SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1WE'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2PCP_C_1PCC212_1 (IMMUNOGLOBULIN)	4lar	SINGLE HEAVY CHAIN VARIABLE FRAGMENT SINGLE LIGHT CHAIN VARIABLE FRAGMENT (Mus musculus)	5 / 10	HIS L 32 PHE L 98 TYR H 50 TYR H 58 SER H 35	None None 1WE L 300 ( 4.5A) None 1WE L 300 (-3.6A)	1.49A	2pcpC-4larL: 20.2 2pcpD-4larL: 14.6	2pcpC-4larL: 50.79 2pcpD-4larL: 22.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3GKZ_A_B40A500_1 (ANTI-METHAMPHETAMINE SINGLE CHAIN FV)	4lar	SINGLE HEAVY CHAIN VARIABLE FRAGMENT SINGLE LIGHT CHAIN VARIABLE FRAGMENT (Mus musculus)	5 / 11	SER H 93 PHE H 95 TYR L 34 HIS L 89 TRP L 91	None 1WE L 300 ( 4.1A) 1WE L 300 ( 4.8A) 1WE L 300 (-4.2A) 1WE L 300 (-4.1A)	1.06A	3gkzA-4larH: 25.1	3gkzA-4larH: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3GKZ_A_B40A500_1 (ANTI-METHAMPHETAMINE SINGLE CHAIN FV)	4lar	SINGLE HEAVY CHAIN VARIABLE FRAGMENT SINGLE LIGHT CHAIN VARIABLE FRAGMENT (Mus musculus)	11 / 11	TYR H 33 SER H 35 TYR H 47 TYR H 50 PHE H 95 GLU H 101 TYR L 34 TYR L 36 HIS L 89 TRP L 91 PHE L 96	1WE L 300 (-3.9A) 1WE L 300 (-3.6A) None 1WE L 300 ( 4.5A) 1WE L 300 ( 4.1A) 1WE L 300 (-3.7A) 1WE L 300 ( 4.8A) None 1WE L 300 (-4.2A) 1WE L 300 (-4.1A) 1WE L 300 ( 4.7A)	0.19A	3gkzA-4larH: 25.1	3gkzA-4larH: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3GM0_A_B41A600_1 (ANTI-METHAMPHETAMINE SINGLE CHAIN FV)	4lar	SINGLE HEAVY CHAIN VARIABLE FRAGMENT SINGLE LIGHT CHAIN VARIABLE FRAGMENT (Mus musculus)	5 / 11	SER H 93 PHE H 95 TYR L 34 HIS L 89 TRP L 91	None 1WE L 300 ( 4.1A) 1WE L 300 ( 4.8A) 1WE L 300 (-4.2A) 1WE L 300 (-4.1A)	1.07A	3gm0A-4larH: 24.2	3gm0A-4larH: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3GM0_A_B41A600_1 (ANTI-METHAMPHETAMINE SINGLE CHAIN FV)	4lar	SINGLE HEAVY CHAIN VARIABLE FRAGMENT SINGLE LIGHT CHAIN VARIABLE FRAGMENT (Mus musculus)	11 / 11	TYR H 33 SER H 35 TYR H 47 TYR H 50 PHE H 95 GLU H 101 TYR L 34 TYR L 36 HIS L 89 TRP L 91 PHE L 96	1WE L 300 (-3.9A) 1WE L 300 (-3.6A) None 1WE L 300 ( 4.5A) 1WE L 300 ( 4.1A) 1WE L 300 (-3.7A) 1WE L 300 ( 4.8A) None 1WE L 300 (-4.2A) 1WE L 300 (-4.1A) 1WE L 300 ( 4.7A)	0.24A	3gm0A-4larH: 24.2	3gm0A-4larH: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3GM0_A_B41A600_1 (ANTI-METHAMPHETAMINE SINGLE CHAIN FV)	4lar	SINGLE HEAVY CHAIN VARIABLE FRAGMENT SINGLE LIGHT CHAIN