SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2CL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S2A_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		5 / 12 TRP A  79
HIS A 110
GLU A 185
TYR A 209
SER A 210
 None
2CL  A 317 ( 3.8A)
None
NAP  A 316 (-3.2A)
NAP  A 316 (-2.7A)
 0.21A 1s2aA-2is7A:
46.4		 1s2aA-2is7A:
48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2INE_A_PACA317_0
(ALDOSE REDUCTASE)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		5 / 5 TRP A  20
VAL A  47
TYR A  48
HIS A 110
TRP A 111
 2CL  A 317 ( 3.4A)
2CL  A 317 (-4.2A)
2CL  A 317 ( 4.5A)
2CL  A 317 ( 3.8A)
NAP  A 316 ( 4.0A)
 0.10A 2ineA-2is7A:
55.3		 2ineA-2is7A:
99.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ISF_A_PACA317_0
(ALDOSE REDUCTASE)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		5 / 5 TRP A  20
VAL A  47
TYR A  48
HIS A 110
TRP A 111
 2CL  A 317 ( 3.4A)
2CL  A 317 (-4.2A)
2CL  A 317 ( 4.5A)
2CL  A 317 ( 3.8A)
NAP  A 316 ( 4.0A)
 0.17A 2isfA-2is7A:
55.0		 2isfA-2is7A:
98.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		5 / 12 TYR A  48
TRP A  79
HIS A 110
ASN A 160
TYR A 209
 2CL  A 317 ( 4.5A)
None
2CL  A 317 ( 3.8A)
NAP  A 316 (-3.4A)
NAP  A 316 (-3.2A)
 0.29A 3r43A-2is7A:
45.8		 3r43A-2is7A:
48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R58_A_NPSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		5 / 10 TYR A  48
HIS A 110
ASN A 160
TYR A 209
PRO A 310
 2CL  A 317 ( 4.5A)
2CL  A 317 ( 3.8A)
NAP  A 316 (-3.4A)
NAP  A 316 (-3.2A)
None
 0.41A 3r58A-2is7A:
44.7		 3r58A-2is7A:
48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		5 / 12 TYR A  48
TRP A  79
HIS A 110
ASN A 160
TYR A 209
 2CL  A 317 ( 4.5A)
None
2CL  A 317 ( 3.8A)
NAP  A 316 (-3.4A)
NAP  A 316 (-3.2A)
 0.29A 3r6iA-2is7A:
44.5		 3r6iA-2is7A:
48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R8G_A_IZPA409_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		5 / 9 TYR A  48
HIS A 110
ASN A 160
TYR A 209
PRO A 310
 2CL  A 317 ( 4.5A)
2CL  A 317 ( 3.8A)
NAP  A 316 (-3.4A)
NAP  A 316 (-3.2A)
None
 0.42A 3r8gA-2is7A:
44.6		 3r8gA-2is7A:
48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		5 / 12 TYR A  48
HIS A 110
ASN A 160
TYR A 209
PRO A 310
 2CL  A 317 ( 4.5A)
2CL  A 317 ( 3.8A)
NAP  A 316 (-3.4A)
NAP  A 316 (-3.2A)
None
 0.48A 3r94A-2is7A:
44.4		 3r94A-2is7A:
48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RX3_A_SUZA317_1
(ALDOSE REDUCTASE)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		10 / 10 TRP A  20
VAL A  47
TYR A  48
HIS A 110
TRP A 111
PHE A 122
TRP A 219
CYH A 298
LEU A 300
SER A 302
 2CL  A 317 ( 3.4A)
2CL  A 317 (-4.2A)
2CL  A 317 ( 4.5A)
2CL  A 317 ( 3.8A)
NAP  A 316 ( 4.0A)
2CL  A 317 ( 4.9A)
None
2CL  A 317 (-3.5A)
None
None
 0.50A 3rx3A-2is7A:
54.2		 3rx3A-2is7A:
99.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3G_A_TLTA317_1
(ALDOSE REDUCTASE)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		7 / 7 TRP A  20
TYR A  48
HIS A 110
TRP A 111
PHE A 122
TRP A 219
CYH A 298
 2CL  A 317 ( 3.4A)
2CL  A 317 ( 4.5A)
2CL  A 317 ( 3.8A)
NAP  A 316 ( 4.0A)
2CL  A 317 ( 4.9A)
None
2CL  A 317 (-3.5A)
 0.34A 3s3gA-2is7A:
54.1		 3s3gA-2is7A:
99.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U2C_A_SUZA2001_1
(ALDOSE REDUCTASE)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		9 / 9 TRP A  20
VAL A  47
TYR A  48
HIS A 110
