SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2FA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JDV_A_ADNA1260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		6 / 10 ARG A  87
VAL A 178
GLU A 179
MET A 180
GLU A 181
ASP A 204
 PO4  A 309 ( 2.8A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 (-3.1A)
 0.36A 1jdvA-1pk9A:
33.4
1jdvD-1pk9A:
33.4		 1jdvA-1pk9A:
32.64
1jdvD-1pk9A:
32.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JDV_B_ADNB2260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		6 / 10 ARG A  87
VAL A 178
GLU A 179
MET A 180
GLU A 181
ASP A 204
 PO4  A 309 ( 2.8A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 (-3.1A)
 0.35A 1jdvB-1pk9A:
33.7
1jdvC-1pk9A:
34.6		 1jdvB-1pk9A:
32.64
1jdvC-1pk9A:
32.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JDV_D_ADND3260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		6 / 10 ARG A  87
VAL A 178
GLU A 179
MET A 180
GLU A 181
ASP A 204
 PO4  A 309 ( 2.8A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 (-3.1A)
 0.35A 1jdvA-1pk9A:
33.4
1jdvD-1pk9A:
33.4		 1jdvA-1pk9A:
32.64
1jdvD-1pk9A:
32.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		8 / 12 ARG A  87
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
SER A 203
ASP A 204
 PO4  A 309 ( 2.8A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 ( 3.9A)
2FA  A 306 (-3.1A)
 0.36A 1jdvE-1pk9A:
33.6
1jdvF-1pk9A:
34.6		 1jdvE-1pk9A:
32.64
1jdvF-1pk9A:
32.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		6 / 12 ARG A  87
GLY A 177
VAL A 178
GLU A 179
MET A 180
GLU A 181
 PO4  A 309 ( 2.8A)
None
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.38A 1jdvE-1pk9A:
33.6
1jdvF-1pk9A:
34.6		 1jdvE-1pk9A:
32.64
1jdvF-1pk9A:
32.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		8 / 11 MET A  64
ARG A  87
GLY A  92
GLU A 179
MET A 180
GLU A 181
SER A 203
ILE A 206
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 ( 3.9A)
None
 0.53A 1odiA-1pk9A:
34.8		 1odiA-1pk9A:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		8 / 11 MET A  64
ARG A  87
GLY A  92
GLU A 179
MET A 180
GLU A 181
SER A 203
ILE A 206
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 ( 3.9A)
None
 0.52A 1odiB-1pk9A:
34.5		 1odiB-1pk9A:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		8 / 11 MET A  64
ARG A  87
GLY A  92
GLU A 179
MET A 180
GLU A 181
SER A 203
ILE A 206
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 ( 3.9A)
None
 0.52A 1odiC-1pk9A:
34.9		 1odiC-1pk9A:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		8 / 11 MET A  64
ARG A  87
GLY A  92
GLU A 179
MET A 180
GLU A 181
SER A 203
ILE A 206
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 ( 3.9A)
None
 0.55A 1odiD-1pk9A:
34.8		 1odiD-1pk9A:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		8 / 11 MET A  64
ARG A  87
GLY A  92
GLU A 179
MET A 180
GLU A 181
SER A 203
ILE A 206
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 ( 3.9A)
None
 0.49A 1odiE-1pk9A:
34.8		 1odiE-1pk9A:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		8 / 11 MET A  64
ARG A  87
GLY A  92
GLU A 179
MET A 180
GLU A 181
SER A 203
ILE A 206
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 ( 3.9A)
None
 0.50A 1odiF-1pk9A:
34.6		 1odiF-1pk9A:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		5 / 9 ARG A  87
GLY A 177
GLU A 179
MET A 180
GLU A 181
 PO4  A 309 ( 2.8A)
None
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.10A 1pk7A-1pk9A:
44.1		 1pk7A-1pk9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		9 / 9 MET A  64
ARG A  87
SER A  90
GLY A  92
GLU A 179
MET A 180
GLU A 181
SER A 203
ASP A 204
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
PO4  A 309 ( 2.7A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 ( 3.9A)
2FA  A 306 (-3.1A)
 0.29A 1pk7A-1pk9A:
44.1		 1pk7A-1pk9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		8 / 8 ARG A  87
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