VARIABLE FRAGMENT (Mus musculus)	8 / 11	TYR H 50 SER H 35 GLU H 101 TYR L 34 TYR L 36 HIS L 89 TRP L 91 PHE L 96	1WE L 300 ( 4.5A) 1WE L 300 (-3.6A) 1WE L 300 (-3.7A) 1WE L 300 ( 4.8A) None 1WE L 300 (-4.2A) 1WE L 300 (-4.1A) 1WE L 300 ( 4.7A)	1.21A	3gm0A-4larH: 24.2	3gm0A-4larH: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4GQP_H_B40H1201_1 (ANTI-METH SCFV)	4lar	SINGLE HEAVY CHAIN VARIABLE FRAGMENT SINGLE LIGHT CHAIN VARIABLE FRAGMENT (Mus musculus)	5 / 11	SER H 93 PHE H 95 TYR L 34 HIS L 89 TRP L 91	None 1WE L 300 ( 4.1A) 1WE L 300 ( 4.8A) 1WE L 300 (-4.2A) 1WE L 300 (-4.1A)	1.08A	4gqpH-4larH: 25.1	4gqpH-4larH: 99.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4GQP_H_B40H1201_1 (ANTI-METH SCFV)	4lar	SINGLE HEAVY CHAIN VARIABLE FRAGMENT SINGLE LIGHT CHAIN VARIABLE FRAGMENT (Mus musculus)	11 / 11	TYR H 33 SER H 35 TYR H 47 TYR H 50 PHE H 95 GLU H 101 TYR L 34 TYR L 36 HIS L 89 TRP L 91 PHE L 96	1WE L 300 (-3.9A) 1WE L 300 (-3.6A) None 1WE L 300 ( 4.5A) 1WE L 300 ( 4.1A) 1WE L 300 (-3.7A) 1WE L 300 ( 4.8A) None 1WE L 300 (-4.2A) 1WE L 300 (-4.1A) 1WE L 300 ( 4.7A)	0.21A	4gqpH-4larH: 25.1	4gqpH-4larH: 99.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4GQP_H_B40H1201_1 (ANTI-METH SCFV)	4lar	SINGLE HEAVY CHAIN VARIABLE FRAGMENT SINGLE LIGHT CHAIN VARIABLE FRAGMENT (Mus musculus)	8 / 11	TYR H 50 SER H 35 GLU H 101 TYR L 34 TYR L 36 HIS L 89 TRP L 91 PHE L 96	1WE L 300 ( 4.5A) 1WE L 300 (-3.6A) 1WE L 300 (-3.7A) 1WE L 300 ( 4.8A) None 1WE L 300 (-4.2A) 1WE L 300 (-4.1A) 1WE L 300 ( 4.7A)	1.25A	4gqpH-4larH: 25.1	4gqpH-4larH: 99.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XUM_A_IMNA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	4lar	SINGLE HEAVY CHAIN VARIABLE FRAGMENT SINGLE LIGHT CHAIN VARIABLE FRAGMENT (Mus musculus)	5 / 12	SER H 93 ILE H 37 HIS L 89 LEU L 46 TYR L 36	None None 1WE L 300 (-4.2A) None None	1.30A	4xumA-4larH: undetectable	4xumA-4larH: 18.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5ACL_A_SASA1111_1 (MCG)	4lar	SINGLE HEAVY CHAIN VARIABLE FRAGMENT (Mus musculus)	4 / 7	TYR H 94 SER H 35 TYR H 47 TYR H 33	None 1WE L 300 (-3.6A) None 1WE L 300 (-3.9A)	0.98A	5aclA-4larH: 14.2	5aclA-4larH: 33.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L1F_A_6ZPA902_1 (GLUTAMATE RECEPTOR 2)	4lar	SINGLE HEAVY CHAIN VARIABLE FRAGMENT SINGLE LIGHT CHAIN VARIABLE FRAGMENT (Mus musculus)	4 / 8	SER H 35 TYR L 36 PHE L 96 SER H 97	1WE L 300 (-3.6A) None 1WE L 300 ( 4.7A) None	1.05A	5l1fA-4larH: undetectable 5l1fB-4larH: undetectable	5l1fA-4larH: 10.06 5l1fB-4larH: 10.06

