SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '29X'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		8 / 12 VAL A 205
ALA A 218
LYS A 220
GLU A 239
LEU A 243
VAL A 255
GLY A 277
LEU A 324
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
None
29X  A 702 (-4.8A)
None
29X  A 702 (-4.6A)
 1.00A 1t46A-4mk0A:
21.4		 1t46A-4mk0A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		3 / 3 ARG A 316
ASP A 335
ASP A 278
 None
29X  A 702 (-4.4A)
29X  A 702 ( 4.8A)
 0.79A 2ejtA-4mk0A:
undetectable		 2ejtA-4mk0A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		6 / 9 VAL A 205
ALA A 218
LEU A 271
MET A 274
LEU A 324
ASP A 335
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 ( 4.7A)
None
29X  A 702 (-4.6A)
29X  A 702 (-4.4A)
 0.84A 2xp2A-4mk0A:
9.0		 2xp2A-4mk0A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 12 ILE A 197
ARG A 199
VAL A 205
ALA A 218
LEU A 273
MET A 274
GLY A 276
 29X  A 702 (-4.7A)
None
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
None
 1.16A 2y7jA-4mk0A:
23.3		 2y7jA-4mk0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 12 ILE A 197
VAL A 205
ALA A 218
LEU A 273
MET A 274
GLY A 276
LEU A 324
 29X  A 702 (-4.7A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
None
29X  A 702 (-4.6A)
 0.78A 2y7jA-4mk0A:
23.3		 2y7jA-4mk0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 12 ILE A 197
VAL A 205
ALA A 218
LEU A 273
MET A 274
LEU A 324
ASP A 335
 29X  A 702 (-4.7A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
29X  A 702 (-4.6A)
29X  A 702 (-4.4A)
 0.95A 2y7jA-4mk0A:
23.3		 2y7jA-4mk0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 10 ILE A 197
VAL A 205
ALA A 218
LEU A 273
MET A 274
GLY A 276
LEU A 324
 29X  A 702 (-4.7A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
None
29X  A 702 (-4.6A)
 0.85A 2y7jB-4mk0A:
30.9		 2y7jB-4mk0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 10 ILE A 197
VAL A 205
ALA A 218
LEU A 273
MET A 274
LEU A 324
ASP A 335
 29X  A 702 (-4.7A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
29X  A 702 (-4.6A)
29X  A 702 (-4.4A)
 0.88A 2y7jB-4mk0A:
30.9		 2y7jB-4mk0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		6 / 10 ILE A 197
VAL A 205
ALA A 218
MET A 274
GLY A 277
LEU A 324
 29X  A 702 (-4.7A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
None
None
29X  A 702 (-4.6A)
 0.72A 2y7jB-4mk0A:
30.9		 2y7jB-4mk0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 10 ILE A 197
VAL A 205
ALA A 218
LEU A 273
MET A 274
GLY A 276
LEU A 324
 29X  A 702 (-4.7A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
None
29X  A 702 (-4.6A)
 0.82A 2y7jC-4mk0A:
30.4		 2y7jC-4mk0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		6 / 10 ILE A 197
VAL A 205
ALA A 218
MET A 274
GLY A 277
LEU A 324
 29X  A 702 (-4.7A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
None
None
29X  A 702 (-4.6A)
 0.72A 2y7jC-4mk0A:
30.4		 2y7jC-4mk0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 10 ILE A 197
VAL A 205
ALA A 218
LEU A 273
MET A 274
GLY A 276
LEU A 324
 29X  A 702 (-4.7A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
None
29X  A 702 (-4.6A)
 0.90A 2y7jD-4mk0A:
30.4		 2y7jD-4mk0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		6 / 10 ILE A 197
VAL A 205
ALA A 218
MET A 274
GLY A 277
LEU A 324
 29X  A 702 (-4.7A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
None
None
29X  A 702 (-4.6A)
 0.79A 2y7jD-4mk0A:
30.4		 2y7jD-4mk0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 12 ALA A 218
LYS A 220
GLU A 239
VAL A 255
MET A 274
GLY A 277
LEU A 324
 29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 (-4.8A)
None
None
29X  A 702 (-4.6A)
 0.82A 2zvaA-4mk0A:
15.6		 2zvaA-4mk0A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		8 / 10 ALA A 218
LYS A 220
VAL A 255
LEU A 271
LEU A 273
MET A 274
GLY A 276
LEU A 324
 29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
29X  A 702 (-4.8A)
29X  A 702 ( 4.7A)
29X  A 702 (-4.6A)
None
None
29X  A 702 (-4.6A)
 0.88A 3aoxA-4mk0A:
21.5		 3aoxA-4mk0A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		8 / 10 ALA A 218
LYS A 220
VAL A 255
LEU A 271
LEU A 273
MET A 274