SER A 203
ILE A 206
 PO4  A 309 ( 2.8A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 ( 3.9A)
None
 0.42A 1pk7B-1pk9A:
43.2		 1pk7B-1pk9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		6 / 8 ARG A  87
GLY A 177
VAL A 178
GLU A 179
MET A 180
GLU A 181
 PO4  A 309 ( 2.8A)
None
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.35A 1pk7B-1pk9A:
43.2		 1pk7B-1pk9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		6 / 10 ARG A  87
GLY A 177
VAL A 178
GLU A 179
MET A 180
GLU A 181
 PO4  A 309 ( 2.8A)
None
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.42A 1pk7C-1pk9A:
42.4		 1pk7C-1pk9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		10 / 10 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
SER A 203
ASP A 204
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
PO4  A 309 ( 2.7A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 ( 3.9A)
2FA  A 306 (-3.1A)
 0.26A 1pk7C-1pk9A:
42.4		 1pk7C-1pk9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		5 / 10 ARG A  87
GLY A 177
GLU A 179
MET A 180
GLU A 181
 PO4  A 309 ( 2.8A)
None
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.08A 1pw7A-1pk9A:
45.0		 1pw7A-1pk9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		10 / 10 MET A  64
ARG A  87
SER A  90
GLY A  92
GLU A 179
MET A 180
GLU A 181
SER A 203
ASP A 204
ILE A 206
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
PO4  A 309 ( 2.7A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 ( 3.9A)
2FA  A 306 (-3.1A)
None
 0.25A 1pw7A-1pk9A:
45.0		 1pw7A-1pk9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		6 / 9 ARG A  87
GLY A 177
VAL A 178
GLU A 179
MET A 180
GLU A 181
 PO4  A 309 ( 2.8A)
None
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.43A 1pw7B-1pk9A:
43.3		 1pw7B-1pk9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		9 / 9 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
ILE A 206
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
PO4  A 309 ( 2.7A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
None
 0.18A 1pw7B-1pk9A:
43.3		 1pw7B-1pk9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_C_RABC647_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		9 / 9 MET A  64
SER A  90
VAL A 178
GLU A 179
MET A 180
GLU A 181
SER A 203
ASP A 204
ILE A 206
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.7A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 ( 3.9A)
2FA  A 306 (-3.1A)
None
 0.30A 1pw7C-1pk9A:
43.0		 1pw7C-1pk9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		6 / 11 ARG A  87
GLY A 177
VAL A 178
GLU A 179
MET A 180
GLU A 181
 PO4  A 309 ( 2.8A)
None
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.35A 1vhwA-1pk9A:
42.3
1vhwD-1pk9A:
42.6		 1vhwA-1pk9A:
79.75
1vhwD-1pk9A:
79.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		9 / 11 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
ILE A 206
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
PO4  A 309 ( 2.7A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
None
 0.33A 1vhwA-1pk9A:
42.3
1vhwD-1pk9A:
42.6		 1vhwA-1pk9A:
79.75
1vhwD-1pk9A:
79.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_B_ADNB252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		5 / 9 ARG A  87
GLY A 177
VAL A 178
MET A 180
GLU A 181
 PO4  A 309 ( 2.8A)
None
2FA  A 306 (-4.8A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.36A 1vhwB-1pk9A:
41.9
1vhwF-1pk9A:
41.5		 1vhwB-1pk9A:
79.75
1vhwF-1pk9A:
79.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_B_ADNB252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		7 / 9 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 178
MET A 180
GLU A 181
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
PO4  A 309 ( 2.7A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.8A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 0.24A 1vhwB-1pk9A:
41.9
1vhwF-1pk9A:
41.5		 1vhwB-1pk9A:
