SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '246'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1a0j TRYPSIN
(Salmo
salar) 		7 / 8 ASP A 189
SER A 190
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 246 (-3.0A)
BEN  A 246 (-3.0A)
None
SO4  A 248 ( 2.5A)
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.80A 1aq7A-1a0jA:
41.1		 1aq7A-1a0jA:
73.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1a0j TRYPSIN
(Salmo
salar) 		7 / 8 HIS A  57
ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 SO4  A 248 (-3.9A)
BEN  A 246 (-3.0A)
BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.48A 1aq7A-1a0jA:
41.1		 1aq7A-1a0jA:
73.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 3beu TRYPSIN
(Streptomyces
griseus) 		6 / 8 HIS A  57
ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 SO4  A 246 ( 3.8A)
BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
 0.52A 1aq7A-3beuA:
32.1		 1aq7A-3beuA:
36.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 1a0j TRYPSIN
(Salmo
salar) 		6 / 9 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.34A 1bcuH-1a0jA:
18.8		 1bcuH-1a0jA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 3beu TRYPSIN
(Streptomyces
griseus) 		6 / 9 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
 0.25A 1bcuH-3beuA:
32.2		 1bcuH-3beuA:
34.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 1a0j TRYPSIN
(Salmo
salar) 		5 / 9 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 SO4  A 248 (-3.9A)
BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
BEN  A 246 (-3.3A)
 0.46A 1dwcH-1a0jA:
33.7		 1dwcH-1a0jA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 3beu TRYPSIN
(Streptomyces
griseus) 		5 / 9 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 SO4  A 246 ( 3.8A)
BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
BEN  A 247 (-3.5A)
 0.30A 1dwcH-3beuA:
31.4		 1dwcH-3beuA:
34.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		5 / 12 PHE A  92
TYR A 150
GLY A 186
VAL A 181
ASP A 138
 PG4  A 241 (-3.6A)
GOL  A 246 ( 4.4A)
PG4  A 241 ( 3.9A)
NJP  A 501 (-3.9A)
GOL  A 246 ( 2.4A)
 1.49A 1e3vA-3l77A:
undetectable		 1e3vA-3l77A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB
(Streptococcus
pneumoniae) 		4 / 5 HIS A   5
HIS A  42
HIS A 136
ASP A 199
 MN  A1246 (-3.4A)
MN  A1247 ( 3.3A)
MN  A1245 ( 3.5A)
MN  A1246 ( 2.8A)
 0.96A 1e9yB-2wjfA:
14.0		 1e9yB-2wjfA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 1zkp HYPOTHETICAL PROTEIN
BA1088
(Bacillus
anthracis) 		4 / 5 ASP A 155
HIS A 211
HIS A  59
HIS A  64
 ZN  A 246 ( 2.4A)
ZN  A 246 (-3.2A)
ZN  A 245 (-3.3A)
ZN  A 246 (-3.2A)
 1.22A 1ei6A-1zkpA:
undetectable		 1ei6A-1zkpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 2v35 ELASTASE-1
(Sus
scrofa) 		4 / 8 PHE A 228
THR A 229
ASP A 102
HIS A  57
 None
None
None
J54  A1246 ( 4.7A)
 0.88A 1ei6C-2v35A:
undetectable		 1ei6C-2v35A:
22.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 1a0j TRYPSIN
(Salmo
salar) 		8 / 12 HIS A  57
LEU A  99
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 SO4  A 248 (-3.9A)
None
BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.56A 1etrH-1a0jA:
33.8		 1etrH-1a0jA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 3beu TRYPSIN
(Streptomyces
griseus) 		7 / 12 HIS A  57
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 SO4  A 246 ( 3.8A)
BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
 0.49A 1etrH-3beuA:
31.3		 1etrH-3beuA:
35.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1a0j TRYPSIN
(Salmo
salar) 		6 / 8 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 246 (-3.0A)
BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.27A 1f5lA-1a0jA:
15.7		 1f5lA-1a0jA:
37.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3beu TRYPSIN
(Streptomyces
griseus) 		6 / 8 ASP A 189
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 247 (-3.0A)
SO4  A 246 ( 4.1A)
SO4  A 246 ( 2.5A)
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
 0.57A 1f5lA-3beuA:
31.1		 1f5lA-3beuA:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		5 / 12 CYH B 154
ALA B 156
ALA B 157
LEU B  93
ALA B  94
 SF4  B 246 (-2.2A)
None
None
None
None
 0.96A 1fbyA-3cirB:
undetectable		 1fbyA-3cirB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		5 / 12 CYH B 154
ALA B 156
ALA B 157
LEU B  93
ALA B  94
 SF4  B 246 (-2.2A)
None
None
None
None
 0.96A 1fbyB-3cirB:
undetectable		 1fbyB-3cirB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 1cyd CARBONYL REDUCTASE
(Mus
musculus) 		5 / 12 VAL A 138
TYR A 241
PRO A 144
SER A 191
PHE A 196
 IPA  A 246 ( 4.8A)
None
None
None
None
 1.44A 1fdsA-1cydA:
27.4		 1fdsA-1cydA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 2fgn PHOSPHOLIPASE C
(Bacillus
cereus) 		5 / 12 TYR A 119
HIS A  69
HIS A  14
ASN A  12
TYR A  52
 None
ZN  A 246 (-3.3A)
ZN  A 248 (-3.3A)
None
None
 0.99A 1ituA-2fgnA:
undetectable		 1ituA-2fgnA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 10 ARG A  18
VAL A  84
ILE A   6
GLY A   7
GLY A   8
 None
None
None
ADP  A 246 (-3.2A)
IPE  A 247 ( 3.5A)
 1.02A 1k6cA-3ll5A:
undetectable		 1k6cA-3ll5A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 8 ILE A 299
LEU A 324
ILE A 260
GLU A 262
ILE A 246
 ILE  A 299 ( 0.7A)
LEU  A 324 ( 0.6A)
ILE  A 260 ( 0.7A)
GLU  A 262 ( 0.6A)
ILE  A 246 ( 0.7A)
 1.45A 1linA-1vhoA:
undetectable		 1linA-1vhoA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 4 ALA A 212
VAL A 246
ALA A 245
HIS A 214
 ALA  A 212 ( 0.0A)
VAL  A 246 ( 0.6A)
ALA  A 245 ( 0.0A)
HIS  A 214 ( 1.0A)
 1.13A 1q23A-2vbfA:
undetectable		 1q23A-2vbfA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 4 ALA A 212
VAL A 246
ALA A 245
HIS A 214
 ALA  A 212 ( 0.0A)
VAL  A 246 ( 0.6A)
ALA  A 245 ( 0.0A)
HIS  A 214 ( 1.0A)
 1.20A 1q23F-2vbfA:
undetectable		 1q23F-2vbfA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2vm5 BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ARG A 162
VAL A 180
TRP A 214
 None
GOL  A1246 ( 4.8A)
None
 1.22A 1qw6A-2vm5A:
undetectable		 1qw6A-2vm5A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2vm5 BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ARG A 162
VAL A 180
TRP A 214
 None
GOL  A1246 ( 4.8A)
None
 1.25A 1qwcA-2vm5A:
undetectable		 1qwcA-2vm5A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		5 / 12 GLY A 314
ALA A 313
ILE A 250
ILE A 303
ALA A 265
 None
OCS  A 246 ( 3.5A)
OCS  A 246 ( 4.2A)
None
OCS  A 246 ( 4.0A)
 0.84A 1sguB-4fdyA:
undetectable		 1sguB-4fdyA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens) 		5 / 11 VAL S 154
ASN S  72
GLU S  77
GLU S  74
ASP S  21
 None
None
CA  S1246 (-2.4A)
None
None
 1.35A 1t6zB-2wpmS:
undetectable		 1t6zB-2wpmS:
20.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 1a0j TRYPSIN
(Salmo
salar) 		6 / 6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 246 (-3.0A)
BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.22A 1tnlA-1a0jA:
41.5		 1tnlA-1a0jA:
73.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 3beu TRYPSIN
