SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1VE'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 4oya ADENYLATE CYCLASE
TYPE 10
(Homo
sapiens) 		4 / 7 ASP A  99
THR A  52
ILE A  79
ASN A  76
 1VE  A 501 (-2.5A)
None
None
None
 1.14A 2jc9A-4oyaA:
undetectable		 2jc9A-4oyaA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4oya ADENYLATE CYCLASE
TYPE 10
(Homo
sapiens) 		4 / 8 ILE A 407
ASN A 412
ARG A 176
SER A  49
 None
None
1VE  A 501 (-3.2A)
None
 1.04A 2zw9B-4oyaA:
undetectable		 2zw9B-4oyaA:
21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4USW_A_ACTA1469_0
(ADENYLATE CYCLASE
TYPE 10)		 4oya ADENYLATE CYCLASE
TYPE 10
(Homo
sapiens) 		4 / 4 LYS A  95
HIS A 164
LYS A 334
VAL A 335
 1VE  A 501 (-3.8A)
None
None
None
 0.42A 4uswA-4oyaA:
59.9		 4uswA-4oyaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 4oya ADENYLATE CYCLASE
TYPE 10
(Homo
sapiens) 		5 / 6 LYS A  95
LEU A 102
LEU A 166
VAL A 167
PHE A 336
 1VE  A 501 (-3.8A)
1VE  A 501 (-3.6A)
1VE  A 501 (-3.9A)
1VE  A 501 (-3.7A)
1VE  A 501 (-3.9A)
 0.57A 4uswA-4oyaA:
59.9		 4uswA-4oyaA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4oya ADENYLATE CYCLASE
TYPE 10
(Homo
sapiens) 		4 / 6 VAL A 167
ARG A  33
ILE A 314
PHE A 157
 1VE  A 501 (-3.7A)
None
None
None
 1.05A 5jw1B-4oyaA:
undetectable		 5jw1B-4oyaA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4oya ADENYLATE CYCLASE
TYPE 10
(Homo
sapiens) 		4 / 4 LEU A 166
ARG A  33
ILE A 314
PHE A 157
 1VE  A 501 (-3.9A)
None
None
None
 1.09A 5kirB-4oyaA:
undetectable		 5kirB-4oyaA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 4oya ADENYLATE CYCLASE
TYPE 10
(Homo
sapiens) 		4 / 5 ALA A  97
VAL A 406
PHE A 336
ILE A 294
 1VE  A 501 (-3.1A)
None
1VE  A 501 (-3.9A)
None
 0.91A 5of1B-4oyaA:
undetectable		 5of1B-4oyaA:
11.06