SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1YO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		 5tlq THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 144
VAL A 157
VAL A  19
GLY A 160
LEU A  63
 1YO  A 201 ( 4.2A)
None
None
None
1YO  A 201 ( 4.0A)
 1.19A 1ikvA-5tlqA:
undetectable		 1ikvA-5tlqA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP0_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5tlq THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 144
VAL A 157
VAL A  19
GLY A 160
LEU A  63
 1YO  A 201 ( 4.2A)
None
None
None
1YO  A 201 ( 4.0A)
 1.26A 3lp0A-5tlqA:
undetectable		 3lp0A-5tlqA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tlq THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA
(Pseudomonas
aeruginosa) 		3 / 3 VAL A  19
LEU A  79
MET A 138
 None
1YO  A 201 ( 3.8A)
None
 0.69A 5ikrA-5tlqA:
undetectable		 5ikrA-5tlqA:
18.25