(Streptomyces
griseus) 		5 / 6 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
 0.29A 1tnlA-3beuA:
32.1		 1tnlA-3beuA:
36.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 2qpm CYTOKININ
DEHYDROGENASE 1
(Zea
mays) 		4 / 7 TYR A 431
GLU A 288
LEU A 458
TYR A 491
 None
None
246  A1536 (-4.3A)
FAD  A1535 ( 4.3A)
 1.05A 1tuvA-2qpmA:
3.8		 1tuvA-2qpmA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 1zkp HYPOTHETICAL PROTEIN
BA1088
(Bacillus
anthracis) 		4 / 7 LEU A 207
HIS A  64
THR A 210
HIS A 134
 None
ZN  A 246 (-3.2A)
None
ZN  A 245 (-3.3A)
 1.21A 1v55C-1zkpA:
undetectable
1v55N-1zkpA:
undetectable
1v55P-1zkpA:
undetectable		 1v55C-1zkpA:
21.53
1v55N-1zkpA:
20.61
1v55P-1zkpA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB
(Streptococcus
pneumoniae) 		5 / 8 GLU A  80
HIS A   7
ASP A 199
HIS A 136
HIS A  42
 MN  A1246 (-2.4A)
MN  A1246 ( 3.3A)
MN  A1246 ( 2.8A)
MN  A1245 ( 3.5A)
MN  A1247 ( 3.3A)
 1.13A 1v7zA-2wjfA:
undetectable		 1v7zA-2wjfA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB
(Streptococcus
pneumoniae) 		5 / 8 GLU A  80
HIS A   7
ASP A 199
HIS A 136
HIS A  42
 MN  A1246 (-2.4A)
MN  A1246 ( 3.3A)
MN  A1246 ( 2.8A)
MN  A1245 ( 3.5A)
MN  A1247 ( 3.3A)
 1.13A 1v7zB-2wjfA:
undetectable		 1v7zB-2wjfA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB
(Streptococcus
pneumoniae) 		5 / 8 GLU A  80
HIS A   7
ASP A 199
HIS A 136
HIS A  42
 MN  A1246 (-2.4A)
MN  A1246 ( 3.3A)
MN  A1246 ( 2.8A)
MN  A1245 ( 3.5A)
MN  A1247 ( 3.3A)
 1.13A 1v7zC-2wjfA:
undetectable		 1v7zC-2wjfA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB
(Streptococcus
pneumoniae) 		5 / 8 GLU A  80
HIS A   7
ASP A 199
HIS A 136
HIS A  42
 MN  A1246 (-2.4A)
MN  A1246 ( 3.3A)
MN  A1246 ( 2.8A)
MN  A1245 ( 3.5A)
MN  A1247 ( 3.3A)
 1.14A 1v7zD-2wjfA:
undetectable		 1v7zD-2wjfA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB
(Streptococcus
pneumoniae) 		5 / 8 GLU A  80
HIS A   7
ASP A 199
HIS A 136
HIS A  42
 MN  A1246 (-2.4A)
MN  A1246 ( 3.3A)
MN  A1246 ( 2.8A)
MN  A1245 ( 3.5A)
MN  A1247 ( 3.3A)
 1.15A 1v7zE-2wjfA:
undetectable		 1v7zE-2wjfA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB
(Streptococcus
pneumoniae) 		5 / 8 GLU A  80
HIS A   7
ASP A 199
HIS A 136
HIS A  42
 MN  A1246 (-2.4A)
MN  A1246 ( 3.3A)
MN  A1246 ( 2.8A)
MN  A1245 ( 3.5A)
MN  A1247 ( 3.3A)
 1.13A 1v7zF-2wjfA:
undetectable		 1v7zF-2wjfA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2vm5 BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ARG A 162
VAL A 180
TRP A 214
 None
GOL  A1246 ( 4.8A)
None
 1.23A 1vagA-2vm5A:
undetectable		 1vagA-2vm5A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3h7j BACILYSIN
BIOSYNTHESIS PROTEIN
BACB
(Bacillus
subtilis) 		4 / 7 LEU A 132
PHE A 218
SER A 214
MET A 188
 None
PPY  A 246 (-4.6A)
PPY  A 246 ( 3.7A)
None
 0.94A 1wrlA-3h7jA:
undetectable
1wrlB-3h7jA:
undetectable		 1wrlA-3h7jA:
18.38
1wrlB-3h7jA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 12 THR A 200
LEU A 199
ILE A 246
VAL A 270
PHE A 228
 THR  A 200 ( 0.8A)
LEU  A 199 ( 0.5A)
ILE  A 246 ( 0.7A)
VAL  A 270 ( 0.6A)
PHE  A 228 ( 1.3A)
 1.22A 1wsvA-6gefA:
undetectable		 1wsvA-6gefA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 12 THR A 200
LEU A 199
ILE A 246
VAL A 270
PHE A 228
 THR  A 200 ( 0.8A)
LEU  A 199 ( 0.5A)
ILE  A 246 ( 0.7A)
VAL  A 270 ( 0.6A)
PHE  A 228 ( 1.3A)
 1.23A 1wsvB-6gefA:
undetectable		 1wsvB-6gefA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		5 / 12 CYH B 154
ALA B 156
ALA B 157
LEU B  93
ALA B  94
 SF4  B 246 (-2.2A)
None
None
None
None
 1.01A 1xiuA-3cirB:
undetectable		 1xiuA-3cirB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Bacillus
anthracis) 		4 / 5 ILE A 266
LEU A 246
ALA A 113
GLU A 110
 ILE  A 266 ( 0.7A)
LEU  A 246 ( 0.6A)
ALA  A 113 ( 0.0A)
GLU  A 110 ( 0.6A)
 1.29A 1xvaA-4dlkA:
2.8
1xvaB-4dlkA:
2.6		 1xvaA-4dlkA:
20.90
1xvaB-4dlkA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5dm6 50S RIBOSOMAL
PROTEIN L16
(Deinococcus
radiodurans) 		3 / 3 LEU J 121
HIS J 124
LYS J 125
 C  X2467 ( 4.8A)
C  X2467 ( 3.5A)
C  X2467 ( 3.0A)
 0.88A 1y7iA-5dm6J:
undetectable		 1y7iA-5dm6J:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 2fgn PHOSPHOLIPASE C
(Bacillus
cereus) 		4 / 7 ALA A   3
ILE A  51
ASP A  55
ILE A  17
 None
None
ZN  A 246 (-2.6A)
None
 0.78A 1yc5A-2fgnA:
undetectable		 1yc5A-2fgnA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2vm5 BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ARG A 162
VAL A 180
TRP A 214
 None
GOL  A1246 ( 4.8A)
None
 1.24A 1zviA-2vm5A:
undetectable		 1zviA-2vm5A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 9 LEU A 162
VAL A  10
GLY A   7
VAL A  84
ILE A  25
 None
None
ADP  A 246 (-3.2A)
None
None
 1.38A 2a1oB-3ll5A:
undetectable		 2a1oB-3ll5A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB
(Streptococcus
pneumoniae) 		4 / 8 HIS A   7
GLU A  80
HIS A  42
ALA A 135
 MN  A1246 ( 3.3A)
MN  A1246 (-2.4A)
MN  A1247 ( 3.3A)
MN  A1245 ( 4.7A)
 1.01A 2bnnA-2wjfA:
undetectable
2bnnB-2wjfA:
undetectable		 2bnnA-2wjfA:
24.49
2bnnB-2wjfA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 1nf3 PAR-6B
(Mus
musculus) 		5 / 12 LEU C 216
VAL C 246
SER C 178
VAL C 231
LEU C 242
 LEU  C 216 ( 0.6A)
VAL  C 246 ( 0.6A)
SER  C 178 ( 0.0A)
VAL  C 231 ( 0.6A)
LEU  C 242 ( 0.6A)
 1.17A 2hc4A-1nf3C:
undetectable		 2hc4A-1nf3C:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 5ool 39S RIBOSOMAL
PROTEIN L14,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LYS L  31
GLY L  93
PRO L  94
 A  A2469 ( 3.8A)
None
None
 0.94A 2hreB-5oolL:
undetectable		 2hreB-5oolL:
18.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 1a0j TRYPSIN
(Salmo
salar) 		6 / 6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 246 (-3.0A)
BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.15A 2otvA-1a0jA:
41.6		 2otvA-1a0jA:
73.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 3beu TRYPSIN
(Streptomyces
griseus) 		5 / 6 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
 0.16A 2otvA-3beuA:
32.3		 2otvA-3beuA:
36.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 GLY A 148
GLY A  14
GLY A  11
GLY A 144
ILE A  17
 None
None
GSP  A2466 (-3.1A)
GSP  A2466 (-3.0A)
None
 0.99A 2oxtA-1z5vA:
undetectable		 2oxtA-1z5vA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3beu TRYPSIN
(Streptomyces
griseus) 		6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
LEU A  53
 None
None
None
SO4  A 246 (-3.6A)
None
None
 1.44A 2oxtD-3beuA:
undetectable		 2oxtD-3beuA:
21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1a0j TRYPSIN
(Salmo
salar) 		7 / 12 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
None
 0.26A 2p16A-1a0jA:
35.4		 2p16A-1a0jA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 3beu TRYPSIN
(Streptomyces
griseus) 		8 / 12 PHE A 174
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
None
 0.48A 2p16A-3beuA:
33.2		 2p16A-3beuA:
