SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1S6'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 4mll BETA-LACTAMASE OXA-1
(Escherichia
coli) 		5 / 9 ALA A 215
PHE A  29
GLY A  36
SER A 258
ALA A 261
 1S6  A 301 (-3.7A)
None
None
1S6  A 301 (-2.4A)
None
 1.35A 2vh3A-4mllA:
undetectable		 2vh3A-4mllA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FH2_A_0RNA303_1
(BETA-LACTAMASE SHV-1)		 4mll BETA-LACTAMASE OXA-1
(Escherichia
coli) 		5 / 10 SER A 115
LYS A 212
THR A 213
GLY A 214
ALA A 215
 1S6  A 301 (-2.9A)
None
1S6  A 301 (-3.6A)
1S6  A 301 (-3.3A)
1S6  A 301 (-3.7A)
 0.66A 4fh2A-4mllA:
19.4		 4fh2A-4mllA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM9_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 4mll BETA-LACTAMASE OXA-1
(Escherichia
coli) 		5 / 12 SER A 115
THR A 213
GLY A 214
ALA A 215
GLY A 216
 1S6  A 301 (-2.9A)
1S6  A 301 (-3.6A)
1S6  A 301 (-3.3A)
1S6  A 301 (-3.7A)
1S6  A 301 ( 3.7A)
 0.44A 4pm9A-4mllA:
20.5		 4pm9A-4mllA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4mll BETA-LACTAMASE OXA-1
(Escherichia
coli) 		5 / 12 LEU A 161
GLY A 214
GLY A 227
ASN A 226
GLU A 230
 1S6  A 301 ( 4.3A)
1S6  A 301 (-3.3A)
None
None
None
 1.30A 4x61A-4mllA:
undetectable		 4x61A-4mllA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4mll BETA-LACTAMASE OXA-1
(Escherichia
coli) 		5 / 12 ILE A 167
TYR A 141
THR A 219
ALA A  72
SER A 258
 None
None
None
None
1S6  A 301 (-2.4A)
 1.16A 5iwuA-4mllA:
undetectable		 5iwuA-4mllA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4mll BETA-LACTAMASE OXA-1
(Escherichia
coli) 		5 / 12 TYR A 141
THR A 219
PHE A  69
ALA A  72
SER A 258
 None
None
None
None
1S6  A 301 (-2.4A)
 0.94A 5iwuA-4mllA:
undetectable		 5iwuA-4mllA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_B_9F2B400_1
(BETA-LACTAMASE)		 4mll BETA-LACTAMASE OXA-1
(Escherichia
coli) 		6 / 12 SER A  67
SER A 115
LYS A 212
THR A 213
GLY A 214
GLY A 216
 1S6  A 301 (-1.3A)
1S6  A 301 (-2.9A)
None
1S6  A 301 (-3.6A)
1S6  A 301 (-3.3A)
1S6  A 301 ( 3.7A)
 0.73A 6b5yB-4mllA:
19.6		 6b5yB-4mllA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_D_9F2D400_1
(BETA-LACTAMASE)		 4mll BETA-LACTAMASE OXA-1
(Escherichia
coli) 		6 / 12 SER A  67
SER A 115
LYS A 212
THR A 213
GLY A 214
GLY A 216
 1S6  A 301 (-1.3A)
1S6  A 301 (-2.9A)
None
1S6  A 301 (-3.6A)
1S6  A 301 (-3.3A)
1S6  A 301 ( 3.7A)
 0.76A 6b5yD-4mllA:
19.5		 6b5yD-4mllA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_B_9F2B301_1
(BETA-LACTAMASE)		 4mll BETA-LACTAMASE OXA-1
(Escherichia
coli) 		6 / 12 SER A  67
SER A 115
LYS A 212
THR A 213
GLY A 214
GLY A 216
 1S6  A 301 (-1.3A)
1S6  A 301 (-2.9A)
None
1S6  A 301 (-3.6A)
1S6  A 301 (-3.3A)
1S6  A 301 ( 3.7A)
 0.73A 6b69A-4mllA:
19.6
6b69B-4mllA:
19.5		 6b69A-4mllA:
12.33
6b69B-4mllA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_D_9F2D301_1
(BETA-LACTAMASE)		 4mll BETA-LACTAMASE OXA-1
(Escherichia
coli) 		6 / 12 SER A  67
SER A 115
LYS A 212
THR A 213
GLY A 214
GLY A 216
 1S6  A 301 (-1.3A)
1S6  A 301 (-2.9A)
None
1S6  A 301 (-3.6A)
1S6  A 301 (-3.3A)
1S6  A 301 ( 3.7A)
 0.73A 6b69D-4mllA:
19.3		 6b69D-4mllA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_B_9F2B301_1
(BETA-LACTAMASE)		 4mll BETA-LACTAMASE OXA-1
(Escherichia
coli) 		6 / 12 SER A  67
SER A 115
LYS A 212
THR A 213
GLY A 214
GLY A 216
 1S6  A 301 (-1.3A)
1S6  A 301 (-2.9A)
None
1S6  A 301 (-3.6A)
1S6  A 301 (-3.3A)
1S6  A 301 ( 3.7A)
 0.67A 6b6aB-4mllA:
19.6		 6b6aB-4mllA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_D_9F2D301_1
(BETA-LACTAMASE)		 4mll BETA-LACTAMASE OXA-1
(Escherichia
coli) 		6 / 12 SER A  67
SER A 115
LYS A 212
THR A 213
GLY A 214
GLY A 216
 1S6  A 301 (-1.3A)
1S6  A 301 (-2.9A)
None
1S6  A 301 (-3.6A)
1S6  A 301 (-3.3A)
1S6  A 301 ( 3.7A)
 0.72A 6b6aD-4mllA:
19.4		 6b6aD-4mllA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6C_A_9F2A301_1
(BETA-LACTAMASE)		 4mll BETA-LACTAMASE OXA-1
(Escherichia
coli) 		6 / 12 SER A  67
SER A 115
LYS A 212
THR A 213
GLY A 214
GLY A 216
 1S6  A 301 (-1.3A)
1S6  A 301 (-2.9A)
None
1S6  A 301 (-3.6A)
1S6  A 301 (-3.3A)
1S6  A 301 ( 3.7A)
 0.82A 6b6cA-4mllA:
19.7		 6b6cA-4mllA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6D_A_9F2A302_1
(BETA-LACTAMASE)		 4mll BETA-LACTAMASE OXA-1
(Escherichia
coli) 		6 / 12 SER A  67
SER A 115
LYS A 212
THR A 213
GLY A 214
GLY A 216
 1S6  A 301 (-1.3A)
1S6  A 301 (-2.9A)
None
1S6  A 301 (-3.6A)
1S6  A 301 (-3.3A)
1S6  A 301 ( 3.7A)
 0.63A 6b6dA-4mllA:
19.5		 6b6dA-4mllA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6E_A_9F2A302_1
(BETA-LACTAMASE)		 4mll BETA-LACTAMASE OXA-1
(Escherichia
coli) 		6 / 12 SER A  67
SER A 115
LYS A 212
THR A 213
GLY A 214
GLY A 216
 1S6  A 301 (-1.3A)
1S6  A 301 (-2.9A)
None
1S6  A 301 (-3.6A)
1S6  A 301 (-3.3A)
1S6  A 301 ( 3.7A)
 0.75A 6b6eA-4mllA:
19.7		 6b6eA-4mllA:
12.33