SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '243'

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1A8U_A_BEZA295_0 (CHLOROPEROXIDASE T)	3e0x	LIPASE-ESTERASE RELATED PROTEIN (Clostridium acetobutylicum)	5 / 10	GLY A  21 LEU A 112 PHE A 118 THR A 199 HIS A 224	OXE  A 243 (-3.8A) None None None OXE  A 243 (-4.1A)	1.50A	1a8uA-3e0xA: 27.5	1a8uA-3e0xA: 25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1BX4_A_ADNA350_2 (PROTEIN (ADENOSINE KINASE))	2wfo	GLYCOPROTEIN 1 (Machupo mammarenavirus)	3 / 3	LEU A 132 SER A 141 ASN A 137	None None NAG  A1243 (-1.8A)	0.79A	1bx4A-2wfoA: undetectable	1bx4A-2wfoA: 17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1D4F_C_ADNC603_1 (S-ADENOSYLHOMOCYSTEI NE HYDROLASE)	4v0h	METALLO-BETA-LACTAMA SE DOMAIN-CONTAINING PROTEIN 1 1 (Homo sapiens)	5 / 12	LEU A 209 HIS A 172 ASP A 121 GLY A 194 HIS A 122	None FE  A1242 (-3.4A) FE  A1243 (-2.9A) None FE  A1243 (-3.5A)	1.38A	1d4fC-4v0hA: undetectable	1d4fC-4v0hA: 21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DRF_A_FOLA187_0 (DIHYDROFOLATE REDUCTASE)	1ng0	COAT PROTEIN (Cocksfoot mottle virus)	5 / 12	ALA A  94 SER A 239 ILE A 241 PRO A 110 LEU A 243	ALA  A  94 ( 0.0A) SER  A 239 ( 0.0A) ILE  A 241 ( 0.7A) PRO  A 110 ( 1.1A) LEU  A 243 ( 0.6A)	0.99A	1drfA-1ng0A: undetectable	1drfA-1ng0A: 23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E7W_A_MTXA301_1 (PTERIDINE REDUCTASE)	3mqt	MANDELATE RACEMASE/MUCONATE LACTONIZING PROTEIN (Shewanella pealeana)	5 / 12	PRO A 141 LEU A 193 TYR A 156 LEU A 229 ASP A 206	None None None None MG  A1243 (-3.3A)	1.41A	1e7wA-3mqtA: undetectable	1e7wA-3mqtA: 22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1H4O_A_BEZA1162_0 (PEROXIREDOXIN 5)	3hvy	CYSTATHIONINE BETA-LYASE FAMILY PROTEIN, YNBB B.SUBTILIS ORTHOLOG (Clostridium acetobutylicum)	5 / 10	GLY A 239 CYH A 219 LEU A 129 THR A 101 GLY A 105	None LLP  A 243 ( 3.5A) None LLP  A 243 ( 3.3A) None	1.26A	1h4oA-3hvyA: undetectable 1h4oB-3hvyA: undetectable	1h4oA-3hvyA: 17.65 1h4oB-3hvyA: 17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HK1_A_T44A3003_1 (SERUM ALBUMIN)	4dlk	PHOSPHORIBOSYLAMINOI MIDAZOLE CARBOXYLASE, ATPASE SUBUNIT (Bacillus anthracis)	4 / 6	HIS A 274 ILE A 194 LYS A 240 ALA A 243	HIS  A 274 (-1.0A) ILE  A 194 ( 0.7A) LYS  A 240 ( 0.0A) ALA  A 243 ( 0.0A)	0.98A	1hk1A-4dlkA: undetectable	1hk1A-4dlkA: 21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIJ_A_NOVA400_1 (DNA GYRASE SUBUNIT B)	3ea0	ATPASE, PARA FAMILY (Chlorobaculum tepidum)	5 / 12	ASP A 205 ASP A 180 ARG A 178 ILE A 202 ILE A 232	None None ATP  A 243 (-3.1A) None None	1.18A	1kijA-3ea0A: undetectable	1kijA-3ea0A: 20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MT1_C_AG2C7004_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN)	5c05	PUTATIVE GAMMA-TERPINENE SYNTHASE (Thymus vulgaris)	4 / 6	LEU A 195 GLU A 223 LEU A 243 LEU A 236	LEU  A 195 ( 0.6A) GLU  A 223 ( 0.5A) LEU  A 243 ( 0.5A) LEU  A 236 ( 0.6A)	1.00A	1mt1D-5c05A: undetectable 1mt1E-5c05A: undetectable	1mt1D-5c05A: 11.27 1mt1E-5c05A: 6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P93_C_DEXC3999_1 (GLUCOCORTICOID RECEPTOR)	3e0x	LIPASE-ESTERASE RELATED PROTEIN (Clostridium acetobutylicum)	5 / 12	MET A 126 LEU A 134 MET A 165 LEU A 169 THR A 199	None None OXE  A 243 ( 4.6A) None None	1.19A	1p93C-3e0xA: undetectable	1p93C-3e0xA: 20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q23_E_FUAE706_2 (CHLORAMPHENICOL ACETYLTRANSFERASE)	3cvj	PUTATIVE PHOSPHOHEPTOSE ISOMERASE (Bacillus halodurans)	4 / 4	ALA A  71 VAL A  46 ALA A  56 HIS A  53	None None None MG  A 243 (-3.5A)	1.17A	1q23F-3cvjA: undetectable	1q23F-3cvjA: 23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q23_J_FUAJ711_2 (CHLORAMPHENICOL ACETYLTRANSFERASE)	3cvj	PUTATIVE PHOSPHOHEPTOSE ISOMERASE (Bacillus halodurans)	4 / 4	ALA A  71 VAL A  46 ALA A  56 HIS A  53	None None None MG  A 243 (-3.5A)	1.22A	1q23K-3cvjA: undetectable	1q23K-3cvjA: 23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1R9O_A_FLPA501_1 (CYTOCHROME P450 2C9)	3hvy	CYSTATHIONINE BETA-LYASE FAMILY PROTEIN, YNBB B.SUBTILIS ORTHOLOG (Clostridium acetobutylicum)	5 / 12	ASN A 244 ILE A 245 ASP A 217 GLY A 239 ALA A 238	LLP  A 243 ( 4.7A) None LLP  A 243 ( 2.9A) None None	1.06A	1r9oA-3hvyA: undetectable	1r9oA-3hvyA: 23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SG9_A_SAMA301_0 (HEMK PROTEIN)	3ea0	ATPASE, PARA FAMILY (Chlorobaculum tepidum)	5 / 12	ILE A 120 GLY A  15 GLU A 140 PHE A   4 ASN A  21	None ATP  A 243 (-3.8A) None None None	1.21A	1sg9A-3ea0A: 3.1	1sg9A-3ea0A: 24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SG9_A_SAMA301_0 (HEMK PROTEIN)	3hvy	CYSTATHIONINE BETA-LYASE FAMILY PROTEIN, YNBB B.SUBTILIS ORTHOLOG (Clostridium acetobutylicum)	5 / 12	PRO A 297 ILE A 242 GLY A 247 ILE A 245 ASN A 244	None LLP  A 243 ( 4.3A) None None LLP  A 243 ( 4.7A)	1.10A	1sg9A-3hvyA: 4.6	1sg9A-3hvyA: 20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TUV_A_VK3A4558_1 (PROTEIN YGIN)	3e0x	LIPASE-ESTERASE RELATED PROTEIN (Clostridium acetobutylicum)	4 / 7	TYR A  88 HIS A 224 LEU A 198 MET A 165	OXE  A 243 (-4.2A) OXE  A 243 (-4.1A) None OXE  A 243 ( 4.6A)	1.10A	1tuvA-3e0xA: undetectable	1tuvA-3e0xA: 16.