SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1G0'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		4 / 8 THR A 205
ASP A 134
GLY A 269
ASP A 270
 1G0  A 401 (-3.2A)
None
None
None
 0.88A 1bu5B-4id7A:
undetectable		 1bu5B-4id7A:
21.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A 132
ALA A 156
GLU A 177
THR A 205
LEU A 207
GLY A 211
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-3.6A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.9A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
 0.96A 1m17A-4id7A:
34.5		 1m17A-4id7A:
35.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A 132
ALA A 156
LYS A 158
THR A 205
LEU A 207
GLY A 211
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.9A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
 0.53A 1m17A-4id7A:
34.5		 1m17A-4id7A:
35.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 9 LEU A 132
GLY A 133
VAL A 140
ALA A 156
ALA A 208
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.8A)
1G0  A 401 (-4.6A)
 0.63A 1muoA-4id7A:
7.8		 1muoA-4id7A:
26.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 9 LEU A 132
VAL A 140
ALA A 156
ALA A 208
GLY A 211
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.8A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
 0.46A 1xbbA-4id7A:
35.5		 1xbbA-4id7A:
38.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		8 / 12 ALA A 156
MET A 181
THR A 205
GLY A 211
LEU A 214
ASP A 215
ARG A 218
LEU A 259
 1G0  A 401 (-3.6A)
1G0  A 401 (-4.0A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
None
None
None
1G0  A 401 (-4.6A)
 1.32A 1xkkA-4id7A:
30.5		 1xkkA-4id7A:
34.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		8 / 12 MET A 181
THR A 205
GLY A 211
LEU A 214
ASP A 215
ARG A 218
LEU A 259
ASP A 270
 1G0  A 401 (-4.0A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
None
None
None
1G0  A 401 (-4.6A)
None
 1.27A 1xkkA-4id7A:
30.5		 1xkkA-4id7A:
34.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		5 / 9 LEU A 132
VAL A 140
LYS A 158
LEU A 192
LEU A 207
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.7A)
1G0  A 401 ( 3.8A)
1G0  A 401 ( 4.9A)
 0.72A 1xkkA-4id7A:
30.5		 1xkkA-4id7A:
34.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 11 GLY A 133
GLY A 135
VAL A 140
ALA A 156
ALA A 208
SER A 212
LEU A 259
 1G0  A 401 ( 4.2A)
None
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.8A)
1G0  A 401 ( 4.3A)
1G0  A 401 (-4.6A)
 0.64A 2evaA-4id7A:
26.1		 2evaA-4id7A:
30.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A 132
ALA A 156
LYS A 158
THR A 205
GLY A 211
ASP A 215
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
None
1G0  A 401 (-4.6A)
 0.77A 2itoA-4id7A:
32.5		 2itoA-4id7A:
36.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		8 / 12 LEU A 132
GLY A 133
VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 211
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
 0.76A 2ityA-4id7A:
32.6		 2ityA-4id7A:
36.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		8 / 12 LEU A 132
VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 211
ASP A 215
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
None
1G0  A 401 (-4.6A)
 0.77A 2itzA-4id7A:
32.1		 2itzA-4id7A:
36.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 12 LEU A 132
GLY A 133
VAL A 140
LYS A 158
ALA A 208
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.8A)
1G0  A 401 (-4.6A)
 0.45A 2ivuA-4id7A:
20.1		 2ivuA-4id7A:
33.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 9 LEU A 132
VAL A 140
ALA A 156
GLY A 211
LEU A 259
GLY A 269
ASP A 270
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
None
None
 0.57A 2xp2A-4id7A:
31.2		 2xp2A-4id7A:
33.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 10 VAL A 140
ALA A 156
ILE A 190
GLY A 211
ASP A 215
LEU A 259
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-4.3A)
1G0  A 401 ( 4.5A)
None
1G0  A 401 (-4.6A)
 0.58A 2y7jC-4id7A:
27.2		 2y7jC-4id7A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 10 VAL A 140
ALA A 156
LEU A 207
GLY A 211
ASP A 215
LEU A 259
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 ( 4.9A)
1G0  A 401 ( 4.5A)
None
1G0  A 401 (-4.6A)
 0.54A 2y7jC-4id7A:
27.2		 2y7jC-4id7A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 10 VAL A 140
ALA A 156
ILE A 190
GLY A 211
ASP A 215
LEU A 259
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-4.3A)
1G0  A 401 ( 4.5A)
None
