SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1VU'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 197
THR A 195
PRO A 200
 1VU  A 601 ( 4.8A)
None
None
 0.89A 1fjaC-5jfmA:
undetectable		 1fjaC-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 197
THR A 195
PRO A 200
 1VU  A 601 ( 4.8A)
None
None
 0.89A 1fjaD-5jfmA:
undetectable		 1fjaD-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 197
THR A 195
PRO A 200
 1VU  A 601 ( 4.8A)
None
None
 0.79A 1unjW-5jfmA:
undetectable		 1unjW-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 201
GLU A 143
HIS A 223
 None
None
1VU  A 601 (-3.9A)
 0.88A 1xwfA-5jfmA:
4.6		 1xwfA-5jfmA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 201
GLU A 143
HIS A 223
 None
None
1VU  A 601 (-3.9A)
 0.88A 1xwfB-5jfmA:
4.3		 1xwfB-5jfmA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 201
GLU A 143
HIS A 223
 None
None
1VU  A 601 (-3.9A)
 0.87A 1xwfC-5jfmA:
undetectable		 1xwfC-5jfmA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 201
GLU A 143
HIS A 223
 None
None
1VU  A 601 (-3.9A)
 0.90A 1xwfD-5jfmA:
4.6		 1xwfD-5jfmA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		4 / 7 GLY A 143
CYH A 180
PHE A 204
PHE A 221
 1VU  A5601 (-3.4A)
None
None
None
 1.02A 2qx4A-1xnyA:
2.3
2qx4B-1xnyA:
undetectable		 2qx4A-1xnyA:
20.58
2qx4B-1xnyA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		4 / 8 GLY A 278
ILE A 282
PRO A 498
THR A 499
 1VU  A 601 (-3.5A)
1VU  A 601 (-3.6A)
None
None
 0.65A 3el9A-5jfmA:
undetectable		 3el9A-5jfmA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		5 / 12 LYS A  45
ASP A 105
GLY A 110
LEU A 113
ASP A 140
 None
None
1VU  A5601 ( 4.2A)
None
None
 1.12A 4blvB-1xnyA:
undetectable		 4blvB-1xnyA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		5 / 12 VAL A 185
ALA A 184
TYR A 186
GLY A 207
GLY A 143
 None
None
None
None
1VU  A5601 (-3.4A)
 1.21A 4mm8A-1xnyA:
undetectable		 4mm8A-1xnyA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		5 / 11 VAL A 185
ALA A 184
TYR A 186
GLY A 207
GLY A 143
 None
None
None
None
1VU  A5601 (-3.4A)
 1.15A 4mm9A-1xnyA:
undetectable		 4mm9A-1xnyA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 11 THR A 201
SER A 230
THR A 197
ALA A 226
THR A 144
 None
None
1VU  A 601 ( 4.8A)
None
None
 1.30A 4qvnH-5jfmA:
undetectable
4qvnI-5jfmA:
undetectable		 4qvnH-5jfmA:
20.84
4qvnI-5jfmA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 10 THR A 201
SER A 230
THR A 197
ALA A 226
THR A 144
 None
None
1VU  A 601 ( 4.8A)
None
None
 1.29A 4qvnV-5jfmA:
undetectable
4qvnW-5jfmA:
undetectable		 4qvnV-5jfmA:
20.84
4qvnW-5jfmA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 11 THR A 201
SER A 230
THR A 197
ALA A 226
THR A 144
 None
None
1VU  A 601 ( 4.8A)
None
None
 1.29A 4qvqH-5jfmA:
undetectable
4qvqI-5jfmA:
undetectable		 4qvqH-5jfmA:
20.84
4qvqI-5jfmA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 11 THR A 201
SER A 230
THR A 197
ALA A 226
THR A 144
 None
None
1VU  A 601 ( 4.8A)
None
None
 1.29A 4qvqV-5jfmA:
undetectable
4qvqW-5jfmA:
undetectable		 4qvqV-5jfmA:
20.84
4qvqW-5jfmA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 10 THR A 201
SER A 230
THR A 197
ALA A 226
THR A 144
 None
None
1VU  A 601 ( 4.8A)
None
None
 1.28A 4qvwH-5jfmA:
0.0
4qvwI-5jfmA:
0.3		 4qvwH-5jfmA:
20.84
4qvwI-5jfmA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 10 THR A 201
SER A 230
THR A 197
ALA A 226
THR A 144
 None
None
1VU  A 601 ( 4.8A)
None
None
 1.27A 4qvwV-5jfmA:
undetectable
4qvwW-5jfmA:
undetectable		 4qvwV-5jfmA:
20.84
4qvwW-5jfmA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 THR A 201
SER A 230
THR A 197
ALA A 226
THR A 144
 None
None
1VU  A 601 ( 4.8A)
None
None
 1.28A 4qw1H-5jfmA:
undetectable
4qw1I-5jfmA:
undetectable		 4qw1H-5jfmA:
20.84
4qw1I-5jfmA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 THR A 201
SER A 230
THR A 197
ALA A 226
THR A 144
 None
None
1VU  A 601 ( 4.8A)
None
None
 1.28A 4qw1V-5jfmA:
undetectable
4qw1W-5jfmA:
undetectable		 4qw1V-5jfmA:
20.84
4qw1W-5jfmA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 11 THR A 201
SER A 230
THR A 197
ALA A 226
THR A 144
 None
None
1VU  A 601 ( 4.8A)
None
None
 1.30A 4qwuH-5jfmA:
undetectable
4qwuI-5jfmA:
undetectable		 4qwuH-5jfmA:
20.84
4qwuI-5jfmA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 11 THR A 201
SER A 230
THR A 197
ALA A 226
THR A 144
 None
None
1VU  A 601 ( 4.8A)
None
None
 1.29A 4qwuV-5jfmA:
undetectable
4qwuW-5jfmA:
undetectable		 4qwuV-5jfmA:
20.84
4qwuW-5jfmA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		4 / 7 THR A 197
MET A 146
VAL A 383
THR A 380
 1VU  A 601 ( 4.8A)
1VU  A 601 ( 4.1A)
1VU  A 601 ( 4.7A)
1VU  A 601 (-3.8A)
 1.02A 5e4dA-5jfmA:
undetectable
5e4dB-5jfmA:
undetectable		 5e4dA-5jfmA:
15.91
5e4dB-5jfmA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 11 THR A 203
PRO A 196
ALA A 226
PHE A 220
GLU A 142
 None
1VU  A 601 (-4.6A)
None
None
None
 1.12A 5ewjA-5jfmA:
undetectable
5ewjB-5jfmA:
3.8		 5ewjA-5jfmA:
22.74
5ewjB-5jfmA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 THR A 203
PRO A 196
ALA A 226
PHE A 220
GLU A 142
 None
1VU  A 601 (-4.6A)
None
None
None
 1.10A 5ewjC-5jfmA:
4.2
5ewjD-5jfmA:
3.8		 5ewjC-5jfmA:
22.74
5ewjD-5jfmA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 483
SER A 479
VAL A 331
PRO A 329
SER A 137
 None
None
1VU  A 601 ( 4.2A)
1VU  A 601 (-4.6A)
None
 1.37A 5f9zB-5jfmA:
3.4		 5f9zB-5jfmA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 THR A 201
SER A 230
THR A 197
ALA A 226
THR A 144
 None
None
1VU  A 601 ( 4.8A)
None
None
 1.28A 5l66V-5jfmA:
undetectable
5l66W-5jfmA:
undetectable		 5l66V-5jfmA:
20.84
5l66W-5jfmA:
17.66