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1UAK_A_SAMA301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3quv	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Mycobacteroides abscessus)	8 / 12	PRO A  85 GLY A 109 SER A 132 ILE A 133 VAL A 137 LEU A 138 GLY A 140 GLY A 141	EDO  A 243 (-3.7A) EDO  A 244 ( 4.1A) None None None EDO  A 243 (-4.0A) EDO  A 243 (-4.1A) EDO  A 243 (-3.6A)	0.77A	1uakA-3quvA: 20.7	1uakA-3quvA: 40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1V2X_A_SAMA400_0 (TRNA (GM18) METHYLTRANSFERASE)	3ilk	UNCHARACTERIZED TRNA/RRNA METHYLTRANSFERASE HI0380 (Haemophilus influenzae)	7 / 12	PHE A 110 GLY A 111 GLY A 116 ILE A 131 SER A 139 LEU A 140 ALA A 145	None EDO  A 242 (-4.6A) None EDO  A 243 (-4.0A) None None EDO  A 242 ( 3.7A)	0.75A	1v2xA-3ilkA: 16.8	1v2xA-3ilkA: 22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WRL_C_TFPC208_1 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	3e0x	LIPASE-ESTERASE RELATED PROTEIN (Clostridium acetobutylicum)	4 / 5	PHE A 155 LEU A 134 PHE A 225 SER A  89	None None None OXE  A 243 (-2.8A)	1.29A	1wrlC-3e0xA: undetectable	1wrlC-3e0xA: 16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X7P_A_SAMA301_0 (RRNA METHYLTRANSFERASE)	3ilk	UNCHARACTERIZED TRNA/RRNA METHYLTRANSFERASE HI0380 (Haemophilus influenzae)	7 / 11	THR A  78 GLY A 111 GLY A 116 ILE A 131 SER A 139 LEU A 140 ALA A 145	EDO  A 242 (-3.4A) EDO  A 242 (-4.6A) None EDO  A 243 (-4.0A) None None EDO  A 242 ( 3.7A)	0.93A	1x7pA-3ilkA: 17.1 1x7pB-3ilkA: 17.3	1x7pA-3ilkA: 22.15 1x7pB-3ilkA: 22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X7P_B_SAMB302_0 (RRNA METHYLTRANSFERASE)	3ilk	UNCHARACTERIZED TRNA/RRNA METHYLTRANSFERASE HI0380 (Haemophilus influenzae)	6 / 10	THR A  78 GLY A 111 GLY A 116 ILE A 131 LEU A 140 ALA A 145	EDO  A 242 (-3.4A) EDO  A 242 (-4.6A) None EDO  A 243 (-4.0A) None EDO  A 242 ( 3.7A)	0.74A	1x7pA-3ilkA: 17.1 1x7pB-3ilkA: 17.3	1x7pA-3ilkA: 22.15 1x7pB-3ilkA: 22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YAJ_B_BEZB12_0 (CES1 PROTEIN)	2bkx	GLUCOSAMINE-6-PHOSPH ATE DEAMINASE (Bacillus subtilis)	4 / 4	GLY A  33 SER A 190 VAL A 120 LEU A  66	None None None F6R  A1243 (-4.0A)	1.22A	1yajB-2bkxA: undetectable	1yajB-2bkxA: 18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AOU_A_CQAA403_0 (HISTAMINE N-METHYLTRANSFERASE)	5gpr	CHITINASE (Ostrinia furnacalis)	4 / 8	LYS A 243 GLY A 247 PHE A 299 ASP A 127	LYS  A 243 ( 0.0A) GLY  A 247 ( 0.0A) PHE  A 299 ( 1.3A) ASP  A 127 ( 0.5A)	1.03A	2aouA-5gprA: undetectable	2aouA-5gprA: 19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BM9_C_SAMC301_1 (CEPHALOSPORIN HYDROXYLASE CMCI)	4bxs	VENOM PROTHROMBIN ACTIVATOR PSEUTARIN-C NON-CATALYTIC SUBUNIT (Pseudonaja textilis)	4 / 4	SER V 147 ASP V 113 ARG V 110 ASP V 107	None CA  V2430 (-2.7A) None None	1.30A	2bm9C-4bxsV: undetectable	2bm9C-4bxsV: 9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CBR_A_A80A201_1 (PROTEIN (CRABP-I))	3hvy	CYSTATHIONINE BETA-LYASE FAMILY PROTEIN, YNBB B.SUBTILIS ORTHOLOG (Clostridium acetobutylicum)	5 / 12	PHE A  86 VAL A  93 LEU A  78 VAL A  81 GLY A 246	None None None None LLP  A 243 ( 4.0A)	1.04A	2cbrA-3hvyA: undetectable	2cbrA-3hvyA: 15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EIM_J_CHDJ60_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART)	2bkx	GLUCOSAMINE-6-PHOSPH ATE DEAMINASE (Bacillus subtilis)	4 / 5	TYR A 116 MET A 182 THR A 181 LEU A  66	None None None F6R  A1243 (-4.0A)	1.39A	2eimJ-2bkxA: undetectable	2eimJ-2bkxA: 10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EIM_W_CHDW1060_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART)	2bkx	GLUCOSAMINE-6-PHOSPH ATE DEAMINASE (Bacillus subtilis)	4 / 5	TYR A 116 MET A 182 THR A 181 LEU A  66	None None None F6R  A1243 (-4.0A)	1.41A	2eimW-2bkxA: undetectable	2eimW-2bkxA: 10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2G72_B_SAMB2002_1 (PHENYLETHANOLAMINE N-METHYLTRANSFERASE)	4bxs	VENOM PROTHROMBIN ACTIVATOR PSEUTARIN-C NON-CATALYTIC SUBUNIT (Pseudonaja textilis)	4 / 7	TYR V 888 GLY V 894 TYR V 942 ASP V 909	None None None CA  V2431 (-3.3A)	0.96A	2g72B-4bxsV: undetectable	2g72B-4bxsV: 11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2GL0_C_ADNC903_1 (CONSERVED HYPOTHETICAL PROTEIN)	3tpu	42F3 ALPHA 42F3 BETA (Homo sapiens; Mus musculus)	5 / 12	ALA B 234 VAL B 193 HIS B 204 PHE B 205 SER A 128	None None SO4  B 243 (-3.9A) None None	1.35A	2gl0A-3tpuB: undetectable 2gl0C-3tpuB: undetectable	2gl0A-3tpuB: 20.52 2gl0C-3tpuB: 20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HKK_A_ALEA300_1 (CARBONIC ANHYDRASE 2)	2r7e	COAGULATION FACTOR VIII (Homo sapiens)	4 / 6	ASN B2019 HIS B2082 ILE B1940 GLN B1874	NAG  B2431 ( 4.8A) None None None	1.20A	2hkkA-2r7eB: undetectable	2hkkA-2r7eB: 16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HKK_A_ALEA300_1 (CARBONIC ANHYDRASE 2)	2r7e	COAGULATION FACTOR VIII (Homo sapiens)	4 / 6	ASN B2019 HIS B2082 ILE B1940 GLN B1938	NAG  B2431 ( 4.8A) None None NAG  B2431 (-3.4A)	1.19A	2hkkA-2r7eB: undetectable	2hkkA-2r7eB: 16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HRE_D_CHDD702_0 (FERROCHELATASE)	1vho	ENDOGLUCANASE (Thermotoga maritima)	3 / 3	ARG A 316 GLY A 243 PRO A 244	ARG  A 316 ( 0.6A) GLY  A 243 ( 0.0A) PRO  A 244 ( 1.1A)	0.70A	2hreD-1vhoA: 2.4	2hreD-1vhoA: 23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NXE_A_SAMA302_1 (RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE)	3ubl	GLUTATHIONE TRANSFERASE (Leptospira interrogans)	3 / 3	THR A  76 ASP A 153 SER A 155	SO4  A 243 (-3.8A) None None	0.67A	2nxeA-3ublA: undetectable	2nxeA-3ublA: 24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NXE_B_SAMB303_1 (RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE)	3ubl	GLUTATHIONE TRANSFERASE (Leptospira interrogans)	3 / 3	THR A  76 ASP A 153 SER A 155	SO4  A 243 (-3.8A) None None	0.70A	2nxeB-3ublA: undetectable	2nxeB-3ublA: 24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OCU_A_TYLA3001_1 (LACTOTRANSFERRIN)	3e0x	LIPASE-ESTERASE RELATED PROTEIN (Clostridium acetobutylicum)	3 / 3	LEU A 227 TYR A  88 GLY A  92	None OXE  A 243 (-4.2A) None	0.50A	2ocuA-3e0xA: undetectable	2ocuA-3e0xA: 21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OUZ_A_C3DA999_0 (ESTROGEN RECEPTOR)	3e0x	LIPASE-ESTERASE RELATED PROTEIN (Clostridium acetobutylicum)	5 / 12	LEU A 158 THR A 157 LEU A 150 LEU A 227 HIS A  20	OXE  A 243 (-4.7A) None None None None	1.07A	2ouzA-3e0xA: undetectable	2ouzA-3e0xA: 19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q0J_B_BEZB500_0 (QUINOLONE SIGNAL RESPONSE PROTEIN)	4v0h	METALLO-BETA-LACTAMA SE DOMAIN-CONTAINING PROTEIN 1 1 (Homo sapiens)	5 / 11	ASP A 121 HIS A 122 HIS A 172 ASP A 195 HIS A 234	FE  A1243 (-2.9A) FE  A1243 (-3.5A) FE  A1242 (-3.4A) FE  A1243 ( 2.4A) FE  A1243 (-3.2A)	0.60A	2q0jB-4v0hA: 13.2	2q0jB-4v0hA: 25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q9R_A_BEZA203_0 (PROTEIN OF UNKNOWN FUNCTION)	3quv	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Mycobacteroides abscessus)	4 / 5	GLY A 141 PRO A  83 ILE A 148 ILE A 133	EDO  A 243 (-3.6A) None None None	0.84A	2q9rA-3quvA: undetectable	2q9rA-3quvA: 21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QWX_B_ML1B233_1 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	2znw	SCFV10 (Mus musculus; synthetic construct)	4 / 7	GLY A 171 GLY A 222 GLN A  89 PHE A  98	None 1PG  A 243 ( 4.7A) 1PG  A 243 (-3.2A) None	0.92A	2qwxA-2znwA: undetectable 2qwxB-2znwA: undetectable	2qwxA-2znwA: 20.61 2qwxB-2znwA: 20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RHM_D_BEZD194_0 (PUTATIVE KINASE)	2w1k	PUTATIVE SORTASE (Streptococcus pneumoniae)	4 / 5	PRO A 131 ILE A 137 ARG A 222 ASP A 133	None None MES  A1243 (-2.7A) MES  A1243 (-3.3A)	1.48A	2rhmD-2w1kA: undetectable	2rhmD-2w1kA: 24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2TSR_B_D16B409_1 (THYMIDYLATE SYNTHASE)	2bkx	GLUCOSAMINE-6-PHOSPH ATE DEAMINASE (Bacillus subtilis)	5 / 8	ARG A 192 ASP A  67 LEU A  66 GLY A 140 TYR A  80	None F6R  A1243 (-3.1A) F6R  A1243 (-4.0A) F6R  A1243 (-3.0A) None	1.46A	2tsrB-2bkxA: undetectable	2tsrB-2bkxA: 24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2TSR_D_D16D609_1 (THYMIDYLATE SYNTHASE)	2bkx	GLUCOSAMINE-6-PHOSPH ATE DEAMINASE (Bacillus subtilis)	5 / 9	ASP A  67 LEU A  66 GLY A 140 TYR A  80 THR A 126	F6R  A1243 (-3.1A) F6R  A1243 (-4.0A) F6R  A1243 (-3.0A) None None	1.26A	2tsrD-2bkxA: undetectable	2tsrD-2bkxA: 24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0Z_O_C41O1327_2 (RENIN)	3bkw	S-ADENOSYLMETHIONINE DEPENDENT METHYLTRANSFERASE (Mesorhizobium japonicum)	4 / 8	SER A 142 PRO A  39 LEU A  44 THR A 196	None None None EDO  A 243 (-3.0A)	1.15A	2v0zO-3bkwA: undetectable	2v0zO-3bkwA: 19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V2G_A_BEZA1222_0 (PEROXIREDOXIN 6)	2hi0	PUTATIVE PHOSPHOGLYCOLATE PHOSPHATASE (Lactobacillus delbrueckii)	4 / 7	THR A 170 VAL A 174 SER A 171 ARG A 181	None ACT  A 243 (-4.7A) None None	1.06A	2v2gA-2hi0A: 2.6 2v2gB-2hi0A: 2.5	2v2gA-2hi0A: 20.97 2v2gB-2hi0A: 20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V2G_C_BEZC1222_0 (PEROXIREDOXIN 6)	2hi0	PUTATIVE PHOSPHOGLYCOLATE PHOSPHATASE (Lactobacillus delbrueckii)	4 / 7	THR A 170 VAL A 174 SER A 171 ARG A 181	None ACT  A 243 (-4.7A) None None	1.07A	2v2gC-2hi0A: 2.6 2v2gD-2hi0A: 2.6	2v2gC-2hi0A: 20.97 2v2gD-2hi0A: 20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V41_E_BEZE1222_0 (PEROXIREDOXIN 6.)	2hi0	PUTATIVE PHOSPHOGLYCOLATE PHOSPHATASE (Lactobacillus delbrueckii)	4 / 7	THR A 170 VAL A 174 SER A 171 ARG A 181	None ACT  A 243 (-4.7A) None None	1.06A	2v41E-2hi0A: 2.5 2v41F-2hi0A: 2.2	2v41E-2hi0A: 20.97 2v41F-2hi0A: 20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V41_F_BEZF1222_0 (PEROXIREDOXIN 6.)	2hi0	PUTATIVE PHOSPHOGLYCOLATE PHOSPHATASE (Lactobacillus delbrueckii)	4 / 7	THR A 170 VAL A 174 SER A 171 ARG A 181	None ACT  A 243 (-4.7A) None None	1.08A	2v41E-2hi0A: 2.5 2v41F-2hi0A: 2.2	2v41E-2hi0A: 20.97 2v41F-2hi0A: 20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VDV_E_SAME1287_0 (TRNA (GUANINE-N(7)-)-METH YLTRANSFERASE)	3mqt	MANDELATE RACEMASE/MUCONATE LACTONIZING PROTEIN (Shewanella pealeana)	5 / 12	GLY A 257 ILE A 232 ALA A 217 ASP A 206 GLU A 259	None None None MG  A1243 (-3.3A) MG  A1243 (-3.0A)	1.14A	2vdvE-3mqtA: undetectable	2vdvE-3mqtA: 20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VDV_F_SAMF1287_0 (TRNA (GUANINE-N(7)-)-METH YLTRANSFERASE)	3mqt	MANDELATE RACEMASE/MUCONATE LACTONIZING PROTEIN (Shewanella pealeana)	5 / 11	GLY A 257 ILE A 232 ALA A 217 ASP A 206 GLU A 259	None None None MG  A1243 (-3.3A) MG  A1243 (-3.0A)	1.14A	2vdvF-3mqtA: undetectable	2vdvF-3mqtA: 20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W3B_A_FOLA401_0 (DIHYDROFOLATE REDUCTASE)	3ilk	UNCHARACTERIZED TRNA/RRNA METHYLTRANSFERASE HI0380 (Haemophilus influenzae)	5 / 12	ILE A   7 ALA A  21 ARG A 112 PHE A 110 ILE A 131	None None None None EDO  A 243 (-4.0A)	1.10A	2w3bA-3ilkA: undetectable	2w3bA-3ilkA: 24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7H_B_SAMB530_0 (TYPE I RESTRICTION ENZYME ECOKI M PROTEIN)	3hvy	CYSTATHIONINE BETA-LYASE FAMILY PROTEIN, YNBB B.SUBTILIS ORTHOLOG (Clostridium acetobutylicum)	5 / 12	THR A 300 ILE A 388 ALA A 307 GLY A 306 GLY A 407	None LLP  A 243 ( 3.8A) None None None	1.08A	2y7hB-3hvyA: undetectable	2y7hB-3hvyA: 22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7H_C_SAMC530_0 (TYPE I RESTRICTION ENZYME ECOKI M PROTEIN)	3hvy	CYSTATHIONINE BETA-LYASE FAMILY PROTEIN, YNBB B.SUBTILIS ORTHOLOG (Clostridium acetobutylicum)	5 / 12	THR A 300 ILE A 388 ALA A 307 GLY A 306 GLY A 407	None LLP  A 243 ( 3.8A) None None None	1.08A	2y7hC-3hvyA: undetectable	2y7hC-3hvyA: 22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7W_B_SALB1300_1 (LYSR-TYPE REGULATORY PROTEIN)	3hvy	CYSTATHIONINE BETA-LYASE FAMILY PROTEIN, YNBB B.SUBTILIS ORTHOLOG (Clostridium acetobutylicum)	5 / 10	THR A 101 ILE A 104 GLY A 105 HIS A 180 THR A 128	LLP  A 243 ( 3.3A) None None None LLP  A 243 ( 4.8A)	1.26A	2y7wB-3hvyA: undetectable	2y7wB-3hvyA: 19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YGP_A_PCFA1213_0 (WNT INHIBITORY FACTOR 1)	4ki5	COAGULATION FACTOR VIII (Homo sapiens)	5 / 12	ILE M2190 ILE M2185 VAL M2243 VAL M2240 PRO M2177	ILE  M2190 ( 0.7A) ILE  M2185 ( 0.7A) VAL  M2243 ( 0.6A) VAL  M2240 ( 0.6A) PRO  M2177 ( 1.1A)	0.94A	2ygpA-4ki5M: undetectable	2ygpA-4ki5M: 18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AG2_J_CHDJ60_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1)	2bkx	GLUCOSAMINE-6-PHOSPH ATE DEAMINASE (Bacillus subtilis)	4 / 5	TYR A 116 MET A 182 THR A 181 LEU A  66	None None None F6R  A1243 (-4.0A)	1.38A	3ag2J-2bkxA: undetectable	3ag2J-2bkxA: 10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AG4_J_CHDJ60_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1)	2bkx	GLUCOSAMINE-6-PHOSPH ATE DEAMINASE (Bacillus subtilis)	4 / 5	TYR A 116 MET A 182 THR A 181 LEU A  66	None None None F6R  A1243 (-4.0A)	1.38A	3ag4J-2bkxA: undetectable	3ag4J-2bkxA: 10.