1G0  A 401 (-4.6A)
 0.59A 2y7jD-4id7A:
27.6		 2y7jD-4id7A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 10 VAL A 140
ALA A 156
LEU A 207
GLY A 211
ASP A 215
LEU A 259
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 ( 4.9A)
1G0  A 401 ( 4.5A)
None
1G0  A 401 (-4.6A)
 0.53A 2y7jD-4id7A:
27.6		 2y7jD-4id7A:
24.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 10 LEU A 132
ALA A 156
LYS A 158
LEU A 207
GLY A 211
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 ( 4.9A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
 0.56A 3aoxA-4id7A:
30.2		 3aoxA-4id7A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 12 VAL A 140
ALA A 156
LEU A 192
THR A 205
LEU A 207
GLY A 211
LEU A 259
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 ( 3.8A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.9A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
 0.77A 3bbtB-4id7A:
30.2		 3bbtB-4id7A:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 12 VAL A 140
ALA A 156
THR A 205
LEU A 207
GLY A 211
LEU A 259
PHE A 271
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.9A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
1G0  A 401 ( 4.8A)
 0.97A 3bbtB-4id7A:
30.2		 3bbtB-4id7A:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 12 ALA A 156
LEU A 189
THR A 205
GLY A 211
HIS A 250
LEU A 259
 1G0  A 401 (-3.6A)
None
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
None
1G0  A 401 (-4.6A)
 0.74A 3cs9A-4id7A:
24.5		 3cs9A-4id7A:
39.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 12 GLU A 177
LEU A 189
THR A 205
GLY A 211
HIS A 250
LEU A 259
 1G0  A 401 ( 4.5A)
None
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
None
1G0  A 401 (-4.6A)
 0.73A 3cs9A-4id7A:
24.5		 3cs9A-4id7A:
39.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		5 / 12 ALA A 156
LEU A 189
THR A 205
GLY A 211
HIS A 250
 1G0  A 401 (-3.6A)
None
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
None
 0.61A 3cs9B-4id7A:
24.7		 3cs9B-4id7A:
39.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		5 / 12 ALA A 156
GLU A 177
LEU A 189
THR A 205
HIS A 250
 1G0  A 401 (-3.6A)
1G0  A 401 ( 4.5A)
None
1G0  A 401 (-3.2A)
None
 0.91A 3cs9C-4id7A:
30.4		 3cs9C-4id7A:
39.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		5 / 12 ALA A 156
LEU A 189
THR A 205
GLY A 211
HIS A 250
 1G0  A 401 (-3.6A)
None
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
None
 0.61A 3cs9D-4id7A:
24.5		 3cs9D-4id7A:
39.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		8 / 12 LEU A 132
GLY A 133
GLY A 135
GLY A 138
VAL A 140
ALA A 156
SER A 212
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.2A)
None
None
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 ( 4.3A)
1G0  A 401 (-4.6A)
 0.59A 3eygA-4id7A:
33.7		 3eygA-4id7A:
36.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		8 / 12 LEU A 132
GLY A 133
GLY A 138
VAL A 140
ALA A 156
LYS A 158
SER A 212
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.2A)
None
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 ( 4.3A)
1G0  A 401 (-4.6A)
 0.66A 3eygA-4id7A:
33.7		 3eygA-4id7A:
36.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 11 LEU A 132
VAL A 140
ALA A 156
THR A 205
GLY A 211
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
 0.68A 3g0fA-4id7A:
29.4		 3g0fA-4id7A:
34.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 10 LEU A 132
VAL A 140
ALA A 156
THR A 205
GLY A 211
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
 0.56A 3g0fB-4id7A:
13.4		 3g0fB-4id7A:
34.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A 132
GLY A 133
GLY A 135
VAL A 140
ALA A 156
SER A 212
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.2A)
None
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 ( 4.3A)
1G0  A 401 (-4.6A)
 0.58A 3lxnA-4id7A:
33.1		 3lxnA-4id7A:
38.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A 132
VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 211
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
 0.61A 3octA-4id7A:
30.6		 3octA-4id7A:
38.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 12 GLY A 133
VAL A 140
ALA A 156
LYS A 158
ILE A 190
LEU A 259
 1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-4.3A)
1G0  A 401 (-4.6A)
 0.99A 3ohtA-4id7A:
16.5		 3ohtA-4id7A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 12 GLY A 133
VAL A 140
ALA A 156
LYS A 158
ILE A 190
THR A 205
