SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '28P'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 12 HIS A1295
GLU A1296
HIS A1299
GLU A1318
TYR A1383
 ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.6A)
 0.70A 1j36A-3u9wA:
4.2		 1j36A-3u9wA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 12 HIS A1295
GLU A1296
HIS A1299
GLU A1318
TYR A1383
 ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.6A)
 0.70A 1j36B-3u9wA:
4.3		 1j36B-3u9wA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 11 HIS A1295
GLU A1296
HIS A1299
GLU A1318
TYR A1383
 ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.6A)
 0.70A 1j37A-3u9wA:
3.6		 1j37A-3u9wA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 11 HIS A1295
GLU A1296
HIS A1299
GLU A1318
TYR A1383
 ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.6A)
 0.70A 1j37B-3u9wA:
4.3		 1j37B-3u9wA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 12 HIS A1295
GLU A1296
HIS A1299
GLU A1318
TYR A1383
 ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.6A)
 0.64A 1o86A-3u9wA:
4.7		 1o86A-3u9wA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 8 GLU A1318
HIS A1295
HIS A1299
GLU A1296
 ZN  A2001 ( 2.2A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
 0.89A 1v7zA-3u9wA:
undetectable		 1v7zA-3u9wA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 8 GLU A1318
HIS A1295
HIS A1299
GLU A1296
 ZN  A2001 ( 2.2A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
 0.89A 1v7zB-3u9wA:
undetectable		 1v7zB-3u9wA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 8 GLU A1318
HIS A1295
HIS A1299
GLU A1296
 ZN  A2001 ( 2.2A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
 0.89A 1v7zC-3u9wA:
undetectable		 1v7zC-3u9wA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 12 HIS A1295
GLU A1296
HIS A1299
GLU A1318
TYR A1383
 ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.6A)
 0.63A 2c6nA-3u9wA:
3.2		 2c6nA-3u9wA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 12 HIS A1295
GLU A1296
HIS A1299
GLU A1318
TYR A1383
 ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.6A)
 0.67A 2c6nB-3u9wA:
4.7		 2c6nB-3u9wA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 11 HIS A1295
GLU A1296
HIS A1299
GLU A1318
TYR A1383
 ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.6A)
 0.61A 2x8zA-3u9wA:
5.3		 2x8zA-3u9wA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 12 HIS A1295
GLU A1296
HIS A1299
GLU A1318
TYR A1383
 ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.6A)
 0.61A 2x91A-3u9wA:
3.3		 2x91A-3u9wA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 8 GLU A1318
HIS A1295
HIS A1299
GLU A1296
 ZN  A2001 ( 2.2A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
 0.88A 3a6jA-3u9wA:
undetectable		 3a6jA-3u9wA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 7 GLU A1318
HIS A1295
HIS A1299
GLU A1296
 ZN  A2001 ( 2.2A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
 0.85A 3a6jB-3u9wA:
undetectable		 3a6jB-3u9wA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 8 GLU A1318
HIS A1295
HIS A1299
GLU A1296
 ZN  A2001 ( 2.2A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
 0.86A 3a6jC-3u9wA:
undetectable		 3a6jC-3u9wA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 8 GLU A1318
HIS A1295
HIS A1299
GLU A1296
 ZN  A2001 ( 2.2A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
 0.89A 3a6jE-3u9wA:
undetectable		 3a6jE-3u9wA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 8 GLU A1318
HIS A1295
HIS A1299
GLU A1296
 ZN  A2001 ( 2.2A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
 0.85A 3a6jF-3u9wA:
undetectable		 3a6jF-3u9wA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 11 HIS A1295
GLU A1296
HIS A1299
GLU A1318
TYR A1383
 ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.6A)
 0.72A 4c2pA-3u9wA:
4.4		 4c2pA-3u9wA:
24.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		9 / 9 TYR A1267
GLY A1268
HIS A1295
GLU A1296
GLU A1318
TYR A1378
TYR A1383
ARG A1563
LYS A1565
 28P  A7001 (-3.6A)
None
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.3A)
28P  A7001 (-4.6A)
None
None
 0.36A 4dprA-3u9wA:
61.2		 4dprA-3u9wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 9 TYR A1267
GLY A1269
GLU A1271
TYR A1378
TYR A1383
 28P  A7001 (-3.6A)
None
28P  A7001 (-3.6A)
28P  A7001 (-4.3A)
28P  A7001 (-4.6A)
 0.99A 4dprA-3u9wA:
61.2		 4dprA-3u9wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		6 / 9 TYR A1267
GLY A1269
HIS A1295
GLU A1318
TYR A1378
TYR A1383
 28P  A7001 (-3.6A)
None
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.3A)
28P  A7001 (-4.6A)
 0.89A 4dprA-3u9wA:
61.2		 4dprA-3u9wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 9 TYR A1267
GLY A1269
HIS A1299
GLU A1271
TYR A1378
 28P  A7001 (-3.6A)
None
ZN  A2001 ( 3.2A)
28P  A7001 (-3.6A)
28P  A7001 (-4.3A)
 1.08A 4dprA-3u9wA:
61.2		 4dprA-3u9wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 9 TYR A1267
GLY A1269
HIS A1299
GLU A1318
TYR A1378
 28P  A7001 (-3.6A)
None
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.3A)
 1.18A 4dprA-3u9wA:
61.2		 4dprA-3u9wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		12 / 12 GLN A1136
ALA A1137
TYR A1267
HIS A1295
GLU A1296
HIS A1299
TRP A1311
PHE A1314
GLU A1318
LEU A1369
TYR A1378
TYR A1383
 28P  A7001 (-3.7A)
28P  A7001 ( 3.8A)
28P  A7001 (-3.6A)
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
28P  A7001 (-4.8A)
28P  A7001 (-3.5A)
ZN  A2001 ( 2.2A)
28P  A7001 ( 4.9A)
28P  A7001 (-4.3A)
28P  A7001 (-4.6A)
 0.35A 4r7lA-3u9wA:
64.7		 4r7lA-3u9wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		5 / 12 TYR A1267
GLU A1271
GLU A1318
TYR A1378
TYR A1383
 28P  A7001 (-3.6A)
28P  A7001 (-3.6A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.3A)
28P  A7001 (-4.6A)
 1.33A 4r7lA-3u9wA:
64.7		 4r7lA-3u9wA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_B_Y70B151_1
(CEREBLON ISOFORM 4)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 8 ASN A1272
MET A1270
TRP A1253
TYR A1251
 None
28P  A7001 (-3.5A)
None
None
 1.47A 4v2zB-3u9wA:
undetectable		 4v2zB-3u9wA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_B_LVYB151_1
(CEREBLON ISOFORM 4)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 8 ASN A1272
MET A1270
TRP A1253
TYR A1251
 None
28P  A7001 (-3.5A)
None
None
 1.46A 4v30B-3u9wA:
undetectable		 4v30B-3u9wA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens) 		4 / 7 GLU A1296
ARG A1338
ILE A1328
MET A1240
 28P  A7001 (-2.6A)
None
None
None
 0.98A 4xumA-3u9wA:
undetectable		 4xumA-3u9wA:
20.16