41.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 6 VAL A 210
LYS A 211
ILE A 244
ILE A 168
 None
None
None
ADP  A 246 ( 4.6A)
 0.89A 2piwA-3ll5A:
undetectable		 2piwA-3ll5A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 1zkp HYPOTHETICAL PROTEIN
BA1088
(Bacillus
anthracis) 		5 / 11 ASP A  63
HIS A  64
HIS A 134
ASP A 155
HIS A 211
 ZN  A 246 (-2.7A)
ZN  A 246 (-3.2A)
ZN  A 245 (-3.3A)
ZN  A 246 ( 2.4A)
ZN  A 246 (-3.2A)
 0.69A 2q0jB-1zkpA:
10.6		 2q0jB-1zkpA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 ARG A  18
VAL A  84
ILE A   6
GLY A   7
GLY A   8
 None
None
None
ADP  A 246 (-3.2A)
IPE  A 247 ( 3.5A)
 1.04A 2r5pA-3ll5A:
undetectable		 2r5pA-3ll5A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 ARG A  18
VAL A  84
ILE A   6
GLY A   7
GLY A   8
 None
None
None
ADP  A 246 (-3.2A)
IPE  A 247 ( 3.5A)
 1.04A 2r5pC-3ll5A:
undetectable		 2r5pC-3ll5A:
18.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1a0j TRYPSIN
(Salmo
salar) 		6 / 8 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 246 (-3.0A)
BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.25A 2vinA-1a0jA:
16.6		 2vinA-1a0jA:
37.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 3beu TRYPSIN
(Streptomyces
griseus) 		6 / 8 ASP A 189
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 247 (-3.0A)
SO4  A 246 ( 4.1A)
SO4  A 246 ( 2.5A)
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
 0.76A 2vinA-3beuA:
32.1		 2vinA-3beuA:
29.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 1a0j TRYPSIN
(Salmo
salar) 		8 / 12 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
None
BEN  A 246 ( 3.9A)
None
BEN  A 246 (-3.3A)
None
 0.35A 2w26A-1a0jA:
14.0		 2w26A-1a0jA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 3beu TRYPSIN
(Streptomyces
griseus) 		9 / 12 PHE A 174
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 None
BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
None
BEN  A 247 (-3.7A)
None
BEN  A 247 (-3.5A)
None
 0.37A 2w26A-3beuA:
33.0		 2w26A-3beuA:
41.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3h7j BACILYSIN
BIOSYNTHESIS PROTEIN
BACB
(Bacillus
subtilis) 		5 / 12 LEU A 131
VAL A 137
ILE A 152
TYR A 177
MET A 179
 None
None
None
None
PPY  A 246 ( 4.3A)
 1.20A 2weyA-3h7jA:
undetectable		 2weyA-3h7jA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 1zkp HYPOTHETICAL PROTEIN
BA1088
(Bacillus
anthracis) 		5 / 12 HIS A 211
GLU A 175
HIS A 189
HIS A  59
VAL A 136
 ZN  A 246 (-3.2A)
None
None
ZN  A 245 (-3.3A)
None
 1.24A 2x91A-1zkpA:
undetectable		 2x91A-1zkpA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A600_1
(ORF12)		 3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
(Escherichia
coli) 		5 / 11 THR A 259
ALA A 542
GLY A 541
SER A 254
ARG A1218
 MGD  A1246 (-2.9A)
MGD  A1246 (-3.2A)
MGD  A1246 (-3.0A)
MGD  A1246 (-4.3A)
MGD  A1246 ( 2.7A)
 1.30A 2xf3A-3egwA:
undetectable		 2xf3A-3egwA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B600_1
(ORF12)		 3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
(Escherichia
coli) 		5 / 11 THR A 259
ALA A 542
GLY A 541
SER A 254
ARG A1218
 MGD  A1246 (-2.9A)
MGD  A1246 (-3.2A)
MGD  A1246 (-3.0A)
MGD  A1246 (-4.3A)
MGD  A1246 ( 2.7A)
 1.30A 2xf3B-3egwA:
undetectable		 2xf3B-3egwA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A600_1
(ORF12)		 3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
(Escherichia
coli) 		5 / 10 THR A 259
ALA A 542
GLY A 541
SER A 254
ARG A1218
 MGD  A1246 (-2.9A)
MGD  A1246 (-3.2A)
MGD  A1246 (-3.0A)
MGD  A1246 (-4.3A)
MGD  A1246 ( 2.7A)
 1.35A 2xfsA-3egwA:
0.0		 2xfsA-3egwA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B600_1
(ORF12)		 3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
(Escherichia
coli) 		5 / 11 THR A 259
ALA A 542
GLY A 541
SER A 254
ARG A1218
 MGD  A1246 (-2.9A)
MGD  A1246 (-3.2A)
MGD  A1246 (-3.0A)
MGD  A1246 (-4.3A)
MGD  A1246 ( 2.7A)
 1.31A 2xfsB-3egwA:
undetectable		 2xfsB-3egwA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		4 / 7 TYR A 251
TYR A 214
CYH A 180
CYH A 181
 LLP  A 246 ( 4.6A)
LLP  A 246 ( 4.0A)
None
None
 1.31A 2xytG-4wd2A:
undetectable		 2xytG-4wd2A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CHDN1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1zkp HYPOTHETICAL PROTEIN
BA1088
(Bacillus
anthracis) 		4 / 8 LEU A 207
HIS A  64
THR A 210
HIS A 134
 None
ZN  A 246 (-3.2A)
None
ZN  A 245 (-3.3A)
 1.22A 2y69C-1zkpA:
undetectable
2y69N-1zkpA:
undetectable
2y69P-1zkpA:
undetectable		 2y69C-1zkpA:
21.53
2y69N-1zkpA:
20.61
2y69P-1zkpA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1nf3 PAR-6B
(Mus
musculus) 		5 / 12 LEU C 216
VAL C 246
SER C 178
VAL C 231
LEU C 242
 LEU  C 216 ( 0.6A)
VAL  C 246 ( 0.6A)
SER  C 178 ( 0.0A)
VAL  C 231 ( 0.6A)
LEU  C 242 ( 0.6A)
 1.32A 2zlcA-1nf3C:
undetectable		 2zlcA-1nf3C:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB
(Streptococcus
pneumoniae) 		5 / 8 GLU A  80
HIS A   7
ASP A 199
HIS A 136
HIS A  42
 MN  A1246 (-2.4A)
MN  A1246 ( 3.3A)
MN  A1246 ( 2.8A)
MN  A1245 ( 3.5A)
MN  A1247 ( 3.3A)
 1.14A 3a6jA-2wjfA:
undetectable		 3a6jA-2wjfA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB
(Streptococcus
pneumoniae) 		5 / 7 GLU A  80
HIS A   7
ASP A 199
HIS A 136
HIS A  42
 MN  A1246 (-2.4A)
MN  A1246 ( 3.3A)
MN  A1246 ( 2.8A)
MN  A1245 ( 3.5A)
MN  A1247 ( 3.3A)
 1.12A 3a6jB-2wjfA:
undetectable		 3a6jB-2wjfA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB
(Streptococcus
pneumoniae) 		5 / 8 GLU A  80
HIS A   7
ASP A 199
HIS A 136
HIS A  42
 MN  A1246 (-2.4A)
MN  A1246 ( 3.3A)
MN  A1246 ( 2.8A)
MN  A1245 ( 3.5A)
MN  A1247 ( 3.3A)
 1.11A 3a6jC-2wjfA:
undetectable		 3a6jC-2wjfA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB
(Streptococcus
pneumoniae) 		5 / 8 GLU A  80
HIS A   7
ASP A 199
HIS A 136
HIS A  42
 MN  A1246 (-2.4A)
MN  A1246 ( 3.3A)
MN  A1246 ( 2.8A)
MN  A1245 ( 3.5A)
MN  A1247 ( 3.3A)
 1.15A 3a6jE-2wjfA:
undetectable		 3a6jE-2wjfA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB
(Streptococcus
pneumoniae) 		5 / 8 GLU A  80
HIS A   7
ASP A 199
HIS A 136
HIS A  42
 MN  A1246 (-2.4A)
MN  A1246 ( 3.3A)
MN  A1246 ( 2.8A)
MN  A1245 ( 3.5A)
MN  A1247 ( 3.3A)
 1.11A 3a6jF-2wjfA:
undetectable		 3a6jF-2wjfA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 3dlt ESTERASE D
(Lactobacillus
rhamnosus) 		4 / 8 ASP A 163
GLY A 157
HIS A 125
TYR A  24
 None
None
BUA  A 246 (-3.5A)
None
 0.77A 3af0A-3dltA:
2.8		 3af0A-3dltA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
(Escherichia
coli) 		3 / 3 HIS A1098
HIS A1092
HIS A1163
 MD1  A1245 ( 3.5A)
MGD  A1246 ( 3.7A)
MD1  A1245 (-3.4A)
 0.74A 3ag4A-3egwA:
undetectable		 3ag4A-3egwA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
(Escherichia
coli) 		3 / 3 HIS A1098
HIS A1092
HIS A1163
 MD1  A1245 ( 3.5A)
MGD  A1246 ( 3.7A)
MD1  A1245 (-3.4A)
 0.75A 3ag4N-3egwA:
undetectable		 3ag4N-3egwA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 2hyk BETA-1,3-GLUCANASE
(Nocardiopsis
sp.
