SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2A3'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		5 / 12 ASN A 376
ASP A 399
GLY A 328
VAL A 326
ASP A 362
 None
None
None
2A3  A 602 (-4.7A)
2A3  A 602 (-3.8A)
 1.29A 2fqyA-3anyA:
undetectable		 2fqyA-3anyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 7 TYR A 404
PHE A 329
ASP A 362
GLU A 287
 None
2A3  A 602 (-3.8A)
2A3  A 602 (-3.8A)
2A3  A 602 (-2.7A)
 1.09A 2qebA-3anyA:
undetectable		 2qebA-3anyA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 7 TYR A 404
PHE A 329
ASP A 362
GLU A 287
 None
2A3  A 602 (-3.8A)
2A3  A 602 (-3.8A)
2A3  A 602 (-2.7A)
 1.07A 2qebB-3anyA:
undetectable		 2qebB-3anyA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN
(Escherichia
coli) 		4 / 6 ARG B  77
ILE A 400
ILE A 209
LEU A 225
 None
None
None
2A3  A 602 ( 4.6A)
 0.97A 2xkwB-3anyB:
undetectable		 2xkwB-3anyB:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		5 / 12 ALA A 296
GLY A 289
GLY A 291
ILE A 330
ASP A 362
 None
None
None
B12  B 601 (-4.3A)
2A3  A 602 (-3.8A)
 1.04A 3o7wA-3anyA:
undetectable		 3o7wA-3anyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		5 / 12 ALA A 296
GLY A 289
GLY A 291
PHE A 329
ILE A 330
 None
None
None
2A3  A 602 (-3.8A)
B12  B 601 (-4.3A)
 0.97A 3o7wA-3anyA:
undetectable		 3o7wA-3anyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_1
(YAEB-LIKE PROTEIN
RPA0152)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 5 SER A 172
ARG A 160
ASP A 399
THR A 166
 None
2A3  A 602 (-3.0A)
None
None
 1.39A 3okxA-3anyA:
0.0		 3okxA-3anyA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_2
(YAEB-LIKE PROTEIN
RPA0152)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 5 SER A 172
ARG A 160
ASP A 399
THR A 166
 None
2A3  A 602 (-3.0A)
None
None
 1.41A 3okxB-3anyA:
0.0		 3okxB-3anyA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 7 MET A 394
ILE A 190
VAL A 189
ARG A 160
 None
None
None
2A3  A 602 (-3.0A)
 0.95A 3p6hA-3anyA:
undetectable		 3p6hA-3anyA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 8 ASN A 193
TYR A 404
LEU A 402
PHE A 329
 2A3  A 602 ( 3.1A)
None
B12  B 601 (-4.5A)
2A3  A 602 (-3.8A)
 1.10A 3rqwC-3anyA:
undetectable
3rqwD-3anyA:
undetectable		 3rqwC-3anyA:
20.76
3rqwD-3anyA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 8 TYR A 404
LEU A 402
PHE A 329
ASN A 193
 None
B12  B 601 (-4.5A)
2A3  A 602 (-3.8A)
2A3  A 602 ( 3.1A)
 1.13A 3rqwF-3anyA:
undetectable
3rqwJ-3anyA:
undetectable		 3rqwF-3anyA:
20.76
3rqwJ-3anyA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_A_ACTA403_0
(3C-LIKE PROTEINASE)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 5 TYR A 285
LEU A 225
MET A 392
GLN A 162
 None
2A3  A 602 ( 4.6A)
2A3  A 602 (-3.6A)
2A3  A 602 (-3.4A)
 1.40A 4yo9A-3anyA:
0.0
4yo9B-3anyA:
0.0		 4yo9A-3anyA:
21.75
4yo9B-3anyA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		5 / 7 VAL A 323
ASN A 324
ILE A 322
PHE A 321
ILE A 248
 None
2A3  A 602 ( 4.9A)
None
None
None
 1.41A 5bmvC-3anyA:
undetectable		 5bmvC-3anyA:
21.40