SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1UL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		7 / 12 GLY A  43
VAL A  50
ALA A  61
VAL A  90
ASN A 161
LEU A 163
ASP A 175
 1UL  A 501 ( 4.1A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
1UL  A 501 (-4.3A)
1UL  A 501 (-4.2A)
 0.63A 1fmoE-4l52A:
23.6		 1fmoE-4l52A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		6 / 9 GLY A  43
VAL A  50
ALA A  61
TYR A 106
ALA A 107
LEU A 163
 1UL  A 501 ( 4.1A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
1UL  A 501 (-4.1A)
1UL  A 501 (-3.6A)
1UL  A 501 (-4.3A)
 0.75A 1muoA-4l52A:
18.7		 1muoA-4l52A:
28.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		8 / 12 ALA A  61
LYS A  63
GLU A  77
LEU A  81
VAL A  90
GLY A 110
LEU A 163
ASP A 175
 1UL  A 501 (-3.1A)
None
None
None
None
1UL  A 501 ( 3.7A)
1UL  A 501 (-4.3A)
1UL  A 501 (-4.2A)
 1.08A 1t46A-4l52A:
19.4		 1t46A-4l52A:
30.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		8 / 12 VAL A  50
ALA A  61
LYS A  63
GLU A  77
LEU A  81
VAL A  90
GLY A 110
LEU A 163
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
None
None
1UL  A 501 ( 3.7A)
1UL  A 501 (-4.3A)
 0.67A 1t46A-4l52A:
19.4		 1t46A-4l52A:
30.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		6 / 12 ALA A  61
LYS A  63
GLU A  77
LEU A  81
LEU A 144
HIS A 154
 1UL  A 501 (-3.1A)
None
None
None
None
None
 0.73A 1uwhB-4l52A:
27.1		 1uwhB-4l52A:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		4 / 7 LYS A  63
LEU A  81
ILE A  89
ASP A 175
 None
None
None
1UL  A 501 (-4.2A)
 0.85A 1uwjA-4l52A:
10.3		 1uwjA-4l52A:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		6 / 9 VAL A  50
ALA A  61
MET A 104
ALA A 107
GLY A 110
LEU A 163
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
1UL  A 501 (-3.6A)
1UL  A 501 (-3.6A)
1UL  A 501 ( 3.7A)
1UL  A 501 (-4.3A)
 0.64A 1xbbA-4l52A:
27.1		 1xbbA-4l52A:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		6 / 12 VAL A  50
LYS A  63
VAL A  90
ASN A 161
LEU A 163
ASP A 175
 1UL  A 501 ( 4.9A)
None
None
None
1UL  A 501 (-4.3A)
1UL  A 501 (-4.2A)
 0.62A 2eufB-4l52A:
18.1		 2eufB-4l52A:
28.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		10 / 11 VAL A  42
GLY A  43
GLY A  45
VAL A  50
ALA A  61
MET A 104
TYR A 106
ALA A 107
SER A 111
LEU A 163
 1UL  A 501 (-4.1A)
1UL  A 501 ( 4.1A)
1UL  A 501 ( 3.7A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
1UL  A 501 (-3.6A)
1UL  A 501 (-4.1A)
1UL  A 501 (-3.6A)
None
1UL  A 501 (-4.3A)
 0.54A 2evaA-4l52A:
45.7		 2evaA-4l52A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		7 / 12 GLY A  43
VAL A  50
ALA A  61
ASP A 156
LYS A 158
ASN A 161
ASP A 175
 1UL  A 501 ( 4.1A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
None
1UL  A 501 (-4.2A)
 0.71A 2fumA-4l52A:
8.8		 2fumA-4l52A:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		8 / 12 GLY A  43
VAL A  50
ALA A  61
MET A 104
TYR A 106
LYS A 158
ASN A 161
ASP A 175
 1UL  A 501 ( 4.1A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
1UL  A 501 (-3.6A)
1UL  A 501 (-4.1A)
None
None
1UL  A 501 (-4.2A)
 0.84A 2fumB-4l52A:
19.5		 2fumB-4l52A:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		6 / 12 GLY A  43
VAL A  50
ALA A  61
MET A 104
TYR A 106
ASN A 161
 1UL  A 501 ( 4.1A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
1UL  A 501 (-3.6A)
1UL  A 501 (-4.1A)
