SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1BM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 251
ALA A 271
GLU A 288
MET A 292
THR A 316
PHE A 318
GLY A 322
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
 0.98A 1iepA-2hk5A:
27.5		 1iepA-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 251
ALA A 271
MET A 292
THR A 316
PHE A 318
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.95A 1iepA-2hk5A:
27.5		 1iepA-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 251
VAL A 259
ALA A 271
GLU A 288
MET A 292
THR A 316
PHE A 318
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
 1.01A 1iepA-2hk5A:
27.5		 1iepA-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 251
VAL A 259
ALA A 271
MET A 292
THR A 316
PHE A 318
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 1.04A 1iepA-2hk5A:
27.5		 1iepA-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 6 LYS A 273
VAL A 291
VAL A 301
ILE A 314
 1BM  A 499 (-3.8A)
None
None
1BM  A 499 (-3.9A)
 0.68A 1iepA-2hk5A:
27.4		 1iepA-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 6 VAL A 291
VAL A 301
ILE A 314
MET A 319
ARG A 363
 None
None
1BM  A 499 (-3.9A)
None
None
 1.01A 1iepA-2hk5A:
27.4		 1iepA-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 251
ALA A 271
MET A 292
THR A 316
PHE A 318
GLY A 322
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 ( 3.7A)
 0.98A 1iepB-2hk5A:
27.6		 1iepB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 251
VAL A 259
ALA A 271
GLU A 288
MET A 292
THR A 316
PHE A 318
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
 0.67A 1iepB-2hk5A:
27.6		 1iepB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 251
VAL A 259
ALA A 271
MET A 292
THR A 316
PHE A 318
ALA A 381
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 1.02A 1iepB-2hk5A:
27.6		 1iepB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 251
ALA A 271
LYS A 273
GLU A 288
THR A 316
MET A 319
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.44A 1m17A-2hk5A:
27.8		 1m17A-2hk5A:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 251
ALA A 271
MET A 292
VAL A 301
THR A 316
PHE A 318
ALA A 381
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.89A 1opjA-2hk5A:
26.5		 1opjA-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 251
VAL A 259
ALA A 271
GLU A 288
MET A 292
VAL A 301
THR A 316
PHE A 318
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
 0.63A 1opjA-2hk5A:
26.5		 1opjA-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 251
VAL A 259
ALA A 271
MET A 292
VAL A 301
THR A 316
PHE A 318
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.88A 1opjA-2hk5A:
26.5		 1opjA-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 5 LYS A 273
VAL A 291
ILE A 314
MET A 319
 1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.9A)
None
 0.67A 1opjA-2hk5A:
26.4		 1opjA-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 ALA A 271
MET A 292
VAL A 301
THR A 316
PHE A 318
GLY A 322
ALA A 381
 1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 ( 3.7A)
 0.79A 1opjB-2hk5A:
26.3		 1opjB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 VAL A 259
ALA A 271
GLU A 288
MET A 292
VAL A 301
THR A 316
PHE A 318
ALA A 381
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.96A 1opjB-2hk5A:
26.3		 1opjB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 6 LEU A 251
LYS A 273
VAL A 291
ILE A 314
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.9A)
 0.56A 1opjB-2hk5A:
26.3		 1opjB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 6 LEU A 251
VAL A 291
ILE A 314
MET A 319
 1BM  A 499 ( 3.7A)
None
1BM  A 499 (-3.9A)
None
 0.69A 1opjB-2hk5A:
26.3		 1opjB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 6 LYS A 273
VAL A 291
ILE A 314
ARG A 363
 1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.9A)
None
 1.02A 1opjB-2hk5A:
26.3		 1opjB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 6 VAL A 291
ILE A 314
MET A 319
ARG A 363
 None
1BM  A 499 (-3.9A)
None
None
 0.98A 1opjB-2hk5A:
26.3		 1opjB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
VAL A 301
THR A 316
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.90A 1t46A-2hk5A:
25.0		 1t46A-2hk5A:
38.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
VAL A 301
THR A 316
LEU A 371
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.84A 1t46A-2hk5A:
25.0		 1t46A-2hk5A:
38.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 7 ASN A 369
HIS A 362
PHE A 383
ILE A 348
 1BM  A 499 (-4.1A)
None
None
None
 1.16A 1tdnA-2hk5A:
undetectable		 1tdnA-2hk5A:
21.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 9 LEU A 251
VAL A 259
ALA A 271
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.39A 1xbbA-2hk5A:
35.0		 1xbbA-2hk5A:
36.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 271
THR A 316
GLY A 322
LEU A 325
ASP A 326
LEU A 371
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
None
None
1BM  A 499 (-4.4A)
 0.66A 1xkkA-2hk5A:
25.3		 1xkkA-2hk5A:
32.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 THR A 316
GLY A 322
LEU A 325
ASP A 326
LEU A 371
ASP A 382
 1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
None
None
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.76A 1xkkA-2hk5A:
25.3		 1xkkA-2hk5A:
32.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		12 / 12 LEU A 251
ALA A 271
LYS A 273
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
PHE A 318
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.51A 2gqgA-2hk5A:
30.6		 2gqgA-2hk5A:
47.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		11 / 12 LEU A 251
VAL A 259
ALA A 271
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.50A 2gqgB-2hk5A:
36.8		 2gqgB-2hk5A:
47.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
ILE A 314
THR A 316
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
 0.51A 2gqgB-2hk5A:
36.8		 2gqgB-2hk5A:
47.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 ALA A 271
MET A 292
THR A 316
PHE A 318
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.66A 2hyyA-2hk5A:
27.6		 2hyyA-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 259
ALA A 271
GLU A 288
MET A 292
THR A 316
PHE A 318
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
 0.98A 2hyyA-2hk5A:
27.6		 2hyyA-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 259
ALA A 271
MET A 292
THR A 316
PHE A 318
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.98A 2hyyA-2hk5A:
27.6		 2hyyA-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 6 LEU A 251
LYS A 273
VAL A 291
VAL A 301
ILE A 314
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.8A)
None
None
1BM  A 499 (-3.9A)
 0.80A 2hyyA-2hk5A:
27.6		 2hyyA-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 ALA A 271
MET A 292
THR A 316
PHE A 318
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.68A 2hyyB-2hk5A:
27.5		 2hyyB-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 VAL A 259
ALA A 271
GLU A 288
MET A 292
THR A 316
PHE A 318
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
 0.50A 2hyyB-2hk5A:
27.5		 2hyyB-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 259
ALA A 271
MET A 292
THR A 316
PHE A 318
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.96A 2hyyB-2hk5A:
27.5		 2hyyB-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 6 LEU A 251
LYS A 273
VAL A 291
VAL A 301
ILE A 314
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.8A)
None
None
1BM  A 499 (-3.9A)
 0.64A 2hyyB-2hk5A:
27.5		 2hyyB-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 6 LEU A 251
VAL A 291
ILE A 314
MET A 319
 1BM  A 499 ( 3.7A)
None
1BM  A 499 (-3.9A)
None
 0.74A 2hyyB-2hk5A:
27.5		 2hyyB-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 259
ALA A 271
GLU A 288
VAL A 301
THR A 316
PHE A 318
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
 0.89A 2hyyC-2hk5A:
27.8		 2hyyC-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 259
ALA A 271
VAL A 301
THR A 316
PHE A 318
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.72A 2hyyC-2hk5A:
27.8		 2hyyC-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 259
ALA A 271
VAL A 301
THR A 316
PHE A 318
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.80A 2hyyC-2hk5A:
27.8		 2hyyC-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 6 LEU A 251
LYS A 273
VAL A 291
MET A 292
ILE A 314
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.8A)
None
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.9A)
 0.61A 2hyyC-2hk5A:
27.8		 2hyyC-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 6 LEU A 251
VAL A 291
MET A 292
ILE A 314
MET A 319
 1BM  A 499 ( 3.7A)
None
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.9A)
None
 0.65A 2hyyC-2hk5A:
27.8		 2hyyC-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 VAL A 259
ALA A 271
GLU A 288
MET A 292
ILE A 314
THR A 316
PHE A 318
ALA A 381
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.95A 2hyyD-2hk5A:
27.4		 2hyyD-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 VAL A 259
ALA A 271
MET A 292
ILE A 314
THR A 316
PHE A 318
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.91A 2hyyD-2hk5A:
27.4		 2hyyD-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 4 LEU A 251
LYS A 273
VAL A 301
MET A 319
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.8A)
None
None
 0.80A 2hyyD-2hk5A:
27.5		 2hyyD-2hk5A:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 251
ALA A 271
LYS A 273
GLU A 288
MET A 292
THR A 316
GLY A 322
ASP A 326
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
None
1BM  A 499 (-4.4A)
 0.68A 2itoA-2hk5A:
32.2		 2itoA-2hk5A:
33.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 251
GLY A 252
VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
THR A 316
GLY A 322
ASP A 382
 1BM  A 499 ( 3.7A)
None
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.72A 2ityA-2hk5A:
26.4		 2ityA-2hk5A:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 251
GLY A 252
VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
THR A 316
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
None
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.64A 2ityA-2hk5A:
26.4		 2ityA-2hk5A:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
THR A 316
GLY A 322
ASP A 326
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
None
1BM  A 499 (-4.4A)
 0.62A 2itzA-2hk5A:
26.3		 2itzA-2hk5A:
33.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 6 PHE A 402
ASN A 369
ASN A 290
LEU A 303
 None
1BM  A 499 (-4.1A)
None
None
 1.24A 2nyrA-2hk5A:
undetectable		 2nyrA-2hk5A:
19.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		10 / 12 VAL A 259
ALA A 271
GLU A 288
MET A 292
ILE A 314
THR A 316
GLY A 322
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.96A 2oiqA-2hk5A:
28.1		 2oiqA-2hk5A:
67.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
ILE A 314
THR A 316
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
 0.42A 2oiqA-2hk5A:
28.1		 2oiqA-2hk5A:
67.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 5 LEU A 251
VAL A 291
LEU A 295
MET A 319
 1BM  A 499 ( 3.7A)
None
None
None
 0.71A 2oiqA-2hk5A:
28.1		 2oiqA-2hk5A:
67.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 ALA A 271
MET A 292
VAL A 301
ILE A 314
THR A 316
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.84A 2pl0A-2hk5A:
28.0		 2pl0A-2hk5A:
73.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 VAL A 259
ALA A 271
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
ALA A 381
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.93A 2pl0A-2hk5A:
28.0		 2pl0A-2hk5A:
73.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
 0.64A 2pl0A-2hk5A:
28.0		 2pl0A-2hk5A:
73.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 GLY A 252
VAL A 259
ALA A 271
MET A 319
GLY A 322
ALA A 381
 None
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-3.5A)
1BM  A 499 ( 3.7A)
 0.75A 2wgjA-2hk5A:
31.1		 2wgjA-2hk5A:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 VAL A 259
ALA A 271
MET A 319
GLY A 322
ALA A 381
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-3.5A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.72A 2wgjA-2hk5A:
31.1		 2wgjA-2hk5A:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 9 LEU A 251
VAL A 259
ALA A 271
MET A 319
GLY A 322
LEU A 371
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.49A 2xp2A-2hk5A:
32.0		 2xp2A-2hk5A:
36.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 ALA A 271
LYS A 273
GLU A 288
MET A 292
ILE A 314
THR A 316
GLY A 322
LEU A 371
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.44A 2y6oA-2hk5A:
28.1		 2y6oA-2hk5A:
42.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 10 VAL A 259
ALA A 271
MET A 319
GLY A 322
ASP A 326
LEU A 371
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-3.5A)
None
1BM  A 499 (-4.4A)
 0.47A 2y7jC-2hk5A:
20.8		 2y7jC-2hk5A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 10 VAL A 259
ALA A 271
MET A 319
GLY A 322
ASP A 326
LEU A 371
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-3.5A)
None
1BM  A 499 (-4.4A)
 0.32A 2y7jD-2hk5A:
21.2		 2y7jD-2hk5A:
23.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 8 LEU A 251
ALA A 271
MET A 319
GLY A 322
LEU A 371
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.48A 2yfxA-2hk5A:
24.7		 2yfxA-2hk5A:
36.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		12 / 12 LEU A 251
ALA A 271
LYS A 273
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
MET A 319
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.41A 2zvaA-2hk5A:
31.0		 2zvaA-2hk5A:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 10 LEU A 251
ALA A 271
LYS A 273
VAL A 301