79.75
1vhwF-1pk9A:
79.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		6 / 11 ARG A  87
GLY A 177
VAL A 178
GLU A 179
MET A 180
GLU A 181
 PO4  A 309 ( 2.8A)
None
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.35A 1vhwC-1pk9A:
42.6
1vhwE-1pk9A:
42.2		 1vhwC-1pk9A:
79.75
1vhwE-1pk9A:
79.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		9 / 11 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
ILE A 206
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
PO4  A 309 ( 2.7A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
None
 0.29A 1vhwC-1pk9A:
42.6
1vhwE-1pk9A:
42.2		 1vhwC-1pk9A:
79.75
1vhwE-1pk9A:
79.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		6 / 11 ARG A  87
GLY A 177
VAL A 178
GLU A 179
MET A 180
GLU A 181
 PO4  A 309 ( 2.8A)
None
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.34A 1vhwA-1pk9A:
42.3
1vhwD-1pk9A:
42.6		 1vhwA-1pk9A:
79.75
1vhwD-1pk9A:
79.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		9 / 11 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
ILE A 206
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
PO4  A 309 ( 2.7A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
None
 0.28A 1vhwA-1pk9A:
42.3
1vhwD-1pk9A:
42.6		 1vhwA-1pk9A:
79.75
1vhwD-1pk9A:
79.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		6 / 11 ARG A  87
GLY A 177
VAL A 178
GLU A 179
MET A 180
GLU A 181
 PO4  A 309 ( 2.8A)
None
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.34A 1vhwC-1pk9A:
42.6
1vhwE-1pk9A:
42.2		 1vhwC-1pk9A:
79.75
1vhwE-1pk9A:
79.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		9 / 11 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
ILE A 206
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
PO4  A 309 ( 2.7A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
None
 0.33A 1vhwC-1pk9A:
42.6
1vhwE-1pk9A:
42.2		 1vhwC-1pk9A:
79.75
1vhwE-1pk9A:
79.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_F_ADNF252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		6 / 10 ARG A  87
GLY A 177
VAL A 178
GLU A 179
MET A 180
GLU A 181
 PO4  A 309 ( 2.8A)
None
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.35A 1vhwB-1pk9A:
41.9
1vhwF-1pk9A:
41.5		 1vhwB-1pk9A:
79.75
1vhwF-1pk9A:
79.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_F_ADNF252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		8 / 10 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
PO4  A 309 ( 2.7A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 0.24A 1vhwB-1pk9A:
41.9
1vhwF-1pk9A:
41.5		 1vhwB-1pk9A:
79.75
1vhwF-1pk9A:
79.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		6 / 10 ARG A  87
GLY A 177
VAL A 178
GLU A 179
MET A 180
GLU A 181
 PO4  A 309 ( 2.8A)
None
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.44A 1z35A-1pk9A:
38.5		 1z35A-1pk9A:
58.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		8 / 10 MET A  64
ARG A  87
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
SER A 203
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 ( 3.9A)
 0.32A 1z35A-1pk9A:
38.5		 1z35A-1pk9A:
58.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		6 / 9 ARG A  87
GLY A 177
VAL A 178
GLU A 179
MET A 180
GLU A 181
 PO4  A 309 ( 2.8A)
None
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.43A 1z37A-1pk9A:
38.2		 1z37A-1pk9A:
58.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		8 / 9 MET A  64
ARG A  87
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
SER A 203
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 ( 3.9A)
 0.36A 1z37A-1pk9A:
38.2		 1z37A-1pk9A:
58.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		6 / 11 ARG A  87
GLY A 177
VAL A 178
GLU A 179
MET A 180
GLU A 181
 PO4  A 309 ( 2.8A)
None
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.42A 2ac7A-1pk9A:
36.0
2ac7B-1pk9A:
36.1		 2ac7A-1pk9A:
55.74
2ac7B-1pk9A:
55.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		8 / 11 MET A  64