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3AXZ_A_ADNA401_1 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3quv	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Mycobacteroides abscessus)	6 / 12	GLY A 109 GLY A 113 ILE A 133 LEU A 138 GLY A 140 GLY A 141	EDO  A 244 ( 4.1A) EDO  A 244 (-3.4A) None EDO  A 243 (-4.0A) EDO  A 243 (-4.1A) EDO  A 243 (-3.6A)	0.51A	3axzA-3quvA: 21.8	3axzA-3quvA: 40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3AXZ_A_ADNA401_1 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3quv	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Mycobacteroides abscessus)	6 / 12	PRO A  85 GLY A 109 GLY A 113 ILE A 133 LEU A 138 GLY A 141	EDO  A 243 (-3.7A) EDO  A 244 ( 4.1A) EDO  A 244 (-3.4A) None EDO  A 243 (-4.0A) EDO  A 243 (-3.6A)	0.78A	3axzA-3quvA: 21.8	3axzA-3quvA: 40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3AXZ_A_ADNA401_1 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3quv	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Mycobacteroides abscessus)	6 / 12	PRO A  85 GLY A 109 GLY A 113 SER A 132 ILE A 133 GLY A 141	EDO  A 243 (-3.7A) EDO  A 244 ( 4.1A) EDO  A 244 (-3.4A) None None EDO  A 243 (-3.6A)	0.96A	3axzA-3quvA: 21.8	3axzA-3quvA: 40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B0W_B_DGXB1_2 (NUCLEAR RECEPTOR ROR-GAMMA)	3bkw	S-ADENOSYLMETHIONINE DEPENDENT METHYLTRANSFERASE (Mesorhizobium japonicum)	3 / 3	LEU A 116 VAL A 193 ARG A 191	None None EDO  A 243 ( 3.8A)	0.74A	3b0wB-3bkwA: undetectable	3b0wB-3bkwA: 24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CKZ_A_ZMRA469_2 (NEURAMINIDASE)	5a3m	CEA1 (Komagataella pastoris)	4 / 6	ASP A  58 ARG A  75 ILE A  62 SER A 174	None PEG  A1243 (-3.6A) None None	1.41A	3ckzA-5a3mA: undetectable	3ckzA-5a3mA: 19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DCM_X_SAMX5452_0 (UNCHARACTERIZED PROTEIN TM_1570)	3ilk	UNCHARACTERIZED TRNA/RRNA METHYLTRANSFERASE HI0380 (Haemophilus influenzae)	6 / 11	THR A  78 GLY A 111 GLY A 116 ILE A 131 LEU A 140 ALA A 145	EDO  A 242 (-3.4A) EDO  A 242 (-4.6A) None EDO  A 243 (-4.0A) None EDO  A 242 ( 3.7A)	0.82A	3dcmX-3ilkA: 15.1	3dcmX-3ilkA: 21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DH0_B_SAMB300_0 (SAM DEPENDENT METHYLTRANSFERASE)	2v4y	URIDYLATE KINASE (Escherichia coli)	5 / 12	LEU A  21 GLY A  56 GLY A  18 ALA A  83 THR A  84	None GTP  A1243 (-3.3A) GTP  A1243 (-3.5A) None None	1.14A	3dh0B-2v4yA: undetectable	3dh0B-2v4yA: 24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DZY_D_BRLD478_2 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3hvy	CYSTATHIONINE BETA-LYASE FAMILY PROTEIN, YNBB B.SUBTILIS ORTHOLOG (Clostridium acetobutylicum)	4 / 4	ILE A 121 GLN A 182 ILE A 202 LEU A 129	None LLP  A 243 ( 4.0A) None None	1.29A	3dzyD-3hvyA: undetectable	3dzyD-3hvyA: 22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_C_SAMC300_1 (PUTATIVE RRNA METHYLASE)	3hvy	CYSTATHIONINE BETA-LYASE FAMILY PROTEIN, YNBB B.SUBTILIS ORTHOLOG (Clostridium acetobutylicum)	3 / 3	ASN A  99 ASP A 217 GLN A 182	LLP  A 243 ( 3.3A) LLP  A 243 ( 2.9A) LLP  A 243 ( 4.0A)	0.81A	3eeyC-3hvyA: 5.6	3eeyC-3hvyA: 19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_D_SAMD300_1 (PUTATIVE RRNA METHYLASE)	3hvy	CYSTATHIONINE BETA-LYASE FAMILY PROTEIN, YNBB B.SUBTILIS ORTHOLOG (Clostridium acetobutylicum)	3 / 3	ASN A  99 ASP A 217 GLN A 182	LLP  A 243 ( 3.3A) LLP  A 243 ( 2.9A) LLP  A 243 ( 4.0A)	0.83A	3eeyD-3hvyA: 5.5	3eeyD-3hvyA: 19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_E_SAME300_1 (PUTATIVE RRNA METHYLASE)	3hvy	CYSTATHIONINE BETA-LYASE FAMILY PROTEIN, YNBB B.SUBTILIS ORTHOLOG (Clostridium acetobutylicum)	3 / 3	ASN A  99 ASP A 217 GLN A 182	LLP  A 243 ( 3.3A) LLP  A 243 ( 2.9A) LLP  A 243 ( 4.0A)	0.83A	3eeyE-3hvyA: 4.3	3eeyE-3hvyA: 19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM0_B_CHDB500_0 (ILEAL BILE ACID-BINDING PROTEIN)	4b0a	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1, LINKER, TATA-BOX-BINDING PROTEIN (Saccharomyces cerevisiae)	4 / 7	THR A 212 VAL A 222 THR A 224 VAL A 171	GOL  A1242 (-3.8A) None GOL  A1243 (-3.0A) None	0.32A	3em0B-4b0aA: undetectable	3em0B-4b0aA: 19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ETE_C_H3PC552_1 (GLUTAMATE DEHYDROGENASE)	2znw	SCFV10 (Mus musculus; synthetic construct)	3 / 3	TYR A  36 TYR A 169 GLY A 222	None None 1PG  A 243 ( 4.7A)	0.71A	3eteB-2znwA: undetectable 3eteD-2znwA: undetectable 3eteF-2znwA: undetectable	3eteB-2znwA: 18.74 3eteD-2znwA: 18.74 3eteF-2znwA: 18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3F8W_A_ADNA300_1 (PURINE-NUCLEOSIDE PHOSPHORYLASE)	3hvy	CYSTATHIONINE BETA-LYASE FAMILY PROTEIN, YNBB B.SUBTILIS ORTHOLOG (Clostridium acetobutylicum)	5 / 12	SER A 391 TYR A 220 ALA A 392 GLY A 402 TYR A 187	None LLP  A 243 ( 3.6A) None None None	1.12A	3f8wA-3hvyA: undetectable	3f8wA-3hvyA: 22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3F8W_C_ADNC302_1 (PURINE-NUCLEOSIDE PHOSPHORYLASE)	3hvy	CYSTATHIONINE BETA-LYASE FAMILY PROTEIN, YNBB B.SUBTILIS ORTHOLOG (Clostridium acetobutylicum)	5 / 12	SER A 391 TYR A 220 ALA A 392 GLY A 402 TYR A 187	None LLP  A 243 ( 3.6A) None None None	1.12A	3f8wC-3hvyA: undetectable	3f8wC-3hvyA: 22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MTE_A_SAMA220_0 (16S RRNA METHYLASE)	3hvy	CYSTATHIONINE BETA-LYASE FAMILY PROTEIN, YNBB B.SUBTILIS ORTHOLOG (Clostridium acetobutylicum)	5 / 12	GLY A 248 GLY A 246 THR A 409 LEU A 408 SER A 240	None LLP  A 243 ( 4.0A) None None LLP  A 243 ( 3.8A)	1.20A	3mteA-3hvyA: 2.1	3mteA-3hvyA: 19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NK7_A_SAMA770_0 (23S RRNA METHYLTRANSFERASE)	