 1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-4.3A)
1G0  A 401 (-3.2A)
 0.69A 3ohtA-4id7A:
16.5		 3ohtA-4id7A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 12 GLY A 133
VAL A 140
ALA A 156
ILE A 190
THR A 205
GLY A 211
 1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-4.3A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
 1.12A 3ohtB-4id7A:
3.2		 3ohtB-4id7A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 12 GLY A 133
VAL A 140
ALA A 156
LYS A 158
ILE A 190
THR A 205
 1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-4.3A)
1G0  A 401 (-3.2A)
 0.68A 3ohtB-4id7A:
3.2		 3ohtB-4id7A:
23.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 12 ALA A 156
GLU A 177
LEU A 189
THR A 205
GLY A 211
HIS A 250
 1G0  A 401 (-3.6A)
1G0  A 401 ( 4.5A)
None
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
None
 0.79A 3oxzA-4id7A:
24.2		 3oxzA-4id7A:
38.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 12 LEU A 132
VAL A 140
ALA A 156
THR A 205
GLY A 211
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
 0.43A 3sxrA-4id7A:
33.1		 3sxrA-4id7A:
39.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 12 LEU A 132
VAL A 140
ALA A 156
THR A 205
GLY A 211
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
 0.45A 3sxrB-4id7A:
32.8		 3sxrB-4id7A:
39.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A 132
ALA A 156
LYS A 158
GLU A 177
THR A 205
GLY A 211
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
 1.10A 3ue4A-4id7A:
34.4		 3ue4A-4id7A:
39.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		8 / 12 LEU A 132
VAL A 140
ALA A 156
LYS A 158
LEU A 207
GLY A 211
ASP A 215
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 ( 4.9A)
1G0  A 401 ( 4.5A)
None
1G0  A 401 (-4.6A)
 0.77A 3ug2A-4id7A:
31.1		 3ug2A-4id7A:
35.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 12 GLY A 135
GLY A 138
VAL A 140
ALA A 156
LYS A 158
LEU A 259
 None
None
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-4.6A)
 0.79A 3v5wA-4id7A:
24.1		 3v5wA-4id7A:
17.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A 132
ALA A 156
LEU A 207
GLY A 211
LEU A 259
GLY A 269
ASP A 270
 1G0  A 401 ( 4.5A)
1G0  A 401 (-3.6A)
1G0  A 401 ( 4.9A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
None
None
 0.74A 3zbfA-4id7A:
32.4		 3zbfA-4id7A:
38.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 12 LEU A 132
VAL A 140
ALA A 156
LYS A 158
GLY A 211
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
 0.47A 4agcA-4id7A:
29.4		 4agcA-4id7A:
33.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 9 LEU A 132
VAL A 140
ALA A 156
GLY A 211
LEU A 259
ASP A 270
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
None
 0.59A 4anqA-4id7A:
31.0		 4anqA-4id7A:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 9 LEU A 132
VAL A 140
ALA A 156
GLY A 211
LEU A 259
ASP A 270
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
None
 0.64A 4ansA-4id7A:
30.9		 4ansA-4id7A:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 12 ALA A 156
GLU A 177
ILE A 190
MET A 203
THR A 205
LEU A 259
ASP A 270
 1G0  A 401 (-3.6A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.3A)
1G0  A 401 ( 3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 (-4.6A)
None
 1.32A 4bkjA-4id7A:
28.3		 4bkjA-4id7A:
36.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 12 VAL A 140
ALA A 156
ILE A 190
MET A 203
THR A 205
LEU A 259
ASP A 270
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-4.3A)
1G0  A 401 ( 3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 (-4.6A)
None
 1.18A 4bkjA-4id7A:
28.3		 4bkjA-4id7A:
36.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 12 VAL A 140
ALA A 156
ILE A 190
MET A 203
THR A 205
LEU A 259
ASP A 270
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-4.3A)
1G0  A 401 ( 3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 (-4.6A)
None
 1.22A 4bkjB-4id7A:
28.4		 4bkjB-4id7A:
36.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 10 LEU A 132
GLY A 133
VAL A 140
ALA A 156
ALA A 208
SER A 212
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.8A)
1G0  A 401 ( 4.3A)
1G0  A 401 (-4.6A)
 0.52A 4ckjA-4id7A:
34.1		 4ckjA-4id7A:
33.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A 132
VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 211
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
 0.81A 4hjoA-4id7A:
31.5		 4hjoA-4id7A:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		8 / 12 LEU A 132
