SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1Y8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2GVC_B_MMZB501_1 (MONOOXYGENASE)	5nxy	OSMOTICALLY ACTIVATED L-CARNITINE/CHOLINE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN OPUCC (Bacillus subtilis)	3 / 3	ASN A 250 TYR A 63 SER A 190	None 1Y8 A 301 ( 3.6A) None	0.86A	2gvcB-5nxyA: undetectable	2gvcB-5nxyA: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2GVC_E_MMZE501_1 (MONOOXYGENASE)	5nxy	OSMOTICALLY ACTIVATED L-CARNITINE/CHOLINE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN OPUCC (Bacillus subtilis)	3 / 3	ASN A 250 TYR A 63 SER A 190	None 1Y8 A 301 ( 3.6A) None	0.87A	2gvcE-5nxyA: undetectable	2gvcE-5nxyA: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ETE_B_H3PB552_1 (GLUTAMATE DEHYDROGENASE)	5nxy	OSMOTICALLY ACTIVATED L-CARNITINE/CHOLINE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN OPUCC (Bacillus subtilis)	3 / 3	TYR A 143 TYR A 189 ILE A 171	None 1Y8 A 301 (-3.5A) None	0.69A	3eteA-5nxyA: 2.3 3eteB-5nxyA: 2.5	3eteA-5nxyA: 11.63 3eteB-5nxyA: 11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IA4_A_MTXA164_1 (DIHYDROFOLATE REDUCTASE)	5nxy	OSMOTICALLY ACTIVATED L-CARNITINE/CHOLINE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN OPUCC (Bacillus subtilis)	5 / 12	ALA A 60 GLN A 25 ILE A 241 LEU A 249 TYR A 63	None None None None 1Y8 A 301 ( 3.6A)	1.20A	3ia4A-5nxyA: undetectable	3ia4A-5nxyA: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IA4_B_MTXB164_1 (DIHYDROFOLATE REDUCTASE)	5nxy	OSMOTICALLY ACTIVATED L-CARNITINE/CHOLINE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN OPUCC (Bacillus subtilis)	5 / 12	ALA A 60 GLN A 25 ILE A 241 LEU A 249 TYR A 63	None None None None 1Y8 A 301 ( 3.6A)	1.21A	3ia4B-5nxyA: undetectable	3ia4B-5nxyA: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IA4_C_MTXC164_1 (DIHYDROFOLATE REDUCTASE)	5nxy	OSMOTICALLY ACTIVATED L-CARNITINE/CHOLINE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN OPUCC (Bacillus subtilis)	5 / 12	ALA A 60 GLN A 25 ILE A 241 LEU A 249 TYR A 63	None None None None 1Y8 A 301 ( 3.6A)	1.23A	3ia4C-5nxyA: undetectable	3ia4C-5nxyA: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PPO_A_DCKA401_0 (GLYCINE BETAINE/CARNITINE/CH OLINE-BINDING PROTEIN)	5nxy	OSMOTICALLY ACTIVATED L-CARNITINE/CHOLINE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN OPUCC (Bacillus subtilis)	5 / 9	ASN A 44 TYR A 63 TYR A 109 TYR A 189 TYR A 213	1Y8 A 301 ( 4.2A) 1Y8 A 301 ( 3.6A) 1Y8 A 301 (-4.1A) 1Y8 A 301 (-3.5A) 1Y8 A 301 (-3.3A)	0.92A	3ppoA-5nxyA: 42.4	3ppoA-5nxyA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PPO_A_DCKA401_0 (GLYCINE BETAINE/CARNITINE/CH OLINE-BINDING PROTEIN)	5nxy	OSMOTICALLY ACTIVATED