3ilk	UNCHARACTERIZED TRNA/RRNA METHYLTRANSFERASE HI0380 (Haemophilus influenzae)	5 / 12	ASN A  17 GLY A 111 GLY A 116 ILE A 131 SER A 139	None EDO  A 242 (-4.6A) None EDO  A 243 (-4.0A) None	0.88A	3nk7A-3ilkA: 15.9	3nk7A-3ilkA: 21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NK7_A_SAMA770_0 (23S RRNA METHYLTRANSFERASE)	3ilk	UNCHARACTERIZED TRNA/RRNA METHYLTRANSFERASE HI0380 (Haemophilus influenzae)	5 / 12	GLY A 111 GLY A 116 ILE A 131 SER A 139 ASN A 141	EDO  A 242 (-4.6A) None EDO  A 243 (-4.0A) None None	0.89A	3nk7A-3ilkA: 15.9	3nk7A-3ilkA: 21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NK7_B_SAMB770_0 (23S RRNA METHYLTRANSFERASE)	3ilk	UNCHARACTERIZED TRNA/RRNA METHYLTRANSFERASE HI0380 (Haemophilus influenzae)	7 / 12	ASN A  17 PHE A 110 GLY A 111 GLY A 116 ILE A 131 SER A 139 LEU A 140	None None EDO  A 242 (-4.6A) None EDO  A 243 (-4.0A) None None	0.76A	3nk7B-3ilkA: 15.9	3nk7B-3ilkA: 21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXC_A_ROCA401_1 (PROTEASE)	3hvy	CYSTATHIONINE BETA-LYASE FAMILY PROTEIN, YNBB B.SUBTILIS ORTHOLOG (Clostridium acetobutylicum)	5 / 12	ASP A 393 GLY A 406 ILE A 388 PRO A 356 VAL A 357	None None LLP  A 243 ( 3.8A) None None	0.95A	3oxcA-3hvyA: undetectable	3oxcA-3hvyA: 11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QOW_A_SAMA417_1 (HISTONE-LYSINE N-METHYLTRANSFERASE)	3nua	PHOSPHORIBOSYLAMINOI MIDAZOLE-SUCCINOCARB OXAMIDE SYNTHASE (Clostridium perfringens)	3 / 3	THR A  34 ASP A 126 GLU A  91	CIT  A 243 (-3.9A) None AMP  A 242 (-4.2A)	0.81A	3qowA-3nuaA: undetectable	3qowA-3nuaA: 21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S79_A_ASDA601_1 (CYTOCHROME P450 19A1)	2v4y	URIDYLATE KINASE (Escherichia coli)	5 / 12	ALA A 148 THR A 145 LEU A  21 MET A  91 LEU A  16	None GTP  A1243 (-4.5A) None None None	1.25A	3s79A-2v4yA: undetectable	3s79A-2v4yA: 19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ARC_A_LEUA1001_0 (LEUCINE--TRNA LIGASE)	2w1k	PUTATIVE SORTASE (Streptococcus pneumoniae)	4 / 7	LEU A 132 SER A  59 TYR A 167 HIS A 124	MES  A1243 (-3.6A) None None None	1.37A	4arcA-2w1kA: undetectable	4arcA-2w1kA: 15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AX8_A_SAMA1474_1 (WBDD)	3sl5	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	4 / 6	TYR A 223 ASP A 203 GLU A 243 LEU A 234	TYR  A 223 ( 1.3A) ASP  A 203 ( 0.6A) GLU  A 243 ( 0.5A) LEU  A 234 ( 0.6A)	1.16A	4ax8A-3sl5A: undetectable	4ax8A-3sl5A: 21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C1D_B_X8ZB350_1 (BETA-LACTAMASE CLASS B VIM-2)	4v0h	METALLO-BETA-LACTAMA SE DOMAIN-CONTAINING PROTEIN 1 1 (Homo sapiens)	5 / 10	HIS A 117 HIS A 119 ASP A 121 HIS A 172 HIS A 234	FE  A1242 (-3.5A) FE  A1242 (-3.4A) FE  A1243 (-2.9A) FE  A1242 (-3.4A) FE  A1243 (-3.2A)	0.66A	4c1dB-4v0hA: 7.3	4c1dB-4v0hA: 25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C1F_A_X8ZA300_1 (BETA-LACTAMASE IMP-1)	4v0h	METALLO-BETA-LACTAMA SE DOMAIN-CONTAINING PROTEIN 1 1 (Homo sapiens)	5 / 11	HIS A 117 HIS A 119 ASP A 121 HIS A 172 HIS A 234	FE  A1242 (-3.5A) FE  A1242 (-3.4A) FE  A1243 (-2.9A) FE  A1242 (-3.4A) FE  A1243 (-3.2A)	0.72A	4c1fA-4v0hA: 14.3 4c1fB-4v0hA: 6.0	4c1fA-4v0hA: 21.55 4c1fB-4v0hA: 21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C1H_A_X8ZA305_1 (BETA-LACTAMASE 2)	4v0h	METALLO-BETA-LACTAMA SE DOMAIN-CONTAINING PROTEIN 1 1 (Homo sapiens)	5 / 9	HIS A 117 HIS A 119 ASP A 121 HIS A 172 HIS A 234	FE  A1242 (-3.5A) FE  A1242 (-3.4A) FE  A1243 (-2.9A) FE  A1242 (-3.4A) FE  A1243 (-3.2A)	0.64A	4c1hA-4v0hA: 5.8	4c1hA-4v0hA: 23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C5N_B_PXLB300_1 (PHOSPHOMETHYLPYRIMID INE KINASE)	4v0h	METALLO-BETA-LACTAMA SE DOMAIN-CONTAINING PROTEIN 1 1 (Homo sapiens)	5 / 10	GLY A 124 ASP A 121 GLY A  88 HIS A 117 HIS A 234	None FE  A1243 (-2.9A) None FE  A1242 (-3.5A) FE  A1243 (-3.2A)	1.11A	4c5nB-4v0hA: undetectable	4c5nB-4v0hA: 21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DXU_A_ACAA711_1 (LACTOTRANSFERRIN)	3ea0	ATPASE, PARA FAMILY (Chlorobaculum tepidum)	4 / 6	GLY A  15 VAL A 144 GLY A   5 GLU A 140	ATP  A 243 (-3.8A) None None None	0.86A	4dxuA-3ea0A: undetectable	4dxuA-3ea0A: 19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EXS_B_X8ZB301_1 (BETA-LACTAMASE NDM-1)	4v0h	METALLO-BETA-LACTAMA SE DOMAIN-CONTAINING PROTEIN 1 1 (Homo sapiens)	4 / 8	HIS A 119 ASP A 121 HIS A 172 HIS A 234	FE  A1242 (-3.4A) FE  A1243 (-2.9A) FE  A1242 (-3.4A) FE  A1243 (-3.2A)	0.65A	4exsB-4v0hA: 14.6	4exsB-4v0hA: 24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FGK_A_0TXA302_1 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	2bkx	GLUCOSAMINE-6-PHOSPH ATE DEAMINASE (Bacillus subtilis)	4 / 7	GLY A  38 GLY A  37 TYR A 168 ASN A 165	F6R  A1243 (-3.7A) F6R  A1243 (-3.5A) None F6R  A1243 ( 4.8A)	1.02A	4fgkB-2bkxA: 2.3	4fgkB-2bkxA: 22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IV0_B_SAMB302_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE, PUTATIVE)	3e0x	LIPASE-ESTERASE RELATED PROTEIN (Clostridium acetobutylicum)	5 / 12	GLY A  21 GLY A  23 MET A 165 ILE A  94 SER A  89	OXE  A 243 (-3.8A) None OXE  A 243 ( 4.6A) None OXE  A 243 (-2.8A)	1.14A	4iv0B-3e0xA: undetectable	4iv0B-3e0xA: 25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JEC_B_478B401_3 (HIV-1 PROTEASE)	3hvy	CYSTATHIONINE BETA-LYASE FAMILY PROTEIN, YNBB B.SUBTILIS ORTHOLOG (Clostridium acetobutylicum)	3 / 3	ASP A 217 LEU A 108 VAL A 270	LLP  A 243 ( 2.9A) None None	0.71A	4jecB-3hvyA: undetectable	4jecB-3hvyA: 11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L39_A_SALA602_1 (4-SUBSTITUTED BENZOATES-GLUTAMATE LIGASE GH3.12)	3e0x	LIPASE-ESTERASE RELATED PROTEIN (Clostridium acetobutylicum)	4 / 6	LEU A 227 TYR A  88 ILE A 143 GLY A 222	None OXE  A 243 (-4.2A) None None	0.94A	4l39A-3e0xA: undetectable	4l39A-3e0xA: 19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LTW_A_486A303_1 (ANCESTRAL STEROID RECEPTOR 2)	1c8x	ENDO-BETA-N-ACETYLGL UCOSAMINIDASE H (Streptomyces plicatus)	5 / 9	ALA A  37 