MET A 319
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
None
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.59A 3aoxA-2hk5A:
30.8		 3aoxA-2hk5A:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 VAL A 259
ALA A 271
LEU A 303
THR A 316
GLY A 322
LEU A 371
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.59A 3bbtB-2hk5A:
24.1		 3bbtB-2hk5A:
34.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 251
GLY A 252
ALA A 271
LYS A 273
VAL A 301
PHE A 318
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
None
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.83A 3c7qA-2hk5A:
23.9		 3c7qA-2hk5A:
39.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 10 LEU A 251
VAL A 259
LYS A 273
VAL A 301
ILE A 314
PHE A 318
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-4.1A)
 0.64A 3cs9A-2hk5A:
27.5		 3cs9A-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 10 LEU A 251
VAL A 259
VAL A 301
ILE A 314
PHE A 318
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
 0.76A 3cs9A-2hk5A:
27.5		 3cs9A-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 271
GLU A 288
VAL A 291
MET A 292
LEU A 300
THR A 316
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
None
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
 0.57A 3cs9A-2hk5A:
27.5		 3cs9A-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 ALA A 271
VAL A 291
MET A 292
LEU A 300
THR A 316
GLY A 322
HIS A 362
LEU A 371
ALA A 381
 1BM  A 499 (-3.6A)
None
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
None
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.64A 3cs9A-2hk5A:
27.5		 3cs9A-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 271
GLU A 288
VAL A 291
MET A 292
LEU A 300
THR A 316
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
None
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
 0.51A 3cs9B-2hk5A:
28.0		 3cs9B-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 ALA A 271
VAL A 291
MET A 292
LEU A 300
THR A 316
GLY A 322
HIS A 362
ALA A 381
 1BM  A 499 (-3.6A)
None
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
None
1BM  A 499 ( 3.7A)
 0.57A 3cs9B-2hk5A:
28.0		 3cs9B-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 9 LEU A 251
VAL A 259
LYS A 273
VAL A 301
ILE A 314
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.9A)
 0.69A 3cs9B-2hk5A:
28.0		 3cs9B-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 9 LEU A 251
VAL A 259
VAL A 301
ILE A 314
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-4.4A)
 0.80A 3cs9B-2hk5A:
28.0		 3cs9B-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 ALA A 271
GLU A 288
VAL A 291
MET A 292
LEU A 300
THR A 316
PHE A 318
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
None
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
 0.56A 3cs9C-2hk5A:
27.7		 3cs9C-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 ALA A 271
VAL A 291
MET A 292
LEU A 300
THR A 316
PHE A 318
HIS A 362
ALA A 381
 1BM  A 499 (-3.6A)
None
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
None
1BM  A 499 ( 3.7A)
 0.78A 3cs9C-2hk5A:
27.7		 3cs9C-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 ALA A 271
VAL A 291
MET A 292
THR A 316
PHE A 318
ALA A 381
ASP A 382
 1BM  A 499 (-3.6A)
None
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.84A 3cs9C-2hk5A:
27.7		 3cs9C-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 9 LEU A 251
VAL A 259
LYS A 273
VAL A 301
ILE A 314
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.9A)
 0.62A 3cs9C-2hk5A:
27.7		 3cs9C-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 9 LEU A 251
VAL A 259
VAL A 301
ILE A 314
MET A 319
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
None
1BM  A 499 (-3.9A)
None
 0.67A 3cs9C-2hk5A:
27.7		 3cs9C-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 ALA A 271
GLU A 288
VAL A 291
MET A 292
LEU A 300
THR A 316
PHE A 318
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
None
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
 0.60A 3cs9D-2hk5A:
27.2		 3cs9D-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 ALA A 271
MET A 292
LEU A 300
THR A 316
PHE A 318
GLY A 322
HIS A 362
ALA A 381
 1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
None
1BM  A 499 ( 3.7A)
 0.66A 3cs9D-2hk5A:
27.2		 3cs9D-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 ALA A 271
VAL A 291
MET A 292
LEU A 300
THR A 316
PHE A 318
GLY A 322
ALA A 381
 1BM  A 499 (-3.6A)
None
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 ( 3.7A)
 0.71A 3cs9D-2hk5A:
27.2		 3cs9D-2hk5A:
48.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 11 LEU A 251
VAL A 259
ALA A 271
VAL A 301
THR A 316
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.94A 3g0eA-2hk5A:
29.1		 3g0eA-2hk5A:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		11 / 12 LEU A 251
VAL A 259
ALA A 271
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.50A 3g5dA-2hk5A:
29.5		 3g5dA-2hk5A:
66.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		11 / 12 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
VAL A 301
THR A 316
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.45A 3g5dB-2hk5A:
29.5		 3g5dB-2hk5A:
66.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 12 VAL A 259
ALA A 271
GLU A 288
THR A 316
ILE A 355
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.2A)
None
 0.80A 3gcsA-2hk5A:
17.7		 3gcsA-2hk5A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 12 VAL A 259
ALA A 271
THR A 316
ILE A 355
HIS A 362
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
None
None
 0.87A 3gcsA-2hk5A:
17.7		 3gcsA-2hk5A:
24.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 251
VAL A 259
ALA A 271
GLU A 288
MET A 292
VAL A 301
THR A 316
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.98A 3gvuA-2hk5A:
27.4		 3gvuA-2hk5A:
44.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 5 LYS A 273
VAL A 291
ILE A 314
MET A 319
 1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.9A)
None
 0.73A 3gvuA-2hk5A:
27.4		 3gvuA-2hk5A:
44.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 VAL A 259
ALA A 271
LYS A 273
GLU A 288
THR A 316
ILE A 355
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.2A)
None
 0.78A 3hegA-2hk5A:
13.2		 3hegA-2hk5A:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 ALA A 271
MET A 292
LEU A 300
VAL A 301
HIS A 362
LEU A 371
ALA A 381
 1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
None
None
None
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.76A 3ik3A-2hk5A:
27.2		 3ik3A-2hk5A:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 271
MET A 292
VAL A 301
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.90A 3ik3A-2hk5A:
27.2		 3ik3A-2hk5A:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 7 LEU A 251
LYS A 273
VAL A 291
ILE A 314
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.9A)
 0.59A 3ik3A-2hk5A:
27.2		 3ik3A-2hk5A:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 7 LEU A 251
VAL A 291
ILE A 314
MET A 319
 1BM  A 499 ( 3.7A)
None
1BM  A 499 (-3.9A)
None
 0.68A 3ik3A-2hk5A:
27.2		 3ik3A-2hk5A:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 ALA A 271
MET A 292
LEU A 300
VAL A 301
HIS A 362
LEU A 371
ALA A 381
 1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
None
None
None
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.80A 3ik3B-2hk5A:
26.9		 3ik3B-2hk5A:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 7 LEU A 251
LYS A 273
VAL A 291
ILE A 314
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.9A)
 0.58A 3ik3B-2hk5A:
26.8		 3ik3B-2hk5A:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 7 LEU A 251
VAL A 291
ILE A 314
MET A 319
 1BM  A 499 ( 3.7A)
None
1BM  A 499 (-3.9A)
None
 0.72A 3ik3B-2hk5A:
26.8		 3ik3B-2hk5A:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 251
ALA A 271
LYS A 273
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.51A 3k54A-2hk5A:
32.3		 3k54A-2hk5A:
39.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 ALA A 271
GLU A 288
MET A 292
THR A 316
PHE A 318
GLY A 322
ALA A 381
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 ( 3.7A)
 0.86A 3k5vA-2hk5A:
31.8		 3k5vA-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 ALA A 271
MET A 292
THR A 316
PHE A 318
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.74A 3k5vA-2hk5A:
31.8		 3k5vA-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 259
ALA A 271
GLU A 288
MET A 292
THR A 316
PHE A 318
ALA A 381
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 1.00A 3k5vA-2hk5A:
31.8		 3k5vA-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 259
ALA A 271
MET A 292
THR A 316
PHE A 318
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 1.00A 3k5vA-2hk5A:
31.8		 3k5vA-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 6 LEU A 251
LYS A 273
VAL A 291
VAL A 301
ILE A 314
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.8A)
None
None
1BM  A 499 (-3.9A)
 0.61A 3k5vA-2hk5A:
31.7		 3k5vA-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 6 LEU A 251
VAL A 291
ILE A 314
MET A 319
 1BM  A 499 ( 3.7A)
None
1BM  A 499 (-3.9A)
None