L-CARNITINE/CHOLINE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN OPUCC (Bacillus subtilis)	5 / 9	TYR A 63 ASN A 107 TYR A 109 TYR A 189 TYR A 213	1Y8 A 301 ( 3.6A) 1Y8 A 301 (-3.8A) 1Y8 A 301 (-4.1A) 1Y8 A 301 (-3.5A) 1Y8 A 301 (-3.3A)	0.49A	3ppoA-5nxyA: 42.4	3ppoA-5nxyA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PPO_B_DCKB401_0 (GLYCINE BETAINE/CARNITINE/CH OLINE-BINDING PROTEIN)	5nxy	OSMOTICALLY ACTIVATED L-CARNITINE/CHOLINE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN OPUCC (Bacillus subtilis)	5 / 9	ASN A 44 TYR A 63 TYR A 109 TYR A 189 TYR A 213	1Y8 A 301 ( 4.2A) 1Y8 A 301 ( 3.6A) 1Y8 A 301 (-4.1A) 1Y8 A 301 (-3.5A) 1Y8 A 301 (-3.3A)	0.93A	3ppoB-5nxyA: 42.3	3ppoB-5nxyA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PPO_B_DCKB401_0 (GLYCINE BETAINE/CARNITINE/CH OLINE-BINDING PROTEIN)	5nxy	OSMOTICALLY ACTIVATED L-CARNITINE/CHOLINE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN OPUCC (Bacillus subtilis)	5 / 9	TYR A 63 ASN A 107 TYR A 109 TYR A 189 TYR A 213	1Y8 A 301 ( 3.6A) 1Y8 A 301 (-3.8A) 1Y8 A 301 (-4.1A) 1Y8 A 301 (-3.5A) 1Y8 A 301 (-3.3A)	0.46A	3ppoB-5nxyA: 42.3	3ppoB-5nxyA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NTX_A_AMRA509_1 (ACID-SENSING ION CHANNEL 1 BASIC PHOSPHOLIPASE A2 HOMOLOG TX-BETA)	5nxy	OSMOTICALLY ACTIVATED L-CARNITINE/CHOLINE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN OPUCC (Bacillus subtilis)	4 / 6	GLU A 17 ASP A 254 ASP A 192 ASN A 107	None None None 1Y8 A 301 (-3.8A)	1.27A	4ntxA-5nxyA: undetectable 4ntxC-5nxyA: undetectable	4ntxA-5nxyA: 11.00 4ntxC-5nxyA: 18.81

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2GVC_B_MMZB501_1","MONOOXYGENASE","5nxy","OSMOTICALLY ACTIVATED L-CARNITINE\/CHOLINE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN OPUCC","Bacillus subtilis",3,"ASN A 250;TYR A  63;SER A 190","None;1Y8 A 301 ( 3.6A);None","0.86A","2gvcB-5nxyA:undetectable",null],["2GVC_E_MMZE501_1","MONOOXYGENASE","5nxy","OSMOTICALLY ACTIVATED L-CARNITINE\/CHOLINE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN OPUCC","Bacillus subtilis",3,"ASN A 250;TYR A  63;SER A 190","None;1Y8 A 301 ( 3.6A);None","0.87A","2gvcE-5nxyA:undetectable","2gvcB-5nxyA:12.47"],["3ETE_B_H3PB552_1","GLUTAMATE DEHYDROGENASE;GLUTAMATE DEHYDROGENASE","5nxy","OSMOTICALLY ACTIVATED L-CARNITINE\/CHOLINE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN OPUCC","Bacillus subtilis",3,"TYR A 143;TYR A 189;ILE A 171","None;1Y8 A 301 (-3.5A);None","0.69A","3eteA-5nxyA:2.3;3eteB-5nxyA:2.5","2gvcE-5nxyA:12.47"],["3IA4_A_MTXA164_1","DIHYDROFOLATE REDUCTASE","5nxy","OSMOTICALLY ACTIVATED L-CARNITINE\/CHOLINE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN OPUCC","Bacillus subtilis",5,"ALA A  60;GLN A  25;ILE A 241;LEU A 249;TYR A  63","None;None;None;None;1Y8 A 301 ( 