SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1WV'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_2
(PROTEASE RETROPEPSIN)		 4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 VAL A1044
GLY A1090
ILE A1094
VAL A1039
ILE A1043
 None
None
1WV  A1403 ( 4.1A)
None
None
 1.02A 2qhcB-4ldeA:
undetectable		 2qhcB-4ldeA:
11.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		3 / 3 VAL A1114
ASN A1312
TRP A1313
 P0G  A1401 (-3.7A)
P0G  A1401 (-2.9A)
1WV  A1403 ( 4.3A)
 1.08A 2y00B-4ldeA:
32.8		 2y00B-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		3 / 3 VAL A1117
ASN A1312
TRP A1313
 P0G  A1401 ( 4.4A)
P0G  A1401 (-2.9A)
1WV  A1403 ( 4.3A)
 0.97A 2y00B-4ldeA:
32.8		 2y00B-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y01_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		10 / 12 TRP A1109
ASP A1113
PHE A1193
SER A1203
PHE A1289
PHE A1290
ASN A1293
ASN A1312
TRP A1313
TYR A1316
 None
P0G  A1401 (-2.9A)
P0G  A1401 (-3.8A)
P0G  A1401 (-2.9A)
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
P0G  A1401 (-3.0A)
P0G  A1401 (-2.9A)
1WV  A1403 ( 4.3A)
None
 0.77A 2y01A-4ldeA:
32.7		 2y01A-4ldeA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AMJ_B_CVDB1360_2
(BETA-1 ADRENERGIC
RECEPTOR)		 4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 4 VAL A1114
ASP A1192
TYR A1199
TRP A1313
 P0G  A1401 (-3.7A)
None
None
1WV  A1403 ( 4.3A)
 0.97A 4amjB-4ldeA:
33.0		 4amjB-4ldeA:
42.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 4z36 LYSOPHOSPHATIDIC
ACID RECEPTOR
1,SOLUBLE CYTOCHROME
B562
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ILE A 176
LEU A 127
GLY A 126
TYR A 102
ALA A  98
 None
1WV  A2001 ( 4.7A)
1WV  A2001 ( 4.0A)
None
None
 1.15A 4foxD-4z36A:
undetectable		 4foxD-4z36A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 4z36 LYSOPHOSPHATIDIC
ACID RECEPTOR
1,SOLUBLE CYTOCHROME
B562
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ILE A 176
LEU A 127
GLY A 126
TYR A 102
ALA A  98
 None
1WV  A2001 ( 4.7A)
1WV  A2001 ( 4.0A)
None
None
 1.02A 5x66A-4z36A:
undetectable
5x66B-4z36A:
undetectable		 5x66A-4z36A:
21.59
5x66B-4z36A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4) 		7 / 12 ASP A1113
SER A1204
SER A1207
ASN A1293
ASN A1312
TRP A1313
TYR A1316
 P0G  A1401 (-2.9A)
P0G  A1401 ( 3.7A)
P0G  A1401 (-2.8A)
P0G  A1401 (-3.0A)
P0G  A1401 (-2.9A)
1WV  A1403 ( 4.3A)
None
 1.15A 6h7lA-4ldeA:
40.9		 6h7lA-4ldeA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4) 		10 / 12 TRP A1109
THR A1110
ASP A1113
VAL A1114
SER A1203
SER A1207
ASN A1293
ASN A1312
TRP A1313
TYR A1316
 None
P0G  A1401 ( 3.9A)
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
P0G  A1401 (-2.9A)
P0G  A1401 (-2.8A)
P0G  A1401 (-3.0A)
P0G  A1401 (-2.9A)
1WV  A1403 ( 4.3A)
None
 0.47A 6h7lA-4ldeA:
40.9		 6h7lA-4ldeA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4) 		7 / 12 ASP A1113
SER A1204
SER A1207
ASN A1293
ASN A1312
TRP A1313
TYR A1316
 P0G  A1401 (-2.9A)
P0G  A1401 ( 3.7A)
P0G  A1401 (-2.8A)
P0G  A1401 (-3.0A)
P0G  A1401 (-2.9A)
1WV  A1403 ( 4.3A)
None
 1.17A 6h7lB-4ldeA:
41.3		 6h7lB-4ldeA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4) 		10 / 12 TRP A1109
THR A1110
ASP A1113
VAL A1114
SER A1203
SER A1207
ASN A1293
ASN A1312
TRP A1313
TYR A1316
 None
P0G  A1401 ( 3.9A)
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
P0G  A1401 (-2.9A)
P0G  A1401 (-2.8A)
P0G  A1401 (-3.0A)
P0G  A1401 (-2.9A)
1WV  A1403 ( 4.3A)
None
 0.49A 6h7lB-4ldeA:
41.3		 6h7lB-4ldeA:
22.22