SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1L7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_C_SAMC300_1 (PUTATIVE RRNA METHYLASE)	4jin	RIO-TYPE SERINE/THREONINE-PRO TEIN KINASE RIO1 (Archaeoglobus fulgidus)	3 / 3	ASN A 62 ASP A 212 GLN A 215	None 1L7 A 301 (-3.6A) None	0.72A	3eeyC-4jinA: undetectable	3eeyC-4jinA: 21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_D_SAMD300_1 (PUTATIVE RRNA METHYLASE)	4jin	RIO-TYPE SERINE/THREONINE-PRO TEIN KINASE RIO1 (Archaeoglobus fulgidus)	3 / 3	ASN A 62 ASP A 212 GLN A 215	None 1L7 A 301 (-3.6A) None	0.74A	3eeyD-4jinA: undetectable	3eeyD-4jinA: 21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_E_SAME300_1 (PUTATIVE RRNA METHYLASE)	4jin	RIO-TYPE SERINE/THREONINE-PRO TEIN KINASE RIO1 (Archaeoglobus fulgidus)	3 / 3	ASN A 62 ASP A 212 GLN A 215	None 1L7 A 301 (-3.6A) None	0.72A	3eeyE-4jinA: undetectable	3eeyE-4jinA: 21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WAR_A_NIOA401_1 (CASEIN KINASE II SUBUNIT ALPHA)	4jin	RIO-TYPE SERINE/THREONINE-PRO TEIN KINASE RIO1 (Archaeoglobus fulgidus)	5 / 8	VAL A 63 LYS A 80 MET A 203 ILE A 211 ASP A 212	1L7 A 301 ( 4.8A) 1L7 A 301 (-2.8A) 1L7 A 301 ( 4.3A) 1L7 A 301 (-4.4A) 1L7 A 301 (-3.6A)	0.89A	3warA-4jinA: 5.2	3warA-4jinA: 24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DTA_B_ADNB401_1 (APH(2'')-ID)	4jin	RIO-TYPE SERINE/THREONINE-PRO TEIN KINASE RIO1 (Archaeoglobus fulgidus)	4 / 8	SER A 56 PRO A 135 ILE A 150 ILE A 211	1L7 A 301 (-2.8A) 1L7 A 301 ( 4.7A) 1L7 A 301 (-4.0A) 1L7 A 301 (-4.4A)	0.82A	4dtaB-4jinA: 6.5	4dtaB-4jinA: 22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAA_A_RTZA401_1 (SERINE/THREONINE-PRO TEIN KINASE PIM-1)	4jin	RIO-TYPE SERINE/THREONINE-PRO TEIN KINASE RIO1 (Archaeoglobus fulgidus)	5 / 11	VAL A 63 ALA A 78 LYS A 80 ILE A 211 ASP A 212	1L7 A 301 ( 4.8A) 1L7 A 301 ( 3.7A) 1L7 A 301 (-2.8A) 1L7 A 301 (-4.4A) 1L7 A 301 (-3.6A)	0.57A	4iaaA-4jinA: 7.1	4iaaA-4jinA: 20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y9M_X_NIOX401_1 (CASEIN KINASE II SUBUNIT ALPHA')	4jin	RIO-TYPE SERINE/THREONINE-PRO TEIN KINASE RIO1 (Archaeoglobus fulgidus)	5 / 8	VAL A 63 LYS A 80 MET A 203 ILE A 211 ASP A 212	1L7 A 301 ( 4.8A) 1L7 A 301 (-2.8A) 1L7 A 301 ( 4.3A) 1L7 A 301 (-4.4A) 1L7 A 301 (-3.6A)	0.78A	5y9mX-4jinA: 10.9	5y9mX-4jinA: 19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YF9_B_NIOB401_1 (CASEIN KINASE II SUBUNIT ALPHA')	4jin	RIO-TYPE SERINE/THREONINE-PRO TEIN KINASE RIO1 (Archaeoglobus fulgidus)	5 / 7	VAL A 63 LYS A 80 MET A 203 ILE A 211 ASP A 212	1L7 A 301 ( 4.8A) 1L7 A 301 (-2.8A) 1L7 A 301 ( 4.3A) 1L7 A 301 (-4.4A) 1L7 A 301 (-3.6A)	0.92A	5yf9B-4jinA: 6.5	5yf9B-4jinA: 19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YF9_X_NIOX401_1 (CASEIN KINASE II SUBUNIT ALPHA')	4jin	RIO-TYPE SERINE/THREONINE-PRO TEIN KINASE RIO1 (Archaeoglobus fulgidus)	5 / 9	VAL A 63 LYS A 80 MET A 203 ILE A 211 ASP A 212	1L7 A 301 ( 4.8A) 1L7 A 301 (-2.8A) 1L7 A 301 ( 4.3A) 1L7 A 301 (-4.4A) 1L7 A 301 (-3.6A)	0.92A	5yf9X-4jinA: 6.5	5yf9X-4jinA: 19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YWM_X_NIOX403_0 (CASEIN KINASE II SUBUNIT ALPHA')	4jin	RIO-TYPE SERINE/THREONINE-PRO TEIN KINASE RIO1 (Archaeoglobus fulgidus)	4 / 7	VAL A 63 LYS A 80 ILE A 211 ASP A 212	1L7 A 301 ( 4.8A) 1L7 A 301 (-2.8A) 1L7 A 301 (-4.4A) 1L7 A 301 (-3.6A)	0.77A	5ywmX-4jinA: 6.1	5ywmX-4jinA: 19.25