F96) 		4 / 6 ASN A  51
SER A  52
HIS A  30
ASP A  47
 None
None
EOH  A 246 ( 4.1A)
None
 1.27A 3aruA-2hykA:
undetectable		 3aruA-2hykA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1zkp HYPOTHETICAL PROTEIN
BA1088
(Bacillus
anthracis) 		4 / 8 HIS A  64
THR A 210
HIS A 134
LEU A 207
 ZN  A 246 (-3.2A)
None
ZN  A 245 (-3.3A)
None
 1.18A 3asoA-1zkpA:
undetectable
3asoC-1zkpA:
undetectable
3asoP-1zkpA:
undetectable		 3asoA-1zkpA:
20.61
3asoC-1zkpA:
21.53
3asoP-1zkpA:
21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2bzg THIOPURINE
S-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 6 PHE A  40
ARG A 152
GLY A 153
ALA A 157
LEU A 185
PRO A 196
 SAH  A1246 (-3.4A)
SAH  A1246 (-4.0A)
SAH  A1246 (-3.9A)
SAH  A1246 ( 3.7A)
None
None
 0.27A 3bgdA-2bzgA:
39.3		 3bgdA-2bzgA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2bzg THIOPURINE
S-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 8 PHE A  40
ARG A 152
GLY A 153
VAL A 156
LEU A 185
PRO A 196
 SAH  A1246 (-3.4A)
SAH  A1246 (-4.0A)
SAH  A1246 (-3.9A)
None
None
None
 0.35A 3bgdB-2bzgA:
39.3		 3bgdB-2bzgA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2bzg THIOPURINE
S-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 8 PHE A  40
GLY A 153
VAL A 156
LEU A 185
PRO A 196
ARG A 226
 SAH  A1246 (-3.4A)
SAH  A1246 (-3.9A)
None
None
None
None
 0.62A 3bgdB-2bzgA:
39.3		 3bgdB-2bzgA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2bzg THIOPURINE
S-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 8 PHE A  40
VAL A 156
PRO A 196
ARG A 226
TRP A 230
 SAH  A1246 (-3.4A)
None
None
None
None
 0.78A 3bgdB-2bzgA:
39.3		 3bgdB-2bzgA:
71.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 1zkp HYPOTHETICAL PROTEIN
BA1088
(Bacillus
anthracis) 		4 / 5 HIS A 134
HIS A 189
HIS A 211
ASP A  63
 ZN  A 245 (-3.3A)
None
ZN  A 246 (-3.2A)
ZN  A 246 (-2.7A)
 1.17A 3c0zA-1zkpA:
undetectable		 3c0zA-1zkpA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 1zkp HYPOTHETICAL PROTEIN
BA1088
(Bacillus
anthracis) 		5 / 6 ASP A  96
HIS A  64
HIS A  59
ASP A  63
HIS A  61
 None
ZN  A 246 (-3.2A)
ZN  A 245 (-3.3A)
ZN  A 246 (-2.7A)
ZN  A 245 (-3.1A)
 1.42A 3c0zC-1zkpA:
undetectable		 3c0zC-1zkpA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 4aej COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		3 / 3 MET A  75
VAL A  71
GLU A  79
 None
None
GOL  A1246 (-3.1A)
 0.83A 3c6gA-4aejA:
undetectable		 3c6gA-4aejA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		5 / 12 CYH B 154
ALA B 156
ALA B 157
LEU B  93
ALA B  94
 SF4  B 246 (-2.2A)
None
None
None
None
 0.98A 3fc6C-3cirB:
undetectable		 3fc6C-3cirB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1gny XYLANASE 10C
(Cellvibrio
japonicus) 		5 / 9 GLY A 219
GLN A 217
ILE A 232
VAL A 235
VAL A  97
 None
XYP  A1246 (-3.2A)
None
None
None
 1.40A 3fi0K-1gnyA:
undetectable		 3fi0K-1gnyA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1gny XYLANASE 10C
(Cellvibrio
japonicus) 		5 / 9 GLY A 219
GLN A 217
ILE A 232
VAL A 235
VAL A  97
 None
XYP  A1246 (-3.2A)
None
None
None
 1.37A 3fi0O-1gnyA:
undetectable		 3fi0O-1gnyA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_A_ETSA302_1
(CARBONIC ANHYDRASE 4)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 12 HIS A 264
VAL A 246
ILE A 280
LEU A 308
THR A 304
 HIS  A 264 ( 1.0A)
VAL  A 246 ( 0.6A)
ILE  A 280 ( 0.7A)
LEU  A 308 ( 0.6A)
THR  A 304 ( 0.8A)
 0.95A 3fw3A-3whlA:
undetectable		 3fw3A-3whlA:
23.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1a0j TRYPSIN
(Salmo
salar) 		8 / 11 HIS A  57
ASP A 189
SER A 190
GLN A 192
SER A 195
TRP A 215
GLY A 216
GLY A 226
 SO4  A 248 (-3.9A)
BEN  A 246 (-3.0A)
BEN  A 246 (-3.0A)
None
SO4  A 248 ( 2.5A)
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.61A 3gy3A-1a0jA:
40.0		 3gy3A-1a0jA:
73.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1a0j TRYPSIN
(Salmo
salar) 		9 / 11 HIS A  57
LEU A  99
GLN A 175
ASP A 189
SER A 190
SER A 195
TRP A 215
GLY A 216
GLY A 226
 SO4  A 248 (-3.9A)
None
None
BEN  A 246 (-3.0A)
BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.45A 3gy3A-1a0jA:
40.0		 3gy3A-1a0jA:
73.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 3beu TRYPSIN
(Streptomyces
griseus) 		6 / 11 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
 SO4  A 246 ( 3.8A)
BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
 0.33A 3gy3A-3beuA:
32.2		 3gy3A-3beuA:
36.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		5 / 12 GLY A 149
GLY A 148
VAL A 151
LEU A  89
ILE A 144
 None
None
None
None
GOL  A 246 (-4.5A)
 1.25A 3h52B-3l77A:
undetectable		 3h52B-3l77A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_C_SRYC403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
(Escherichia
coli) 		5 / 12 ASN A 545
ASP A 222
ASN A  52
SER A 719
ASN A1217
 None
6MO  A1247 (-2.1A)
MGD  A1246 ( 3.6A)
MD1  A1245 (-3.0A)
MD1  A1245 (-3.0A)
 1.27A 3havC-3egwA:
1.2		 3havC-3egwA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
(Escherichia
coli) 		5 / 9 ARG A 260
PRO A 224
SER A 227
VAL A 578
GLY A 541
 MGD  A1246 ( 3.7A)
None
None
MGD  A1246 (-3.9A)
MGD  A1246 (-3.0A)
 1.49A 3hcnB-3egwA:
1.9		 3hcnB-3egwA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
(Escherichia
coli) 		5 / 9 ARG A 260
PRO A 224
SER A 227
VAL A 578
GLY A 541
 MGD  A1246 ( 3.7A)
None
None
MGD  A1246 (-3.9A)
MGD  A1246 (-3.0A)
 1.43A 3hcoA-3egwA:
0.0		 3hcoA-3egwA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
(Escherichia
coli) 		5 / 10 ARG A 260
PRO A 224
SER A 227
VAL A 578
GLY A 541
 MGD  A1246 ( 3.7A)
None
None
MGD  A1246 (-3.9A)
MGD  A1246 (-3.0A)
 1.45A 3hcoB-3egwA:
1.7		 3hcoB-3egwA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 GLY A 146
GLY A 144
ILE A 118
ASP A  68
LEU A  67
 GSP  A2466 (-4.0A)
GSP  A2466 (-3.0A)
None
MG  A 475 ( 4.0A)
None
 0.91A 3ihtA-1z5vA:
2.2		 3ihtA-1z5vA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1tj5 SUCROSE-PHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A 185
SER A 187
ASP A   9
ILE A   7
LEU A 193
 None
MG  A 247 (-2.6A)
PO4  A 246 (-2.1A)
None
None
 1.32A 3iv6B-1tj5A:
undetectable		 3iv6B-1tj5A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		5 / 12 GLY B 152
PRO B  73
GLY B  63
ALA B 171
ILE B 149
 SF4  B 246 (-4.2A)
None
FES  B 244 (-3.7A)
SF4  B 246 ( 3.8A)
SF4  B 246 (-4.9A)
 1.12A 3ku1G-3cirB:
undetectable		 3ku1G-3cirB:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
(Escherichia
coli) 		6 / 12 GLY A 541
GLY A 543
ASP A 263
ARG A 260
PRO A 257
LEU A 290
 MGD  A1246 (-3.0A)
MGD  A1246 (-3.5A)
None
MGD  A1246 ( 3.7A)
None
None
 1.41A 3m6vA-3egwA:
2.9		 3m6vA-3egwA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
(Escherichia
coli) 		6 / 12 GLY A 541
GLY A 543
ASP A 263
ARG A 260
PRO A 257
LEU A 290
 MGD  A1246 (-3.0A)
MGD  A1246 (-3.5A)
None
MGD  A1246 ( 3.7A)
None
None
 1.43A 3m6vB-3egwA:
undetectable		 3m6vB-3egwA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_D_AG2D1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 3tlx ADENYLATE KINASE 2
(Plasmodium
falciparum) 		5 / 10 ASP A  61
SER A  58
GLY A  42
ARG A 155
ASP A 190
 None
AMP  A 245 ( 4.9A)
ADP  A 246 (-3.5A)
