SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1NB'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1AQ7_B_AG2B4_1 (TRYPSIN AERUGINOSIN 98-B)	1bru	ELASTASE (Sus scrofa)	5 / 8	HIS P 57 SER P 190 SER P 195 VAL P 213 GLY P 216	1NB P 1 (-3.9A) 1NB P 1 (-3.5A) 1NB P 1 ( 1.2A) None 1NB P 1 ( 4.4A)	0.55A	1aq7A-1bruP: 36.3	1aq7A-1bruP: 40.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	1bru	ELASTASE (Sus scrofa)	5 / 12	HIS P 57 LEU P 99 SER P 195 VAL P 213 GLY P 216	1NB P 1 (-3.9A) None 1NB P 1 ( 1.2A) None 1NB P 1 ( 4.4A)	0.77A	1etrH-1bruP: 34.5	1etrH-1bruP: 36.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1F5L_A_AMRA301_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR)	1bru	ELASTASE (Sus scrofa)	4 / 8	SER P 190 SER P 195 VAL P 213 GLY P 216	1NB P 1 (-3.5A) 1NB P 1 ( 1.2A) None 1NB P 1 ( 4.4A)	0.45A	1f5lA-1bruP: 36.4	1f5lA-1bruP: 36.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	1bru	ELASTASE (Sus scrofa)	4 / 6	SER P 190 SER P 195 VAL P 213 GLY P 216	1NB P 1 (-3.5A) 1NB P 1 ( 1.2A) None 1NB P 1 ( 4.4A)	0.48A	1tnlA-1bruP: 16.5	1tnlA-1bruP: 40.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2OTV_A_NCAA1301_0 (CATIONIC TRYPSIN)	1bru	ELASTASE (Sus scrofa)	4 / 6	SER P 190 SER P 195 VAL P 213 GLY P 216	1NB P 1 (-3.5A) 1NB P 1 ( 1.2A) None 1NB P 1 ( 4.4A)	0.45A	2otvA-1bruP: 16.7	2otvA-1bruP: 40.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	1bru	ELASTASE (Sus scrofa)	4 / 8	SER P 190 SER P 195 VAL P 213 GLY P 216	1NB P 1 (-3.5A) 1NB P 1 ( 1.2A) None 1NB P 1 ( 4.4A)	0.54A	2vinA-1bruP: 37.1	2vinA-1bruP: 36.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3GY3_A_PNTA246_0 (CATIONIC TRYPSIN)	1bru	ELASTASE (Sus scrofa)	5 / 11	HIS P 57 LEU P 99 SER P 190 SER P 195 GLY P 216	1NB P 1 (-3.9A) None 1NB P 1 (-3.5A) 1NB P 1 ( 1.2A) 1NB P 1 ( 4.4A)	0.74A	3gy3A-1bruP: 16.8	3gy3A-1bruP: 40.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3I5U_B_SAMB401_0 (O-METHYLTRANSFERASE)	1bru	ELASTASE (Sus scrofa)	5 / 12	LEU P 106 GLY P 43 GLY P 44 SER P 190 ASP P 102	None None None 1NB P 1 (-3.5A) None	1.14A	3i5uB-1bruP: undetectable	3i5uB-1bruP: 21.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RXF_A_4APA9_1 (CATIONIC TRYPSIN)	1bru	ELASTASE (Sus scrofa)	4 / 6	SER P 190 SER P 195 VAL P 213 GLY P 216	1NB P 1 (-3.5A) 1NB P 1 ( 1.2A) None 1NB P 1 ( 4.4A)	0.31A	3rxfA-1bruP: 17.6	3rxfA-1bruP: 40.