None
 0.39A 2fumC-4l52A:
25.2		 2fumC-4l52A:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		6 / 12 GLY A  43
VAL A  50
ALA A  61
MET A 104
LYS A 158
ASN A 161
 1UL  A 501 ( 4.1A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
1UL  A 501 (-3.6A)
None
None
 0.58A 2fumD-4l52A:
19.3		 2fumD-4l52A:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		7 / 12 VAL A  50
ALA A  61
LYS A  63
GLU A  77
VAL A  90
GLY A 110
LEU A 163
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
None
1UL  A 501 ( 3.7A)
1UL  A 501 (-4.3A)
 0.59A 2gqgB-4l52A:
7.3		 2gqgB-4l52A:
25.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		7 / 12 VAL A  50
ALA A  61
LYS A  63
GLU A  77
TYR A 106
GLY A 110
LEU A 163
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
1UL  A 501 (-4.1A)
1UL  A 501 ( 3.7A)
1UL  A 501 (-4.3A)
 0.73A 2oiqA-4l52A:
21.0		 2oiqA-4l52A:
31.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		10 / 12 GLY A  43
GLY A  45
GLY A  48
VAL A  50
ALA A  61
LYS A  63
MET A 104
SER A 111
ASN A 161
LEU A 163
 1UL  A 501 ( 4.1A)
1UL  A 501 ( 3.7A)
None
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
1UL  A 501 (-3.6A)
None
None
1UL  A 501 (-4.3A)
 0.76A 3eygA-4l52A:
26.6		 3eygA-4l52A:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		8 / 12 GLY A  43
GLY A  48
VAL A  50
ALA A  61
SER A 111
ASN A 161
LEU A 163
ASP A 175
 1UL  A 501 ( 4.1A)
None
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
1UL  A 501 (-4.3A)
1UL  A 501 (-4.2A)
 0.70A 3eygA-4l52A:
26.6		 3eygA-4l52A:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		9 / 12 GLY A  43
GLY A  45
GLY A  48
VAL A  50
ALA A  61
LYS A  63
MET A 104
TYR A 106
SER A 111
 1UL  A 501 ( 4.1A)
1UL  A 501 ( 3.7A)
None
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
1UL  A 501 (-3.6A)
1UL  A 501 (-4.1A)
None
 0.74A 3fupA-4l52A:
27.3		 3fupA-4l52A:
28.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		9 / 12 GLY A  43
GLY A  48
VAL A  50
ALA A  61
LYS A  63
MET A 104
TYR A 106
SER A 111
LEU A 163
 1UL  A 501 ( 4.1A)
None
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
1UL  A 501 (-3.6A)
1UL  A 501 (-4.1A)
None
1UL  A 501 (-4.3A)
 0.65A 3fupA-4l52A:
27.3		 3fupA-4l52A:
28.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		8 / 12 GLY A  43
VAL A  50
ALA A  61
LYS A  63
VAL A  90
MET A 104
TYR A 106
LEU A 163
 1UL  A 501 ( 4.1A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
1UL  A 501 (-3.6A)
1UL  A 501 (-4.1A)
1UL  A 501 (-4.3A)
 0.53A 3fupB-4l52A:
26.6		 3fupB-4l52A:
28.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		7 / 11 VAL A  50
ALA A  61
VAL A  90
TYR A 106
GLY A 110
LEU A 163
CYH A 174
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
1UL  A 501 (-4.1A)
1UL  A 501 ( 3.7A)
1UL  A 501 (-4.3A)
1UL  A 501 (-3.6A)
 0.73A 3g0eA-4l52A:
17.6		 3g0eA-4l52A:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		6 / 10 VAL A  50
ALA A  61
TYR A 106
GLY A 110
LEU A 163
CYH A 174
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
1UL  A 501 (-4.1A)
1UL  A 501 ( 3.7A)
1UL  A 501 (-4.3A)
1UL  A 501 (-3.6A)
 0.66A 3g0fB-4l52A:
25.2		 3g0fB-4l52A:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		6 / 12 VAL A  42
VAL A  50
ALA A  61
LYS A  63
GLU A  77
LEU A  81
 1UL  A 501 (-4.1A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
None
 0.89A 3hegA-4l52A:
15.6		 3hegA-4l52A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		8 / 12 GLY A  43
VAL A  50
ALA A  61
LYS A  63
VAL A  90
MET A 104
TYR A 106
LEU A 163
 1UL  A 501 ( 4.1A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
1UL  A 501 (-3.6A)
1UL  A 501 (-4.1A)
1UL  A 501 (-4.3A)
 0.64A 3lxkA-4l52A:
26.7		 3lxkA-4l52A:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		7 / 12 GLY A  43
VAL A  50
ALA A  61
LYS A  63
TYR A 106
SER A 111
LEU A 163
 1UL  A 501 ( 4.1A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
1UL  A 501 (-4.1A)
None
1UL  A 501 (-4.3A)
 0.55A 3lxnA-4l52A:
27.7		 3lxnA-4l52A:
27.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		6 / 12 ALA A  61
GLU A  77
VAL A  90
TYR A 106
GLY A 110
LEU A 163
 1UL  A 501 (-3.1A)
None
None
1UL  A 501 (-4.1A)
1UL  A 501 ( 3.7A)
1UL  A 501 (-4.3A)
 0.52A 3oezA-4l52A:
21.2		 3oezA-4l52A:
31.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		6 / 12 VAL A  42
GLY A  43
VAL A  50
ALA A  61
LYS A  63
LEU A  81
 1UL  A 501 (-4.1A)
1UL  A 501 ( 4.1A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
 0.75A 3ohtA-4l52A:
15.8		 3ohtA-4l52A:
26.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		8 / 12 VAL A  50
ALA A  61
LYS A  63
GLU A  77
VAL A  90
TYR A 106
GLY A 110
LEU A 163
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
None
1UL  A 501 (-4.1A)
1UL  A 501 ( 3.7A)
1UL  A 501 (-4.3A)
 0.72A 3qlgA-4l52A:
21.5		 3qlgA-4l52A:
31.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		8 / 12 VAL A  50
ALA A  61
GLU A  77
LEU A  81
TYR A 106
ALA A 107
LEU A 144
HIS A 154
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
1UL  A 501 (-4.1A)
1UL  A 501 (-3.6A)
None
None
 0.83A 3rgfA-4l52A:
4.3		 3rgfA-4l52A:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		5 / 9 ASP A 175
GLY A  45
ALA A  46
GLY A 191
LEU A 157
 1UL  A 501 (-4.2A)
1UL  A 501 ( 3.7A)
None
None
None
 1.02A 3u7sB-4l52A:
undetectable		 3u7sB-4l52A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		7 / 12 VAL A  50
ALA A  61
GLU A  77
LEU A  81
GLY A 110
LEU A 144
HIS A 154
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
1UL  A 501 ( 3.7A)
None
None
 0.59A 3wzeA-4l52A:
19.7		 3wzeA-4l52A:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		5 / 8 VAL A  90
LEU A 163
ILE A 173
CYH A 174
ASP A 175
 None
1UL  A 501 (-4.3A)
None
1UL  A 501 (-3.6A)
1UL  A 501 (-4.2A)
 0.78A 3wzeA-4l52A:
19.7		 3wzeA-4l52A:
29.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		8 / 12 VAL A  50
ALA A  61
LYS A  63
GLU A  77
VAL A  90
GLY A 110
LEU A 163
CYH A 174
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
None
1UL  A 501 ( 3.7A)
1UL  A 501 (-4.3A)
1UL  A 501 (-3.6A)
 0.73A 4ag8A-4l52A:
19.5		 4ag8A-4l52A:
30.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		7 / 12 VAL A  50
ALA A  61
GLU A  77
LEU A  81
GLY A 110
LEU A 163
CYH A 174
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
1UL  A 501 ( 3.7A)
1UL  A 501 (-4.3A)
1UL  A 501 (-3.6A)
 0.62A 4agcA-4l52A:
19.2		 4agcA-4l52A:
28.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		8 / 12 VAL A  50
ALA A  61
LYS A  63
GLU A  77
LEU A  81
GLY A 110
LEU A 144
HIS A 154
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
None
1UL  A 501 ( 3.7A)
None
None
 0.76A 4asdA-4l52A:
19.9		 4asdA-4l52A:
28.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		4 / 6 VAL A  90