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2PCP_C_1PCC212_1","IMMUNOGLOBULIN;IMMUNOGLOBULIN","4lar","SINGLE HEAVY CHAIN VARIABLE FRAGMENT;SINGLE LIGHT CHAIN VARIABLE FRAGMENT","Mus musculus",5,"HIS L  32;PHE L  98;TYR H  50;TYR H  58;SER H  35","None;None;1WE L 300 ( 4.5A);None;1WE L 300 (-3.6A)","1.49A","2pcpC-4larL:20.2;2pcpD-4larL:14.6",null],["3GKZ_A_B40A500_1","ANTI-METHAMPHETAMINE SINGLE CHAIN FV","4lar","SINGLE HEAVY CHAIN VARIABLE FRAGMENT;SINGLE LIGHT CHAIN VARIABLE FRAGMENT","Mus musculus",5,"SER H  93;PHE H  95;TYR L  34;HIS L  89;TRP L  91","None;1WE L 300 ( 4.1A);1WE L 300 ( 4.8A);1WE L 300 (-4.2A);1WE L 300 (-4.1A)","1.06A","3gkzA-4larH:25.1","2pcpC-4larL:50.79;2pcpD-4larL:22.60"],["3GKZ_A_B40A500_1","ANTI-METHAMPHETAMINE SINGLE CHAIN FV","4lar","SINGLE HEAVY CHAIN VARIABLE FRAGMENT;SINGLE LIGHT CHAIN VARIABLE FRAGMENT","Mus musculus",11,"TYR H  33;SER H  35;TYR H  47;TYR H  50;PHE H  95;GLU H 101;TYR L  34;TYR L  36;HIS L  89;TRP L  91;PHE L  96","1WE L 300 (-3.9A);1WE L 300 (-3.6A);None;1WE L 300 ( 4.5A);1WE L 300 ( 4.1A);1WE L 300 (-3.7A);1WE L 300 ( 4.8A);None;1WE L 300 (-4.2A);1WE L 300 (-4.1A);1WE L 300 ( 4.7A)","0.19A","3gkzA-4larH:25.1","3gkzA-4larH:100.00"],["3GM0_A_B41A600_1","ANTI-METHAMPHETAMINE SINGLE CHAIN FV","4lar","SINGLE HEAVY CHAIN VARIABLE FRAGMENT;SINGLE LIGHT CHAIN VARIABLE FRAGMENT","Mus musculus",5,"SER H  93;PHE H  95;TYR L  34;HIS L  89;TRP L  91","None;1WE L 300 ( 4.1A);1WE L 300 ( 4.8A);1WE L 300 (-4.2A);1WE L 300 (-4.1A)","1.07A","3gm0A-4larH:24.2","3gkzA-4larH:100.00"],["3GM0_A_B41A600_1","ANTI-METHAMPHETAMINE SINGLE CHAIN FV","4lar","SINGLE HEAVY CHAIN VARIABLE FRAGMENT;SINGLE LIGHT CHAIN VARIABLE FRAGMENT","Mus musculus",11,"TYR H  33;SER H  35;TYR H  47;TYR H  50;PHE H  95;GLU H 101;TYR L  34;TYR L  36;HIS L  89;TRP L  91;PHE L  96","1WE L 300 (-3.9A);1WE L 300 (-3.6A);None;1WE L 300 ( 4.5A);1WE L 300 ( 4.1A);1WE L 300 (-3.7A);1WE L 300 ( 4.8A);None;1WE L 300 (-4.2A);1WE L 300 (-4.1A);1WE L 300 ( 4.7A)","0.24A","3gm0A-4larH:24.2","3gm0A-4larH:100.00"],["3GM0_A_B41A600_1","ANTI-METHAMPHETAMINE SINGLE CHAIN FV","4lar","SINGLE HEAVY CHAIN VARIABLE FRAGMENT;SINGLE LIGHT CHAIN VARIABLE