SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1X8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A3A_A_TEPA1434_1 (CHITINASE)	4lh7	DNA LIGASE (Enterococcus faecalis)	3 / 3	TRP A 310 THR A 228 TYR A 227	None None 1X8 A 401 (-3.6A)	1.18A	2a3aA-4lh7A: undetectable	2a3aA-4lh7A: 21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A3A_B_TEPB2434_1 (CHITINASE)	4lh7	DNA LIGASE (Enterococcus faecalis)	3 / 3	TRP A 310 THR A 228 TYR A 227	None None 1X8 A 401 (-3.6A)	1.18A	2a3aB-4lh7A: undetectable	2a3aB-4lh7A: 21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A3B_A_CFFA1434_1 (CHITINASE)	4lh7	DNA LIGASE (Enterococcus faecalis)	3 / 3	TRP A 310 THR A 228 TYR A 227	None None 1X8 A 401 (-3.6A)	1.19A	2a3bA-4lh7A: undetectable	2a3bA-4lh7A: 21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QWU_A_ADNA501_1 (DNA LIGASE)	4lh7	DNA LIGASE (Enterococcus faecalis)	5 / 12	GLU A 118 LYS A 120 GLU A 175 VAL A 289 LYS A 291	1X8 A 401 (-3.4A) 1X8 A 401 (-3.6A) 1X8 A 401 (-3.6A) 1X8 A 401 ( 4.3A) 1X8 A 401 (-2.7A)	0.58A	3qwuA-4lh7A: 9.9	3qwuA-4lh7A: 22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QWU_A_ADNA501_1 (DNA LIGASE)	4lh7	DNA LIGASE (Enterococcus faecalis)	5 / 12	TYR A 87 GLU A 118 LYS A 120 VAL A 289 LYS A 291	1X8 A 401 (-4.4A) 1X8 A 401 (-3.4A) 1X8 A 401 (-3.6A) 1X8 A 401 ( 4.3A) 1X8 A 401 (-2.7A)	0.94A	3qwuA-4lh7A: 9.9	3qwuA-4lh7A: 22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QWU_B_ADNB501_1 (DNA LIGASE)	4lh7	DNA LIGASE (Enterococcus faecalis)	5 / 11	GLU A 118 LYS A 120 GLU A 175 VAL A 289 LYS A 291	1X8 A 401 (-3.4A) 1X8 A 401 (-3.6A) 1X8 A 401 (-3.6A) 1X8 A 401 ( 4.3A) 1X8 A 401 (-2.7A)	0.55A	3qwuB-4lh7A: 10.7	3qwuB-4lh7A: 22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QWU_B_ADNB501_1 (DNA LIGASE)	4lh7	DNA LIGASE (Enterococcus faecalis)	5 / 11	TYR A 87 GLU A 118 LYS A 120 VAL A 289 LYS A 291	1X8 A 401 (-4.4A) 1X8 A 401 (-3.4A) 1X8 A 401 (-3.6A) 1X8 A 401 ( 4.3A) 1X8 A 401 (-2.7A)	1.12A	3qwuB-4lh7A: 10.7	3qwuB-4lh7A: 22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VT7_A_VDXA500_2 (VITAMIN D3 RECEPTOR)	4lh7	DNA LIGASE (Enterococcus faecalis)	4 / 4	LEU A 89 ILE A 285 TYR A 314 TYR A 227	1X8 A 401 (-4.0A) None None 1X8 A 401 (-3.6A)	1.41A	3vt7A-4lh7A: 1.3	3vt7A-4lh7A: 21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QZT_C_RTLC201_0 (RETINOL-BINDING PROTEIN 2)	4lh7	DNA LIGASE (Enterococcus faecalis)	5 / 12	PHE A 232 ALA A 237 GLN A 240 LYS A 291 LEU A 247	None None None 1X8 A 401 (-2.7A) None	1.48A	4qztC-4lh7A: undetectable	4qztC-4lh7A: 17.05