GLY A 133
VAL A 140
ALA A 156
LYS A 158
GLY A 211
ASP A 215
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 ( 4.5A)
None
1G0  A 401 (-4.6A)
 0.78A 4i22A-4id7A:
25.4		 4i22A-4id7A:
34.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		8 / 12 LEU A 132
VAL A 140
ALA A 156
LYS A 158
LEU A 207
GLY A 211
LEU A 259
ASP A 270
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 ( 4.9A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
None
 0.60A 4mkcA-4id7A:
31.4		 4mkcA-4id7A:
32.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		8 / 12 LEU A 132
VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 211
LEU A 259
ASP A 270
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
None
 0.85A 4mxoB-4id7A:
20.1		 4mxoB-4id7A:
39.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A 132
VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 211
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
 0.73A 4mxxB-4id7A:
29.8		 4mxxB-4id7A:
39.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 11 LEU A 132
GLY A 133
VAL A 140
ALA A 156
LYS A 158
ASN A 257
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
None
1G0  A 401 (-4.6A)
 0.65A 4o0sA-4id7A:
27.8		 4o0sA-4id7A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		5 / 6 LEU A 132
GLY A 133
VAL A 140
ALA A 156
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-4.6A)
 0.48A 4o0wA-4id7A:
26.9		 4o0wA-4id7A:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A 132
GLY A 133
GLY A 135
GLY A 138
VAL A 140
ALA A 156
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.2A)
None
None
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-4.6A)
 0.62A 4otiA-4id7A:
20.5		 4otiA-4id7A:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A 132
GLY A 133
GLY A 135
GLY A 138
VAL A 140
ALA A 156
LYS A 158
 1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.2A)
None
None
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
 0.59A 4otiA-4id7A:
20.5		 4otiA-4id7A:
25.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 12 VAL A 140
ALA A 156
LYS A 158
THR A 205
LEU A 259
GLY A 269
ASP A 270
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 (-4.6A)
None
None
 0.69A 4r7iA-4id7A:
29.7		 4r7iA-4id7A:
32.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 10 ALA A 156
LYS A 158
ILE A 190
THR A 205
LEU A 207
LEU A 259
 1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-4.3A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.9A)
1G0  A 401 (-4.6A)
 0.81A 4rz7A-4id7A:
7.7		 4rz7A-4id7A:
15.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 12 ALA A 156
LYS A 158
THR A 205
SER A 212
GLY A 269
PHE A 271
 1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.3A)
None
1G0  A 401 ( 4.8A)
 1.10A 4rzvA-4id7A:
7.4		 4rzvA-4id7A:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 12 VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 269
PHE A 271
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
None
1G0  A 401 ( 4.8A)
 0.87A 4rzvB-4id7A:
26.4		 4rzvB-4id7A:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 12 VAL A 140
ALA A 156
LYS A 158
THR A 205
SER A 212
GLY A 269
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.3A)
None
 1.06A 4rzvB-4id7A:
26.4		 4rzvB-4id7A:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		8 / 11 LEU A 132
GLY A 135
VAL A 140
ALA A 156
GLY A 211
ASN A 257
LEU A 259
ASP A 270
 1G0  A 401 ( 4.5A)
None
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 ( 4.5A)
None
1G0  A 401 (-4.6A)
None
 0.67A 4u5jA-4id7A:
32.7		 4u5jA-4id7A:
39.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 9 LEU A 132
VAL A 140
ALA A 156
GLY A 211
LEU A 259
ASP A 270
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
None
 0.62A 4u5jB-4id7A:
25.2		 4u5jB-4id7A:
39.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		5 / 12 ALA A 156
GLU A 177
ALA A 208
LEU A 243
HIS A 250
 1G0  A 401 (-3.6A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-3.8A)
None
None
 0.72A 4v01A-4id7A:
22.9		 4v01A-4id7A:
37.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		5 / 9 LEU A 132
VAL A 140
ILE A 190
LEU A 259
ILE A 268
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-4.3A)
1G0  A 401 (-4.6A)
None
 0.49A 4v01A-4id7A:
12.9		 4v01A-4id7A:
37.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		5 / 12 ALA A 156
GLU A 177
ALA A 208
LEU A 243
HIS A 250
 1G0  A 401 (-3.6A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-3.8A)