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CTK_C_SAMC1263_0 (POLYPROTEIN)	1bru	ELASTASE (Sus scrofa)	6 / 12	GLY P 142 GLY P 44 GLY P 196 GLY P 193 THR P 54 VAL P 52	None None None 1NB P 1 (-3.5A) None None	1.27A	4ctkC-1bruP: undetectable	4ctkC-1bruP: 21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EIW_C_SAMC4000_0 (NS5 METHYLTRANSFERASE)	1bru	ELASTASE (Sus scrofa)	6 / 12	GLY P 142 GLY P 44 GLY P 196 GLY P 193 THR P 54 VAL P 52	None None None 1NB P 1 (-3.5A) None None	1.26A	5eiwC-1bruP: undetectable	5eiwC-1bruP: 21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EKX_B_SAMB4000_0 (NS5 METHYLTRANSFERASE)	1bru	ELASTASE (Sus scrofa)	6 / 12	GLY P 142 GLY P 44 GLY P 196 GLY P 193 THR P 54 VAL P 52	None None None 1NB P 1 (-3.5A) None None	1.28A	5ekxB-1bruP: undetectable	5ekxB-1bruP: 21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M5B_A_SAMA1001_0 (NS5 METHYLTRANSFERASE)	1bru	ELASTASE (Sus scrofa)	6 / 12	GLY P 142 GLY P 44 GLY P 196 GLY P 193 THR P 54 VAL P 52	None None None 1NB P 1 (-3.5A) None None	1.28A	5m5bA-1bruP: undetectable	5m5bA-1bruP: 20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HU9_H_PCFH604_0 (CYTOCHROME B-C1 COMPLEX SUBUNIT 8 CYTOCHROME C OXIDASE POLYPEPTIDE 5A, MITOCHONDRIAL)	1bru	ELASTASE (Sus scrofa)	4 / 8	GLY P 216 GLY P 193 SER P 195 ALA P 55	1NB P 1 ( 4.4A) 1NB P 1 (-3.5A) 1NB P 1 ( 1.2A) None	0.76A	6hu9H-1bruP: 0.0 6hu9e-1bruP: undetectable	6hu9H-1bruP: 18.33 6hu9e-1bruP: 18.15

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1AQ7_B_AG2B4_1","TRYPSIN;AERUGINOSIN 98-B","1bru","ELASTASE","Sus scrofa",5,"HIS P  57;SER P 190;SER P 195;VAL P 213;GLY P 216","1NB P   1 (-3.9A);1NB P   1 (-3.5A);1NB P   1 ( 1.2A);None;1NB P   1 ( 4.4A)","0.55A","1aq7A-1bruP:36.3",null],["1ETR_H_MITH1_1","EPSILON-THROMBIN","1bru","ELASTASE","Sus scrofa",5,"HIS P  57;LEU P  99;SER P 195;VAL P 213;GLY P 216","1NB P   1 (-3.9A);None;1NB P   1 ( 1.2A);None;1NB P   1 ( 4.4A)","0.77A","1etrH-1bruP:34.5","1aq7A-1bruP:40.96"],["1F5L_A_AMRA301_1","UROKINASE-TYPE PLASMINOGEN ACTIVATOR","1bru","ELASTASE","Sus scrofa",4,"SER P 190;SER P 195;VAL P 213;GLY P 216","1NB P   1 (-3.5A);1NB P   1 ( 1.2A);None;1NB P   1 ( 4.4A)","0.45A","1f5lA-1bruP:36.4","1etrH-1bruP:36.12"],["1TNL_A_TPAA900_1","TRYPSIN","1bru","ELASTASE","Sus scrofa",4,"SER P 190;SER P 195;VAL P 213;GLY P 216","1NB P   1 (-3.5A);1NB P   1 ( 1.2A);None;1NB P   1 ( 4.4A)","0.48A","1tnlA-1bruP:16.5","1f5lA-1bruP:36.05"],["2OTV_A_NCAA1301_0","CATIONIC