ADP  A 246 (-3.2A)
None
 1.41A 3n2oC-3tlxA:
undetectable
3n2oD-3tlxA:
undetectable		 3n2oC-3tlxA:
17.28
3n2oD-3tlxA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 5jja SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM
(Homo
sapiens) 		5 / 12 PHE A 246
GLU A 226
ILE A 227
ALA A 222
ILE A 204
 PHE  A 246 ( 1.3A)
GLU  A 226 ( 0.5A)
ILE  A 227 ( 0.6A)
ALA  A 222 ( 0.0A)
ILE  A 204 ( 0.7A)
 1.26A 3ndiA-5jjaA:
undetectable		 3ndiA-5jjaA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 11 LEU A 153
GLY A 146
LEU A  67
ASN A  15
LEU A  69
 None
GSP  A2466 (-4.0A)
None
None
None
 1.16A 3ndvA-1z5vA:
0.0
3ndvB-1z5vA:
0.0		 3ndvA-1z5vA:
19.39
3ndvB-1z5vA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NJZ_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
(Escherichia
coli) 		5 / 12 HIS A1163
HIS A1098
HIS A1092
HIS A 546
ILE A 191
 MD1  A1245 (-3.4A)
MD1  A1245 ( 3.5A)
MGD  A1246 ( 3.7A)
MD1  A1245 (-4.0A)
None
 1.30A 3njzA-3egwA:
undetectable		 3njzA-3egwA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5xlu GAMMA GLUTAMYL
TRANSPEPTIDASE
(Bacillus
licheniformis) 		5 / 12 ALA A 235
ILE A 245
ASP A 247
ALA A 246
ASP A 238
 ALA  A 235 ( 0.0A)
ILE  A 245 ( 0.6A)
ASP  A 247 ( 0.6A)
ALA  A 246 ( 0.0A)
ASP  A 238 ( 0.5A)
 1.10A 3nvkI-5xluA:
undetectable		 3nvkI-5xluA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 1a0j TRYPSIN
(Salmo
salar) 		6 / 6 SER A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.32A 3rxfA-1a0jA:
41.6		 3rxfA-1a0jA:
73.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 3beu TRYPSIN
(Streptomyces
griseus) 		5 / 6 SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 SO4  A 246 ( 2.5A)
None
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
 0.25A 3rxfA-3beuA:
17.4		 3rxfA-3beuA:
36.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 1a0j TRYPSIN
(Salmo
salar) 		5 / 5 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 BEN  A 246 (-3.0A)
BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
BEN  A 246 (-3.3A)
 0.31A 3rxhA-1a0jA:
41.5		 3rxhA-1a0jA:
73.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 3beu TRYPSIN
(Streptomyces
griseus) 		4 / 5 ASP A 189
SER A 195
VAL A 213
GLY A 226
 BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
BEN  A 247 (-3.5A)
 0.34A 3rxhA-3beuA:
32.2		 3rxhA-3beuA:
36.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1zkp HYPOTHETICAL PROTEIN
BA1088
(Bacillus
anthracis) 		3 / 3 HIS A  61
SER A  20
ASN A 177
 ZN  A 245 (-3.1A)
ZN  A 246 ( 4.8A)
None
 0.85A 3s8pB-1zkpA:
undetectable		 3s8pB-1zkpA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 1ng0 COAT PROTEIN
(Cocksfoot
mottle
virus) 		3 / 3 SER A 246
PHE A  64
LYS A 244
 SER  A 246 ( 0.0A)
PHE  A  64 ( 1.3A)
LYS  A 244 ( 0.0A)
 1.02A 3u88A-1ng0A:
undetectable		 3u88A-1ng0A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		4 / 8 VAL A 218
ILE A 221
TYR A 254
ILE A 250
 None
None
None
OCS  A 246 ( 4.2A)
 0.84A 3uqbA-4fdyA:
undetectable		 3uqbA-4fdyA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 3gnr OS03G0212800 PROTEIN
(Oryza
sativa) 		6 / 12 LEU A 223
ILE A 222
LEU A 274
LEU A 176
ILE A 246
ALA A 247
 LEU  A 223 ( 0.5A)
ILE  A 222 ( 0.6A)
LEU  A 274 ( 0.6A)
LEU  A 176 ( 0.6A)
ILE  A 246 ( 0.7A)
ALA  A 247 ( 0.0A)
 1.41A 3uwlB-3gnrA:
undetectable		 3uwlB-3gnrA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 122
ALA A 106
GLY A 104
GLU A 109
ASN A 110
 None
None
SO4  A1246 (-3.4A)
None
SO4  A1252 (-3.7A)
 1.04A 3v3oB-2y89A:
undetectable		 3v3oB-2y89A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5ep8 PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE
(Bacillus
subtilis) 		4 / 7 ALA A 246
ILE A 247
ARG A 381
GLY A 377
 ALA  A 246 ( 0.0A)
ILE  A 247 ( 0.6A)
ARG  A 381 ( 0.6A)
GLY  A 377 ( 0.0A)
 0.96A 3v4tH-5ep8A:
undetectable		 3v4tH-5ep8A:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1zkp HYPOTHETICAL PROTEIN
BA1088
(Bacillus
anthracis) 		4 / 8 HIS A  64
THR A 210
HIS A 134
LEU A 207
 ZN  A 246 (-3.2A)
None
ZN  A 245 (-3.3A)
None
 1.23A 3wg7A-1zkpA:
undetectable
3wg7C-1zkpA:
undetectable
3wg7P-1zkpA:
undetectable		 3wg7A-1zkpA:
20.61
3wg7C-1zkpA:
21.53
3wg7P-1zkpA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1zkp HYPOTHETICAL PROTEIN
BA1088
(Bacillus
anthracis) 		4 / 8 LEU A 207
HIS A  64
THR A 210
HIS A 134
 None
ZN  A 246 (-3.2A)
None
ZN  A 245 (-3.3A)
 1.24A 3wg7C-1zkpA:
undetectable
3wg7N-1zkpA:
undetectable
3wg7P-1zkpA:
undetectable		 3wg7C-1zkpA:
21.53
3wg7N-1zkpA:
20.61
3wg7P-1zkpA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1gc7 RADIXIN
(Mus
musculus) 		3 / 3 ASP A 266
ARG A 246
LYS A 258
 ASP  A 266 ( 0.6A)
ARG  A 246 ( 0.6A)
LYS  A 258 ( 0.0A)
 0.98A 3wipG-1gc7A:
0.0		 3wipG-1gc7A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		4 / 7 TYR A 233
ASP A 245
SER A 247
HIS A 300
 None
OCS  A 246 ( 4.2A)
OCS  A 246 ( 3.5A)
OCS  A 246 ( 3.8A)
 1.36A 4arcA-4fdyA:
undetectable		 4arcA-4fdyA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB
(Streptococcus
pneumoniae) 		4 / 6 HIS A   5
HIS A 201
GLU A 138
ASP A 141
 MN  A1246 (-3.4A)
MN  A1247 ( 3.3A)
None
None
 1.37A 4blvA-2wjfA:
undetectable		 4blvA-2wjfA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 1zkp HYPOTHETICAL PROTEIN
BA1088
(Bacillus
anthracis) 		5 / 10 HIS A  59
HIS A  61
ASP A  63
HIS A 134
HIS A 211
 ZN  A 245 (-3.3A)
ZN  A 245 (-3.1A)
ZN  A 246 (-2.7A)
ZN  A 245 (-3.3A)
ZN  A 246 (-3.2A)
 0.73A 4c1dB-1zkpA:
9.6		 4c1dB-1zkpA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 1zkp HYPOTHETICAL PROTEIN
BA1088
(Bacillus
anthracis) 		5 / 11 HIS A  59
HIS A  61
ASP A  63
HIS A 134
HIS A 211
 ZN  A 245 (-3.3A)
ZN  A 245 (-3.1A)
ZN  A 246 (-2.7A)
ZN  A 245 (-3.3A)
ZN  A 246 (-3.2A)
 0.74A 4c1fA-1zkpA:
3.0
4c1fB-1zkpA:
4.7		 4c1fA-1zkpA:
20.36
4c1fB-1zkpA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 1zkp HYPOTHETICAL PROTEIN
BA1088
(Bacillus
anthracis) 		5 / 9 HIS A  59
HIS A  61
ASP A  63
HIS A 134
HIS A 211
 ZN  A 245 (-3.3A)
ZN  A 245 (-3.1A)
ZN  A 246 (-2.7A)
ZN  A 245 (-3.3A)
ZN  A 246 (-3.2A)
 0.72A 4c1hA-1zkpA:
10.6		 4c1hA-1zkpA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 SER A 140
VAL A 171
GLN A 230
ILE A 228
SER A 226
 GSP  A2466 (-3.1A)
None
None
GSP  A2466 (-4.5A)
None
 1.28A 4c49A-1z5vA:
undetectable		 4c49A-1z5vA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 SER A 140
VAL A 171
GLN A 230
ILE A 228
SER A 226
 GSP  A2466 (-3.1A)
None
None
GSP  A2466 (-4.5A)
None
 1.28A 4c49B-1z5vA:
undetectable		 4c49B-1z5vA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 SER A 140
VAL A 171
GLN A 230
ILE A 228
SER A 226
 GSP  A2466 (-3.1A)
None
None
GSP  A2466 (-4.5A)
None
 1.23A 4c49C-1z5vA:
undetectable		 4c49C-1z5vA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 SER A 140
VAL A 171
GLN A 230
ILE A 228
SER A 226
 GSP  A2466 (-3.1A)
None
None
GSP  A2466 (-4.5A)
None
 1.30A 4c49D-1z5vA:
undetectable		 4c49D-1z5vA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3r9r PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Mycobacteroides
abscessus) 		3 / 3 GLY A 253
SER A 252
TRP A 246
 GLY  A 253 ( 0.0A)
SER  A 252 ( 0.0A)
TRP  A 246 ( 0.5A)
 0.97A 4e7cD-3r9rA:
undetectable		 4e7cD-3r9rA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 1zkp HYPOTHETICAL PROTEIN
BA1088
(Bacillus
anthracis) 		4 / 8 HIS A  61
ASP A  63
HIS A 134
HIS A 211
 ZN  A 245 (-3.1A)
ZN  A 246 (-2.7A)
ZN  A 245 (-3.3A)
ZN  A 246 (-3.2A)
 0.70A 4exsB-1zkpA:
10.0		 4exsB-1zkpA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 5xym 50S RIBOSOMAL
PROTEIN L2
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLY C 251
VAL C 247
PRO C 249
GLY C 223
 G  A2466 ( 3.7A)
None
A  A2045 ( 3.9A)
C  A2046 ( 3.3A)
 0.83A 4forA-5xymC:
undetectable		 4forA-5xymC:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_B_15UB402_1
(PROTHROMBIN)		 1a0j TRYPSIN
(Salmo
salar) 		5 / 12 HIS A  57
LEU A  99
ASP A 189
GLY A 216
GLY A 226
 SO4  A 248 (-3.9A)
None
BEN  A 246 (-3.0A)
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.33A 4hfpB-1a0jA:
34.4		 4hfpB-1a0jA:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 1a0j TRYPSIN
(Salmo
salar) 		6 / 12 HIS A  57
LEU A  99
ASP A 189
VAL A 213
TRP A 215
GLY A 226
 SO4  A 248 (-3.9A)
None
BEN  A 246 (-3.0A)
None
None
BEN  A 246 (-3.3A)
 0.38A 4hfpD-1a0jA:
33.7		 4hfpD-1a0jA:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 3beu TRYPSIN
(Streptomyces
griseus) 		5 / 12 HIS A  57
ASP A 189
VAL A 213
TRP A 215
GLY A 226
 SO4  A 246 ( 3.8A)
BEN  A 247 (-3.0A)
None
None
BEN  A 247 (-3.5A)
 0.22A 4hfpD-3beuA:
31.3		 4hfpD-3beuA:
33.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 1cyd CARBONYL REDUCTASE
(Mus
musculus) 		4 / 7 VAL A  87
SER A 136
TYR A 149
MET A 186
 None
IPA  A 246 ( 2.7A)
IPA  A 246 ( 4.4A)
NDP  A 245 (-3.6A)
 0.40A 4hxyB-1cydA:
19.2		 4hxyB-1cydA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3tje FAB E09, HEAVY CHAIN
(Homo
sapiens) 		4 / 7 ALA H  74
GLU H  48
TYR H 100
LEU H  89
 None
EDO  H 246 (-3.5A)
None
None
 1.07A 4iomA-3tjeH:
undetectable		 4iomA-3tjeH:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB
(Streptococcus
pneumoniae) 		5 / 11 HIS A   7
ASN A 163
HIS A   5
ARG A 139
GLU A  80
 MN  A1246 ( 3.3A)
None
MN  A1246 (-3.4A)
PO4  A1244 (-2.8A)
MN  A1246 (-2.4A)
 1.20A 4ir0A-2wjfA:
undetectable
4ir0B-2wjfA:
undetectable		 4ir0A-2wjfA:
23.98
4ir0B-2wjfA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB
(Streptococcus
pneumoniae) 		5 / 12 HIS A   7
ASN A 163
HIS A   5
ARG A 139
GLU A  80
 MN  A1246 ( 3.3A)
None
MN  A1246 (-3.4A)
PO4  A1244 (-2.8A)
MN  A1246 (-2.4A)
 1.20A 4jd1A-2wjfA:
undetectable
4jd1B-2wjfA:
undetectable		 4jd1A-2wjfA:
23.98
4jd1B-2wjfA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		4 / 8 SER A 247
GLN A 268
VAL A 298
THR A 296
 OCS  A 246 ( 3.5A)
None
None
None
 1.12A 4lnwA-4fdyA:
undetectable		 4lnwA-4fdyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		4 / 6 SER A 247
GLN A 268
VAL A 298
THR A 296
 OCS  A 246 ( 3.5A)
None
None
None
 1.25A 4lnxA-4fdyA:
undetectable		 4lnxA-4fdyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		5 / 9 ALA A  37
LEU A 262
PHE A 258
THR A 243
LEU A 246
 ALA  A  37 ( 0.0A)
LEU  A 262 ( 0.6A)
PHE  A 258 ( 1.3A)
THR  A 243 ( 0.8A)
LEU  A 246 ( 0.6A)
 1.34A 4ltwA-1c8xA:
undetectable		 4ltwA-1c8xA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		5 / 12 ILE A 221
ASP A 245
ARG A 263
LEU A 285
ILE A 303
 None
OCS  A 246 ( 4.2A)
None
None
None
 1.08A 4m2xE-4fdyA:
undetectable		 4m2xE-4fdyA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 3tlx ADENYLATE KINASE 2
(Plasmodium
falciparum) 		5 / 10 ASP A  61
GLY A  42
SER A  58
GLY A 113
ASP A 191
 None
ADP  A 246 (-3.5A)
AMP  A 245 ( 4.9A)
AMP  A 245 (-4.1A)
None
 1.18A 4mmcA-3tlxA:
undetectable		 4mmcA-3tlxA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Sulfolobus
solfataricus) 		3 / 3 ARG B 136
ASP B 185
ARG B  96
 SO4  B 246 (-3.9A)
None
SO4  B 246 ( 4.8A)
 0.81A 4mx0A-3l7zB:
undetectable		 4mx0A-3l7zB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3ghg FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens) 		6 / 12 MET C 384
VAL C 248
LEU C 246
LEU C 344
PHE C 295
ALA C 289
 MET  C 384 ( 0.0A)
VAL  C 248 ( 0.6A)
LEU  C 246 ( 0.6A)
LEU  C 344 ( 0.6A)
PHE  C 295 ( 1.3A)
ALA  C 289 ( 0.0A)
 1.50A 4o1zB-3ghgC:
undetectable		 4o1zB-3ghgC:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 1zkp HYPOTHETICAL PROTEIN
BA1088
(Bacillus
anthracis) 		4 / 7 HIS A 189
HIS A 211
HIS A  59
HIS A  61
 None
ZN  A 246 (-3.2A)
ZN  A 245 (-3.3A)
ZN  A 245 (-3.1A)
 0.91A 4p6sB-1zkpA:
undetectable		 4p6sB-1zkpA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		5 / 11 ALA A  92
ALA A  91
GLY A  82
GLY A  83
ASP A  86
 None
None
SO4  A1246 (-3.3A)
SO4  A1246 (-3.4A)
None
 1.10A 4qvwK-2y89A:
undetectable
4qvwL-2y89A:
undetectable		 4qvwK-2y89A:
24.51
4qvwL-2y89A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		5 / 11 ALA A  92
ALA A  91
GLY A  82
GLY A  83
ASP A  86
 None
None
SO4  A1246 (-3.3A)
SO4  A1246 (-3.4A)
None
 1.10A 4qvwY-2y89A:
undetectable
4qvwZ-2y89A:
undetectable		 4qvwY-2y89A:
24.51
4qvwZ-2y89A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 3beu TRYPSIN
(Streptomyces
griseus) 		3 / 3 ASP A 102
HIS A  57
LYS A  96
 None
SO4  A 246 ( 3.8A)
None
 0.85A 4qzuD-3beuA:
undetectable		 4qzuD-3beuA:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 1a0j TRYPSIN
(Salmo
salar) 		6 / 12 HIS A  57
LEU A  99
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 SO4  A 248 (-3.9A)
None
None
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.33A 4rn6B-1a0jA:
28.3		 4rn6B-1a0jA:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 3beu TRYPSIN
(Streptomyces
griseus) 		5 / 12 HIS A  57
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 SO4  A 246 ( 3.8A)
None
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
 0.29A 4rn6B-3beuA:
26.5		 4rn6B-3beuA:
30.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		 2bzg THIOPURINE
S-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 185
GLY A 153
TRP A 150
ARG A 226
ILE A 204
 None
SAH  A1246 (-3.9A)
None
None
None
 1.46A 4udcA-2bzgA:
undetectable		 4udcA-2bzgA:
22.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4uqm URACIL-DNA
GLYCOSYLASE
(Deinococcus
radiodurans) 		8 / 8 GLY A  81
GLN A  82
TYR A  85
SER A  95
PHE A  96
SER A 107
ASN A 142
HIS A 206
 None
GOL  A1246 (-3.0A)
CL  A1245 (-4.3A)
None
None
None
CL  A1245 (-4.0A)
None
 0.33A 4wryA-4uqmA:
34.1		 4wryA-4uqmA:
45.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		4 / 8 GLY A 130
SER A 152
ASN A 134
HIS A 142
 CA  A 246 ( 4.4A)
MN  A 245 ( 4.3A)
MFU  A 501 ( 3.0A)
MN  A 245 (-3.8A)
 1.04A 4wrzA-1jxnA:
undetectable		 4wrzA-1jxnA:
21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4uqm URACIL-DNA
GLYCOSYLASE
(Deinococcus
radiodurans) 		8 / 8 GLY A  81
GLN A  82
TYR A  85
SER A  95
PHE A  96
SER A 107
ASN A 142
HIS A 206
 None
GOL  A1246 (-3.0A)
CL  A1245 (-4.3A)
None
None
None
CL  A1245 (-4.0A)
None
 0.28A 4wrzA-4uqmA:
34.3		 4wrzA-4uqmA:
45.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 4uqm URACIL-DNA
GLYCOSYLASE
(Deinococcus
radiodurans) 		7 / 7 GLY A  81
GLN A  82
TYR A  85
SER A  95
PHE A  96
ASN A 142
HIS A 206
 None
GOL  A1246 (-3.0A)
CL  A1245 (-4.3A)
None
None
CL  A1245 (-4.0A)
None
 0.75A 4ws0A-4uqmA:
33.4		 4ws0A-4uqmA:
45.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 4uqm URACIL-DNA
GLYCOSYLASE
(Deinococcus
radiodurans) 		8 / 8 GLY A  81
GLN A  82
TYR A  85
SER A  95
PHE A  96
SER A 107
ASN A 142
HIS A 206
 None
GOL  A1246 (-3.0A)
CL  A1245 (-4.3A)
None
None
None
CL  A1245 (-4.0A)
None
 0.71A 4ws1A-4uqmA:
33.6		 4ws1A-4uqmA:
45.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Sulfolobus
solfataricus) 		3 / 3 ASP B 185
LEU B 137
GLY B 134
 None
None
SO4  B 246 (-3.7A)
 0.57A 4xmfA-3l7zB:
undetectable		 4xmfA-3l7zB:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 3tlx ADENYLATE KINASE 2
(Plasmodium
falciparum) 		5 / 12 LEU A  48
PHE A 141
LEU A 223
GLY A  40
SER A 237
 None
None
None
ADP  A 246 (-3.0A)
None
 0.95A 4zbrA-3tlxA:
undetectable		 4zbrA-3tlxA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 1zkp HYPOTHETICAL PROTEIN
BA1088
(Bacillus
anthracis) 		4 / 8 HIS A  61
ASP A  63
HIS A 134
HIS A 211
 ZN  A 245 (-3.1A)
ZN  A 246 (-2.7A)
ZN  A 245 (-3.3A)
ZN  A 246 (-3.2A)
 0.70A 5a5zA-1zkpA:
10.1		 5a5zA-1zkpA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 1zkp HYPOTHETICAL PROTEIN
BA1088
(Bacillus
anthracis) 		6 / 11 HIS A  59
HIS A  61
ASP A  63
HIS A  64
HIS A 134
HIS A 211
 ZN  A 245 (-3.3A)
ZN  A 245 (-3.1A)
ZN  A 246 (-2.7A)
ZN  A 246 (-3.2A)
ZN  A 245 (-3.3A)
ZN  A 246 (-3.2A)
 0.44A 5ayaA-1zkpA:
10.6		 5ayaA-1zkpA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1zkp HYPOTHETICAL PROTEIN
BA1088
(Bacillus
anthracis) 		4 / 8 HIS A  64
THR A 210
HIS A 134
LEU A 207
 ZN  A 246 (-3.2A)
None
ZN  A 245 (-3.3A)
None
 1.22A 5b1aA-1zkpA:
undetectable
5b1aC-1zkpA:
undetectable
5b1aP-1zkpA:
undetectable		 5b1aA-1zkpA:
20.61
5b1aC-1zkpA:
21.53
5b1aP-1zkpA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1zkp HYPOTHETICAL PROTEIN
BA1088
(Bacillus
anthracis) 		4 / 8 HIS A  64
THR A 210
HIS A 134
LEU A 207
 ZN  A 246 (-3.2A)
None
ZN  A 245 (-3.3A)
None
 1.18A 5b3sA-1zkpA:
undetectable
5b3sC-1zkpA:
undetectable
5b3sP-1zkpA:
undetectable		 5b3sA-1zkpA:
20.61
5b3sC-1zkpA:
21.53
5b3sP-1zkpA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 GLY A 148
GLY A 144
GLY A  11
LEU A  10
ALA A 105
 None
GSP  A2466 (-3.0A)
GSP  A2466 (-3.1A)
None
None
 0.91A 5c0oE-1z5vA:
2.9		 5c0oE-1z5vA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 106
GLY A 128
GLY A 104
GLY A 142
ALA A 126
 None
None
SO4  A1246 (-3.4A)
None
None
 1.19A 5c0oE-2y89A:
undetectable		 5c0oE-2y89A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 GLY A 148
GLY A 144
GLY A  11
LEU A  10
ALA A 105
 None
GSP  A2466 (-3.0A)
GSP  A2466 (-3.1A)
None
None
 0.90A 5c0oG-1z5vA:
2.1		 5c0oG-1z5vA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1zkp HYPOTHETICAL PROTEIN
BA1088
(Bacillus
anthracis) 		3 / 3 HIS A  61
SER A  20
ASN A 177
 ZN  A 245 (-3.1A)
ZN  A 246 ( 4.8A)
None
 0.89A 5cprB-1zkpA:
undetectable		 5cprB-1zkpA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
(Escherichia
coli) 		5 / 12 PRO A 190
SER A1099
HIS A1092
ASP A 222
GLY A 579
 MD1  A1245 (-4.5A)
MD1  A1245 (-2.7A)
MGD  A1246 ( 3.7A)
6MO  A1247 (-2.1A)
MGD  A1246 (-3.5A)
 1.32A 5eenA-3egwA:
3.5		 5eenA-3egwA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2vm5 BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ARG A 162
VAL A 180
TRP A 214
 None
GOL  A1246 ( 4.8A)
None
 1.23A 5fvoA-2vm5A:
undetectable		 5fvoA-2vm5A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_C_RIOC600_0
(BIFUNCTIONAL AAC/APH)		 2qpm CYTOKININ
DEHYDROGENASE 1
(Zea
mays) 		5 / 12 SER A 456
ASN A 399
GLU A 288
GLU A 331
GLU A 381
 246  A1536 (-3.3A)
246  A1536 (-3.4A)
None
None
246  A1536 (-3.3A)
 1.42A 5iqdC-2qpmA:
0.0		 5iqdC-2qpmA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_D_NMYD600_1
(BIFUNCTIONAL AAC/APH)		 2qpm CYTOKININ
DEHYDROGENASE 1
(Zea
mays) 		5 / 12 SER A 456
ASN A 399
GLU A 288
GLU A 331
GLU A 381
 246  A1536 (-3.3A)
246  A1536 (-3.4A)
None
None
246  A1536 (-3.3A)
 1.33A 5iqeD-2qpmA:
0.0		 5iqeD-2qpmA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3beu TRYPSIN
(Streptomyces
griseus) 		3 / 3 SER A 214
SER A 195
PHE A  94
 None
SO4  A 246 ( 2.5A)
None
 0.85A 5mugA-3beuA:
undetectable		 5mugA-3beuA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB
(Streptococcus
pneumoniae) 		4 / 6 ASP A 199
HIS A   7
HIS A 201
HIS A 136
 MN  A1246 ( 2.8A)
MN  A1246 ( 3.3A)
MN  A1247 ( 3.3A)
MN  A1245 ( 3.5A)
 0.83A 5ncdA-2wjfA:
2.2
5ncdD-2wjfA:
5.5		 5ncdA-2wjfA:
22.34
5ncdD-2wjfA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB
(Streptococcus
pneumoniae) 		4 / 6 ASP A 199
HIS A   7
HIS A 201
HIS A 136
 MN  A1246 ( 2.8A)
MN  A1246 ( 3.3A)
MN  A1247 ( 3.3A)
MN  A1245 ( 3.5A)
 0.88A 5ncdB-2wjfA:
5.3
5ncdC-2wjfA:
2.2		 5ncdB-2wjfA:
22.34
5ncdC-2wjfA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB
(Streptococcus
pneumoniae) 		4 / 8 ASP A 199
HIS A   7
HIS A 201
HIS A 136
 MN  A1246 ( 2.8A)
MN  A1246 ( 3.3A)
MN  A1247 ( 3.3A)
MN  A1245 ( 3.5A)
 0.93A 5nekB-2wjfA:
5.4		 5nekB-2wjfA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1zkp HYPOTHETICAL PROTEIN
BA1088
(Bacillus
anthracis) 		4 / 8 ASP A 155
HIS A 134
HIS A  59
HIS A 211
 ZN  A 246 ( 2.4A)
ZN  A 245 (-3.3A)
ZN  A 245 (-3.3A)
ZN  A 246 (-3.2A)
 0.87A 5nekD-1zkpA:
undetectable		 5nekD-1zkpA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB
(Streptococcus
pneumoniae) 		4 / 6 ASP A 199
HIS A   7
HIS A 201
HIS A 136
 MN  A1246 ( 2.8A)
MN  A1246 ( 3.3A)
MN  A1247 ( 3.3A)
MN  A1245 ( 3.5A)
 0.81A 5nelA-2wjfA:
5.2
5nelD-2wjfA:
5.4		 5nelA-2wjfA:
22.34
5nelD-2wjfA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB
(Streptococcus
pneumoniae) 		5 / 6 HIS A 136
HIS A   7
HIS A 201
LEU A 106
HIS A   5
 MN  A1245 ( 3.5A)
MN  A1246 ( 3.3A)
MN  A1247 ( 3.3A)
None
MN  A1246 (-3.4A)
 1.23A 5nelB-2wjfA:
5.1
5nelC-2wjfA:
5.3		 5nelB-2wjfA:
22.34
5nelC-2wjfA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens) 		5 / 12 LEU A 149
GLY A  11
LEU A 153
LEU A 157
LEU A   8
 None
GSP  A2466 (-3.1A)
None
None
None
 0.98A 5nfjA-1z5vA:
2.6		 5nfjA-1z5vA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1zkp HYPOTHETICAL PROTEIN
BA1088
(Bacillus
anthracis) 		6 / 10 HIS A  59
HIS A  61
HIS A  64
HIS A 134
ASP A 155
HIS A 189
 ZN  A 245 (-3.3A)
ZN  A 245 (-3.1A)
ZN  A 246 (-3.2A)
ZN  A 245 (-3.3A)
ZN  A 246 ( 2.4A)
None
 0.46A 5nzwA-1zkpA:
10.1		 5nzwA-1zkpA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB
(Streptococcus
pneumoniae) 		3 / 3 HIS A   5
SER A 198
ARG A 206
 MN  A1246 (-3.4A)
None
PO4  A1244 (-3.6A)
 0.99A 5u63A-2wjfA:
undetectable		 5u63A-2wjfA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 1zkp HYPOTHETICAL PROTEIN
BA1088
(Bacillus
anthracis) 		5 / 12 ALA A 199
GLU A 175
LEU A 209
VAL A 151
ASP A 155
 None
None
None
None
ZN  A 246 ( 2.4A)
 1.27A 5vlmC-1zkpA:
undetectable		 5vlmC-1zkpA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
(Escherichia
coli) 		3 / 3 HIS A1098
HIS A1092
HIS A1163
 MD1  A1245 ( 3.5A)
MGD  A1246 ( 3.7A)
MD1  A1245 (-3.4A)
 0.74A 5waua-3egwA:
undetectable		 5waua-3egwA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 3nut PRECORRIN-3
METHYLASE
(Rhodobacter
capsulatus) 		5 / 11 GLY A  84