None
None
 0.65A 4v01B-4id7A:
29.3		 4v01B-4id7A:
37.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 9 LEU A 132
VAL A 140
LYS A 158
ILE A 190
LEU A 259
ILE A 268
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.7A)
1G0  A 401 (-4.3A)
1G0  A 401 (-4.6A)
None
 0.50A 4v01B-4id7A:
29.3		 4v01B-4id7A:
37.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 10 LEU A 132
VAL A 140
LYS A 158
ILE A 190
LEU A 259
ILE A 268
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.7A)
1G0  A 401 (-4.3A)
1G0  A 401 (-4.6A)
None
 0.66A 4v04B-4id7A:
10.6		 4v04B-4id7A:
37.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 11 LEU A 132
ALA A 156
THR A 205
GLY A 211
ASN A 257
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
None
1G0  A 401 (-4.6A)
 0.74A 4wa9A-4id7A:
30.4		 4wa9A-4id7A:
40.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		8 / 12 LEU A 132
ALA A 156
GLU A 177
THR A 205
LEU A 207
GLY A 211
ASP A 215
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-3.6A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.9A)
1G0  A 401 ( 4.5A)
None
1G0  A 401 (-4.6A)
 1.03A 4wkqA-4id7A:
34.4		 4wkqA-4id7A:
35.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		8 / 12 LEU A 132
ALA A 156
LYS A 158
THR A 205
LEU A 207
GLY A 211
ASP A 215
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.9A)
1G0  A 401 ( 4.5A)
None
1G0  A 401 (-4.6A)
 0.74A 4wkqA-4id7A:
34.4		 4wkqA-4id7A:
35.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A 132
VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 211
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
 0.65A 4xeyA-4id7A:
33.7		 4xeyA-4id7A:
31.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A 132
VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 211
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
 0.66A 4xeyB-4id7A:
33.2		 4xeyB-4id7A:
31.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 12 ALA A 156
LYS A 158
THR A 205
GLY A 269
ASP A 270
PHE A 271
 1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
None
None
1G0  A 401 ( 4.8A)
 1.23A 4xv2A-4id7A:
27.0		 4xv2A-4id7A:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 12 VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 269
PHE A 271
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
None
1G0  A 401 ( 4.8A)
 0.80A 4xv2A-4id7A:
27.0		 4xv2A-4id7A:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 12 ALA A 156
LYS A 158
THR A 205
GLY A 269
ASP A 270
PHE A 271
 1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
None
None
1G0  A 401 ( 4.8A)
 1.19A 4xv2B-4id7A:
27.3		 4xv2B-4id7A:
29.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 9 LEU A 132
VAL A 140
ALA A 156
GLY A 211
LEU A 259
GLY A 269
ASP A 270
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
None
None
 0.61A 5aaaA-4id7A:
31.5		 5aaaA-4id7A:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		8 / 10 LEU A 132
VAL A 140
ALA A 156
LYS A 158
GLY A 211
LEU A 259
GLY A 269
ASP A 270
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
None
None
 0.72A 5aabA-4id7A:
31.0		 5aabA-4id7A:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		8 / 10 LEU A 132
VAL A 140
ALA A 156
LYS A 158
GLY A 211
LEU A 259
GLY A 269
ASP A 270
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
None
None
 0.70A 5aacA-4id7A:
30.9		 5aacA-4id7A:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		8 / 12 LEU A 132
VAL A 140
ALA A 156
LYS A 158
ILE A 190
THR A 205
GLY A 211
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-4.3A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
 0.88A 5bvwA-4id7A:
29.1		 5bvwA-4id7A:
36.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 12 VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 269
PHE A 271
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
None
1G0  A 401 ( 4.8A)
 0.90A 5cswA-4id7A:
26.8		 5cswA-4id7A:
29.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 12 VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 269
PHE A 271
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
None
1G0  A 401 ( 4.8A)
 0.88A 5cswB-4id7A:
26.9		 5cswB-4id7A:
29.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		8 / 12 LEU A 132
VAL A 140
ALA A 156
THR A 205
LEU A 207
GLY A 211
LEU A 259
GLY A 269
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.9A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
None
 0.80A 5h2uA-4id7A:
25.8		 5h2uA-4id7A:
40.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 12 LEU A 132
ALA A 156
THR A 205
GLY A 211
LEU A 259
GLY A 269
 1G0  A 401 ( 4.5A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
None
 0.81A 5h2uC-4id7A:
25.8		 5h2uC-4id7A:
40.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		8 / 12 LEU A 132
VAL A 140
ALA A 156
THR A 205
LEU A 207
GLY A 211
LEU A 259
GLY A 269
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.9A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
None
 0.81A 5h2uD-4id7A:
25.9		 5h2uD-4id7A:
40.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 12 VAL A 140
ALA A 156
ILE A 190
THR A 205
ALA A 208
ASP A 215
PHE A 271
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-4.3A)
1G0  A 401 (-3.2A)
1G0  A 401 (-3.8A)
None
1G0  A 401 ( 4.8A)
 0.95A 5hesA-4id7A:
9.5		 5hesA-4id7A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 12 VAL A 140
ALA A 156
LYS A 158
THR A 205
ALA A 208
ASP A 215
PHE A 271
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 (-3.8A)
None
1G0  A 401 ( 4.8A)
 0.88A 5hesB-4id7A:
25.8		 5hesB-4id7A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		5 / 12 VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 269
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
None
 0.53A 5hieA-4id7A:
25.8		 5hieA-4id7A:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		5 / 12 VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 269
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
None
 0.53A 5hieB-4id7A:
25.9		 5hieB-4id7A:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 12 GLY A 133
VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 269
 1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
None
 0.64A 5hieC-4id7A:
26.2		 5hieC-4id7A:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		5 / 12 VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 269
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
None
 0.53A 5hieD-4id7A:
26.1		 5hieD-4id7A:
30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 11 LEU A 132
GLY A 133
VAL A 140
ALA A 156
ALA A 208
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.8A)
1G0  A 401 (-4.6A)
 0.41A 5lvnA-4id7A:
26.9		 5lvnA-4id7A:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		5 / 10 GLY A 133
VAL A 140
ALA A 156
ILE A 190
LEU A 207
 1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-4.3A)
1G0  A 401 ( 4.9A)
 0.64A 5lw1E-4id7A:
20.8		 5lw1E-4id7A:
14.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 12 VAL A 140
ALA A 156
THR A 205
GLY A 211
LEU A 259
PHE A 271
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
1G0  A 401 ( 4.8A)
 0.85A 5p9iA-4id7A:
26.6		 5p9iA-4id7A:
37.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 12 GLU A 130
GLY A 133
ALA A 156
GLU A 177
GLY A 211
ASP A 270
 None
1G0  A 401 ( 4.2A)
1G0  A 401 (-3.6A)
1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.5A)
None
 0.97A 5vc3A-4id7A:
25.6		 5vc3A-4id7A:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A 132
VAL A 140
ALA A 156
THR A 205
LEU A 207
GLY A 211
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.9A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
 0.62A 5y80A-4id7A:
23.8		 5y80A-4id7A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A 132
GLY A 133
VAL A 140
ALA A 156
LYS A 158
MET A 181
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-4.0A)
1G0  A 401 (-4.6A)
 1.47A 5yu9A-4id7A:
29.4		 5yu9A-4id7A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		7 / 12 GLY A 133
VAL A 140
ALA A 156
LYS A 158
MET A 181
ASP A 215
LEU A 259
 1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-4.0A)
None
1G0  A 401 (-4.6A)
 1.39A 5yu9B-4id7A:
29.7		 5yu9B-4id7A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		5 / 12 VAL A 140
ALA A 156
LYS A 158
GLY A 211
ASP A 215
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 ( 4.5A)
None
 0.68A 5yu9C-4id7A:
24.4		 5yu9C-4id7A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 12 VAL A 140
ALA A 156
LYS A 158
MET A 181
ASP A 215
LEU A 259
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-4.0A)
None
1G0  A 401 (-4.6A)
 1.40A 5yu9D-4id7A:
25.0		 5yu9D-4id7A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens) 		6 / 12 LEU A 132
VAL A 140
ALA A 156
LYS A 158
ALA A 208
GLY A 211
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.8A)
1G0  A 401 ( 4.5A)
 0.71A 5zv2B-4id7A:
29.5		 5zv2B-4id7A:
19.88