SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2DG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 4ccd GALACTOCEREBROSIDASE
(Mus
musculus) 		6 / 12 TRP A 135
ASN A 181
GLU A 182
HIS A 237
TYR A 238
GLU A 258
 2DG  A1001 (-4.1A)
2DG  A1001 ( 4.2A)
2DG  A1001 (-3.5A)
None
2DG  A1001 (-4.8A)
2DG  A1001 (-1.6A)
 0.61A 2v3dA-4ccdA:
28.6		 2v3dA-4ccdA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 4ccd GALACTOCEREBROSIDASE
(Mus
musculus) 		6 / 12 TRP A 135
ASN A 181
GLU A 182
HIS A 237
TYR A 238
SER A 261
 2DG  A1001 (-4.1A)
2DG  A1001 ( 4.2A)
2DG  A1001 (-3.5A)
None
2DG  A1001 (-4.8A)
2DG  A1001 (-2.6A)
 1.11A 2v3dA-4ccdA:
28.6		 2v3dA-4ccdA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 4ccd GALACTOCEREBROSIDASE
(Mus
musculus) 		5 / 11 TRP A 135
ASN A 181
GLU A 182
TYR A 238
GLU A 258
 2DG  A1001 (-4.1A)
2DG  A1001 ( 4.2A)
2DG  A1001 (-3.5A)
2DG  A1001 (-4.8A)
2DG  A1001 (-1.6A)
 0.68A 2v3dB-4ccdA:
28.5		 2v3dB-4ccdA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4ccd GALACTOCEREBROSIDASE
(Mus
musculus) 		3 / 3 TYR A 238
GLU A 182
THR A  93
 2DG  A1001 (-4.8A)
2DG  A1001 (-3.5A)
2DG  A1001 (-3.0A)
 0.69A 2y7hB-4ccdA:
undetectable		 2y7hB-4ccdA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4ccd GALACTOCEREBROSIDASE
(Mus
musculus) 		5 / 12 GLY A  48
GLY A  49
SER A  99
ALA A 525
ASP A 527
 2DG  A1001 (-3.5A)
None
None
None
None
 1.16A 3i5uB-4ccdA:
2.3		 3i5uB-4ccdA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 4ccd GALACTOCEREBROSIDASE
(Mus
musculus) 		4 / 6 GLU A 182
ARG A 183
GLU A 258
ARG A 380
 2DG  A1001 (-3.5A)
None
2DG  A1001 (-1.6A)
None
 1.45A 4kr3A-4ccdA:
undetectable		 4kr3A-4ccdA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4ccd GALACTOCEREBROSIDASE
(Mus
musculus) 		3 / 3 VAL A  45
SER A  46
TRP A 291
 None
None
2DG  A1001 ( 3.7A)
 1.00A 5jwaA-4ccdA:
undetectable		 5jwaA-4ccdA:
22.47