 0.76A 3k5vA-2hk5A:
31.7		 3k5vA-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 ALA A 271
GLU A 288
MET A 292
THR A 316
PHE A 318
GLY A 322
ALA A 381
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 ( 3.7A)
 0.83A 3k5vB-2hk5A:
26.6		 3k5vB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 ALA A 271
MET A 292
THR A 316
PHE A 318
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.71A 3k5vB-2hk5A:
26.6		 3k5vB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 259
ALA A 271
GLU A 288
MET A 292
THR A 316
PHE A 318
ALA A 381
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.98A 3k5vB-2hk5A:
26.6		 3k5vB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 259
ALA A 271
MET A 292
THR A 316
PHE A 318
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.98A 3k5vB-2hk5A:
26.6		 3k5vB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 6 LEU A 251
LYS A 273
VAL A 301
ILE A 314
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.9A)
 0.70A 3k5vB-2hk5A:
26.6		 3k5vB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 6 LEU A 251
VAL A 301
ILE A 314
MET A 319
 1BM  A 499 ( 3.7A)
None
1BM  A 499 (-3.9A)
None
 0.70A 3k5vB-2hk5A:
26.6		 3k5vB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 6 LYS A 273
VAL A 291
VAL A 301
ILE A 314
 1BM  A 499 (-3.8A)
None
None
1BM  A 499 (-3.9A)
 0.59A 3k5vB-2hk5A:
26.6		 3k5vB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 6 VAL A 291
VAL A 301
ILE A 314
MET A 319
 None
None
1BM  A 499 (-3.9A)
None
 0.59A 3k5vB-2hk5A:
26.6		 3k5vB-2hk5A:
46.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 8 ALA A 271
LYS A 273
GLU A 288
THR A 316
MET A 319
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.2A)
None
 0.70A 3lfaA-2hk5A:
20.4		 3lfaA-2hk5A:
24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 11 ALA A 271
LYS A 273
VAL A 301
PHE A 318
MET A 319
GLY A 322
LEU A 371
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-4.1A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.58A 3miyA-2hk5A:
26.0		 3miyA-2hk5A:
39.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 9 ALA A 271
LYS A 273
PHE A 318
MET A 319
GLY A 322
LEU A 371
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-4.1A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.58A 3miyB-2hk5A:
32.7		 3miyB-2hk5A:
39.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 251
VAL A 259
ALA A 271
GLU A 288
MET A 292
THR A 316
PHE A 318
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
 0.91A 3ms9A-2hk5A:
27.5		 3ms9A-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 251
VAL A 259
ALA A 271
MET A 292
THR A 316
PHE A 318
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.96A 3ms9A-2hk5A:
27.5		 3ms9A-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 6 LYS A 273
VAL A 291
VAL A 301
ILE A 314
 1BM  A 499 (-3.8A)
None
None
1BM  A 499 (-3.9A)
 0.60A 3ms9A-2hk5A:
27.5		 3ms9A-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 6 VAL A 291
VAL A 301
ILE A 314
MET A 319
 None
None
1BM  A 499 (-3.9A)
None
 0.60A 3ms9A-2hk5A:
27.5		 3ms9A-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 251
ALA A 271
MET A 292
THR A 316
PHE A 318
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.90A 3ms9B-2hk5A:
27.6		 3ms9B-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 251
VAL A 259
ALA A 271
GLU A 288
MET A 292
THR A 316
PHE A 318
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
 0.96A 3ms9B-2hk5A:
27.6		 3ms9B-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 251
VAL A 259
ALA A 271
MET A 292
THR A 316
PHE A 318
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 1.01A 3ms9B-2hk5A:
27.6		 3ms9B-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 7 LYS A 273
VAL A 291
VAL A 301
ILE A 314
 1BM  A 499 (-3.8A)
None
None
1BM  A 499 (-3.9A)
 0.61A 3ms9B-2hk5A:
27.6		 3ms9B-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 7 VAL A 291
VAL A 301
ILE A 314
MET A 319
 None
None
1BM  A 499 (-3.9A)
None
 0.60A 3ms9B-2hk5A:
27.6		 3ms9B-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 251
VAL A 259
ALA A 271
GLU A 288
MET A 292
THR A 316
PHE A 318
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
 0.97A 3mssA-2hk5A:
27.6		 3mssA-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 251
VAL A 259
ALA A 271
MET A 292
THR A 316
PHE A 318
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 1.00A 3mssA-2hk5A:
27.6		 3mssA-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 6 LYS A 273
VAL A 291
VAL A 301
ILE A 314
 1BM  A 499 (-3.8A)
None
None
1BM  A 499 (-3.9A)
