SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2A1'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 4xf5 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Chromohalobacter
salexigens) 		5 / 11 ALA A 227
THR A 230
ILE A 213
ASP A 155
GLY A 217
 None
None
None
2A1  A 403 (-2.8A)
None
 1.15A 1b02A-4xf5A:
undetectable		 1b02A-4xf5A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xf5 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Chromohalobacter
salexigens) 		5 / 10 PHE A 179
TYR A 113
LEU A  46
VAL A 224
VAL A  50
 2A1  A 403 (-4.5A)
None
2A1  A 403 (-4.9A)
None
None
 1.48A 3u9fI-4xf5A:
0.9		 3u9fI-4xf5A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xf5 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Chromohalobacter
salexigens) 		5 / 11 PHE A 179
TYR A 113
LEU A  46
VAL A 224
VAL A  50
 2A1  A 403 (-4.5A)
None
2A1  A 403 (-4.9A)
None
None
 1.49A 3u9fN-4xf5A:
undetectable
3u9fO-4xf5A:
undetectable		 3u9fN-4xf5A:
19.51
3u9fO-4xf5A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOF_A_HQEA200_1
(FLAVOREDOXIN)		 4xf5 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Chromohalobacter
salexigens) 		4 / 5 TYR A  41
VAL A  50
TRP A 154
HIS A 272
 2A1  A 403 (-4.3A)
None
2A1  A 403 (-4.6A)
None
 1.35A 3zofA-4xf5A:
0.0		 3zofA-4xf5A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOF_B_HQEB200_1
(FLAVOREDOXIN)		 4xf5 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Chromohalobacter
salexigens) 		4 / 5 TYR A  41
VAL A  50
TRP A 154
HIS A 272
 2A1  A 403 (-4.3A)
None
2A1  A 403 (-4.6A)
None
 1.32A 3zofB-4xf5A:
0.0		 3zofB-4xf5A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4xf5 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Chromohalobacter
salexigens) 		5 / 12 ILE A 213
GLY A 212
ASP A 155
SER A 239
ILE A 238
 None
None
2A1  A 403 (-2.8A)
None
None
 1.00A 5igvA-4xf5A:
undetectable		 5igvA-4xf5A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4xf5 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Chromohalobacter
salexigens) 		5 / 12 ILE A 213
GLY A 212
ASP A 155
SER A 239
ILE A 238
 None
None
2A1  A 403 (-2.8A)
None
None
 1.11A 5igwA-4xf5A:
undetectable		 5igwA-4xf5A:
22.95