TRP A 111
PHE A 122
TRP A 219
CYH A 298
SER A 302
 2CL  A 317 ( 3.4A)
2CL  A 317 (-4.2A)
2CL  A 317 ( 4.5A)
2CL  A 317 ( 3.8A)
NAP  A 316 ( 4.0A)
2CL  A 317 ( 4.9A)
None
2CL  A 317 (-3.5A)
None
 0.20A 3u2cA-2is7A:
54.6		 3u2cA-2is7A:
98.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		7 / 12 TYR A  48
TRP A  79
HIS A 110
ASN A 160
TYR A 209
SER A 210
PRO A 310
 2CL  A 317 ( 4.5A)
None
2CL  A 317 ( 3.8A)
NAP  A 316 (-3.4A)
NAP  A 316 (-3.2A)
NAP  A 316 (-2.7A)
None
 0.57A 3ug8A-2is7A:
44.6		 3ug8A-2is7A:
48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		5 / 12 TRP A  79
HIS A 110
TYR A 209
SER A 210
SER A 214
 None
2CL  A 317 ( 3.8A)
NAP  A 316 (-3.2A)
NAP  A 316 (-2.7A)
NAP  A 316 (-2.7A)
 0.79A 3ugrA-2is7A:
44.9		 3ugrA-2is7A:
48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		4 / 7 TYR A  48
ASN A 160
GLU A 185
PRO A 310
 2CL  A 317 ( 4.5A)
NAP  A 316 (-3.4A)
None
None
 0.59A 3ugrA-2is7A:
44.9		 3ugrA-2is7A:
48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		8 / 8 TRP A  20
VAL A  47
TRP A  79
HIS A 110
TRP A 111
PHE A 122
PRO A 218
TRP A 219
 2CL  A 317 ( 3.4A)
2CL  A 317 (-4.2A)
None
2CL  A 317 ( 3.8A)
NAP  A 316 ( 4.0A)
2CL  A 317 ( 4.9A)
None
None
 0.34A 3v35A-2is7A:
54.0		 3v35A-2is7A:
99.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		4 / 8 TRP A  79
HIS A 110
TRP A 111
PHE A 115
 None
2CL  A 317 ( 3.8A)
NAP  A 316 ( 4.0A)
None
 1.38A 3v35A-2is7A:
54.0		 3v35A-2is7A:
99.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		4 / 8 VAL A  47
TYR A  48
TRP A  79
HIS A 110
 2CL  A 317 (-4.2A)
2CL  A 317 ( 4.5A)
None
2CL  A 317 ( 3.8A)
 0.43A 4jq1B-2is7A:
46.5		 4jq1B-2is7A:
49.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQ4_A_IMNA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		5 / 10 VAL A  47
TYR A  48
HIS A 110
TYR A 209
LEU A 300
 2CL  A 317 (-4.2A)
2CL  A 317 ( 4.5A)
2CL  A 317 ( 3.8A)
NAP  A 316 (-3.2A)
None
 0.67A 4jq4A-2is7A:
46.6		 4jq4A-2is7A:
49.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQ4_B_IMNB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		5 / 10 TYR A  48
HIS A 110
ASN A 160
TYR A 209
LEU A 300
 2CL  A 317 ( 4.5A)
2CL  A 317 ( 3.8A)
NAP  A 316 (-3.4A)
NAP  A 316 (-3.2A)
None
 0.57A 4jq4B-2is7A:
46.2		 4jq4B-2is7A:
49.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQA_B_ID8B401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		5 / 9 VAL A  47
TYR A  48
TRP A  79
HIS A 110
LEU A 300
 2CL  A 317 (-4.2A)
2CL  A 317 ( 4.5A)
None
2CL  A 317 ( 3.8A)
None
 0.86A 4jqaB-2is7A:
46.8		 4jqaB-2is7A:
49.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		4 / 8 VAL A  47
TRP A  79
HIS A 110
LEU A 300
 2CL  A 317 (-4.2A)
None
2CL  A 317 ( 3.8A)
None
 1.01A 4jtrA-2is7A:
46.7		 4jtrA-2is7A:
49.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		4 / 8 VAL A  47
TYR A  48
TRP A  79
HIS A 110
 2CL  A 317 (-4.2A)
2CL  A 317 ( 4.5A)
None
2CL  A 317 ( 3.8A)
 0.22A 4jtrA-2is7A:
46.7		 4jtrA-2is7A:
49.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_B_IZPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		4 / 6 VAL A  47
TYR A  48
TRP A  79
HIS A 110
 2CL  A 317 (-4.2A)
2CL  A 317 ( 4.5A)
None
2CL  A 317 ( 3.8A)
 0.22A 4jtrB-2is7A:
46.8		 4jtrB-2is7A:
49.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		4 / 8 THR A 140
HIS A 306
TRP A  79
PHE A 122
 None
None
None
2CL  A 317 ( 4.9A)