GLY A 277
LEU A 324
 29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
29X  A 702 (-4.8A)
29X  A 702 ( 4.7A)
29X  A 702 (-4.6A)
None
None
29X  A 702 (-4.6A)
 0.76A 3aoxA-4mk0A:
21.5		 3aoxA-4mk0A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 12 ALA A 218
LYS A 220
GLU A 239
LEU A 243
LEU A 273
 29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
None
29X  A 702 (-4.6A)
 0.51A 3hecA-4mk0A:
22.7		 3hecA-4mk0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		6 / 12 VAL A 205
ALA A 218
LYS A 220
GLU A 239
LEU A 243
MET A 274
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
None
None
 1.26A 3hegA-4mk0A:
22.4		 3hegA-4mk0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 8 ALA A 218
LYS A 220
GLU A 239
LEU A 273
MET A 274
 29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 (-4.6A)
None
 0.99A 3lfaA-4mk0A:
22.9		 3lfaA-4mk0A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 11 ALA A 218
LYS A 220
VAL A 255
MET A 274
LEU A 324
SER A 334
ASP A 335
 29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
29X  A 702 (-4.8A)
None
29X  A 702 (-4.6A)
29X  A 702 (-3.4A)
29X  A 702 (-4.4A)
 0.93A 3miyA-4mk0A:
15.9		 3miyA-4mk0A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 11 LYS A 220
VAL A 255
MET A 274
GLY A 277
LEU A 324
SER A 334
ASP A 335
 29X  A 702 (-3.6A)
29X  A 702 (-4.8A)
None
None
29X  A 702 (-4.6A)
29X  A 702 (-3.4A)
29X  A 702 (-4.4A)
 0.89A 3miyA-4mk0A:
15.9		 3miyA-4mk0A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 9 ALA A 218
LYS A 220
MET A 274
LEU A 324
SER A 334
 29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 (-4.6A)
29X  A 702 (-3.4A)
 0.68A 3miyB-4mk0A:
21.8		 3miyB-4mk0A:
17.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		11 / 12 ILE A 197
GLY A 200
GLY A 203
VAL A 205
ALA A 218
LYS A 220
LEU A 222
VAL A 255
LEU A 324
SER A 334
ALA A 482
 29X  A 702 (-4.7A)
29X  A 702 (-3.6A)
29X  A 702 (-3.5A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 (-4.8A)
29X  A 702 (-4.6A)
29X  A 702 (-3.4A)
29X  A 702 ( 4.3A)
 0.47A 3v5wA-4mk0A:
56.4		 3v5wA-4mk0A:
97.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		11 / 12 ILE A 197
GLY A 200
GLY A 203
VAL A 205
ALA A 218
LYS A 220
LEU A 222
VAL A 255
SER A 334
ASP A 335
ALA A 482
 29X  A 702 (-4.7A)
29X  A 702 (-3.6A)
29X  A 702 (-3.5A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 (-4.8A)
29X  A 702 (-3.4A)
29X  A 702 (-4.4A)
29X  A 702 ( 4.3A)
 0.61A 3v5wA-4mk0A:
56.4		 3v5wA-4mk0A:
97.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 12 ILE A 197
GLY A 203
VAL A 205
ALA A 218
VAL A 255
SER A 334
ASP A 335
 29X  A 702 (-4.7A)
29X  A 702 (-3.5A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.8A)
29X  A 702 (-3.4A)
29X  A 702 (-4.4A)
 1.26A 3v5wA-4mk0A:
56.4		 3v5wA-4mk0A:
97.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		3 / 3 LEU A 271
MET A 274
ASP A 278
 29X  A 702 ( 4.7A)
None
29X  A 702 ( 4.8A)
 0.23A 3v5wA-4mk0A:
56.2		 3v5wA-4mk0A:
97.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 12 ALA A 218
LEU A 271
LEU A 273
MET A 274
ASP A 335
 29X  A 702 (-3.1A)
29X  A 702 ( 4.7A)
29X  A 702 (-4.6A)
None
29X  A 702 (-4.4A)
 0.48A 3zbfA-4mk0A:
23.5		 3zbfA-4mk0A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 5 VAL A 205
ILE A 254
MET A 274
ILE A 333
 29X  A 702 (-4.7A)
None
None
None
 0.77A 4c8bA-4mk0A:
13.2		 4c8bA-4mk0A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		8 / 12 VAL A 205
ALA A 218
ASP A 278
ASP A 317
LYS A 319
ASN A 322
LEU A 324
ASP A 335
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 ( 4.8A)
None
None
29X  A 702 ( 4.7A)
29X  A 702 (-4.6A)
29X  A 702 (-4.4A)
 0.92A 4i41A-4mk0A:
18.2		 4i41A-4mk0A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 11 VAL A 205
ALA A 218
LYS A 220
LEU A 271
ASP A 335
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
29X  A 702 ( 4.7A)
29X  A 702 (-4.4A)
 0.50A 4iaaA-4mk0A:
18.2		 4iaaA-4mk0A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		3 / 3 LEU A 243
MET A 257
ASP A 278
 None
None
29X  A 702 ( 4.8A)
 0.74A 4j7xB-4mk0A:
undetectable		 4j7xB-4mk0A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		8 / 12 VAL A 205
