SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2DE'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 ILE B 139
LEU B 181
HIS B  83
LEU B 120
ILE B 123
 None
None
2DE  B 329 ( 4.5A)
None
None
 1.24A 1fmlB-3aqcB:
undetectable		 1fmlB-3aqcB:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 SER A 107
VAL B  82
HIS B  83
LEU B 115
HIS B 113
 None
None
2DE  B 329 ( 4.5A)
None
None
 1.18A 1ie9A-3aqcA:
3.0		 1ie9A-3aqcA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 11 ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.92A 1rqjA-3aqcB:
30.7		 1rqjA-3aqcB:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 11 SER B  80
LEU B  81
ASP B  84
ARG B  93
LYS B 170
THR B 171
GLN B 208
 2DE  B 329 (-3.6A)
None
MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.81A 1rqjA-3aqcB:
30.7		 1rqjA-3aqcB:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 11 SER B  80
LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 2DE  B 329 (-3.6A)
None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.76A 1rqjA-3aqcB:
30.7		 1rqjA-3aqcB:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 11 ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.91A 1rqjB-3aqcB:
30.8		 1rqjB-3aqcB:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 11 SER B  80
LEU B  81
ASP B  84
ARG B  93
LYS B 170
THR B 171
GLN B 208
 2DE  B 329 (-3.6A)
None
MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.79A 1rqjB-3aqcB:
30.8		 1rqjB-3aqcB:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 11 SER B  80
LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 2DE  B 329 (-3.6A)
None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.75A 1rqjB-3aqcB:
30.8		 1rqjB-3aqcB:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		3 / 3 ASP B 212
GLU B 146
ARG B  48
 None
2DE  B 329 (-3.9A)
None
 0.77A 1wopA-3aqcB:
undetectable		 1wopA-3aqcB:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 11 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.03A 1yhlA-3aqcB:
28.2		 1yhlA-3aqcB:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 11 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.85A 1yhlA-3aqcB:
28.2		 1yhlA-3aqcB:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 11 ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.99A 1yq7A-3aqcB:
27.8		 1yq7A-3aqcB:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 11 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.86A 1yq7A-3aqcB:
27.8		 1yq7A-3aqcB:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.03A 1yv5A-3aqcB:
28.1		 1yv5A-3aqcB:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.85A 1yv5A-3aqcB:
28.1		 1yv5A-3aqcB:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.93A 1zw5A-3aqcB:
28.2		 1zw5A-3aqcB:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  88
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.96A 1zw5A-3aqcB:
28.2		 1zw5A-3aqcB:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ARG B  93
LYS B 170
THR B 171
GLN B 208
 MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.85A 2e91A-3aqcB:
23.2		 2e91A-3aqcB:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ARG B  93
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
None
None
MG  B 328 (-3.1A)
 0.85A 2e91A-3aqcB:
23.2		 2e91A-3aqcB:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.79A 2e91A-3aqcB:
23.2		 2e91A-3aqcB:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ASP B  88
ARG B  93
THR B 171
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
None
MG  B 328 (-3.1A)
 0.91A 2e91A-3aqcB:
23.2		 2e91A-3aqcB:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.06A 2e91B-3aqcB:
22.0		 2e91B-3aqcB:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.96A 2f89F-3aqcB:
28.7		 2f89F-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 11 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.05A 2f8cF-3aqcB:
28.5		 2f8cF-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 11 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.85A 2f8cF-3aqcB:
28.5		 2f8cF-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 10 ASP B  84
ASP B  88
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.98A 2f8zF-3aqcB:
28.6		 2f8zF-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.83A 2f8zF-3aqcB:
28.6		 2f8zF-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 12 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.00A 2f94F-3aqcB:
28.3		 2f94F-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 12 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.78A 2f94F-3aqcB:
28.3		 2f94F-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.00A 2f9kF-3aqcB:
28.4		 2f9kF-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.81A 2f9kF-3aqcB:
28.4		 2f9kF-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 9 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.67A 2o1oA-3aqcB:
26.2		 2o1oA-3aqcB:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 9 LEU B  81
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.95A 2o1oA-3aqcB:
26.2		 2o1oA-3aqcB:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 10 LEU B  81
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.99A 2o1oB-3aqcB:
26.9		 2o1oB-3aqcB:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.92A 2o1oB-3aqcB:
26.9		 2o1oB-3aqcB:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 1.05A 2q58A-3aqcB:
26.3		 2q58A-3aqcB:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 1.00A 2q58B-3aqcB:
26.7		 2q58B-3aqcB:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 1.15A 2q58B-3aqcB:
26.7		 2q58B-3aqcB:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 10 ASP B  84
ASP B  88
ARG B  93
LYS B 170
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
MG  B 328 (-3.1A)
 1.07A 2qisA-3aqcB:
28.4		 2qisA-3aqcB:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.83A 2qisA-3aqcB:
28.4		 2qisA-3aqcB:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 6 LEU B 174
ALA B  79
LEU B 116
ALA B 119
 None
2DE  B 329 ( 4.4A)
2DE  B 329 ( 4.6A)
None
 0.98A 2vcvB-3aqcB:
1.7		 2vcvB-3aqcB:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 7 LEU B 174
ALA B  79
LEU B 116
ALA B 119
 None
2DE  B 329 ( 4.4A)
2DE  B 329 ( 4.6A)
None
 0.99A 2vcvG-3aqcB:
undetectable		 2vcvG-3aqcB:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 6 LEU B 174
ALA B  79
LEU B 116
ALA B 119
 None
2DE  B 329 ( 4.4A)
2DE  B 329 ( 4.6A)
None
 0.97A 2vcvK-3aqcB:
undetectable		 2vcvK-3aqcB:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ARG B  93
LYS B 170
THR B 171
GLN B 208
 MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.82A 3ez3A-3aqcB:
28.6		 3ez3A-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.83A 3ez3A-3aqcB:
28.6		 3ez3A-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.95A 3ez3B-3aqcB:
28.3		 3ez3B-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ARG B  93
LYS B 170
THR B 171
GLN B 208
 MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.85A 3ez3B-3aqcB:
28.3		 3ez3B-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.79A 3ez3B-3aqcB:
28.3		 3ez3B-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ARG B  93
LYS B 170
THR B 171
GLN B 208
 MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.84A 3ez3C-3aqcB:
28.7		 3ez3C-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.83A 3ez3C-3aqcB:
28.7		 3ez3C-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.82A 3ez3D-3aqcB:
28.0		 3ez3D-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 10 LEU B  81
ASP B  88
LYS B 170
THR B 171
GLN B 208
ASP B 211
 None
MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.98A 3ez3D-3aqcB:
28.0		 3ez3D-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 8 ASP A  73
SER A  76
ASP A  58
TYR B  86
 2DE  B 329 (-3.4A)
None
None
None
 1.21A 3havA-3aqcA:
2.6		 3havA-3aqcA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.06A 3ibaA-3aqcB:
28.1		 3ibaA-3aqcB:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.85A 3ldwA-3aqcB:
28.6		 3ldwA-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ARG B  93
LYS B 170
THR B 171
GLN B 208
 MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.84A 3ldwA-3aqcB:
28.6		 3ldwA-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.87A 3ldwA-3aqcB:
28.6		 3ldwA-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ARG B  93
LYS B 170
THR B 171
GLN B 208
 MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.84A 3ldwB-3aqcB:
28.3		 3ldwB-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.79A 3ldwB-3aqcB:
28.3		 3ldwB-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.89A 3ldwC-3aqcB:
28.5		 3ldwC-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ARG B  93
LYS B 170
THR B 171
GLN B 208
 MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.85A 3ldwC-3aqcB:
28.5		 3ldwC-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.85A 3ldwC-3aqcB:
28.5		 3ldwC-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  88
ARG B  93
LYS B 170
THR B 171
ASP B 211
 MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
MG  B 328 (-3.1A)
 1.04A 3ldwC-3aqcB:
28.5		 3ldwC-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ARG B  93
LYS B 170
THR B 171
GLN B 208
 MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.81A 3ldwD-3aqcB:
28.1		 3ldwD-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.80A 3ldwD-3aqcB:
28.1		 3ldwD-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 LEU B  73
LEU B 116
THR B 138
ILE B 139
ALA B 119
 None
2DE  B 329 ( 4.6A)
None
None
None
 0.97A 3mdvB-3aqcB:
undetectable		 3mdvB-3aqcB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 11 ASP B  84
ASP B  88
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.01A 3n45F-3aqcB:
28.5		 3n45F-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 11 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.84A 3n45F-3aqcB:
28.5		 3n45F-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.98A 3n46F-3aqcB:
28.4		 3n46F-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.80A 3n46F-3aqcB:
28.4		 3n46F-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 7 ASN A 103
ASP A  73
ILE B 109
HIS B  83
 None
2DE  B 329 (-3.4A)
None
2DE  B 329 ( 4.5A)
 1.04A 3t01A-3aqcA:
undetectable		 3t01A-3aqcA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus;
Micrococcus
luteus) 		5 / 12 PHE B 147
SER A  53
LEU B 116
VAL B  76
HIS B  83
 None
None
2DE  B 329 ( 4.6A)
2DE  B 329 ( 4.5A)
2DE  B 329 ( 4.5A)
 1.16A 3u9fH-3aqcB:
undetectable
3u9fI-3aqcB:
undetectable		 3u9fH-3aqcB:
19.38
3u9fI-3aqcB:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 ILE B 123
GLN A  89
LEU A  93
PHE A  92
VAL B  76
 None
None
None
None
2DE  B 329 ( 4.5A)
 1.22A 3uvvB-3aqcB:
undetectable		 3uvvB-3aqcB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 7 ASP B  88
ASP B 212
GLU B 146
ASP B 230
 MG  B 327 (-2.4A)
None
2DE  B 329 (-3.9A)
MG  B 328 ( 3.6A)
 1.18A 4feuB-3aqcB:
undetectable		 4feuB-3aqcB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 8 ASP B  88
ASP B 212
GLU B 146
ASP B 230
 MG  B 327 (-2.4A)
None
2DE  B 329 (-3.9A)
MG  B 328 ( 3.6A)
 1.15A 4feuF-3aqcB:
undetectable		 4feuF-3aqcB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 7 ASP B  88
ASP B 212
GLU B 146
ASP B 230
 MG  B 327 (-2.4A)
None
2DE  B 329 (-3.9A)
MG  B 328 ( 3.6A)
 1.19A 4fevD-3aqcB:
undetectable		 4fevD-3aqcB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 7 ASP B  88
ASP B 212
GLU B 146
ASP B 230
 MG  B 327 (-2.4A)
None
2DE  B 329 (-3.9A)
MG  B 328 ( 3.6A)
 1.17A 4fevF-3aqcB:
undetectable		 4fevF-3aqcB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 8 ASP B  88
ASP B 212
GLU B 146
ASP B 230
 MG  B 327 (-2.4A)
None
2DE  B 329 (-3.9A)
MG  B 328 ( 3.6A)
 1.15A 4fewD-3aqcB:
undetectable		 4fewD-3aqcB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 8 ASP B  88
ASP B 212
GLU B 146
ASP B 230
 MG  B 327 (-2.4A)
None
2DE  B 329 (-3.9A)
MG  B 328 ( 3.6A)
 1.14A 4fewF-3aqcB:
undetectable		 4fewF-3aqcB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 7 ASP B  88
ASP B 212
GLU B 146
ASP B 230
 MG  B 327 (-2.4A)
None
2DE  B 329 (-3.9A)
MG  B 328 ( 3.6A)
 1.16A 4fexB-3aqcB:
undetectable		 4fexB-3aqcB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 8 ASP B  88
ASP B 212
GLU B 146
ASP B 230
 MG  B 327 (-2.4A)
None
2DE  B 329 (-3.9A)
MG  B 328 ( 3.6A)
 1.19A 4gkhB-3aqcB:
undetectable		 4gkhB-3aqcB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 8 ASP B  88
ASP B 212
GLU B 146
ASP B 230
 MG  B 327 (-2.4A)
None
2DE  B 329 (-3.9A)
MG  B 328 ( 3.6A)
 1.16A 4gkhF-3aqcB:
undetectable		 4gkhF-3aqcB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 7 ASP B  88
ASP B 212
GLU B 146
ASP B 230
 MG  B 327 (-2.4A)
None
2DE  B 329 (-3.9A)
MG  B 328 ( 3.6A)
 1.16A 4gkhG-3aqcB:
undetectable		 4gkhG-3aqcB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 8 ASP B  88
ASP B 212
GLU B 146
ASP B 230
 MG  B 327 (-2.4A)
None
2DE  B 329 (-3.9A)
MG  B 328 ( 3.6A)
 1.14A 4gkhC-3aqcB:
undetectable
4gkhK-3aqcB:
undetectable		 4gkhC-3aqcB:
21.10
4gkhK-3aqcB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 8 ASP B  88