 1.47A 4tzcB-2is7A:
0.0
4tzcD-2is7A:
0.0		 4tzcB-2is7A:
15.46
4tzcD-2is7A:
15.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WEV_X_SUZX402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		6 / 10 TRP A  20
TYR A  48
HIS A 110
PHE A 122
TRP A 219
CYH A 298
 2CL  A 317 ( 3.4A)
2CL  A 317 ( 4.5A)
2CL  A 317 ( 3.8A)
2CL  A 317 ( 4.9A)
None
2CL  A 317 (-3.5A)
 1.01A 4wevX-2is7A:
50.6		 4wevX-2is7A:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WEV_X_SUZX402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		7 / 10 TRP A  20
VAL A  47
TYR A  48
HIS A 110
TRP A 219
CYH A 298
LEU A 300
 2CL  A 317 ( 3.4A)
2CL  A 317 (-4.2A)
2CL  A 317 ( 4.5A)
2CL  A 317 ( 3.8A)
None
2CL  A 317 (-3.5A)
None
 0.44A 4wevX-2is7A:
50.6		 4wevX-2is7A:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		5 / 12 TYR A  48
TRP A  79
HIS A 110
ASN A 160
LEU A 300
 2CL  A 317 ( 4.5A)
None
2CL  A 317 ( 3.8A)
NAP  A 316 (-3.4A)
None
 1.07A 4yvpB-2is7A:
47.7		 4yvpB-2is7A:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVV_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		5 / 9 TYR A  48
TRP A  79
HIS A 110
ASN A 160
TYR A 209
 2CL  A 317 ( 4.5A)
None
2CL  A 317 ( 3.8A)
NAP  A 316 (-3.4A)
NAP  A 316 (-3.2A)
 0.27A 4yvvA-2is7A:
46.5		 4yvvA-2is7A:
48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVX_A_GMRA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		5 / 12 TYR A  48
TRP A  79
HIS A 110
ASN A 160
SER A 302
 2CL  A 317 ( 4.5A)
None
2CL  A 317 ( 3.8A)
NAP  A 316 (-3.4A)
None
 0.90A 4yvxA-2is7A:
46.2		 4yvxA-2is7A:
48.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_K_EF2K501_1
(PROTEIN CEREBLON)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		4 / 7 HIS A 306
TRP A  79
PHE A 122
THR A 140
 None
None
2CL  A 317 ( 4.9A)
None
 1.47A 5yizk-2is7A:
undetectable
5yizt-2is7A:
0.0		 5yizk-2is7A:
12.50
5yizt-2is7A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_Y_EF2Y501_1
(PROTEIN CEREBLON)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		4 / 7 THR A 140
HIS A 306
TRP A  79
PHE A 122
 None
None
None
2CL  A 317 ( 4.9A)
 1.47A 5yizG-2is7A:
0.0
5yizY-2is7A:
0.0		 5yizG-2is7A:
12.50
5yizY-2is7A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_K_EF2K501_1
(PROTEIN CEREBLON)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		4 / 7 HIS A 306
TRP A  79
PHE A 122
THR A 140
 None
None
2CL  A 317 ( 4.9A)
None
 1.47A 5yj0k-2is7A:
0.0
5yj0t-2is7A:
0.0		 5yj0k-2is7A:
12.50
5yj0t-2is7A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_Y_EF2Y501_1
(PROTEIN CEREBLON)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		4 / 7 THR A 140
HIS A 306
TRP A  79
PHE A 122
 None
None
None
2CL  A 317 ( 4.9A)
 1.48A 5yj0G-2is7A:
0.0
5yj0Y-2is7A:
0.0		 5yj0G-2is7A:
12.50
5yj0Y-2is7A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_K_6ELK501_0
(PROTEIN CEREBLON)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		4 / 7 HIS A 306
TRP A  79
PHE A 122
THR A 140
 None
None
2CL  A 317 ( 4.9A)
None
 1.47A 5yj1k-2is7A:
0.0
5yj1t-2is7A:
undetectable		 5yj1k-2is7A:
15.11
5yj1t-2is7A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_Y_6ELY501_0
(PROTEIN CEREBLON)		 2is7 ALDOSE REDUCTASE
(Homo
sapiens) 		4 / 7 THR A 140
HIS A 306
TRP A  79
PHE A 122
 None
None
None
2CL  A 317 ( 4.9A)
 1.48A 5yj1G-2is7A:
undetectable
5yj1Y-2is7A:
undetectable		 5yj1G-2is7A:
15.11
5yj1Y-2is7A:
15.11