LEU A 262 PHE A 258 THR A 243 LEU A 246	ALA  A  37 ( 0.0A) LEU  A 262 ( 0.6A) PHE  A 258 ( 1.3A) THR  A 243 ( 0.8A) LEU  A 246 ( 0.6A)	1.34A	4ltwA-1c8xA: undetectable	4ltwA-1c8xA: 22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MWZ_A_SAMA301_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE, PUTATIVE)	3e0x	LIPASE-ESTERASE RELATED PROTEIN (Clostridium acetobutylicum)	5 / 12	GLY A  21 GLY A  23 MET A 165 ILE A  94 SER A  89	OXE  A 243 (-3.8A) None OXE  A 243 ( 4.6A) None OXE  A 243 (-2.8A)	1.13A	4mwzA-3e0xA: 2.4	4mwzA-3e0xA: 25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NKX_D_STRD601_1 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	2v4y	URIDYLATE KINASE (Escherichia coli)	5 / 12	ALA A 164 ASN A  87 GLY A  18 THR A 145 VAL A  53	None None GTP  A1243 (-3.5A) GTP  A1243 (-4.5A) None	1.10A	4nkxD-2v4yA: undetectable	4nkxD-2v4yA: 20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4O1E_B_C2FB4000_0 (DIHYDROPTEROATE SYNTHASE DHPS)	1ng0	COAT PROTEIN (Cocksfoot mottle virus)	5 / 12	ILE A 115 ILE A 101 LEU A 243 GLY A  67 ILE A  69	ILE  A 115 ( 0.4A) ILE  A 101 ( 0.7A) LEU  A 243 ( 0.6A) GLY  A  67 ( 0.0A) ILE  A  69 ( 0.7A)	1.06A	4o1eB-1ng0A: undetectable	4o1eB-1ng0A: 19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PBH_A_BEZA401_0 (TRAP DICARBOXYLATE TRANSPORTER, DCTP SUBUNIT, PUTATIVE)	3ea0	ATPASE, PARA FAMILY (Chlorobaculum tepidum)	5 / 12	ILE A 232 THR A 231 ALA A 179 LEU A 228 ASP A 180	None None None ATP  A 243 ( 4.6A) None	1.48A	4pbhA-3ea0A: 1.6	4pbhA-3ea0A: 22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QA0_A_SHHA404_1 (HISTONE DEACETYLASE 8)	4v0h	METALLO-BETA-LACTAMA SE DOMAIN-CONTAINING PROTEIN 1 1 (Homo sapiens)	5 / 12	HIS A 172 HIS A 119 GLY A 118 ASP A 195 GLY A 194	FE  A1242 (-3.4A) FE  A1242 (-3.4A) None FE  A1243 ( 2.4A) None	1.32A	4qa0A-4v0hA: undetectable	4qa0A-4v0hA: 22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R3A_B_RBFB402_1 (BLUE-LIGHT-ACTIVATED HISTIDINE KINASE 2)	2v4y	URIDYLATE KINASE (Escherichia coli)	5 / 10	GLU A  19 ASN A  59 LEU A  34 LEU A  16 MET A 220	GTP  A1243 (-2.7A) None None None None	1.38A	4r3aB-2v4yA: undetectable	4r3aB-2v4yA: 23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XQE_A_AG2A505_1 (HOMOSPERMIDINE SYNTHASE)	3hvy	CYSTATHIONINE BETA-LYASE FAMILY PROTEIN, YNBB B.SUBTILIS ORTHOLOG (Clostridium acetobutylicum)	5 / 12	ALA A 250 GLU A 222 SER A 240 TYR A  82 LEU A 289	None None LLP  A 243 ( 3.8A) None None	1.47A	4xqeA-3hvyA: 2.8	4xqeA-3hvyA: 22.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YVG_A_SAMA301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3quv	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Mycobacteroides abscessus)	6 / 12	GLY A 109 GLY A 113 ILE A 133 LEU A 138 GLY A 140 GLY A 141	EDO  A 244 ( 4.1A) EDO  A 244 (-3.4A) None EDO  A 243 (-4.0A) EDO  A 243 (-4.1A) EDO  A 243 (-3.6A)	0.49A	4yvgA-3quvA: 20.7	4yvgA-3quvA: 40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YVG_A_SAMA301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3quv	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Mycobacteroides abscessus)	6 / 12	PRO A  85 GLY A 109 GLY A 113 ILE A 133 LEU A 138 GLY A 141	EDO  A 243 (-3.7A) EDO  A 244 ( 4.1A) EDO  A 244 (-3.4A) None EDO  A 243 (-4.0A) EDO  A 243 (-3.6A)	0.77A	4yvgA-3quvA: 20.7	4yvgA-3quvA: 40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YVG_A_SAMA301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3quv	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Mycobacteroides abscessus)	5 / 12	PRO A  85 GLY A 109 GLY A 113 SER A 132 ILE A 133	EDO  A 243 (-3.7A) EDO  A 244 ( 4.1A) EDO  A 244 (-3.4A) None None	1.01A	4yvgA-3quvA: 20.7	4yvgA-3quvA: 40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z90_F_4LEF401_1 (GAMMA-AMINOBUTYRIC-A CID RECEPTOR SUBUNIT BETA-1)	5c05	PUTATIVE GAMMA-TERPINENE SYNTHASE (Thymus vulgaris)	4 / 8	LEU A 243 LEU A 195 THR A 219 LEU A 222	LEU  A 243 ( 0.5A) LEU  A 195 ( 0.6A) THR  A 219 ( 0.8A) LEU  A 222 ( 0.6A)	0.77A	4z90F-5c05A: 5.9 4z90G-5c05A: 5.9 4z90H-5c05A: 3.4 4z90I-5c05A: 5.8 4z90J-5c05A: 5.9	4z90F-5c05A: 21.23 4z90G-5c05A: 21.23 4z90H-5c05A: 21.23 4z90I-5c05A: 21.23 4z90J-5c05A: 21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZBQ_A_ACTA605_0 (SERUM ALBUMIN)	3e0x	LIPASE-ESTERASE RELATED PROTEIN (Clostridium acetobutylicum)	4 / 6	TYR A  88 HIS A 224 GLY A 114 GLU A 196	OXE  A 243 (-4.2A) OXE  A 243 (-4.1A) None None	1.35A	4zbqA-3e0xA: undetectable	4zbqA-3e0xA: 18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZBQ_A_DIFA601_1 (SERUM ALBUMIN)	2v4y	URIDYLATE KINASE (Escherichia coli)	5 / 11	LEU A  89 VAL A  85 LEU A  21 GLY A  56 LEU A  60	None None None GTP  A1243 (-3.3A) None	1.27A	4zbqA-2v4yA: undetectable	4zbqA-2v4yA: 15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A5Z_A_WJZA304_0 (BETA-LACTAMASE NDM-1)	4v0h	METALLO-BETA-LACTAMA SE DOMAIN-CONTAINING PROTEIN 1 1 (Homo sapiens)	4 / 8	HIS A 119 ASP A 121 HIS A 172 HIS A 234	FE  A1242 (-3.4A) FE  A1243 (-2.9A) FE  A1242 (-3.4A) FE  A1243 (-3.2A)	0.68A	5a5zA-4v0hA: 15.2	5a5zA-4v0hA: 23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AYA_A_X8ZA307_1 (METALLO-BETA-LACTAMA SE)	4v0h	METALLO-BETA-LACTAMA SE DOMAIN-CONTAINING PROTEIN 1 1 (Homo sapiens)	6 / 11	HIS A 117 HIS A 119 ASP A 121 HIS A 122 HIS A 172 HIS A 234	FE  A1242 (-3.5A) FE  A1242 (-3.4A) FE  A1243 (-2.9A) FE  A1243 (-3.5A) FE  A1242 (-3.4A) FE  A1243 (-3.2A)	0.49A	5ayaA-4v0hA: 13.8	5ayaA-4v0hA: 25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5E5J_A_017A201_3 (PROTEASE)	1wqa	PHOSPHO-SUGAR MUTASE (Pyrococcus horikoshii)	3 / 3	ASP A 243 VAL A 250 LEU A 224	ASP  A 243 (-0.6A) VAL  A 250 ( 0.6A) LEU  A 224 ( 0.6A)	0.66A	5e5jB-1wqaA: undetectable	5e5jB-1wqaA: 14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FA8_A_SAMA301_1 (RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE, PUTATIVE)	3nua	PHOSPHORIBOSYLAMINOI MIDAZOLE-SUCCINOCARB OXAMIDE SYNTHASE (Clostridium perfringens)	3 / 3	THR A  34 