SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '25L'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 7 ALA A 167
GLY A 166
GLY A 165
ASN A 198
PHE A 124
 25L  A1000 ( 4.4A)
None
25L  A1000 ( 4.3A)
None
25L  A1000 (-3.5A)
 1.12A 2c49B-4o1oA:
undetectable		 2c49B-4o1oA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 12 ALA A 167
ARG A 153
ALA A 173
LEU A 223
ILE A 219
 25L  A1000 ( 4.4A)
25L  A1000 (-3.9A)
None
None
None
 1.16A 2h77A-4o1oA:
undetectable		 2h77A-4o1oA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		4 / 8 HIS A 178
GLY A 134
TYR A 133
ARG A 135
 None
None
25L  A1000 (-4.7A)
None
 1.16A 3ccfA-4o1oA:
undetectable		 3ccfA-4o1oA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 12 ALA A 167
ARG A 153
ALA A 173
LEU A 223
ILE A 219
 25L  A1000 ( 4.4A)
25L  A1000 (-3.9A)
None
None
None
 1.13A 4lnwA-4o1oA:
undetectable		 4lnwA-4o1oA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		5 / 12 ALA A 167
ARG A 153
ALA A 173
LEU A 223
ILE A 219
 25L  A1000 ( 4.4A)
25L  A1000 (-3.9A)
None
None
None
 1.12A 4lnxA-4o1oA:
undetectable		 4lnxA-4o1oA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		4 / 8 ILE A  99
ILE A  96
ALA A  91
LYS A  87
 None
None
None
25L  A1000 (-3.5A)
 0.80A 4ou1A-4o1oA:
undetectable		 4ou1A-4o1oA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4o1o RIBONUCLEASE L
(Sus
scrofa) 		4 / 6 ASP A 120
ASP A 197
ASN A 122
GLN A 159
 25L  A1000 ( 4.4A)
None
25L  A1000 (-3.3A)
None
 1.06A 5l6eA-4o1oA:
undetectable		 5l6eA-4o1oA:
17.03