SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1KH'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NBH_C_SAMC2293_0 (GLYCINE N-METHYLTRANSFERASE)	4jd0	NUCLEOTIDYL TRANSFERASE (Thermotoga maritima)	5 / 12	ILE A 152 GLY A 156 VAL A 145 ASP A 166 SER A 190	None PO4 A 306 (-3.4A) None 1KH A 301 ( 2.6A) NA A 312 ( 2.8A)	1.24A	1nbhC-4jd0A: undetectable	1nbhC-4jd0A: 24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_J_SAMJ300_0 (PUTATIVE RRNA METHYLASE)	4jd0	NUCLEOTIDYL TRANSFERASE (Thermotoga maritima)	5 / 12	GLY A 168 ASP A 166 ILE A 155 GLY A 156 ASN A 85	1KH A 301 (-3.4A) 1KH A 301 ( 2.6A) None PO4 A 306 (-3.4A) GOL A 314 ( 2.9A)	0.99A	3eeyJ-4jd0A: undetectable	3eeyJ-4jd0A: 26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3F8W_B_ADNB301_1 (PURINE-NUCLEOSIDE PHOSPHORYLASE)	4jd0	NUCLEOTIDYL TRANSFERASE (Thermotoga maritima)	5 / 12	SER A 143 GLY A 129 VAL A 169 GLY A 168 VAL A 145	1KH A 301 (-4.6A) None None 1KH A 301 (-3.4A) None	1.34A	3f8wB-4jd0A: undetectable	3f8wB-4jd0A: 22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HWA_A_GCSA301_1 (CHITOSANASE)	4jd0	NUCLEOTIDYL TRANSFERASE (Thermotoga maritima)	4 / 8	ASP A 219 GLY A 168 LEU A 191 ASN A 85	NA A 315 (-3.5A) 1KH A 301 (-3.4A) 1KH A 301 (-4.3A) GOL A 314 ( 2.9A)	0.79A	5hwaA-4jd0A: undetectable	5hwaA-4jd0A: 22.90

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1NBH_C_SAMC2293_0","GLYCINE N-METHYLTRANSFERASE","4jd0","NUCLEOTIDYL TRANSFERASE","Thermotoga maritima",5,"ILE A 152;GLY A 156;VAL A 145;ASP A 166;SER A 190","None;PO4 A 306 (-3.4A);None;1KH A 301 ( 2.6A); NA A 312 ( 2.8A)","1.24A","1nbhC-4jd0A:undetectable",null],["3EEY_J_SAMJ300_0","PUTATIVE RRNA METHYLASE","4jd0","NUCLEOTIDYL TRANSFERASE","Thermotoga maritima",5,"GLY A 168;ASP A 166;ILE A 155;GLY A 156;ASN A  85","1KH A 301 (-3.4A);1KH A 301 ( 2.6A);None;PO4 A 306 (-3.4A);GOL A 314 ( 2.9A)","0.99A","3eeyJ-4jd0A:undetectable","1nbhC-4jd0A:24.10"],["3F8W_B_ADNB301_1","PURINE-NUCLEOSIDE PHOSPHORYLASE","4jd0","NUCLEOTIDYL TRANSFERASE","Thermotoga maritima",5,"SER A 143;GLY A 129;VAL A 169;GLY A 168;VAL A 145","1KH A 301 (-4.6A);None;None;1KH A 301 (-3.4A);None","1.34A","3f8wB-4jd0A:undetectable","3eeyJ-4jd0A:26.27"],["5HWA_A_GCSA301_1","CHITOSANASE","4jd0","NUCLEOTIDYL TRANSFERASE","Thermotoga maritima",4,"ASP A 219;GLY A 168;LEU A 191;ASN A  85"," NA A 315 (-3.5A);1KH A 301 (-3.4A);1KH A 301 (-4.3A);GOL A 314 ( 2.9A)","0.79A","5hwaA-4jd0A:undetectable","3f8wB-4jd0A:22.92"]]