3.6A)","1.20A","3ia4A-5nxyA:undetectable","3eteA-5nxyA:11.63;3eteB-5nxyA:11.63"],["3IA4_B_MTXB164_1","DIHYDROFOLATE REDUCTASE","5nxy","OSMOTICALLY ACTIVATED L-CARNITINE\/CHOLINE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN OPUCC","Bacillus subtilis",5,"ALA A  60;GLN A  25;ILE A 241;LEU A 249;TYR A  63","None;None;None;None;1Y8 A 301 ( 3.6A)","1.21A","3ia4B-5nxyA:undetectable","3ia4A-5nxyA:16.67"],["3IA4_C_MTXC164_1","DIHYDROFOLATE REDUCTASE","5nxy","OSMOTICALLY ACTIVATED L-CARNITINE\/CHOLINE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN OPUCC","Bacillus subtilis",5,"ALA A  60;GLN A  25;ILE A 241;LEU A 249;TYR A  63","None;None;None;None;1Y8 A 301 ( 3.6A)","1.23A","3ia4C-5nxyA:undetectable","3ia4B-5nxyA:16.67"],["3PPO_A_DCKA401_0","GLYCINE BETAINE\/CARNITINE\/CHOLINE-BINDING PROTEIN","5nxy","OSMOTICALLY ACTIVATED L-CARNITINE\/CHOLINE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN OPUCC","Bacillus subtilis",5,"ASN A  44;TYR A  63;TYR A 109;TYR A 189;TYR A 213","1Y8 A 301 ( 4.2A);1Y8 A 301 ( 3.6A);1Y8 A 301 (-4.1A);1Y8 A 301 (-3.5A);1Y8 A 301 (-3.3A)","0.92A","3ppoA-5nxyA:42.4","3ia4C-5nxyA:16.67"],["3PPO_A_DCKA401_0","GLYCINE BETAINE\/CARNITINE\/CHOLINE-BINDING PROTEIN","5nxy","OSMOTICALLY ACTIVATED L-CARNITINE\/CHOLINE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN OPUCC","Bacillus subtilis",5,"TYR A  63;ASN A 107;TYR A 109;TYR A 189;TYR A 213","1Y8 A 301 ( 3.6A);1Y8 A 301 (-3.8A);1Y8 A 301 (-4.1A);1Y8 A 301 (-3.5A);1Y8 A 301 (-3.3A)","0.49A","3ppoA-5nxyA:42.4","3ppoA-5nxyA:undetectable"],["3PPO_B_DCKB401_0","GLYCINE BETAINE\/CARNITINE\/CHOLINE-BINDING PROTEIN","5nxy","OSMOTICALLY ACTIVATED L-CARNITINE\/CHOLINE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN OPUCC","Bacillus subtilis",5,"ASN A  44;TYR A  63;TYR A 109;TYR A 189;TYR A 213","1Y8 A 301 ( 4.2A);1Y8 A 301 ( 3.6A);1Y8 A 301 (-4.1A);1Y8 A 301 (-3.5A);1Y8 A 301 (-3.3A)","0.93A","3ppoB-5nxyA:42.3","3ppoA-5nxyA:undetectable"],["3PPO_B_DCKB401_0","GLYCINE BETAINE\/CARNITINE\/CHOLINE-BINDING PROTEIN","5nxy","OSMOTICALLY ACTIVATED L-CARNITINE\/CHOLINE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN OPUCC","Bacillus subtilis",5,"TYR A  63;ASN A 107;TYR A 109;TYR A 189;TYR A 213","1Y8 A 301 ( 3.6A);1Y8 A 301 (-3.8A);1Y8 A 301 (-4.1A);1Y8 A 301 (-3.5A);1Y8 A 301 (-3.3A)","0.46A","3ppoB-5nxyA:42.3","3ppoB-5nxyA:undetectable"],["4NTX_A_AMRA509_1","ACID-SENSING ION CHANNEL 1;BASIC PHOSPHOLIPASE A2 HOMOLOG TX-BETA","5nxy","OSMOTICALLY ACTIVATED L-CARNITINE\/CHOLINE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN OPUCC","Bacillus subtilis",4,"GLU A  17;ASP A 254;ASP A 192;ASN A 107","None;None;None;1Y8 A 301 (-3.8A)","1.27A","4ntxA-5nxyA:undetectable;4ntxC-5nxyA:undetectable","3ppoB-5nxyA:undetectable"]]