SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1SH'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		3 / 3 PHE A 195
TYR A 325
PRO A 202
 None
1SH  A 702 (-4.2A)
None
 1.15A 1mcnA-4kriA:
undetectable
1mcnB-4kriA:
undetectable
1mcnP-4kriA:
undetectable		 1mcnA-4kriA:
15.94
1mcnB-4kriA:
15.94
1mcnP-4kriA:
0.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		4 / 7 GLU A 338
TYR A 339
GLY A 407
LYS A 411
 None
1SH  A 702 (-4.6A)
None
1SH  A 702 (-2.6A)
 1.08A 4fgzA-4kriA:
38.6		 4fgzA-4kriA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		4 / 7 TYR A 339
ARG A 343
GLY A 407
LYS A 411
 1SH  A 702 (-4.6A)
1SH  A 702 (-4.0A)
None
1SH  A 702 (-2.6A)
 0.58A 4fgzA-4kriA:
38.6		 4fgzA-4kriA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		4 / 8 TYR A 339
ARG A 343
GLY A 407
LYS A 411
 1SH  A 702 (-4.6A)
1SH  A 702 (-4.0A)
None
1SH  A 702 (-2.6A)
 0.60A 4fgzA-4kriA:
38.6
4fgzB-4kriA:
38.5		 4fgzA-4kriA:
23.80
4fgzB-4kriA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		3 / 3 TYR A 345
TYR A 191
GLN A 182
 1SH  A 702 (-4.8A)
1SH  A 702 (-4.1A)
1SH  A 702 (-4.0A)
 0.92A 5jsdA-4kriA:
undetectable
5jsdB-4kriA:
undetectable		 5jsdA-4kriA:
20.78
5jsdB-4kriA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2
(Haemonchus
contortus) 		3 / 3 TYR A 345
TYR A 191
GLN A 182
 1SH  A 702 (-4.8A)
1SH  A 702 (-4.1A)
1SH  A 702 (-4.0A)
 0.92A 5jsdB-4kriA:
undetectable
5jsdC-4kriA:
undetectable		 5jsdB-4kriA:
20.78
5jsdC-4kriA:
20.78