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2A3A_A_TEPA1434_1","CHITINASE","4lh7","DNA LIGASE","Enterococcus faecalis",3,"TRP A 310;THR A 228;TYR A 227","None;None;1X8 A 401 (-3.6A)","1.18A","2a3aA-4lh7A:undetectable",null],["2A3A_B_TEPB2434_1","CHITINASE","4lh7","DNA LIGASE","Enterococcus faecalis",3,"TRP A 310;THR A 228;TYR A 227","None;None;1X8 A 401 (-3.6A)","1.18A","2a3aB-4lh7A:undetectable","2a3aA-4lh7A:21.90"],["2A3B_A_CFFA1434_1","CHITINASE","4lh7","DNA LIGASE","Enterococcus faecalis",3,"TRP A 310;THR A 228;TYR A 227","None;None;1X8 A 401 (-3.6A)","1.19A","2a3bA-4lh7A:undetectable","2a3aB-4lh7A:21.90"],["3QWU_A_ADNA501_1","DNA LIGASE","4lh7","DNA LIGASE","Enterococcus faecalis",5,"GLU A 118;LYS A 120;GLU A 175;VAL A 289;LYS A 291","1X8 A 401 (-3.4A);1X8 A 401 (-3.6A);1X8 A 401 (-3.6A);1X8 A 401 ( 4.3A);1X8 A 401 (-2.7A)","0.58A","3qwuA-4lh7A:9.9","2a3bA-4lh7A:21.90"],["3QWU_A_ADNA501_1","DNA LIGASE","4lh7","DNA LIGASE","Enterococcus faecalis",5,"TYR A  87;GLU A 118;LYS A 120;VAL A 289;LYS A 291","1X8 A 401 (-4.4A);1X8 A 401 (-3.4A);1X8 A 401 (-3.6A);1X8 A 401 ( 4.3A);1X8 A 401 (-2.7A)","0.94A","3qwuA-4lh7A:9.9","3qwuA-4lh7A:22.96"],["3QWU_B_ADNB501_1","DNA LIGASE","4lh7","DNA LIGASE","Enterococcus faecalis",5,"GLU A 118;LYS A 120;GLU A 175;VAL A 289;LYS A 291","1X8 A 401 (-3.4A);1X8 A 401 (-3.6A);1X8 A 401 (-3.6A);1X8 A 401 ( 4.3A);1X8 A 401 (-2.7A)","0.55A","3qwuB-4lh7A:10.7","3qwuA-4lh7A:22.96"],["3QWU_B_ADNB501_1","DNA LIGASE","4lh7","DNA LIGASE","Enterococcus faecalis",5,"TYR A  87;GLU A 118;LYS A 120;VAL A 289;LYS A 291","1X8 A 401 (-4.4A);1X8 A 401 (-3.4A);1X8 A 401 (-3.6A);1X8 A 401 ( 4.3A);1X8 A 401 (-2.7A)","1.12A","3qwuB-4lh7A:10.7","3qwuB-4lh7A:22.96"],["3VT7_A_VDXA500_2","VITAMIN D3 RECEPTOR","4lh7","DNA LIGASE","Enterococcus faecalis",4,"LEU A  89;ILE A 285;TYR A 314;TYR A 227","1X8 A 401 (-4.0A);None;None;1X8 A 401 (-3.6A)","1.41A","3vt7A-4lh7A:1.3","3qwuB-4lh7A:22.96"],["4QZT_C_RTLC201_0","RETINOL-BINDING PROTEIN 2","4lh7","DNA LIGASE","Enterococcus faecalis",5,"PHE A 232;ALA A 237;GLN A 240;LYS A 291;LEU A 247","None;None;None;1X8 A 401 (-2.7A);None","1.48A","4qztC-4lh7A:undetectable","3vt7A-4lh7A:21.05"]]