SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1V8'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 4l2k TANKYRASE-2
(Homo
sapiens) 		4 / 7 HIS A1031
GLY A1032
TYR A1060
TYR A1071
 1V8  A1201 (-4.2A)
1V8  A1201 (-3.7A)
1V8  A1201 (-4.7A)
1V8  A1201 (-3.3A)
 0.21A 1dmaA-4l2kA:
2.8		 1dmaA-4l2kA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 4l2k TANKYRASE-2
(Homo
sapiens) 		5 / 6 HIS A1031
GLY A1032
TYR A1060
ALA A1062
TYR A1071
 1V8  A1201 (-4.2A)
1V8  A1201 (-3.7A)
1V8  A1201 (-4.7A)
1V8  A1201 (-3.6A)
1V8  A1201 (-3.3A)
 0.41A 1dmaB-4l2kA:
2.4		 1dmaB-4l2kA:
20.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4l2k TANKYRASE-2
(Homo
sapiens) 		7 / 8 HIS A1031
GLY A1032
TYR A1060
ALA A1062
LYS A1067
SER A1068
TYR A1071
 1V8  A1201 (-4.2A)
1V8  A1201 (-3.7A)
1V8  A1201 (-4.7A)
1V8  A1201 (-3.6A)
SO4  A1203 ( 2.8A)
1V8  A1201 (-2.7A)
1V8  A1201 (-3.3A)
 0.13A 3u9hA-4l2kA:
25.7		 3u9hA-4l2kA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4l2k TANKYRASE-2
(Homo
sapiens) 		7 / 8 HIS A1031
GLY A1032
TYR A1060
ALA A1062
LYS A1067
SER A1068
TYR A1071
 1V8  A1201 (-4.2A)
1V8  A1201 (-3.7A)
1V8  A1201 (-4.7A)
1V8  A1201 (-3.6A)
SO4  A1203 ( 2.8A)
1V8  A1201 (-2.7A)
1V8  A1201 (-3.3A)
 0.15A 3u9hB-4l2kA:
25.4		 3u9hB-4l2kA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 4l2k TANKYRASE-2
(Homo
sapiens) 		4 / 6 HIS A1031
GLY A1032
TYR A1060
TYR A1071
 1V8  A1201 (-4.2A)
1V8  A1201 (-3.7A)
1V8  A1201 (-4.7A)
1V8  A1201 (-3.3A)
 0.39A 4ae1A-4l2kA:
2.9		 4ae1A-4l2kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 4l2k TANKYRASE-2
(Homo
sapiens) 		4 / 5 HIS A1031
GLY A1032
TYR A1060
TYR A1071
 1V8  A1201 (-4.2A)
1V8  A1201 (-3.7A)
1V8  A1201 (-4.7A)
1V8  A1201 (-3.3A)
 0.41A 4ae1B-4l2kA:
undetectable		 4ae1B-4l2kA:
15.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4l2k TANKYRASE-2
(Homo
sapiens) 		7 / 8 HIS A1031
GLY A1032
TYR A1060
ALA A1062
LYS A1067
SER A1068
TYR A1071
 1V8  A1201 (-4.2A)
1V8  A1201 (-3.7A)
1V8  A1201 (-4.7A)
1V8  A1201 (-3.6A)
SO4  A1203 ( 2.8A)
1V8  A1201 (-2.7A)
1V8  A1201 (-3.3A)
 0.18A 4bjcA-4l2kA:
22.8		 4bjcA-4l2kA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 4l2k TANKYRASE-2
(Homo
sapiens) 		6 / 7 HIS A1031
GLY A1032
TYR A1060
ALA A1062
SER A1068
TYR A1071
 1V8  A1201 (-4.2A)
1V8  A1201 (-3.7A)
1V8  A1201 (-4.7A)
1V8  A1201 (-3.6A)
1V8  A1201 (-2.7A)
1V8  A1201 (-3.3A)
 0.41A 4hyfA-4l2kA:
22.5		 4hyfA-4l2kA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 4l2k TANKYRASE-2
(Homo
sapiens) 		5 / 8 HIS A1031
GLY A1032
TYR A1050
LYS A1067
SER A1068
 1V8  A1201 (-4.2A)
1V8  A1201 (-3.7A)
1V8  A1201 (-4.1A)
