SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1KV'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		4 / 7 ARG A 327
TYR A 472
ARG A 562
ASN A 566
 None
1KV  A 701 (-3.8A)
1KV  A 701 (-4.0A)
None
 1.12A 1f9gA-4jhzA:
undetectable		 1f9gA-4jhzA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		5 / 11 ASN A 412
GLU A 413
TYR A 468
GLU A 504
TRP A 549
 None
1KV  A 701 (-3.4A)
1KV  A 701 ( 4.5A)
None
None
 0.76A 2v3dB-4jhzA:
18.2		 2v3dB-4jhzA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		4 / 7 TYR A 468
TYR A 533
GLU A 546
TYR A 505
 1KV  A 701 ( 4.5A)
None
None
None
 1.33A 2xytD-4jhzA:
undetectable		 2xytD-4jhzA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		4 / 7 TYR A 468
TYR A 533
GLU A 546
TYR A 505
 1KV  A 701 ( 4.5A)
None
None
None
 1.41A 2xytG-4jhzA:
undetectable		 2xytG-4jhzA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		4 / 8 TRP A 471
TYR A 472
TRP A 521
VAL A 563
 None
1KV  A 701 (-3.8A)
None
None
 0.98A 5vlmF-4jhzA:
undetectable		 5vlmF-4jhzA:
14.33