SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2AK'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4FR8_A_TNGA601_1 (ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL)	4kwg	ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL (Homo sapiens)	8 / 11	ASN A 169 PHE A 170 LEU A 173 MET A 174 TRP A 177 CYH A 302 ASP A 457 PHE A 459	None 2AK A 601 (-4.1A) 2AK A 601 (-4.9A) 2AK A 601 ( 3.9A) None 2AK A 601 (-4.6A) 2AK A 601 (-2.6A) 2AK A 601 (-4.0A)	0.24A	4fr8A-4kwgA: 66.3	4fr8A-4kwgA: 99.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5FHZ_A_REAA602_1 (ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3)	4kwg	ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL (Homo sapiens)	6 / 12	ASN A 169 PHE A 170 LEU A 173 MET A 174 CYH A 301 CYH A 302	None 2AK A 601 (-4.1A) 2AK A 601 (-4.9A) 2AK A 601 ( 3.9A) 2AK A 601 (-2.8A) 2AK A 601 (-4.6A)	0.91A	5fhzA-4kwgA: 60.2	5fhzA-4kwgA: 63.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5FHZ_A_REAA602_1 (ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3)	4kwg	ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL (Homo sapiens)	6 / 12	ASN A 169 PHE A 170 LEU A 173 MET A 174 TRP A 177 CYH A 301	None 2AK A 601 (-4.1A) 2AK A 601 (-4.9A) 2AK A 601 ( 3.9A) None 2AK A 601 (-2.8A)	0.59A	5fhzA-4kwgA: 60.2	5fhzA-4kwgA: 63.81

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4FR8_A_TNGA601_1","ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL","4kwg","ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL","Homo sapiens",8,"ASN A 169;PHE A 170;LEU A 173;MET A 174;TRP A 177;CYH A 302;ASP A 457;PHE A 459","None;2AK A 601 (-4.1A);2AK A 601 (-4.9A);2AK A 601 ( 3.9A);None;2AK A 601 (-4.6A);2AK A 601 (-2.6A);2AK A 601 (-4.0A)","0.24A","4fr8A-4kwgA:66.3",null],["5FHZ_A_REAA602_1","ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3","4kwg","ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL","Homo sapiens",6,"ASN A 169;PHE A 170;LEU A 173;MET A 174;CYH A 301;CYH A 302","None;2AK A 601 (-4.1A);2AK A 601 (-4.9A);2AK A 601 ( 3.9A);2AK A 601 (-2.8A);2AK A 601 (-4.6A)","0.91A","5fhzA-4kwgA:60.2","4fr8A-4kwgA:99.39"],["5FHZ_A_REAA602_1","ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3","4kwg","ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL","Homo sapiens",6,"ASN A 169;PHE A 170;LEU A 173;MET A 174;TRP A 177;CYH A 301","None;2AK A 601 (-4.1A);2AK A 601 (-4.9A);2AK A 601 ( 3.9A);None;2AK A 601 (-2.8A)","0.59A","5fhzA-4kwgA:60.2","5fhzA-4kwgA:63.81"]]