ARG A  87
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
ASP A 204
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 (-3.1A)
 0.38A 2ac7A-1pk9A:
36.0
2ac7B-1pk9A:
36.1		 2ac7A-1pk9A:
55.74
2ac7B-1pk9A:
55.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		6 / 11 ARG A  87
GLY A 177
VAL A 178
GLU A 179
MET A 180
GLU A 181
 PO4  A 309 ( 2.8A)
None
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.42A 2ac7A-1pk9A:
36.0
2ac7B-1pk9A:
36.1		 2ac7A-1pk9A:
55.74
2ac7B-1pk9A:
55.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		8 / 11 MET A  64
ARG A  87
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
ASP A 204
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 (-3.1A)
 0.38A 2ac7A-1pk9A:
36.0
2ac7B-1pk9A:
36.1		 2ac7A-1pk9A:
55.74
2ac7B-1pk9A:
55.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		3 / 3 MET A 180
MET A 166
PHE A 159
 2FA  A 306 (-3.8A)
None
2FA  A 306 (-4.4A)
 1.12A 3gn8A-1pk9A:
0.0		 3gn8A-1pk9A:
22.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U40_A_ADNA251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		7 / 9 MET A  64
ARG A  87
SER A  90
VAL A 178
GLU A 179
MET A 180
GLU A 181
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
PO4  A 309 ( 2.7A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 0.52A 3u40A-1pk9A:
36.0
3u40F-1pk9A:
35.2		 3u40A-1pk9A:
48.35
3u40F-1pk9A:
48.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U40_B_ADNB251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		7 / 10 MET A  64
ARG A  87
SER A  90
VAL A 178
GLU A 179
MET A 180
GLU A 181
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
PO4  A 309 ( 2.7A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 0.48A 3u40B-1pk9A:
35.7
3u40C-1pk9A:
35.6		 3u40B-1pk9A:
48.35
3u40C-1pk9A:
48.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 GLY A 177
VAL A 178
GLU A 179
MET A 180
GLU A 181
 None
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.44A 3u40B-1pk9A:
35.7
3u40C-1pk9A:
35.6		 3u40B-1pk9A:
48.35
3u40C-1pk9A:
48.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		9 / 12 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
ASP A 204
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
PO4  A 309 ( 2.7A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 (-3.1A)
 0.39A 3u40B-1pk9A:
35.7
3u40C-1pk9A:
35.6		 3u40B-1pk9A:
48.35
3u40C-1pk9A:
48.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U40_D_ADND251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		6 / 11 ARG A  87
GLY A 177
VAL A 178
GLU A 179
MET A 180
GLU A 181
 PO4  A 309 ( 2.8A)
None
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.39A 3u40D-1pk9A:
35.8
3u40E-1pk9A:
17.6		 3u40D-1pk9A:
48.35
3u40E-1pk9A:
48.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U40_D_ADND251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		9 / 11 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
ASP A 204
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
PO4  A 309 ( 2.7A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 (-3.1A)
 0.37A 3u40D-1pk9A:
35.8
3u40E-1pk9A:
17.6		 3u40D-1pk9A:
48.35
3u40E-1pk9A:
48.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 GLY A 177
VAL A 178
GLU A 179
MET A 180
GLU A 181
 None
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.46A 3u40D-1pk9A:
35.8
3u40E-1pk9A:
17.6		 3u40D-1pk9A:
48.35
3u40E-1pk9A:
48.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		9 / 12 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
ASP A 204
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
PO4  A 309 ( 2.7A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 (-3.1A)
 0.42A 3u40D-1pk9A:
35.8
3u40E-1pk9A:
17.6		 3u40D-1pk9A:
48.35
3u40E-1pk9A:
48.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U40_F_ADNF251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		8 / 10 MET A  64
ARG A  87
SER A  90
VAL A 178
GLU A 179