LEU A 163
ILE A 173
CYH A 174
 None
1UL  A 501 (-4.3A)
None
1UL  A 501 (-3.6A)
 0.29A 4asdA-4l52A:
19.9		 4asdA-4l52A:
28.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		7 / 12 ALA A  61
LYS A  63
GLU A  77
LEU A  81
HIS A 154
LEU A 163
ASP A 175
 1UL  A 501 (-3.1A)
None
None
None
None
1UL  A 501 (-4.3A)
1UL  A 501 (-4.2A)
 1.21A 4c8bA-4l52A:
28.9		 4c8bA-4l52A:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		4 / 5 VAL A  50
ILE A  89
TYR A 106
ILE A 173
 1UL  A 501 ( 4.9A)
None
1UL  A 501 (-4.1A)
None
 0.64A 4c8bA-4l52A:
28.9		 4c8bA-4l52A:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		7 / 12 ALA A  61
LYS A  63
GLU A  77
LEU A  81
ILE A  89
HIS A 154
LEU A 163
 1UL  A 501 (-3.1A)
None
None
None
None
None
1UL  A 501 (-4.3A)
 0.81A 4c8bB-4l52A:
28.8		 4c8bB-4l52A:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		7 / 10 GLY A  43
VAL A  50
ALA A  61
TYR A 106
ALA A 107
SER A 111
LEU A 163
 1UL  A 501 ( 4.1A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
1UL  A 501 (-4.1A)
1UL  A 501 (-3.6A)
None
1UL  A 501 (-4.3A)
 0.51A 4ckjA-4l52A:
21.2		 4ckjA-4l52A:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		7 / 12 VAL A  50
ALA A  61
ASP A 156
LYS A 158
ASN A 161
LEU A 163
ASP A 175
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
None
1UL  A 501 (-4.3A)
1UL  A 501 (-4.2A)
 0.73A 4i41A-4l52A:
16.4		 4i41A-4l52A:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		5 / 12 LEU A  81
ASN A 161
ASP A 175
PHE A 176
GLY A 177
 None
None
1UL  A 501 (-4.2A)
None
None
 0.98A 4lmnA-4l52A:
24.3		 4lmnA-4l52A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		5 / 12 LEU A  81
MET A 104
ASN A 161
PHE A 176
GLY A 177
 None
1UL  A 501 (-3.6A)
None
None
None
 0.89A 4lmnA-4l52A:
24.3		 4lmnA-4l52A:
28.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		9 / 12 VAL A  50
ALA A  61
LYS A  63
GLU A  77
VAL A  90
TYR A 106
GLY A 110
LEU A 163
ASP A 175
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
None
1UL  A 501 (-4.1A)
1UL  A 501 ( 3.7A)
1UL  A 501 (-4.3A)
1UL  A 501 (-4.2A)
 0.98A 4mxyA-4l52A:
21.1		 4mxyA-4l52A:
31.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		9 / 12 VAL A  50
ALA A  61
LYS A  63
GLU A  77
VAL A  90
TYR A 106
GLY A 110
LEU A 163
ASP A 175
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
None
1UL  A 501 (-4.1A)
1UL  A 501 ( 3.7A)
1UL  A 501 (-4.3A)
1UL  A 501 (-4.2A)
 0.98A 4mxzA-4l52A:
21.1		 4mxzA-4l52A:
31.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		4 / 6 GLY A  43
VAL A  50
ALA A  61
LEU A 163
 1UL  A 501 ( 4.1A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
1UL  A 501 (-4.3A)
 0.21A 4o0wA-4l52A:
24.7		 4o0wA-4l52A:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		5 / 7 GLY A  43
ALA A  61
ASN A 161
LEU A 163
ASP A 175
 1UL  A 501 ( 4.1A)
1UL  A 501 (-3.1A)
None
1UL  A 501 (-4.3A)
1UL  A 501 (-4.2A)
 0.68A 4ogrE-4l52A:
17.1		 4ogrE-4l52A:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		6 / 9 GLY A  45
VAL A  50
ALA A  61
ASN A 161
LEU A 163
ASP A 175
 1UL  A 501 ( 3.7A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
1UL  A 501 (-4.3A)
1UL  A 501 (-4.2A)
 0.76A 4ogrI-4l52A:
17.7		 4ogrI-4l52A:
27.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		6 / 12 ALA A  61
LYS A  63
GLU A  77
TYR A 106
LEU A 163
ASP A 175
 1UL  A 501 (-3.1A)