ASP A 126 GLU A  91	CIT  A 243 (-3.9A) None AMP  A 242 (-4.2A)	0.84A	5fa8A-3nuaA: undetectable	5fa8A-3nuaA: 21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GQB_A_GCSA602_1 (CHITINASE)	3mqt	MANDELATE RACEMASE/MUCONATE LACTONIZING PROTEIN (Shewanella pealeana)	3 / 3	TRP A 311 GLU A 334 ASP A 206	None MG  A1243 ( 4.9A) MG  A1243 (-3.3A)	0.81A	5gqbA-3mqtA: 8.5	5gqbA-3mqtA: 20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5J7W_D_MTXD402_1 (THYMIDYLATE SYNTHASE)	4bxs	VENOM PROTHROMBIN ACTIVATOR PSEUTARIN-C NON-CATALYTIC SUBUNIT (Pseudonaja textilis)	5 / 12	GLU V 893 LEU V 599 ASP V 654 LEU V 631 GLY V 632	CA  V2431 ( 4.6A) None None None None	0.98A	5j7wD-4bxsV: undetectable	5j7wD-4bxsV: 13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JKV_A_ASDA602_1 (AROMATASE)	2v4y	URIDYLATE KINASE (Escherichia coli)	5 / 12	ALA A 148 THR A 145 LEU A  21 MET A  91 LEU A  16	None GTP  A1243 (-4.5A) None None None	1.24A	5jkvA-2v4yA: undetectable	5jkvA-2v4yA: 19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L0Z_A_SAMA304_0 (PROBABLE RNA METHYLTRANSFERASE, TRMH FAMILY)	3ilk	UNCHARACTERIZED TRNA/RRNA METHYLTRANSFERASE HI0380 (Haemophilus influenzae)	8 / 12	THR A  78 GLY A 111 GLY A 116 ILE A 131 SER A 139 LEU A 140 LEU A 142 ALA A 145	EDO  A 242 (-3.4A) EDO  A 242 (-4.6A) None EDO  A 243 (-4.0A) None None EDO  A 242 ( 4.5A) EDO  A 242 ( 3.7A)	0.71A	5l0zA-3ilkA: 17.1	5l0zA-3ilkA: 24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L0Z_B_SAMB304_0 (PROBABLE RNA METHYLTRANSFERASE, TRMH FAMILY)	3ilk	UNCHARACTERIZED TRNA/RRNA METHYLTRANSFERASE HI0380 (Haemophilus influenzae)	8 / 10	THR A  78 GLY A 111 GLY A 116 ILE A 131 SER A 139 LEU A 140 LEU A 142 ALA A 145	EDO  A 242 (-3.4A) EDO  A 242 (-4.6A) None EDO  A 243 (-4.0A) None None EDO  A 242 ( 4.5A) EDO  A 242 ( 3.7A)	0.80A	5l0zB-3ilkA: 7.2	5l0zB-3ilkA: 24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NEK_D_AZMD302_1 (PEPTIDOGLYCAN N-ACETYLGLUCOSAMINE DEACETYLASE)	4v0h	METALLO-BETA-LACTAMA SE DOMAIN-CONTAINING PROTEIN 1 1 (Homo sapiens)	4 / 8	ASP A 195 HIS A 172 HIS A 117 HIS A 234	FE  A1243 ( 2.4A) FE  A1242 (-3.4A) FE  A1242 (-3.5A) FE  A1243 (-3.2A)	0.92A	5nekD-4v0hA: undetectable	5nekD-4v0hA: 14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NKN_A_LOCA201_1 (NEUTROPHIL GELATINASE-ASSOCIATE D LIPOCALIN)	2rch	CYTOCHROME P450 74A (Arabidopsis thaliana)	5 / 12	GLY A 324 LEU A 147 TRP A 246 THR A 138 TYR A 141	243  A 601 (-3.8A) None None None None	1.29A	5nknA-2rchA: 0.0	5nknA-2rchA: 10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NWU_A_ACAA18_1 (WTFP-TAG,GP41)	3ulk	KETOL-ACID REDUCTOISOMERASE (Escherichia coli)	5 / 12	ALA A 231 GLY A 232 SER A 233 GLU A 243 LEU A 444	ALA  A 231 ( 0.0A) GLY  A 232 ( 0.0A) SER  A 233 ( 0.0A) GLU  A 243 ( 0.6A) LEU  A 444 ( 0.6A)	0.94A	5nwuA-3ulkA: undetectable	5nwuA-3ulkA: 6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NZW_A_9F2A1102_1 (DNA CROSS-LINK REPAIR 1A PROTEIN)	4v0h	METALLO-BETA-LACTAMA SE DOMAIN-CONTAINING PROTEIN 1 1 (Homo sapiens)	5 / 10	HIS A 117 HIS A 119 HIS A 122 HIS A 172 ASP A 195	FE  A1242 (-3.5A) FE  A1242 (-3.4A) FE  A1243 (-3.5A) FE  A1242 (-3.4A) FE  A1243 ( 2.4A)	0.29A	5nzwA-4v0hA: 4.0	5nzwA-4v0hA: 20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5O96_H_SAMH501_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE E)	3quv	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Mycobacteroides abscessus)	5 / 10	PRO A  85 GLY A 109 GLY A 113 VAL A 137 LEU A 138	EDO  A 243 (-3.7A) EDO  A 244 ( 4.1A) EDO  A 244 (-3.4A) None EDO  A 243 (-4.0A)	0.92A	5o96G-3quvA: 8.3 5o96H-3quvA: 8.9	5o96G-3quvA: 23.19 5o96H-3quvA: 23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TWJ_C_SAMC201_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE H)	2bkx	GLUCOSAMINE-6-PHOSPH ATE DEAMINASE (Bacillus subtilis)	5 / 12	ILE A 139 GLY A 140 LEU A  66 SER A 189 LEU A 188	None F6R  A1243 (-3.0A) F6R  A1243 (-4.0A) None None	0.67A	5twjC-2bkxA: undetectable	5twjC-2bkxA: 23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UL4_A_SAMA803_0 (OXSB PROTEIN)	2aee	OROTATE PHOSPHORIBOSYLTRANSF ERASE (Streptococcus pyogenes)	5 / 12	ALA A  74 ARG A  40 GLY A  77 GLY A  81 ILE A  83	None GOL  A2431 (-3.6A) None None None	1.20A	5ul4A-2aeeA: 3.7	5ul4A-2aeeA: 15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_A_PCFA1807_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	2bkx	GLUCOSAMINE-6-PHOSPH ATE DEAMINASE (Bacillus subtilis)	5 / 7	GLY A 183 ILE A 139 GLY A 140 LEU A  66 ILE A 128	None None F6R  A1243 (-3.0A) F6R  A1243 (-4.0A) None	1.16A	5vkqA-2bkxA: undetectable 5vkqB-2bkxA: undetectable	5vkqA-2bkxA: 9.78 5vkqB-2bkxA: 9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_B_PCFB1802_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	3bkw	S-ADENOSYLMETHIONINE DEPENDENT METHYLTRANSFERASE (Mesorhizobium japonicum)	4 / 7	THR A 196 HIS A 145 PRO A 146 ILE A 147	EDO  A 243 (-3.0A) None None None	1.18A	5vkqA-3bkwA: undetectable 5vkqB-3bkwA: undetectable	5vkqA-3bkwA: 9.81 5vkqB-3bkwA: 9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_B_PCFB1804_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	2bkx	GLUCOSAMINE-6-PHOSPH ATE DEAMINASE (Bacillus subtilis)	5 / 8	GLY A 183 ILE A 139 GLY A 140 LEU A  66 ILE A 128	None None F6R  A1243 (-3.0A) F6R  A1243 (-4.0A) None	1.13A	5vkqB-2bkxA: undetectable 5vkqC-2bkxA: undetectable	5vkqB-2bkxA: 9.78 5vkqC-2bkxA: 9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_C_PCFC1803_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	3bkw	S-ADENOSYLMETHIONINE DEPENDENT METHYLTRANSFERASE (Mesorhizobium japonicum)	4 / 8	THR A 196 HIS A 145 PRO A 146 ILE A 147	EDO  A 243 (-3.0A) None None None	1.14A	5vkqB-3bkwA: undetectable 5vkqC-3bkwA: undetectable	5vkqB-3bkwA: 9.81 5vkqC-3bkwA: 9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_D_PCFD1803_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	3bkw	S-ADENOSYLMETHIONINE DEPENDENT METHYLTRANSFERASE (Mesorhizobium japonicum)	4 / 7	THR A 196 HIS A 145 PRO A 146 ILE A 147	EDO  A 243 (-3.0A) None None None	1.15A	5vkqC-3bkwA: undetectable 5vkqD-3bkwA: undetectable	5vkqC-3bkwA: 9.81 5vkqD-3bkwA: 9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WAU_J_CHDJ101_1 (CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	2bkx	GLUCOSAMINE-6-PHOSPH ATE DEAMINASE (Bacillus subtilis)	4 / 5	TYR A 116 MET A 182 THR A 181 LEU A  66	None None None F6R  A1243 (-4.0A)	1.41A	5wauJ-2bkxA: undetectable	5wauJ-2bkxA: 10.