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3EEY_C_SAMC300_1","PUTATIVE RRNA METHYLASE","4jin","RIO-TYPE SERINE\/THREONINE-PROTEIN KINASE RIO1","Archaeoglobus fulgidus",3,"ASN A  62;ASP A 212;GLN A 215","None;1L7 A 301 (-3.6A);None","0.72A","3eeyC-4jinA:undetectable",null],["3EEY_D_SAMD300_1","PUTATIVE RRNA METHYLASE","4jin","RIO-TYPE SERINE\/THREONINE-PROTEIN KINASE RIO1","Archaeoglobus fulgidus",3,"ASN A  62;ASP A 212;GLN A 215","None;1L7 A 301 (-3.6A);None","0.74A","3eeyD-4jinA:undetectable","3eeyC-4jinA:21.58"],["3EEY_E_SAME300_1","PUTATIVE RRNA METHYLASE","4jin","RIO-TYPE SERINE\/THREONINE-PROTEIN KINASE RIO1","Archaeoglobus fulgidus",3,"ASN A  62;ASP A 212;GLN A 215","None;1L7 A 301 (-3.6A);None","0.72A","3eeyE-4jinA:undetectable","3eeyD-4jinA:21.58"],["3WAR_A_NIOA401_1","CASEIN KINASE II SUBUNIT ALPHA","4jin","RIO-TYPE SERINE\/THREONINE-PROTEIN KINASE RIO1","Archaeoglobus fulgidus",5,"VAL A  63;LYS A  80;MET A 203;ILE A 211;ASP A 212","1L7 A 301 ( 4.8A);1L7 A 301 (-2.8A);1L7 A 301 ( 4.3A);1L7 A 301 (-4.4A);1L7 A 301 (-3.6A)","0.89A","3warA-4jinA:5.2","3eeyE-4jinA:21.58"],["4DTA_B_ADNB401_1","APH(2'')-ID","4jin","RIO-TYPE SERINE\/THREONINE-PROTEIN KINASE RIO1","Archaeoglobus fulgidus",4,"SER A  56;PRO A 135;ILE A 150;ILE A 211","1L7 A 301 (-2.8A);1L7 A 301 ( 4.7A);1L7 A 301 (-4.0A);1L7 A 301 (-4.4A)","0.82A","4dtaB-4jinA:6.5","3warA-4jinA:24.32"],["4IAA_A_RTZA401_1","SERINE\/THREONINE-PROTEIN KINASE PIM-1","4jin","RIO-TYPE SERINE\/THREONINE-PROTEIN KINASE RIO1","Archaeoglobus fulgidus",5,"VAL A  63;ALA A  78;LYS A  80;ILE A 211;ASP A 212","1L7 A 301 ( 4.8A);1L7 A 301 ( 3.7A);1L7 A 301 (-2.8A);1L7 A 301 (-4.4A);1L7 A 301 (-3.6A)","0.57A","4iaaA-4jinA:7.1","4dtaB-4jinA:22.22"],["5Y9M_X_NIOX401_1","CASEIN KINASE II SUBUNIT ALPHA'","4jin","RIO-TYPE SERINE\/THREONINE-PROTEIN KINASE RIO1","Archaeoglobus fulgidus",5,"VAL A  63;LYS A  80;MET A 203;ILE A 211;ASP A 212","1L7 A 301 ( 4.8A);1L7 A 301 (-2.8A);1L7 A 301 ( 4.3A);1L7 A 301 (-4.4A);1L7 A 301 (-3.6A)","0.78A","5y9mX-4jinA:10.9","4iaaA-4jinA:20.46"],["5YF9_B_NIOB401_1","CASEIN KINASE II SUBUNIT ALPHA'","4jin","RIO-TYPE SERINE\/THREONINE-PROTEIN KINASE RIO1","Archaeoglobus fulgidus",5,"VAL A  63;LYS A  80;MET A 203;ILE A 211;ASP A 212","1L7 A 301 ( 4.8A);1L7 A 301 (-2.8A);1L7 A 301 ( 4.3A);1L7 A 301 (-4.4A);1L7 A 301 (-3.6A)","0.92A","5yf9B-4jinA:6.5","5y9mX-4jinA:19.25"],["5YF9_X_NIOX401_1","CASEIN KINASE II SUBUNIT ALPHA'","4jin","RIO-TYPE SERINE\/THREONINE-PROTEIN KINASE RIO1","Archaeoglobus fulgidus",5,"VAL A  63;LYS A  80;MET A 203;ILE A 211;ASP A 212","1L7 A 301 ( 4.8A);1L7 A 301 (-2.8A);1L7 A 301 ( 4.3A);1L7 A 301 (-4.4A);1L7 A 301 (-3.6A)","0.92A","5yf9X-4jinA:6.5","5yf9B-4jinA:19.25"],["5YWM_X_NIOX403_0","CASEIN KINASE II SUBUNIT ALPHA'","4jin","RIO-TYPE SERINE\/THREONINE-PROTEIN KINASE RIO1","Archaeoglobus fulgidus",4,"VAL A  63;LYS A  80;ILE A 211;ASP A 212","1L7 A 301 ( 4.8A);1L7 A 301 (-2.8A);1L7 A 301 (-4.4A);1L7 A 301 (-3.6A)","0.77A","5ywmX-4jinA:6.1","5yf9X-4jinA:19.25"]]