None
None
1UL  A 501 (-4.1A)
1UL  A 501 (-4.3A)
1UL  A 501 (-4.2A)
 0.73A 4qmnA-4l52A:
25.4		 4qmnA-4l52A:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		6 / 11 ALA A  61
LYS A  63
GLU A  77
TYR A 106
LEU A 163
ASP A 175
 1UL  A 501 (-3.1A)
None
None
1UL  A 501 (-4.1A)
1UL  A 501 (-4.3A)
1UL  A 501 (-4.2A)
 0.86A 4qmsA-4l52A:
25.7		 4qmsA-4l52A:
32.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		5 / 12 ALA A  61
GLU A  77
ALA A 107
HIS A 154
LEU A 163
 1UL  A 501 (-3.1A)
None
1UL  A 501 (-3.6A)
None
1UL  A 501 (-4.3A)
 0.57A 4tyjA-4l52A:
20.5		 4tyjA-4l52A:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		4 / 6 VAL A  50
LYS A  63
ILE A  89
ILE A 173
 1UL  A 501 ( 4.9A)
None
None
None
 0.64A 4tyjA-4l52A:
20.5		 4tyjA-4l52A:
28.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		6 / 10 VAL A  50
GLU A  77
ILE A  89
VAL A  90
TYR A 106
ILE A 173
 1UL  A 501 ( 4.9A)
None
None
None
1UL  A 501 (-4.1A)
None
 0.73A 4u0iA-4l52A:
19.5		 4u0iA-4l52A:
30.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		8 / 12 ALA A  61
LYS A  63
LEU A  81
GLY A 110
HIS A 154
LEU A 163
CYH A 174
ASP A 175
 1UL  A 501 (-3.1A)
None
None
1UL  A 501 ( 3.7A)
None
1UL  A 501 (-4.3A)
1UL  A 501 (-3.6A)
1UL  A 501 (-4.2A)
 0.92A 4u0iA-4l52A:
19.5		 4u0iA-4l52A:
30.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		4 / 7 VAL A  50
LYS A  63
ALA A 107
ILE A 173
 1UL  A 501 ( 4.9A)
None
1UL  A 501 (-3.6A)
None
 0.64A 4uxqA-4l52A:
19.8		 4uxqA-4l52A:
29.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		5 / 12 ALA A  61
GLU A  77
ALA A 107
LEU A 144
HIS A 154
 1UL  A 501 (-3.1A)
None
1UL  A 501 (-3.6A)
None
None
 0.84A 4v01A-4l52A:
20.9		 4v01A-4l52A:
30.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		5 / 12 ALA A  61
GLU A  77
ALA A 107
LEU A 144
HIS A 154
 1UL  A 501 (-3.1A)
None
1UL  A 501 (-3.6A)
None
None
 0.76A 4v01B-4l52A:
21.3		 4v01B-4l52A:
30.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		5 / 10 LEU A 162
GLU A 221
LEU A 116
GLY A 110
LEU A 164
 None
None
None
1UL  A 501 ( 3.7A)
None
 1.36A 5dxbA-4l52A:
undetectable		 5dxbA-4l52A:
20.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		6 / 12 VAL A  50
ALA A  61
LYS A  63
ALA A 107
CYH A 174
PHE A 176
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
1UL  A 501 (-3.6A)
1UL  A 501 (-3.6A)
None
 0.81A 5hesB-4l52A:
27.9		 5hesB-4l52A:
35.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		6 / 12 ALA A  61
LYS A  63
GLU A  77
LEU A  81
LEU A 144
HIS A 154
 1UL  A 501 (-3.1A)
None
None
None
None
None
 0.78A 5hi2A-4l52A:
18.9		 5hi2A-4l52A:
31.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		6 / 12 GLY A  43
GLY A  45
PHE A  47
VAL A  50
LYS A  63
ASP A 175
 1UL  A 501 ( 4.1A)
1UL  A 501 ( 3.7A)
None
1UL  A 501 ( 4.9A)
None
1UL  A 501 (-4.2A)
 0.66A 5hieC-4l52A:
21.7		 5hieC-4l52A:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		6 / 12 GLY A  43
GLY A  45
VAL A  50
ALA A  61
LYS A  63
ASP A 175
 1UL  A 501 ( 4.1A)
1UL  A 501 ( 3.7A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
1UL  A 501 (-4.2A)
 0.82A 5hieC-4l52A:
21.7		 5hieC-4l52A:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		6 / 11 GLY A  43
VAL A  50
ALA A  61
TYR A 106
ALA A 107
LEU A 163
 1UL  A 501 ( 4.1A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
1UL  A 501 (-4.1A)
