SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2DC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SS4_A_ACTA411_0
(GLYOXALASE FAMILY
PROTEIN)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 VAL A 392
THR A 393
GLN A 395
ILE A 123
 2DC  A 602 ( 4.7A)
2DC  A 602 ( 4.7A)
2DC  A 602 (-3.0A)
None
 1.49A 1ss4A-3na0A:
0.9		 1ss4A-3na0A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 273
ALA A 325
ILE A 123
HIS A 130
PHE A 274
 None
2DC  A 602 ( 3.8A)
None
None
None
 1.35A 1y0xX-3na0A:
2.1		 1y0xX-3na0A:
18.83