SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1DO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 121
LEU A 243
ARG A 312
THR A 145
 None
1DO  A1655 ( 4.7A)
1DO  A1655 (-4.3A)
None
 1.45A 4p3qA-2cfzA:
undetectable		 4p3qA-2cfzA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 122
ASP A 121
LEU A  82
TYR A  79
TYR A 223
 None
None
None
None
1DO  A1655 (-3.9A)
 1.01A 5uxdB-2cfzA:
undetectable		 5uxdB-2cfzA:
19.94