1UL  A 501 (-3.6A)
1UL  A 501 (-4.3A)
 0.48A 5lvnA-4l52A:
17.5		 5lvnA-4l52A:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		8 / 12 GLU A  40
GLY A  43
VAL A  50
ALA A  61
LYS A  63
GLU A  77
TYR A 106
GLY A 110
 None
1UL  A 501 ( 4.1A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
1UL  A 501 (-4.1A)
1UL  A 501 ( 3.7A)
 1.02A 5mafA-4l52A:
24.2		 5mafA-4l52A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		6 / 10 VAL A  50
ALA A  61
VAL A  90
MET A 104
TYR A 106
LEU A 163
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
1UL  A 501 (-3.6A)
1UL  A 501 (-4.1A)
1UL  A 501 (-4.3A)
 0.60A 5n3hA-4l52A:
22.9		 5n3hA-4l52A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		4 / 8 ALA A  61
GLU A  77
LEU A 163
ASP A 175
 1UL  A 501 (-3.1A)
None
1UL  A 501 (-4.3A)
1UL  A 501 (-4.2A)
 0.53A 5owrA-4l52A:
21.4		 5owrA-4l52A:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		6 / 12 GLU A  40
ALA A  61
GLU A  77
VAL A  90
GLY A 110
ASN A 114
 None
1UL  A 501 (-3.1A)
None
None
1UL  A 501 ( 3.7A)
1UL  A 501 ( 4.4A)
 0.90A 5te0A-4l52A:
14.4		 5te0A-4l52A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		6 / 12 GLU A  40
ALA A  61
GLU A  77
VAL A  90
GLY A 110
LEU A 163
 None
1UL  A 501 (-3.1A)
None
None
1UL  A 501 ( 3.7A)
1UL  A 501 (-4.3A)
 0.72A 5te0A-4l52A:
14.4		 5te0A-4l52A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		6 / 12 GLU A  40
ALA A  61
GLU A  77
TYR A 106
GLY A 110
ASP A 175
 None
1UL  A 501 (-3.1A)
None
1UL  A 501 (-4.1A)
1UL  A 501 ( 3.7A)
1UL  A 501 (-4.2A)
 1.13A 5vc3A-4l52A:
22.6		 5vc3A-4l52A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		4 / 4 VAL A  50
LYS A  63
VAL A  90
ASN A 161
 1UL  A 501 ( 4.9A)
None
None
None
 0.92A 5vc3A-4l52A:
22.6		 5vc3A-4l52A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		6 / 12 VAL A  50
ALA A  61
LYS A  63
GLU A  77
LEU A 102
GLY A 109
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
None
1UL  A 501 ( 4.7A)
 0.85A 5vcyA-4l52A:
21.9		 5vcyA-4l52A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		8 / 12 ALA A  61
LYS A  63
GLU A  77
LEU A 102
GLY A 110
LEU A 163
CYH A 174
ASP A 175
 1UL  A 501 (-3.1A)
None
None
None
1UL  A 501 ( 3.7A)
1UL  A 501 (-4.3A)
1UL  A 501 (-3.6A)
1UL  A 501 (-4.2A)
 0.77A 5y7zB-4l52A:
22.6		 5y7zB-4l52A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		6 / 12 VAL A  50
ALA A  61
GLU A  77
TYR A 106
ALA A 107
GLY A 110
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
1UL  A 501 (-4.1A)
1UL  A 501 (-3.6A)
1UL  A 501 ( 3.7A)
 0.67A 5zv2A-4l52A:
20.7		 5zv2A-4l52A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		6 / 12 VAL A  50
ALA A  61
LYS A  63
GLU A  77
ALA A 107
GLY A 110
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
1UL  A 501 (-3.6A)
1UL  A 501 ( 3.7A)
 0.74A 5zv2B-4l52A:
27.0		 5zv2B-4l52A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		7 / 12 VAL A  50
ALA A  61
LYS A  63
GLU A  77
TYR A 106
GLY A 110
LEU A 163
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
1UL  A 501 (-4.1A)
1UL  A 501 ( 3.7A)
1UL  A 501 (-4.3A)
 0.45A 6bsdA-4l52A:
18.3		 6bsdA-4l52A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens) 		6 / 12 VAL A  50
ALA A  61
LYS A  63
GLU A  77
VAL A  90
LEU A 163
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
None
1UL  A 501 (-4.3A)
 0.57A 6hd4B-4l52A:
19.9		 6hd4B-4l52A:
15.11