SO4  A1203 ( 2.8A)
1V8  A1201 (-2.7A)
 1.00A 4hyfB-4l2kA:
22.5		 4hyfB-4l2kA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 4l2k TANKYRASE-2
(Homo
sapiens) 		7 / 8 HIS A1031
GLY A1032
TYR A1060
ALA A1062
LYS A1067
SER A1068
TYR A1071
 1V8  A1201 (-4.2A)
1V8  A1201 (-3.7A)
1V8  A1201 (-4.7A)
1V8  A1201 (-3.6A)
SO4  A1203 ( 2.8A)
1V8  A1201 (-2.7A)
1V8  A1201 (-3.3A)
 0.48A 4hyfB-4l2kA:
22.5		 4hyfB-4l2kA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 4l2k TANKYRASE-2
(Homo
sapiens) 		6 / 8 HIS A1031
GLY A1032
TYR A1060
ALA A1062
SER A1068
TYR A1071
 1V8  A1201 (-4.2A)
1V8  A1201 (-3.7A)
1V8  A1201 (-4.7A)
1V8  A1201 (-3.6A)
1V8  A1201 (-2.7A)
1V8  A1201 (-3.3A)
 0.40A 4hyfC-4l2kA:
22.1		 4hyfC-4l2kA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 4l2k TANKYRASE-2
(Homo
sapiens) 		6 / 8 HIS A1031
GLY A1032
TYR A1060
LYS A1067
SER A1068
TYR A1071
 1V8  A1201 (-4.2A)
1V8  A1201 (-3.7A)
1V8  A1201 (-4.7A)
SO4  A1203 ( 2.8A)
1V8  A1201 (-2.7A)
1V8  A1201 (-3.3A)
 1.04A 4hyfC-4l2kA:
22.1		 4hyfC-4l2kA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4l2k TANKYRASE-2
(Homo
sapiens) 		6 / 11 HIS A1031
GLY A1032
TYR A1060
ALA A1062
LYS A1067
SER A1068
 1V8  A1201 (-4.2A)
1V8  A1201 (-3.7A)
1V8  A1201 (-4.7A)
1V8  A1201 (-3.6A)
SO4  A1203 ( 2.8A)
1V8  A1201 (-2.7A)
 1.06A 4rv6A-4l2kA:
11.6		 4rv6A-4l2kA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4l2k TANKYRASE-2
(Homo
sapiens) 		6 / 11 HIS A1031
GLY A1032
TYR A1060
ALA A1062
SER A1068
TYR A1071
 1V8  A1201 (-4.2A)
1V8  A1201 (-3.7A)
1V8  A1201 (-4.7A)
1V8  A1201 (-3.6A)
1V8  A1201 (-2.7A)
1V8  A1201 (-3.3A)
 0.47A 4rv6A-4l2kA:
11.6		 4rv6A-4l2kA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4l2k TANKYRASE-2
(Homo
sapiens) 		6 / 11 HIS A1031
GLY A1032
TYR A1060
ALA A1062
LYS A1067
SER A1068
 1V8  A1201 (-4.2A)
1V8  A1201 (-3.7A)
1V8  A1201 (-4.7A)
1V8  A1201 (-3.6A)
SO4  A1203 ( 2.8A)
1V8  A1201 (-2.7A)
 1.05A 4rv6B-4l2kA:
11.7		 4rv6B-4l2kA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4l2k TANKYRASE-2
(Homo
sapiens) 		6 / 11 HIS A1031
GLY A1032
TYR A1060
ALA A1062
SER A1068
TYR A1071
 1V8  A1201 (-4.2A)
1V8  A1201 (-3.7A)
1V8  A1201 (-4.7A)
1V8  A1201 (-3.6A)
1V8  A1201 (-2.7A)
1V8  A1201 (-3.3A)
 0.46A 4rv6B-4l2kA:
11.7		 4rv6B-4l2kA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HA9_B_TP0B406_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4l2k TANKYRASE-2
(Homo
sapiens) 		6 / 9 HIS A1031
SER A1033
ILE A1039
TYR A1060
SER A1068
TYR A1071
 1V8  A1201 (-4.2A)
1V8  A1201 (-3.2A)
None
1V8  A1201 (-4.7A)
1V8  A1201 (-2.7A)
1V8  A1201 (-3.3A)
 0.66A 5ha9B-4l2kA:
10.1		 5ha9B-4l2kA:
21.08