SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '22E'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2J2P_A_SC2A1290_1 (FICOLIN-2)	4aw2	SERINE/THREONINE-PRO TEIN KINASE MRCK ALPHA (Rattus norvegicus)	4 / 5	ASP A 412 SER A 27 GLY A 401 ARG A 71	None None None 22E A 500 ( 4.0A)	0.84A	2j2pA-4aw2A: undetectable 2j2pB-4aw2A: undetectable	2j2pA-4aw2A: 20.28 2j2pB-4aw2A: 20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2J2P_C_SC2C1289_1 (FICOLIN-2)	4aw2	SERINE/THREONINE-PRO TEIN KINASE MRCK ALPHA (Rattus norvegicus)	4 / 6	ARG A 71 ASP A 412 SER A 27 GLY A 401	22E A 500 ( 4.0A) None None None	0.90A	2j2pA-4aw2A: undetectable 2j2pC-4aw2A: undetectable	2j2pA-4aw2A: 20.28 2j2pC-4aw2A: 20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2J2P_F_SC2F1289_1 (FICOLIN-2)	4aw2	SERINE/THREONINE-PRO TEIN KINASE MRCK ALPHA (Rattus norvegicus)	4 / 6	ARG A 71 ASP A 412 SER A 27 GLY A 401	22E A 500 ( 4.0A) None None None	0.90A	2j2pD-4aw2A: undetectable 2j2pF-4aw2A: undetectable	2j2pD-4aw2A: 20.28 2j2pF-4aw2A: 20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HP1_A_PPFA602_1 (HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT)	4aw2	SERINE/THREONINE-PRO TEIN KINASE MRCK ALPHA (Rattus norvegicus)	4 / 6	ARG A 71 ASP A 412 GLY A 401 ASP A 33	22E A 500 ( 4.0A) None None 22E A 500 (-3.6A)	1.31A	5hp1A-4aw2A: undetectable	5hp1A-4aw2A: 20.49

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2J2P_A_SC2A1290_1","FICOLIN-2;FICOLIN-2","4aw2","SERINE\/THREONINE-PROTEIN KINASE MRCK ALPHA","Rattus norvegicus",4,"ASP A 412;SER A  27;GLY A 401;ARG A  71","None;None;None;22E A 500 ( 4.0A)","0.84A","2j2pA-4aw2A:undetectable;2j2pB-4aw2A:undetectable",null],["2J2P_C_SC2C1289_1","FICOLIN-2;FICOLIN-2","4aw2","SERINE\/THREONINE-PROTEIN KINASE MRCK ALPHA","Rattus norvegicus",4,"ARG A  71;ASP A 412;SER A  27;GLY A 401","22E A 500 ( 4.0A);None;None;None","0.90A","2j2pA-4aw2A:undetectable;2j2pC-4aw2A:undetectable","2j2pA-4aw2A:20.28;2j2pB-4aw2A:20.28"],["2J2P_F_SC2F1289_1","FICOLIN-2;FICOLIN-2","4aw2","SERINE\/THREONINE-PROTEIN KINASE MRCK ALPHA","Rattus norvegicus",4,"ARG A  71;ASP A 412;SER A  27;GLY A 401","22E A 500 ( 4.0A);None;None;None","0.90A","2j2pD-4aw2A:undetectable;2j2pF-4aw2A:undetectable","2j2pA-4aw2A:20.28;2j2pC-4aw2A:20.28"],["5HP1_A_PPFA602_1","HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT","4aw2","SERINE\/THREONINE-PROTEIN KINASE MRCK ALPHA","Rattus norvegicus",4,"ARG A  71;ASP A 412;GLY A 401;ASP A  33","22E A 500 ( 4.0A);None;None;22E A 500 (-3.6A)","1.31A","5hp1A-4aw2A:undetectable","2j2pD-4aw2A:20.28;2j2pF-4aw2A:20.28"]]