ALA A 218
LYS A 220
LEU A 271
GLY A 277
ASP A 278
LEU A 324
ASP A 335
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
29X  A 702 ( 4.7A)
None
29X  A 702 ( 4.8A)
29X  A 702 (-4.6A)
29X  A 702 (-4.4A)
 1.01A 4mkcA-4mk0A:
13.8		 4mkcA-4mk0A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 12 VAL A 205
ALA A 218
LYS A 220
LEU A 271
LEU A 273
GLY A 276
LEU A 324
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
29X  A 702 ( 4.7A)
29X  A 702 (-4.6A)
None
29X  A 702 (-4.6A)
 0.88A 4mkcA-4mk0A:
13.8		 4mkcA-4mk0A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 12 VAL A 205
ALA A 218
LYS A 220
LEU A 271
LEU A 273
LEU A 324
ASP A 335
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
29X  A 702 ( 4.7A)
29X  A 702 (-4.6A)
29X  A 702 (-4.6A)
29X  A 702 (-4.4A)
 0.82A 4mkcA-4mk0A:
13.8		 4mkcA-4mk0A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 11 GLY A 198
VAL A 205
ALA A 218
LYS A 220
ASN A 322
LEU A 324
ASP A 335
 29X  A 702 ( 4.1A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
29X  A 702 ( 4.7A)
29X  A 702 (-4.6A)
29X  A 702 (-4.4A)
 0.92A 4o0sA-4mk0A:
22.9		 4o0sA-4mk0A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 10 ILE A 197
ALA A 218
LYS A 220
PHE A 269
LEU A 273
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 (-4.6A)
 0.52A 4rz7A-4mk0A:
25.4		 4rz7A-4mk0A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 10 ILE A 197
ALA A 218
PHE A 269
LEU A 273
LEU A 324
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
None
29X  A 702 (-4.6A)
29X  A 702 (-4.6A)
 0.60A 4rz7A-4mk0A:
25.4		 4rz7A-4mk0A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 6 ALA A 218
LEU A 273
MET A 274
LEU A 324
 29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
29X  A 702 (-4.6A)
 0.42A 4xoyA-4mk0A:
19.4		 4xoyA-4mk0A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 6 ALA A 218
LEU A 273
MET A 274
LEU A 324
 29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
29X  A 702 (-4.6A)
 0.42A 4xp3A-4mk0A:
26.5		 4xp3A-4mk0A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 7 GLY A 198
GLY A 200
GLY A 203
VAL A 205
LEU A 222
 29X  A 702 ( 4.1A)
29X  A 702 (-3.6A)
29X  A 702 (-3.5A)
29X  A 702 (-4.7A)
None
 0.40A 5izjB-4mk0A:
26.8		 5izjB-4mk0A:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 7 GLY A 198
GLY A 200
VAL A 205
LYS A 220
LEU A 222
 29X  A 702 ( 4.1A)
29X  A 702 (-3.6A)
29X  A 702 (-4.7A)
29X  A 702 (-3.6A)
None
 0.52A 5izjA-4mk0A:
36.2		 5izjA-4mk0A:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 9 ILE A 197
GLY A 198
VAL A 205
ALA A 218
MET A 274
 29X  A 702 (-4.7A)
29X  A 702 ( 4.1A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
None
 0.67A 5lw1B-4mk0A:
23.7		 5lw1B-4mk0A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 10 GLY A 198
VAL A 205
ALA A 218
LEU A 273
MET A 274
 29X  A 702 ( 4.1A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
 0.78A 5lw1E-4mk0A:
23.4		 5lw1E-4mk0A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 9 GLY A 198
VAL A 205
ALA A 218
LEU A 273
MET A 274
 29X  A 702 ( 4.1A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
 0.83A 5lw1H-4mk0A:
23.7		 5lw1H-4mk0A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 12 ILE A 197
GLY A 198
VAL A 205
ALA A 218
LYS A 220
GLU A 239
LEU A 271
 29X  A 702 (-4.7A)
29X  A 702 ( 4.1A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 ( 4.7A)
 0.49A 5mafA-4mk0A:
29.2		 5mafA-4mk0A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 12 ILE A 197
VAL A 205
ALA A 218
LYS A 220
GLU A 239
LEU A 271
GLY A 277
 29X  A 702 (-4.7A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 ( 4.7A)
None
 0.81A 5mafA-4mk0A:
29.2		 5mafA-4mk0A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		6 / 12 VAL A 205
ALA A 218
LYS A 220
GLY A 277
LEU A 324
SER A 334
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 (-4.6A)
29X  A 702 (-3.4A)
 0.87A 5p9iA-4mk0A:
15.8		 5p9iA-4mk0A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		6 / 12 VAL A 205
ALA A 218
LYS A 220
GLY A 277
LEU A 324
ASP A 335
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 (-4.6A)
29X  A 702 (-4.4A)
 0.97A 5yu9D-4mk0A:
15.1		 5yu9D-4mk0A:
7.84