MET A 180
GLU A 181
ASP A 204
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
PO4  A 309 ( 2.7A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 (-3.1A)
 0.67A 3u40A-1pk9A:
36.0
3u40F-1pk9A:
35.2		 3u40A-1pk9A:
48.35
3u40F-1pk9A:
48.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		10 / 11 MET A  64
ARG A  87
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
SER A 203
ASP A 204
ILE A 206
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 ( 3.9A)
2FA  A 306 (-3.1A)
None
 0.46A 3uawA-1pk9A:
36.7		 3uawA-1pk9A:
55.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		6 / 10 ARG A  87
GLY A 177
VAL A 178
GLU A 179
MET A 180
GLU A 181
 PO4  A 309 ( 2.8A)
None
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.42A 3uayA-1pk9A:
37.4		 3uayA-1pk9A:
55.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		8 / 10 MET A  64
ARG A  87
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
ILE A 206
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
None
 0.41A 3uayA-1pk9A:
37.4		 3uayA-1pk9A:
55.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		6 / 11 ARG A  87
GLY A 177
VAL A 178
GLU A 179
MET A 180
GLU A 181
 PO4  A 309 ( 2.8A)
None
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.33A 4d9hA-1pk9A:
37.2		 4d9hA-1pk9A:
53.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		5 / 11 ARG A  87
GLY A 177
VAL A 178
GLU A 179
VAL A  94
 PO4  A 309 ( 2.8A)
None
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
None
 1.18A 4d9hA-1pk9A:
37.2		 4d9hA-1pk9A:
53.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		10 / 11 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
SER A 203
ASP A 204
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
PO4  A 309 ( 2.7A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 ( 3.9A)
2FA  A 306 (-3.1A)
 0.61A 4d9hA-1pk9A:
37.2		 4d9hA-1pk9A:
53.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		7 / 9 MET A  64
SER A  90
GLY A  92
MET A 180
GLU A 181
SER A 203
ASP A 204
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.7A)
2FA  A 306 (-3.5A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 ( 3.9A)
2FA  A 306 (-3.1A)
 0.81A 4da6A-1pk9A:
36.7		 4da6A-1pk9A:
53.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		7 / 9 MET A  64
SER A  90
GLY A  92
VAL A 178
MET A 180
GLU A 181
ASP A 204
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.7A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.8A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 (-3.1A)
 0.69A 4da6A-1pk9A:
36.7		 4da6A-1pk9A:
53.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		7 / 10 ARG A  87
GLY A 177
ALA A 156
VAL A 178
GLU A 179
MET A 180
GLU A 181
 PO4  A 309 ( 2.8A)
None
2FA  A 306 ( 4.2A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.26A 4da7A-1pk9A:
37.1		 4da7A-1pk9A:
53.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		6 / 10 ARG A  87
GLY A 177
ALA A 156
VAL A 178
GLU A 179
VAL A  94
 PO4  A 309 ( 2.8A)
None
2FA  A 306 ( 4.2A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
None
 1.23A 4da7A-1pk9A:
37.1		 4da7A-1pk9A:
53.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		9 / 10 MET A  64
ARG A  87
GLY A  92
ALA A 156
VAL A 178
GLU A 179
MET A 180
GLU A 181
SER A 203
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
2FA  A 306 (-3.5A)
2FA  A 306 ( 4.2A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 ( 3.9A)
 0.42A 4da7A-1pk9A:
37.1		 4da7A-1pk9A:
53.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		6 / 11 ARG A  87
GLY A 177
VAL A 178
GLU A 179
GLU A 181
VAL A  94
 PO4  A 309 ( 2.8A)
None
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-2.9A)
None
 1.33A 4danA-1pk9A:
36.5		 4danA-1pk9A:
53.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		6 / 11 ARG A  87
GLY A 177
VAL A 178
GLU A 179
MET A 180
GLU A 181
 PO4  A 309 ( 2.8A)
None
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.31A 4danA-1pk9A:
36.5		 4danA-1pk9A:
53.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		10 / 11 MET A  64
ARG A  87
SER A  90
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
SER A 203
ASP A 204
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
PO4  A 309 ( 2.7A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 ( 3.9A)
2FA  A 306 (-3.1A)
 0.63A 4danA-1pk9A:
36.5		 4danA-1pk9A:
53.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		6 / 12 ARG A  87
GLY A 177
VAL A 178
GLU A 179
MET A 180
GLU A 181
 PO4  A 309 ( 2.8A)
None
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.30A 4danA-1pk9A:
36.5
4danB-1pk9A:
36.9		 4danA-1pk9A:
53.15
4danB-1pk9A:
53.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 ARG A  87
GLY A 177
VAL A 178
GLU A 179
VAL A  94
 PO4  A 309 ( 2.8A)
None
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
None
 1.10A 4danA-1pk9A:
36.5
4danB-1pk9A:
36.9		 4danA-1pk9A:
53.15
4danB-1pk9A:
53.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		9 / 12 ARG A  87
SER A  90
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
SER A 203
ASP A 204
 PO4  A 309 ( 2.8A)
PO4  A 309 ( 2.7A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 ( 3.9A)
2FA  A 306 (-3.1A)
 0.66A 4danA-1pk9A:
36.5
4danB-1pk9A:
36.9		 4danA-1pk9A:
53.15
4danB-1pk9A:
53.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		3 / 3 MET A 180
MET A 166
TYR A 160
 2FA  A 306 (-3.8A)
None
None
 0.73A 4p6xI-1pk9A:
undetectable		 4p6xI-1pk9A:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		6 / 9 ARG A  87
GLY A 177
ALA A 156
VAL A 178
MET A 180
GLU A 181
 PO4  A 309 ( 2.8A)
None
2FA  A 306 ( 4.2A)
2FA  A 306 (-4.8A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.29A 5i3cA-1pk9A:
42.8		 5i3cA-1pk9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		9 / 9 MET A  64
ARG A  87
SER A  90
GLY A  92
ALA A 156
VAL A 178
MET A 180
GLU A 181
ILE A 206
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.8A)
PO4  A 309 ( 2.7A)
2FA  A 306 (-3.5A)
2FA  A 306 ( 4.2A)
2FA  A 306 (-4.8A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
None
 0.22A 5i3cA-1pk9A:
42.8		 5i3cA-1pk9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		6 / 10 GLY A 177
ALA A 156
VAL A 178
GLU A 179
MET A 180
GLU A 181
 None
2FA  A 306 ( 4.2A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.39A 5i3cB-1pk9A:
43.0		 5i3cB-1pk9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		9 / 10 MET A  64
SER A  90
GLY A  92
ALA A 156
VAL A 178
GLU A 179
MET A 180
GLU A 181
ILE A 206
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.7A)
2FA  A 306 (-3.5A)
2FA  A 306 ( 4.2A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
None
 0.37A 5i3cB-1pk9A:
43.0		 5i3cB-1pk9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		6 / 11 GLY A 177
ALA A 156
VAL A 178
GLU A 179
MET A 180
GLU A 181
 None
2FA  A 306 ( 4.2A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.37A 5i3cC-1pk9A:
43.4		 5i3cC-1pk9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		7 / 11 MET A  64
ALA A 156
VAL A 178
MET A 180
SER A 203
ASP A 204
ILE A 206
 2FA  A 306 (-3.6A)
2FA  A 306 ( 4.2A)
2FA  A 306 (-4.8A)
2FA  A 306 (-3.8A)
2FA  A 306 ( 3.9A)
2FA  A 306 (-3.1A)
None
 0.75A 5i3cC-1pk9A:
43.4		 5i3cC-1pk9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		10 / 11 MET A  64
SER A  90
GLY A  92
ALA A 156
VAL A 178
GLU A 179
MET A 180
GLU A 181
SER A 203
ILE A 206
 2FA  A 306 (-3.6A)
PO4  A 309 ( 2.7A)
2FA  A 306 (-3.5A)
2FA  A 306 ( 4.2A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 ( 3.9A)
None
 0.22A 5i3cC-1pk9A:
43.4		 5i3cC-1pk9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNC_A_QI9A301_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Escherichia
coli) 		5 / 9 SER A  90
GLY A  92
VAL A 178
GLU A 179
MET A 180
 PO4  A 309 ( 2.7A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
 0.38A 5zncA-1pk9A:
17.4		 5zncA-1pk9A:
28.02