FRAGMENT","Mus musculus",8,"TYR H  50;SER H  35;GLU H 101;TYR L  34;TYR L  36;HIS L  89;TRP L  91;PHE L  96","1WE L 300 ( 4.5A);1WE L 300 (-3.6A);1WE L 300 (-3.7A);1WE L 300 ( 4.8A);None;1WE L 300 (-4.2A);1WE L 300 (-4.1A);1WE L 300 ( 4.7A)","1.21A","3gm0A-4larH:24.2","3gm0A-4larH:100.00"],["4GQP_H_B40H1201_1","ANTI-METH SCFV","4lar","SINGLE HEAVY CHAIN VARIABLE FRAGMENT;SINGLE LIGHT CHAIN VARIABLE FRAGMENT","Mus musculus",5,"SER H  93;PHE H  95;TYR L  34;HIS L  89;TRP L  91","None;1WE L 300 ( 4.1A);1WE L 300 ( 4.8A);1WE L 300 (-4.2A);1WE L 300 (-4.1A)","1.08A","4gqpH-4larH:25.1","3gm0A-4larH:100.00"],["4GQP_H_B40H1201_1","ANTI-METH SCFV","4lar","SINGLE HEAVY CHAIN VARIABLE FRAGMENT;SINGLE LIGHT CHAIN VARIABLE FRAGMENT","Mus musculus",11,"TYR H  33;SER H  35;TYR H  47;TYR H  50;PHE H  95;GLU H 101;TYR L  34;TYR L  36;HIS L  89;TRP L  91;PHE L  96","1WE L 300 (-3.9A);1WE L 300 (-3.6A);None;1WE L 300 ( 4.5A);1WE L 300 ( 4.1A);1WE L 300 (-3.7A);1WE L 300 ( 4.8A);None;1WE L 300 (-4.2A);1WE L 300 (-4.1A);1WE L 300 ( 4.7A)","0.21A","4gqpH-4larH:25.1","4gqpH-4larH:99.15"],["4GQP_H_B40H1201_1","ANTI-METH SCFV","4lar","SINGLE HEAVY CHAIN VARIABLE FRAGMENT;SINGLE LIGHT CHAIN VARIABLE FRAGMENT","Mus musculus",8,"TYR H  50;SER H  35;GLU H 101;TYR L  34;TYR L  36;HIS L  89;TRP L  91;PHE L  96","1WE L 300 ( 4.5A);1WE L 300 (-3.6A);1WE L 300 (-3.7A);1WE L 300 ( 4.8A);None;1WE L 300 (-4.2A);1WE L 300 (-4.1A);1WE L 300 ( 4.7A)","1.25A","4gqpH-4larH:25.1","4gqpH-4larH:99.15"],["4XUM_A_IMNA501_1","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","4lar","SINGLE HEAVY CHAIN VARIABLE FRAGMENT;SINGLE LIGHT CHAIN VARIABLE FRAGMENT","Mus musculus",5,"SER H  93;ILE H  37;HIS L  89;LEU L  46;TYR L  36","None;None;1WE L 300 (-4.2A);None;None","1.30A","4xumA-4larH:undetectable","4gqpH-4larH:99.15"],["5ACL_A_SASA1111_1","MCG","4lar","SINGLE HEAVY CHAIN VARIABLE FRAGMENT","Mus musculus",4,"TYR H  94;SER H  35;TYR H  47;TYR H  33","None;1WE L 300 (-3.6A);None;1WE L 300 (-3.9A)","0.98A","5aclA-4larH:14.2","4xumA-4larH:18.11"],["5L1F_A_6ZPA902_1","GLUTAMATE RECEPTOR 2;GLUTAMATE RECEPTOR 2","4lar","SINGLE HEAVY CHAIN VARIABLE FRAGMENT;SINGLE LIGHT CHAIN VARIABLE FRAGMENT","Mus musculus",4,"SER H  35;TYR L  36;PHE L  96;SER H  97","1WE L 300 (-3.6A);None;1WE L 300 ( 4.7A);None","1.05A","5l1fA-4larH:undetectable;5l1fB-4larH:undetectable","5aclA-4larH:33.61"]]