselae) 		4 / 6 LYS A 223
ALA A 261
LEU A  12
THR A 290
 2FP  A 350 (-2.2A)
None
None
None
 0.91A 3d2tB-3mmtA:
undetectable		 3d2tB-3mmtA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		3 / 3 GLU A1187
LEU A1270
LEU A1030
 2FP  A5001 (-4.3A)
2FP  A5001 ( 3.9A)
None
 0.77A 3ohtB-1fdjA:
undetectable		 3ohtB-1fdjA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3mbf FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Encephalitozoon
cuniculi) 		5 / 12 GLY A 267
ASP A 299
ARG A  54
ALA A 294
ALA A  26
 None
None
None
2FP  A 345 (-3.5A)
2FP  A 345 (-3.4A)
 1.19A 3sueB-3mbfA:
undetectable		 3sueB-3mbfA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		5 / 12 LEU A1062
PHE A1063
GLY A1302
GLU A1034
GLN A1306
 None
None
2FP  A5001 (-3.6A)
None
None
 1.35A 3tbgA-1fdjA:
0.0		 3tbgA-1fdjA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		5 / 12 LEU A1062
PHE A1063
GLY A1302
GLU A1034
GLN A1306
 None
None
2FP  A5001 (-3.6A)
None
None
 1.35A 3tbgC-1fdjA:
0.0		 3tbgC-1fdjA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Bartonella
henselae) 		5 / 12 LEU A  52
PHE A  53
GLY A 294
GLU A  24
GLN A 298
 None
None
2FP  A 350 (-3.3A)
2FP  A 350 ( 4.9A)
None
 1.35A 3tbgC-3mmtA:
undetectable		 3tbgC-3mmtA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		5 / 12 THR A1122
VAL A1150
ASP A1193
ILE A1191
GLU A1187
 None
None
None
None
2FP  A5001 (-4.3A)
 1.30A 4i41A-1fdjA:
undetectable		 4i41A-1fdjA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		4 / 7 THR A1259
LEU A1151
ASN A1231
LEU A1270
 None
None
None
2FP  A5001 ( 3.9A)
 1.04A 4ib4A-1fdjA:
0.0		 4ib4A-1fdjA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Bartonella
henselae) 		4 / 7 LYS A 223
ALA A 261
LEU A  12
THR A 290
 2FP  A 350 (-2.2A)
None
None
None
 1.00A 4ikjA-3mmtA:
undetectable
4ikjB-3mmtA:
undetectable		 4ikjA-3mmtA:
15.70
4ikjB-3mmtA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		4 / 6 LEU A1283
LEU A1270
THR A1234
VAL A1248
 None
2FP  A5001 ( 3.9A)
None
None
 1.01A 4udaA-1fdjA:
0.0		 4udaA-1fdjA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Bartonella
henselae) 		4 / 8 ASN A 225
PRO A 224
PHE A 262
SER A 264
 None
None
None
2FP  A 350 (-2.3A)
 1.44A 5amiB-3mmtA:
undetectable		 5amiB-3mmtA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Bartonella
henselae) 		4 / 6 LYS A 223
ALA A 261
LEU A  12
THR A 290
 2FP  A 350 (-2.2A)
None
None
None
 1.06A 5bojA-3mmtA:
undetectable		 5bojA-3mmtA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Bartonella
henselae) 		5 / 12 PHE A 207
VAL A 206
PRO A 179
PHE A 262
GLY A 265
 None
None
None
None
2FP  A 350 (-3.5A)
 1.35A 5f9zB-3mmtA:
undetectable		 5f9zB-3mmtA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Bartonella
henselae) 		4 / 6 LYS A 223
ALA A 261
LEU A  12
THR A 290
 2FP  A 350 (-2.2A)
None
None
None
 0.99A 5l4iA-3mmtA:
undetectable		 5l4iA-3mmtA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 3mbf FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Encephalitozoon
cuniculi) 		4 / 8 ILE A 177
PHE A 291
LEU A 297
ALA A 294
 None
None
None
2FP  A 345 (-3.5A)
 0.87A 5y7pC-3mbfA:
undetectable		 5y7pC-3mbfA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 3mbf FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Encephalitozoon
cuniculi) 		3 / 3 PHE A  53
ARG A  37
ALA A  26
 None
2FP  A 345 ( 4.9A)
2FP  A 345 (-3.4A)
 0.85A 6ecfB-3mbfA:
2.4		 6ecfB-3mbfA:
23.37