ASP B 212
GLU B 146
ASP B 230
 MG  B 327 (-2.4A)
None
2DE  B 329 (-3.9A)
MG  B 328 ( 3.6A)
 1.15A 4gkiA-3aqcB:
undetectable		 4gkiA-3aqcB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 8 ASP B  88
ASP B 212
GLU B 146
ASP B 230
 MG  B 327 (-2.4A)
None
2DE  B 329 (-3.9A)
MG  B 328 ( 3.6A)
 1.14A 4gkiE-3aqcB:
undetectable
4gkiG-3aqcB:
undetectable		 4gkiE-3aqcB:
21.10
4gkiG-3aqcB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ASP B  88
LYS B 170
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
MG  B 328 (-3.1A)
 1.04A 4kfaA-3aqcB:
28.4		 4kfaA-3aqcB:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 9 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.80A 4kfaA-3aqcB:
28.4		 4kfaA-3aqcB:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 10 ASP B  88
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.90A 4kpdA-3aqcB:
28.5		 4kpdA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.80A 4kpdA-3aqcB:
28.5		 4kpdA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 9 ASP B  84
ASP B  88
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.02A 4kpjA-3aqcB:
28.3		 4kpjA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 9 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.85A 4kpjA-3aqcB:
28.3		 4kpjA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 10 ASP B  88
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.97A 4kq5A-3aqcB:
28.2		 4kq5A-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.84A 4kq5A-3aqcB:
28.2		 4kq5A-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 10 ASP B  84
ASP B  88
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.01A 4kqsA-3aqcB:
28.6		 4kqsA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.85A 4kqsA-3aqcB:
28.6		 4kqsA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 10 ASP B  88
ARG B  93
THR B 171
GLN B 208
ASP B 211
 MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
None
None
MG  B 328 (-3.1A)
 0.96A 4n9uA-3aqcB:
28.2		 4n9uA-3aqcB:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
None
None
 0.80A 4n9uA-3aqcB:
28.2		 4n9uA-3aqcB:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 12 LEU B  81
ASP B  84
ASP B  88
ARG B  93
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
None
None
 0.74A 4ng6A-3aqcB:
28.2		 4ng6A-3aqcB:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 10 ASP B  88
LYS B 170
THR B 171
GLN B 208
LYS B 225
 MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
2DE  B 329 ( 3.7A)
 1.36A 4nkeA-3aqcB:
28.2		 4nkeA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.85A 4nkeA-3aqcB:
28.2		 4nkeA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 LEU B  81
ASP B  84
ASP B  88
LYS B 170
THR B 171
GLN B 208
ASP B 211
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.04A 4nkeA-3aqcB:
28.2		 4nkeA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.07A 4nkfA-3aqcB:
28.4		 4nkfA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 9 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.88A 4nkfA-3aqcB:
28.4		 4nkfA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.04A 4nuaA-3aqcB:
28.3		 4nuaA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 10 ASP B  84
ASP B  88
LYS B 170
THR B 171
GLN B 208
LYS B 225
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
2DE  B 329 ( 3.7A)
 1.29A 4nuaA-3aqcB:
28.3		 4nuaA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.84A 4nuaA-3aqcB:
28.3		 4nuaA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 9 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.83A 4oguA-3aqcB:
28.2		 4oguA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 9 LEU B  81
ASP B  84
ASP B  88
LYS B 170
THR B 171
GLN B 208
ASP B 211
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.98A 4oguA-3aqcB:
28.2		 4oguA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.90A 4p0vA-3aqcB:
28.5		 4p0vA-3aqcB:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  88
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.95A 4p0vA-3aqcB:
28.5		 4p0vA-3aqcB:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 11 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.84A 4p0wA-3aqcB:
28.4		 4p0wA-3aqcB:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.88A 4q23A-3aqcB:
28.1		 4q23A-3aqcB:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		8 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.01A 4rxdA-3aqcB:
27.7		 4rxdA-3aqcB:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		8 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.01A 4rxdB-3aqcB:
28.0		 4rxdB-3aqcB:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		8 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.01A 4rxdC-3aqcB:
28.2		 4rxdC-3aqcB:
23.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 8 SER B  80
LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
 2DE  B 329 (-3.6A)
None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
 0.94A 4umjA-3aqcB:
28.4		 4umjA-3aqcB:
32.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 9 SER B  80
LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 2DE  B 329 (-3.6A)
None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.82A 4umjB-3aqcB:
28.8		 4umjB-3aqcB:
32.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 12 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.02A 5cg5A-3aqcB:
28.0		 5cg5A-3aqcB:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 12 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.83A 5cg5A-3aqcB:
28.0		 5cg5A-3aqcB:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 12 ASP B  84
ASP B  88
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.98A 5cg6A-3aqcB:
28.6		 5cg6A-3aqcB:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 12 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.82A 5cg6A-3aqcB:
28.6		 5cg6A-3aqcB:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
 1.10A 5eroA-3aqcB:
27.4		 5eroA-3aqcB:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
ASP B 230
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
MG  B 328 ( 3.6A)
 1.49A 5eroB-3aqcB:
27.2		 5eroB-3aqcB:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 10 ASP B  84
ASP B  85
ASP B  88
ARG B  93
ASP B 230
 MG  B 326 (-2.6A)
MG  B 326 ( 4.8A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
MG  B 328 ( 3.6A)
 1.09A 5eroC-3aqcB:
27.0		 5eroC-3aqcB:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 10 ASP B  84
ASP B  85
ASP B  88
LYS B 170
ASP B 230
 MG  B 326 (-2.6A)
MG  B 326 ( 4.8A)
MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
MG  B 328 ( 3.6A)
 1.39A 5eroC-3aqcB:
27.0		 5eroC-3aqcB:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 10 ASP B  85
ASP B  88
ARG B  93
GLN B 208
ASP B 211
 MG  B 326 ( 4.8A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
None
MG  B 328 (-3.1A)
 1.02A 5eroC-3aqcB:
27.0		 5eroC-3aqcB:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 7 PHE A  59
ILE A  24
ASP A  73
PHE A  68
 None
None
2DE  B 329 (-3.4A)
None
 0.86A 5h3aA-3aqcA:
undetectable		 5h3aA-3aqcA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 11 ILE B 123
GLN A  89
LEU A  93
PHE A  92
VAL B  76
 None
None
None
None
2DE  B 329 ( 4.5A)
 1.24A 5ji0A-3aqcB:
undetectable		 5ji0A-3aqcB:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 7 ASP B  84
ARG B  93
LYS B 170
GLN B 208
 MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 1.28A 6g31A-3aqcB:
26.6		 6g31A-3aqcB:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 7 ASP B  84
ASP B  88
ARG B  93
LYS B 170
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
 0.94A 6g31A-3aqcB:
26.6		 6g31A-3aqcB:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_C_ZOLC401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 5 ASP B  84
ASP B  88
ARG B  93
LYS B 170
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
 1.00A 6g31C-3aqcB:
26.4		 6g31C-3aqcB:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 7 LEU B  81
ASP B  84
ASP B  88
ARG B  93
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
None
 0.77A 6g31D-3aqcB:
26.2		 6g31D-3aqcB:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_E_ZOLE401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 4 LEU B  81
ASP B  84
ASP B  88
ARG B  93
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
 0.46A 6g31E-3aqcB:
20.6		 6g31E-3aqcB:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 7 ASP B  84
ARG B  93
LYS B 170
GLN B 208
 MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.98A 6g31G-3aqcB:
25.8		 6g31G-3aqcB:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 7 ASP B  84
ASP B  88
ARG B  93
LYS B 170
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
 0.95A 6g31G-3aqcB:
25.8		 6g31G-3aqcB:
13.62