SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1GP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		5 / 9 LEU A 191
ILE A 194
VAL A 228
GLY A 208
ALA A 225
 None
None
None
1GP  A 301 (-3.4A)
None
 1.03A 1e7aA-4jejA:
undetectable		 1e7aA-4jejA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		4 / 6 LEU A 102
GLU A 180
THR A 143
ALA A 146
 PGE  A 302 ( 3.7A)
1GP  A 301 (-2.1A)
None
None
 1.27A 1etb2-4jejA:
undetectable		 1etb2-4jejA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Thermoplasma
acidophilum) 		5 / 12 HIS A 181
ALA A 174
VAL A 200
GLY A 201
ALA A 212
 None
None
None
1GP  A 501 (-3.4A)
None
 1.02A 1kxhA-5b69A:
6.1		 1kxhA-5b69A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LBC_A_CYZA330_1
(GLUTAMINE RECEPTOR 2)		 3ew5 MACRO DOMAIN OF
NON-STRUCTURAL
PROTEIN 3
(Alphacoronavirus
1) 		5 / 12 PRO A 155
LEU A 173
SER A 169
ILE A 145
SER A 158
 None
None
None
None
1GP  A   9 (-4.8A)
 1.43A 1lbcA-3ew5A:
undetectable
1lbcC-3ew5A:
undetectable		 1lbcA-3ew5A:
23.05
1lbcC-3ew5A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 4nae HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Geobacillus
kaustophilus) 		5 / 12 TYR A 118
GLU A 161
ALA A 115
LEU A 152
ASN A  86
 None
1GP  A 301 (-2.7A)
None
None
None
 1.34A 1nw3A-4naeA:
undetectable		 1nw3A-4naeA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Thermoplasma
acidophilum) 		5 / 12 ILE A 204
GLY A 203
GLY A 177
GLU A 184
ILE A 226
 None
1GP  A 501 (-3.7A)
1GP  A 501 (-3.7A)
None
None
 0.99A 2fk8A-5b69A:
undetectable		 2fk8A-5b69A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		5 / 12 LEU A 100
ILE A  13
SER A 104
VAL A 145
VAL A 229
 PGE  A 302 (-3.7A)
None
None
PGE  A 302 ( 4.7A)
1GP  A 301 (-4.1A)
 1.08A 2po7A-4jejA:
3.0		 2po7A-4jejA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 4nae HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Geobacillus
kaustophilus) 		5 / 11 THR A 222
ILE A 190
ALA A 215
ALA A 211
VAL A 208
 None
None
None
None
1GP  A 301 ( 4.6A)
 1.10A 2qhfA-4naeA:
undetectable		 2qhfA-4naeA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Thermoplasma
acidophilum) 		5 / 12 PHE A  78
ALA A 159
LEU A 194
VAL A 200
GLY A 201
 1GP  A 501 (-4.8A)
None
None
None
1GP  A 501 (-3.4A)
 0.96A 2ve3A-5b69A:
undetectable		 2ve3A-5b69A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4mm1 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 GLY A 176
GLY A 140
GLY A 136
 1GP  A 301 ( 4.2A)
None
None
 0.38A 3bogC-4mm1A:
undetectable		 3bogC-4mm1A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4mm1 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 GLY A 176
GLY A 140
GLY A 136
 1GP  A 301 ( 4.2A)
None
None
 0.40A 3bogD-4mm1A:
undetectable		 3bogD-4mm1A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2f6x (S)-3-O-GERANYLGERAN
YLGLYCERYL PHOSPHATE
SYNTHASE
(Archaeoglobus
fulgidus) 		5 / 12 SER A1037
MET A1035
PRO A1081
GLY A1193
ASN A1216
 None
None
MPD  A4001 (-3.7A)
1GP  A3001 (-3.0A)
1GP  A3001 (-3.9A)
 1.49A 3jb2A-2f6xA:
undetectable		 3jb2A-2f6xA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 3ew5 MACRO DOMAIN OF
NON-STRUCTURAL
PROTEIN 3
(Alphacoronavirus
1) 		4 / 8 ILE A 145
LEU A 122
ALA A  67
ALA A  68
 None
None
1GP  A   9 (-3.4A)
None
 0.73A 3r9tA-3ew5A:
undetectable		 3r9tA-3ew5A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 3ew5 MACRO DOMAIN OF
NON-STRUCTURAL
PROTEIN 3
(Alphacoronavirus
1) 		4 / 7 ILE A 145
LEU A 122
ALA A  67
ALA A  68
 None
None
1GP  A   9 (-3.4A)
None
 0.74A 3r9tB-3ew5A:
undetectable		 3r9tB-3ew5A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Thermoplasma
acidophilum) 		5 / 11 GLY A 224
ALA A 227
ILE A  35
ILE A  67
ILE A  47
 1GP  A 501 (-3.4A)
None
None
None
None
 0.78A 4dt8A-5b69A:
undetectable		 4dt8A-5b69A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Thermoplasma
acidophilum) 		5 / 10 GLY A 224
ALA A 227
ILE A  35
ILE A  67
ILE A  47
 1GP  A 501 (-3.4A)
None
None
None
None
 0.86A 4dt8B-5b69A:
undetectable		 4dt8B-5b69A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		4 / 8 GLY A 208
VAL A 207
ILE A 217
PHE A 240
 1GP  A 301 (-3.4A)
None
None
None
 0.86A 4fglD-4jejA:
undetectable		 4fglD-4jejA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		4 / 7 GLY A 208
VAL A 207
ILE A 217
PHE A 240
 1GP  A 301 (-3.4A)
None
None
None
 0.82A 4fglC-4jejA:
undetectable		 4fglC-4jejA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2f6x (S)-3-O-GERANYLGERAN
YLGLYCERYL PHOSPHATE
SYNTHASE
(Archaeoglobus
fulgidus) 		4 / 8 THR A1229
ILE A1213
LEU A1012
ILE A1022
 None
1GP  A3001 ( 4.6A)
None
None
 0.82A 4r38A-2f6xA:
undetectable		 4r38A-2f6xA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2f6x (S)-3-O-GERANYLGERAN
YLGLYCERYL PHOSPHATE
SYNTHASE
(Archaeoglobus
fulgidus) 		4 / 8 THR A1229
ILE A1213
LEU A1012
ILE A1022
 None
1GP  A3001 ( 4.6A)
None
None
 0.75A 4r38D-2f6xA:
undetectable		 4r38D-2f6xA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 2f6x (S)-3-O-GERANYLGERAN
YLGLYCERYL PHOSPHATE
SYNTHASE
(Archaeoglobus
fulgidus) 		5 / 10 ARG A1135
ALA A1132
GLY A1170
THR A1171
ALA A1134
 None
None
1GP  A3001 (-3.7A)
None
None
 1.28A 5vyhA-2f6xA:
undetectable		 5vyhA-2f6xA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		4 / 8 LEU A 102
TYR A 134
GLU A 180
THR A 151
 PGE  A 302 ( 3.7A)
PGE  A 302 ( 4.0A)
1GP  A 301 (-2.1A)
PO4  A 303 (-4.0A)
 1.13A 6c71B-4jejA:
undetectable		 6c71B-4jejA:
17.21