SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1LF'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PFG_A_SAMA264_0 (N-METHYLTRANSFERASE)	4jnc	BIFUNCTIONAL EPOXIDE HYDROLASE 2 (Homo sapiens)	5 / 12	GLY A 337 LEU A 358 SER A 357 PHE A 267 HIS A 524	None None None 1LF A 601 (-4.8A) 1LF A 601 (-3.3A)	1.38A	3pfgA-4jncA: undetectable	3pfgA-4jncA: 20.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4J03_A_FVSA603_1 (BIFUNCTIONAL EPOXIDE HYDROLASE 2)	4jnc	BIFUNCTIONAL EPOXIDE HYDROLASE 2 (Homo sapiens)	12 / 12	ASP A 335 TYR A 343 ILE A 363 PHE A 381 TYR A 383 PHE A 387 LEU A 408 LEU A 428 TYR A 466 LEU A 499 HIS A 524 TRP A 525	1LF A 601 (-2.6A) None None 1LF A 601 (-4.5A) 1LF A 601 (-4.4A) None 1LF A 601 (-4.5A) None 1LF A 601 (-4.5A) 1LF A 601 (-4.6A) 1LF A 601 (-3.3A) None	0.62A	4j03A-4jncA: 52.9	4j03A-4jncA: 85.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4J03_A_FVSA603_2 (BIFUNCTIONAL EPOXIDE HYDROLASE 2)	4jnc	BIFUNCTIONAL EPOXIDE HYDROLASE 2 (Homo sapiens)	4 / 5	TRP A 336 SER A 374 GLN A 384 ASN A 472	1LF A 601 (-3.4A) None 1LF A 601 ( 4.1A) None	0.47A	4j03A-4jncA: 52.9	4j03A-4jncA: 85.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UG5_A_H4BA902_1 (NITRIC OXIDE SYNTHASE OXYGENASE)	4jnc	BIFUNCTIONAL EPOXIDE HYDROLASE 2 (Homo sapiens)	3 / 3	ARG A 516 THR A 360 TRP A 342	None 1LF A 601 ( 4.0A) None	1.20A	4ug5A-4jncA: undetectable	4ug5A-4jncA: 22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GS4_A_ESTA603_1 (ESTROGEN RECEPTOR)	4jnc	BIFUNCTIONAL EPOXIDE HYDROLASE 2 (Homo sapiens)	5 / 12	THR A 360 LEU A 358 LEU A 489 MET A 507 ILE A 511	1LF A 601 ( 4.0A) None None None None	1.16A	5gs4A-4jncA: undetectable	5gs4A-4jncA: 21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BRD_C_RFPC502_1 (RIFAMPIN MONOOXYGENASE)	4jnc	BIFUNCTIONAL EPOXIDE HYDROLASE 2 (Homo sapiens)	5 / 12	VAL A 261 VAL A 330 GLY A 517 THR A 360 GLY A 338	None None None 1LF A 601 ( 4.0A) None	1.08A	6brdC-4jncA: undetectable	6brdC-4jncA: 13.97

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3PFG_A_SAMA264_0","N-METHYLTRANSFERASE","4jnc","BIFUNCTIONAL EPOXIDE HYDROLASE 2","Homo sapiens",5,"GLY A 337;LEU A 358;SER A 357;PHE A 267;HIS A 524","None;None;None;1LF A 601 (-4.8A);1LF A 601 (-3.3A)","1.38A","3pfgA-4jncA:undetectable",null],["4J03_A_FVSA603_1","BIFUNCTIONAL EPOXIDE HYDROLASE 2","4jnc","BIFUNCTIONAL EPOXIDE HYDROLASE 2","Homo sapiens",12,"ASP A 335;TYR A 343;ILE A 363;PHE A 381;TYR A 383;PHE A 387;LEU A 408;LEU A 428;TYR A 466;LEU A 499;HIS A 524;TRP A 525","1LF A 601 (-2.6A);None;None;1LF A 601 (-4.5A);1LF A 601 (-4.4A);None;1LF A 601 (-4.5A);None;1LF A 601 (-4.5A);1LF A 601 (-4.6A);1LF A 601 (-3.3A);None","0.62A","4j03A-4jncA:52.9","3pfgA-4jncA:20.30"],["4J03_A_FVSA603_2","BIFUNCTIONAL EPOXIDE HYDROLASE 2","4jnc","BIFUNCTIONAL EPOXIDE HYDROLASE 2","Homo sapiens",4,"TRP A 336;SER A 374;GLN A 384;ASN A 472","1LF A 601 (-3.4A);None;1LF A 601 ( 4.1A);None","0.47A","4j03A-4jncA:52.9","4j03A-4jncA:85.75"],["4UG5_A_H4BA902_1","NITRIC OXIDE SYNTHASE OXYGENASE","4jnc","BIFUNCTIONAL EPOXIDE HYDROLASE 2","Homo sapiens",3,"ARG A 516;THR A 360;TRP A 342","None;1LF A 601 ( 4.0A);None","1.20A","4ug5A-4jncA:undetectable","4j03A-4jncA:85.75"],["5GS4_A_ESTA603_1","ESTROGEN RECEPTOR","4jnc","BIFUNCTIONAL EPOXIDE HYDROLASE 2","Homo sapiens",5,"THR A 360;LEU A 358;LEU A 489;MET A 507;ILE A 511","1LF A 601 ( 4.0A);None;None;None;None","1.16A","5gs4A-4jncA:undetectable","4ug5A-4jncA:22.03"],["6BRD_C_RFPC502_1","RIFAMPIN MONOOXYGENASE","4jnc","BIFUNCTIONAL EPOXIDE HYDROLASE 2","Homo sapiens",5,"VAL A 261;VAL A 330;GLY A 517;THR A 360;GLY A 338","None;None;None;1LF A 601 ( 4.0A);None","1.08A","6brdC-4jncA:undetectable","5gs4A-4jncA:21.36"]]