SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1FT'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXF_A_MTXA1278_1 (PTERIDINE REDUCTASE 2)	4ipn	6-PHOSPHO-BETA-GLUCO SIDASE (Streptococcus pneumoniae)	5 / 10	ARG B 80 SER B 124 TYR B 126 LEU B 178 LEU B 229	None None 1FT B 501 (-4.7A) None None	1.00A	1mxfA-4ipnB: 3.2	1mxfA-4ipnB: 18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXF_B_MTXB2278_1 (PTERIDINE REDUCTASE 2)	4ipn	6-PHOSPHO-BETA-GLUCO SIDASE (Streptococcus pneumoniae)	5 / 11	ARG B 80 SER B 124 TYR B 126 LEU B 178 LEU B 229	None None 1FT B 501 (-4.7A) None None	0.99A	1mxfB-4ipnB: 2.5	1mxfB-4ipnB: 18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXF_C_MTXC3278_1 (PTERIDINE REDUCTASE 2)	4ipn	6-PHOSPHO-BETA-GLUCO SIDASE (Streptococcus pneumoniae)	5 / 11	ARG B 80 SER B 124 TYR B 126 LEU B 178 LEU B 229	None None 1FT B 501 (-4.7A) None None	0.98A	1mxfC-4ipnB: 2.9	1mxfC-4ipnB: 18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXF_D_MTXD4278_1 (PTERIDINE REDUCTASE 2)	4ipn	6-PHOSPHO-BETA-GLUCO SIDASE (Streptococcus pneumoniae)	5 / 11	ARG B 80 SER B 124 TYR B 126 LEU B 178 LEU B 229	None None 1FT B 501 (-4.7A) None None	0.97A	1mxfD-4ipnB: 2.5	1mxfD-4ipnB: 18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TUV_A_VK3A4558_1 (PROTEIN YGIN)	4ipn	6-PHOSPHO-BETA-GLUCO SIDASE (Streptococcus pneumoniae)	4 / 7	TYR B 391 HIS B 395 LEU B 345 TYR B 303	None None None 1FT B 501 ( 4.6A)	1.05A	1tuvA-4ipnB: undetectable	1tuvA-4ipnB: 11.39

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MXF_A_MTXA1278_1","PTERIDINE REDUCTASE 2","4ipn","6-PHOSPHO-BETA-GLUCOSIDASE","Streptococcus pneumoniae",5,"ARG B  80;SER B 124;TYR B 126;LEU B 178;LEU B 229","None;None;1FT B 501 (-4.7A);None;None","1.00A","1mxfA-4ipnB:3.2",null],["1MXF_B_MTXB2278_1","PTERIDINE REDUCTASE 2","4ipn","6-PHOSPHO-BETA-GLUCOSIDASE","Streptococcus pneumoniae",5,"ARG B  80;SER B 124;TYR B 126;LEU B 178;LEU B 229","None;None;1FT B 501 (-4.7A);None;None","0.99A","1mxfB-4ipnB:2.5","1mxfA-4ipnB:18.24"],["1MXF_C_MTXC3278_1","PTERIDINE REDUCTASE 2","4ipn","6-PHOSPHO-BETA-GLUCOSIDASE","Streptococcus pneumoniae",5,"ARG B  80;SER B 124;TYR B 126;LEU B 178;LEU B 229","None;None;1FT B 501 (-4.7A);None;None","0.98A","1mxfC-4ipnB:2.9","1mxfB-4ipnB:18.24"],["1MXF_D_MTXD4278_1","PTERIDINE REDUCTASE 2","4ipn","6-PHOSPHO-BETA-GLUCOSIDASE","Streptococcus pneumoniae",5,"ARG B  80;SER B 124;TYR B 126;LEU B 178;LEU B 229","None;None;1FT B 501 (-4.7A);None;None","0.97A","1mxfD-4ipnB:2.5","1mxfC-4ipnB:18.24"],["1TUV_A_VK3A4558_1","PROTEIN YGIN","4ipn","6-PHOSPHO-BETA-GLUCOSIDASE","Streptococcus pneumoniae",4,"TYR B 391;HIS B 395;LEU B 345;TYR B 303","None;None;None;1FT B 501 ( 4.6A)","1.05A","1tuvA-4ipnB:undetectable","1mxfD-4ipnB:18.24"]]