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5WYQ_A_SAMA401_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3quv	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Mycobacteroides abscessus)	7 / 12	GLY A 109 GLY A 113 ILE A 133 VAL A 137 LEU A 138 GLY A 140 GLY A 141	EDO  A 244 ( 4.1A) EDO  A 244 (-3.4A) None None EDO  A 243 (-4.0A) EDO  A 243 (-4.1A) EDO  A 243 (-3.6A)	0.50A	5wyqA-3quvA: 21.0	5wyqA-3quvA: 41.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5WYQ_A_SAMA401_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3quv	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Mycobacteroides abscessus)	7 / 12	PRO A  85 GLY A 109 GLY A 113 ILE A 133 VAL A 137 LEU A 138 GLY A 141	EDO  A 243 (-3.7A) EDO  A 244 ( 4.1A) EDO  A 244 (-3.4A) None None EDO  A 243 (-4.0A) EDO  A 243 (-3.6A)	0.67A	5wyqA-3quvA: 21.0	5wyqA-3quvA: 41.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5WYQ_B_SAMB301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3quv	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Mycobacteroides abscessus)	8 / 12	PRO A  85 GLY A 109 SER A 132 ILE A 133 TYR A 136 LEU A 138 GLY A 140 GLY A 141	EDO  A 243 (-3.7A) EDO  A 244 ( 4.1A) None None None EDO  A 243 (-4.0A) EDO  A 243 (-4.1A) EDO  A 243 (-3.6A)	0.64A	5wyqB-3quvA: 21.1	5wyqB-3quvA: 41.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y80_A_IREA402_0 (CYCLIN-G-ASSOCIATED KINASE)	2wfo	GLYCOPROTEIN 1 (Machupo mammarenavirus)	5 / 11	ASP A 222 SER A 224 VAL A 215 ILE A 217 ASN A 174	NAG  A1243 ( 4.1A) None None None None	1.30A	5y80A-2wfoA: undetectable	5y80A-2wfoA: 18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z86_J_CHDJ101_0 (CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	2bkx	GLUCOSAMINE-6-PHOSPH ATE DEAMINASE (Bacillus subtilis)	4 / 5	TYR A 116 MET A 182 THR A 181 LEU A  66	None None None F6R  A1243 (-4.0A)	1.40A	5z86J-2bkxA: undetectable	5z86J-2bkxA: 10.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5ZHM_B_SAMB301_1 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3quv	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Mycobacteroides abscessus)	6 / 12	PRO A  85 GLU A 112 GLY A 113 ILE A 133 LEU A 138 GLY A 141	EDO  A 243 (-3.7A) None EDO  A 244 (-3.4A) None EDO  A 243 (-4.0A) EDO  A 243 (-3.6A)	1.21A	5zhmB-3quvA: 22.2	5zhmB-3quvA: 40.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5ZHM_B_SAMB301_1 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3quv	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Mycobacteroides abscessus)	6 / 12	PRO A  85 GLU A 112 GLY A 113 ILE A 133 VAL A 137 LEU A 138	EDO  A 243 (-3.7A) None EDO  A 244 (-3.4A) None None EDO  A 243 (-4.0A)	1.23A	5zhmB-3quvA: 22.2	5zhmB-3quvA: 40.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5ZHM_B_SAMB301_1 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3quv	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Mycobacteroides abscessus)	6 / 12	PRO A  85 GLY A 109 GLY A 113 ILE A 133 LEU A 138 GLY A 141	EDO  A 243 (-3.7A) EDO  A 244 ( 4.1A) EDO  A 244 (-3.4A) None EDO  A 243 (-4.0A) EDO  A 243 (-3.6A)	1.26A	5zhmB-3quvA: 22.2	5zhmB-3quvA: 40.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5ZHM_B_SAMB301_1 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3quv	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Mycobacteroides abscessus)	9 / 12	PRO A  85 GLY A 109 GLY A 113 SER A 132 ILE A 133 VAL A 137 LEU A 138 GLY A 140 GLY A 141	EDO  A 243 (-3.7A) EDO  A 244 ( 4.1A) EDO  A 244 (-3.4A) None None None EDO  A 243 (-4.0A) EDO  A 243 (-4.1A) EDO  A 243 (-3.6A)	0.73A	5zhmB-3quvA: 22.2	5zhmB-3quvA: 40.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZJ8_A_9DCA303_0 (METALLO-BETA-LACTAMA SE TYPE 2)	4v0h	METALLO-BETA-LACTAMA SE DOMAIN-CONTAINING PROTEIN 1 1 (Homo sapiens)	4 / 8	HIS A 119 ASP A 121 HIS A 172 HIS A 234	FE  A1242 (-3.4A) FE  A1243 (-2.9A) FE  A1242 (-3.4A) FE  A1243 (-3.2A)	0.68A	5zj8A-4v0hA: 15.3	5zj8A-4v0hA: 23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6D8P_A_ACTA810_0 (UNCHARACTERIZED PROTEIN)	1fxj	UDP-N-ACETYLGLUCOSAM INE PYROPHOSPHORYLASE (Escherichia coli)	4 / 6	TYR A 239 GLU A 242 GLN A 243 LYS A 246	TYR  A 239 ( 1.3A) GLU  A 242 ( 0.6A) GLN  A 243 ( 0.6A) LYS  A 246 ( 0.0A)	1.02A	6d8pA-1fxjA: 0.0	6d8pA-1fxjA: 18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MKE_A_FK5A201_0 (PEPTIDYLPROLYL ISOMERASE)	4b0a	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1, LINKER, TATA-BOX-BINDING PROTEIN (Saccharomyces cerevisiae)	5 / 12	TYR A  19 PHE A 216 ILE A  32 PHE A  23 ILE A 243	GOL  A1070 ( 4.9A) None GOL  A1243 (-4.5A) GOL  A1070 (-3.7A) None	1.19A	6mkeA-4b0aA: undetectable 6mkeD-4b0aA: undetectable	6mkeA-4b0aA: 20.20 6mkeD-4b0aA: 20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MKE_B_FK5B201_0 (PEPTIDYLPROLYL ISOMERASE)	4b0a	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1, LINKER, TATA-BOX-BINDING PROTEIN (Saccharomyces cerevisiae)	5 / 12	TYR A  19 PHE A 216 ILE A  32 PHE A  23 ILE A 243	GOL  A1070 ( 4.9A) None GOL  A1243 (-4.5A) GOL  A1070 (-3.7A) None	1.19A	6mkeB-4b0aA: undetectable 6mkeC-4b0aA: undetectable	6mkeB-4b0aA: 20.20 6mkeC-4b0aA: 20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN5_B_LLLB301_0 (AMINOGLYCOSIDE N(3)-ACETYLTRANSFERA SE, AAC(3)-IVA)	3hvy	CYSTATHIONINE BETA-LYASE FAMILY PROTEIN, YNBB B.SUBTILIS ORTHOLOG (Clostridium acetobutylicum)	4 / 7	ASP A 217 TYR A 255 GLU A 222 GLU A 225	LLP  A 243 ( 2.9A) None None None	1.32A	6mn5B-3hvyA: undetectable	6mn5B-3hvyA: 10.87