ASP A  82
ALA A  87
ALA A  89
ILE A 109
 None
None
SAH  A1501 (-3.5A)
None
GOL  A 246 (-4.5A)
 0.92A 5yk2A-3nutA:
undetectable		 5yk2A-3nutA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1zkp HYPOTHETICAL PROTEIN
BA1088
(Bacillus
anthracis) 		4 / 8 HIS A  64
THR A 210
HIS A 134
LEU A 207
 ZN  A 246 (-3.2A)
None
ZN  A 245 (-3.3A)
None
 1.23A 5z85A-1zkpA:
undetectable
5z85C-1zkpA:
undetectable
5z85P-1zkpA:
undetectable		 5z85A-1zkpA:
20.61
5z85C-1zkpA:
21.53
5z85P-1zkpA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1zkp HYPOTHETICAL PROTEIN
BA1088
(Bacillus
anthracis) 		4 / 7 LEU A 207
HIS A  64
THR A 210
HIS A 134
 None
ZN  A 246 (-3.2A)
None
ZN  A 245 (-3.3A)
 1.24A 5z85C-1zkpA:
undetectable
5z85N-1zkpA:
undetectable
5z85P-1zkpA:
undetectable		 5z85C-1zkpA:
21.53
5z85N-1zkpA:
20.61
5z85P-1zkpA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 1zkp HYPOTHETICAL PROTEIN
BA1088
(Bacillus
anthracis) 		4 / 8 HIS A  61
ASP A  63
HIS A 134
HIS A 211
 ZN  A 245 (-3.1A)
ZN  A 246 (-2.7A)
ZN  A 245 (-3.3A)
ZN  A 246 (-3.2A)
 0.73A 5zj8A-1zkpA:
10.0		 5zj8A-1zkpA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 4ikn AP-3 COMPLEX SUBUNIT
MU-1
(Rattus
norvegicus) 		5 / 12 VAL A 183
LEU A 220
ARG A 246
PHE A 222
LEU A 387
 VAL  A 183 ( 0.6A)
LEU  A 220 ( 0.6A)
ARG  A 246 ( 0.6A)
PHE  A 222 ( 1.3A)
LEU  A 387 ( 0.6A)
 1.45A 6a7pB-4iknA:
undetectable		 6a7pB-4iknA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
(Escherichia
coli) 		5 / 12 ASP A 263
SER A 240
VAL A 578
ALA A 575
ASN A 798
 None
None
MGD  A1246 (-3.9A)
None
None
 1.19A 6bqgA-3egwA:
undetectable		 6bqgA-3egwA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_B_84GB600_0
(BIFUNCTIONAL AAC/APH)		 2qpm CYTOKININ
DEHYDROGENASE 1
(Zea
mays) 		5 / 10 SER A 456
ASN A 399
GLU A 288
GLU A 331
GLU A 381
 246  A1536 (-3.3A)
246  A1536 (-3.4A)
None
None
246  A1536 (-3.3A)
 1.44A 6cggB-2qpmA:
0.0		 6cggB-2qpmA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_D_84GD600_0
(BIFUNCTIONAL AAC/APH)		 2qpm CYTOKININ
DEHYDROGENASE 1
(Zea
mays) 		5 / 11 SER A 456
ASN A 399
GLU A 288
GLU A 331
GLU A 381
 246  A1536 (-3.3A)
246  A1536 (-3.4A)
None
None
246  A1536 (-3.3A)
 1.35A 6cggD-2qpmA:
0.3		 6cggD-2qpmA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA810_0
(UNCHARACTERIZED
PROTEIN)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		4 / 6 TYR A 239
GLU A 242
GLN A 243
LYS A 246
 TYR  A 239 ( 1.3A)
GLU  A 242 ( 0.6A)
GLN  A 243 ( 0.6A)
LYS  A 246 ( 0.0A)
 1.02A 6d8pA-1fxjA:
0.0		 6d8pA-1fxjA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
(Escherichia
coli) 		3 / 3 HIS A1098
HIS A1092
HIS A1163
 MD1  A1245 ( 3.5A)
MGD  A1246 ( 3.7A)
MD1  A1245 (-3.4A)
 0.62A 6giqa-3egwA:
undetectable		 6giqa-3egwA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		5 / 12 GLY A 103
GLY A 105
VAL A 109
GLN A 287
PRO A 286
 LLP  A 246 ( 3.8A)
None
None
None
None
 1.14A 6gneA-4wd2A:
undetectable		 6gneA-4wd2A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		5 / 12 GLY A 103
GLY A 105
VAL A 279
GLN A 287
PRO A 286
 LLP  A 246 ( 3.8A)
None
None
None
None
 1.11A 6gneA-4wd2A:
undetectable		 6gneA-4wd2A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		5 / 12 GLY A 103
GLY A 105
VAL A 109
GLN A 287
PRO A 286
 LLP  A 246 ( 3.8A)
None
None
None
None
 1.13A 6gneB-4wd2A:
3.4		 6gneB-4wd2A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		5 / 12 GLY A 103
GLY A 105
VAL A 279
GLN A 287
PRO A 286
 LLP  A 246 ( 3.8A)
None
None
None
None
 1.10A 6gneB-4wd2A:
3.4		 6gneB-4wd2A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3pu5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
parapertussis) 		4 / 8 ASP A 249
ILE A 246
ARG A 320
ASN A 223
 ASP  A 249 ( 0.6A)
ILE  A 246 ( 0.7A)
ARG  A 320 ( 0.6A)
ASN  A 223 ( 0.6A)
 1.24A 6hisA-3pu5A:
undetectable
6hisB-3pu5A:
undetectable		 6hisA-3pu5A:
13.65
6hisB-3pu5A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3pu5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
parapertussis) 		4 / 8 ASP A 249
ILE A 246
ARG A 320
ASN A 223
 ASP  A 249 ( 0.6A)
ILE  A 246 ( 0.7A)
ARG  A 320 ( 0.6A)
ASN  A 223 ( 0.6A)
 1.23A 6hisB-3pu5A:
undetectable
6hisC-3pu5A:
undetectable		 6hisB-3pu5A:
13.65
6hisC-3pu5A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3pu5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
parapertussis) 		4 / 8 ASP A 249
ILE A 246
ARG A 320
ASN A 223
 ASP  A 249 ( 0.6A)
ILE  A 246 ( 0.7A)
ARG  A 320 ( 0.6A)
ASN  A 223 ( 0.6A)
 1.23A 6hisC-3pu5A:
undetectable
6hisD-3pu5A:
undetectable		 6hisC-3pu5A:
13.65
6hisD-3pu5A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3pu5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
parapertussis) 		4 / 8 ASP A 249
ILE A 246
ARG A 320
ASN A 223
 ASP  A 249 ( 0.6A)
ILE  A 246 ( 0.7A)
ARG  A 320 ( 0.6A)
ASN  A 223 ( 0.6A)
 1.23A 6hisD-3pu5A:
undetectable
6hisE-3pu5A:
undetectable		 6hisD-3pu5A:
13.65
6hisE-3pu5A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3pu5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
parapertussis) 		4 / 8 ASN A 223
ASP A 249
ILE A 246
ARG A 320
 ASN  A 223 ( 0.6A)
ASP  A 249 ( 0.6A)
ILE  A 246 ( 0.7A)
ARG  A 320 ( 0.6A)
 1.23A 6hisA-3pu5A:
undetectable
6hisE-3pu5A:
undetectable		 6hisA-3pu5A:
13.65
6hisE-3pu5A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
(Escherichia
coli) 		3 / 3 HIS A1098
HIS A1092
HIS A1163
 MD1  A1245 ( 3.5A)
MGD  A1246 ( 3.7A)
MD1  A1245 (-3.4A)
 0.74A 6hu9a-3egwA:
undetectable		 6hu9a-3egwA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1a0j TRYPSIN
(Salmo
salar) 		4 / 8 GLY A 216
GLY A 193
SER A 195
ALA A  55
 BEN  A 246 ( 3.9A)
SO4  A 248 (-3.8A)
SO4  A 248 ( 2.5A)
None
 0.79A 6hu9H-1a0jA:
0.0
6hu9e-1a0jA:
undetectable		 6hu9H-1a0jA:
17.33
6hu9e-1a0jA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 3beu TRYPSIN
(Streptomyces
griseus) 		4 / 8 GLY A 216
GLY A 193
SER A 195
ALA A  55
 BEN  A 247 (-3.7A)
SO4  A 246 (-3.6A)
SO4  A 246 ( 2.5A)
None
 0.79A 6hu9H-3beuA:
undetectable
6hu9e-3beuA:
undetectable		 6hu9H-3beuA:
17.06
6hu9e-3beuA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
(Escherichia
coli) 		5 / 12 MET A 194
ALA A 193
THR A 587
VAL A 578
TYR A 220
 None
None
None
MGD  A1246 (-3.9A)
MD1  A1245 (-3.5A)
 1.43A 6hu9N-3egwA:
undetectable		 6hu9N-3egwA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 2y89 PHOSPHORIBOSYL
ISOMERASE A
(Mycobacterium
tuberculosis) 		4 / 6 ARG A  60
ARG A  85
THR A 105
ALA A  57
 None
SO4  A1246 (-4.1A)
SO4  A1246 (-3.0A)
SO4  A1246 ( 3.9A)
 1.16A 6ma6A-2y89A:
undetectable		 6ma6A-2y89A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 3gnr OS03G0212800 PROTEIN
(Oryza
sativa) 		5 / 12 ILE A 222
LEU A 274
LEU A 176
ILE A 246
ALA A 247
 ILE  A 222 ( 0.6A)
LEU  A 274 ( 0.6A)
LEU  A 176 ( 0.6A)
ILE  A 246 ( 0.7A)
ALA  A 247 ( 0.0A)
 1.24A 6qxsD-3gnrA:
undetectable		 6qxsD-3gnrA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 3gnr OS03G0212800 PROTEIN
(Oryza
sativa) 		5 / 12 ILE A 222
LEU A 274
LEU A 176
ILE A 246
ALA A 247
 ILE  A 222 ( 0.6A)
LEU  A 274 ( 0.6A)
LEU  A 176 ( 0.6A)
ILE  A 246 ( 0.7A)
ALA  A 247 ( 0.0A)
 1.27A 6qyaB-3gnrA:
undetectable		 6qyaB-3gnrA:
20.66