TRYPSIN","1bru","ELASTASE","Sus scrofa",4,"SER P 190;SER P 195;VAL P 213;GLY P 216","1NB P   1 (-3.5A);1NB P   1 ( 1.2A);None;1NB P   1 ( 4.4A)","0.45A","2otvA-1bruP:16.7","1tnlA-1bruP:40.39"],["2VIN_A_505A1247_1","UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B","1bru","ELASTASE","Sus scrofa",4,"SER P 190;SER P 195;VAL P 213;GLY P 216","1NB P   1 (-3.5A);1NB P   1 ( 1.2A);None;1NB P   1 ( 4.4A)","0.54A","2vinA-1bruP:37.1","2otvA-1bruP:40.96"],["3GY3_A_PNTA246_0","CATIONIC TRYPSIN","1bru","ELASTASE","Sus scrofa",5,"HIS P  57;LEU P  99;SER P 190;SER P 195;GLY P 216","1NB P   1 (-3.9A);None;1NB P   1 (-3.5A);1NB P   1 ( 1.2A);1NB P   1 ( 4.4A)","0.74A","3gy3A-1bruP:16.8","2vinA-1bruP:36.05"],["3I5U_B_SAMB401_0","O-METHYLTRANSFERASE","1bru","ELASTASE","Sus scrofa",5,"LEU P 106;GLY P  43;GLY P  44;SER P 190;ASP P 102","None;None;None;1NB P   1 (-3.5A);None","1.14A","3i5uB-1bruP:undetectable","3gy3A-1bruP:40.96"],["3RXF_A_4APA9_1","CATIONIC TRYPSIN","1bru","ELASTASE","Sus scrofa",4,"SER P 190;SER P 195;VAL P 213;GLY P 216","1NB P   1 (-3.5A);1NB P   1 ( 1.2A);None;1NB P   1 ( 4.4A)","0.31A","3rxfA-1bruP:17.6","3i5uB-1bruP:21.04"],["4CTK_C_SAMC1263_0","POLYPROTEIN","1bru","ELASTASE","Sus scrofa",6,"GLY P 142;GLY P  44;GLY P 196;GLY P 193;THR P  54;VAL P  52","None;None;None;1NB P   1 (-3.5A);None;None","1.27A","4ctkC-1bruP:undetectable","3rxfA-1bruP:40.96"],["5EIW_C_SAMC4000_0","NS5 METHYLTRANSFERASE","1bru","ELASTASE","Sus scrofa",6,"GLY P 142;GLY P  44;GLY P 196;GLY P 193;THR P  54;VAL P  52","None;None;None;1NB P   1 (-3.5A);None;None","1.26A","5eiwC-1bruP:undetectable","4ctkC-1bruP:21.58"],["5EKX_B_SAMB4000_0","NS5 METHYLTRANSFERASE","1bru","ELASTASE","Sus scrofa",6,"GLY P 142;GLY P  44;GLY P 196;GLY P 193;THR P  54;VAL P  52","None;None;None;1NB P   1 (-3.5A);None;None","1.28A","5ekxB-1bruP:undetectable","5eiwC-1bruP:21.58"],["5M5B_A_SAMA1001_0","NS5 METHYLTRANSFERASE","1bru","ELASTASE","Sus scrofa",6,"GLY P 142;GLY P  44;GLY P 196;GLY P 193;THR P  54;VAL P  52","None;None;None;1NB P   1 (-3.5A);None;None","1.28A","5m5bA-1bruP:undetectable","5ekxB-1bruP:21.58"],["6HU9_H_PCFH604_0","CYTOCHROME B-C1 COMPLEX SUBUNIT 8;CYTOCHROME C OXIDASE POLYPEPTIDE 5A, MITOCHONDRIAL","1bru","ELASTASE","Sus scrofa",4,"GLY P 216;GLY P 193;SER P 195;ALA P  55","1NB P   1 ( 4.4A);1NB P   1 (-3.5A);1NB P   1 ( 1.2A);None","0.76A","6hu9H-1bruP:0.0;6hu9e-1bruP:undetectable","5m5bA-1bruP:20.83"]]