SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1PG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 5b7z UNCHARACTERIZED
PROTEIN TM_0416
(Thermotoga
maritima) 		4 / 8 LEU A 108
HIS A 208
GLU A  39
ALA A  66
 1PG  A 306 (-4.8A)
NI  A 305 (-3.0A)
None
None
 0.94A 2bnnA-5b7zA:
undetectable
2bnnB-5b7zA:
undetectable		 2bnnA-5b7zA:
25.00
2bnnB-5b7zA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2znw SCFV10
(Mus
musculus;
synthetic
construct) 		4 / 7 GLY A 171
GLY A 222
GLN A  89
PHE A  98
 None
1PG  A 243 ( 4.7A)
1PG  A 243 (-3.2A)
None
 0.92A 2qwxA-2znwA:
undetectable
2qwxB-2znwA:
undetectable		 2qwxA-2znwA:
20.61
2qwxB-2znwA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		4 / 4 LEU A 388
ASP A 296
VAL A 290
THR A 259
 None
1PG  A 851 (-4.3A)
None
None
 1.32A 3cyxB-3a5vA:
undetectable		 3cyxB-3a5vA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 2znw SCFV10
(Mus
musculus;
synthetic
construct) 		3 / 3 TYR A  36
TYR A 169
GLY A 222
 None
None
1PG  A 243 ( 4.7A)
 0.71A 3eteB-2znwA:
undetectable
3eteD-2znwA:
undetectable
3eteF-2znwA:
undetectable		 3eteB-2znwA:
18.74
3eteD-2znwA:
18.74
3eteF-2znwA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 5b7z UNCHARACTERIZED
PROTEIN TM_0416
(Thermotoga
maritima) 		5 / 12 HIS A 206
ALA A  37
ILE A  64
LEU A  62
LEU A   3
 None
None
None
None
1PG  A 307 ( 4.6A)
 1.19A 3lcvB-5b7zA:
undetectable		 3lcvB-5b7zA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		5 / 12 VAL A 293
ASP A 296
LEU A 313
ALA A 263
PRO A 301
 1PG  A 851 ( 4.5A)
1PG  A 851 (-4.3A)
None
None
None
 1.03A 5nd3B-3a5vA:
undetectable		 5nd3B-3a5vA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		5 / 12 SER A  62
GLY A 163
ILE A  70
THR A 154
GLY A 147
 None
None
None
1PG  A 964 ( 3.9A)
None
 1.05A 5veuH-3a21A:
undetectable		 5veuH-3a21A:
20.06