 0.58A 3mssA-2hk5A:
27.6		 3mssA-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 6 VAL A 291
VAL A 301
ILE A 314
MET A 319
 None
None
1BM  A 499 (-3.9A)
None
 0.61A 3mssA-2hk5A:
27.6		 3mssA-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 ALA A 271
MET A 292
THR A 316
PHE A 318
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.74A 3mssB-2hk5A:
27.8		 3mssB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 VAL A 259
ALA A 271
GLU A 288
MET A 292
THR A 316
PHE A 318
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
 0.48A 3mssB-2hk5A:
27.8		 3mssB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 7 LYS A 273
VAL A 291
VAL A 301
ILE A 314
 1BM  A 499 (-3.8A)
None
None
1BM  A 499 (-3.9A)
 0.59A 3mssB-2hk5A:
27.8		 3mssB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 7 VAL A 291
VAL A 301
ILE A 314
MET A 319
ARG A 363
 None
None
1BM  A 499 (-3.9A)
None
None
 1.02A 3mssB-2hk5A:
27.8		 3mssB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 251
VAL A 259
ALA A 271
GLU A 288
MET A 292
THR A 316
PHE A 318
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
 0.98A 3mssC-2hk5A:
27.5		 3mssC-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 251
VAL A 259
ALA A 271
MET A 292
THR A 316
PHE A 318
ALA A 381
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.94A 3mssC-2hk5A:
27.5		 3mssC-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 251
VAL A 259
ALA A 271
MET A 292
THR A 316
PHE A 318
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.96A 3mssC-2hk5A:
27.5		 3mssC-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 6 LYS A 273
VAL A 291
VAL A 301
ILE A 314
 1BM  A 499 (-3.8A)
None
None
1BM  A 499 (-3.9A)
 0.61A 3mssC-2hk5A:
27.5		 3mssC-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 6 VAL A 291
VAL A 301
ILE A 314
MET A 319
 None
None
1BM  A 499 (-3.9A)
None
 0.64A 3mssC-2hk5A:
27.5		 3mssC-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 251
ALA A 271
GLU A 288
MET A 292
THR A 316
PHE A 318
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
 0.98A 3mssD-2hk5A:
27.8		 3mssD-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 251
ALA A 271
MET A 292
THR A 316
PHE A 318
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.95A 3mssD-2hk5A:
27.8		 3mssD-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 251
ALA A 271
MET A 292
THR A 316
PHE A 318
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 1.00A 3mssD-2hk5A:
27.8		 3mssD-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 6 VAL A 259
LYS A 273
VAL A 291
VAL A 301
ILE A 314
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.8A)
None
None
1BM  A 499 (-3.9A)
 0.60A 3mssD-2hk5A:
27.8		 3mssD-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 6 VAL A 259
VAL A 291
VAL A 301
ILE A 314
MET A 319
 1BM  A 499 ( 4.8A)
None
None
1BM  A 499 (-3.9A)
None
 0.76A 3mssD-2hk5A:
27.8		 3mssD-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 251
VAL A 259
ALA A 271
LYS A 273
MET A 292
VAL A 301
THR A 316
GLY A 322
GLU A 332
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
None
1BM  A 499 (-4.4A)
 1.07A 3octA-2hk5A:
31.8		 3octA-2hk5A:
40.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 ALA A 271
MET A 292
VAL A 301
THR A 316
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.61A 3oezA-2hk5A:
27.8		 3oezA-2hk5A:
66.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 VAL A 259
ALA A 271
GLU A 288
MET A 292
VAL A 301
THR A 316
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
 0.48A 3oezA-2hk5A:
27.8		 3oezA-2hk5A:
66.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 259
ALA A 271
MET A 292
VAL A 301
THR A 316
LEU A 371
ALA A 381
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.72A 3oezA-2hk5A:
27.8		 3oezA-2hk5A:
66.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 ALA A 271
GLU A 288
VAL A 291
MET A 292
ILE A 314
THR A 316
LEU A 371
ASP A 382
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
None
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.92A 3oezB-2hk5A:
27.7		 3oezB-2hk5A:
66.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 ALA A 271
VAL A 291
MET A 292
ILE A 314
THR A 316
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 (-3.6A)
None
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.91A 3oezB-2hk5A:
27.7		 3oezB-2hk5A:
66.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 VAL A 259
ALA A 271
LYS A 273
GLU A 288
VAL A 291
MET A 292
ILE A 314
THR A 316
LEU A 371
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
 0.60A 3oezB-2hk5A:
27.7		 3oezB-2hk5A:
66.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 VAL A 259
ALA A 271
LYS A 273
VAL A 291
MET A 292
ILE A 314
THR A 316
LEU A 371
ALA A 381
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
None
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.57A 3oezB-2hk5A:
27.7		 3oezB-2hk5A:
66.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 12 VAL A 259
ALA A 271
LYS A 273
THR A 316
PHE A 383
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
 0.65A 3og7A-2hk5A:
27.0		 3og7A-2hk5A:
31.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 GLY A 252
VAL A 259
ALA A 271
LYS A 273
THR A 316
LEU A 371
 None
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
 0.82A 3ohtA-2hk5A:
17.0		 3ohtA-2hk5A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 GLY A 252
VAL A 259
ALA A 271
LYS A 273
THR A 316
LEU A 371
 None
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
 0.84A 3ohtB-2hk5A:
17.1		 3ohtB-2hk5A:
24.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 ALA A 271
GLU A 288
MET A 292
LEU A 300
VAL A 301
THR A 316
GLY A 322
HIS A 362
ALA A 381
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
None
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
None
1BM  A 499 ( 3.7A)
 0.72A 3oxzA-2hk5A:
27.3		 3oxzA-2hk5A:
46.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 ALA A 271
GLU A 288
MET A 292
VAL A 301
THR A 316
GLY A 322
ALA A 381
ASP A 382
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.96A 3oxzA-2hk5A:
27.3		 3oxzA-2hk5A:
46.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 9 LEU A 251
LYS A 273
VAL A 291
ILE A 314
MET A 319
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.9A)
None
1BM  A 499 (-4.4A)
 0.76A 3oxzA-2hk5A:
27.3		 3oxzA-2hk5A:
46.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 271
MET A 292
THR A 316
PHE A 318
ALA A 381
ASP A 382
 1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.75A 3pyyA-2hk5A:
27.6		 3pyyA-2hk5A:
45.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 ALA A 271
MET A 292
THR A 316
PHE A 318
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.76A 3pyyA-2hk5A:
27.6		 3pyyA-2hk5A:
45.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 VAL A 259
ALA A 271
GLU A 288
MET A 292
THR A 316
PHE A 318
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
 0.41A 3pyyA-2hk5A:
27.6		 3pyyA-2hk5A:
45.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 VAL A 259
ALA A 271
MET A 292
THR A 316
PHE A 318
ALA A 381
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 ( 3.7A)
 0.80A 3pyyA-2hk5A:
27.6		 3pyyA-2hk5A:
45.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 6 LYS A 273
VAL A 291
VAL A 301
ILE A 314
ARG A 363
 1BM  A 499 (-3.8A)
None
None
1BM  A 499 (-3.9A)
None
 1.13A 3pyyA-2hk5A:
27.6		 3pyyA-2hk5A:
45.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 251
VAL A 259
ALA A 271
GLU A 288
MET A 292
VAL A 301
THR A 316
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 1.02A 3pyyB-2hk5A:
27.3		 3pyyB-2hk5A:
45.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 5 LYS A 273
VAL A 291
ILE A 314
MET A 319
 1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.9A)
None
 0.72A 3pyyB-2hk5A:
27.3		 3pyyB-2hk5A:
45.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		11 / 12 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
VAL A 301
THR A 316
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.53A 3qlgA-2hk5A:
28.0		 3qlgA-2hk5A:
66.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 251
VAL A 259
ALA A 271
GLU A 288
MET A 292
VAL A 301
THR A 316
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.48A 3qlgB-2hk5A:
28.9		 3qlgB-2hk5A:
66.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 4 LYS A 273
ILE A 314
MET A 319
LYS A 321
 1BM  A 499 (-3.8A)
1BM  A 499 (-3.9A)
None
None
 0.38A 3qlgB-2hk5A:
28.9		 3qlgB-2hk5A:
66.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 7 LEU A 371
VAL A 301
LEU A 295
ASP A 382
 1BM  A 499 (-4.4A)
None
None
1BM  A 499 (-4.4A)
 0.86A 3rgfA-2hk5A:
15.9		 3rgfA-2hk5A:
24.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 251
VAL A 259
ALA A 271
MET A 292
VAL A 301
ILE A 314
THR A 316
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.47A 3sxrA-2hk5A:
34.7		 3sxrA-2hk5A:
41.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 251
VAL A 259
ALA A 271
MET A 292
VAL A 301
THR A 316
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.49A 3sxrB-2hk5A:
22.0		 3sxrB-2hk5A:
41.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 251
ALA A 271
LYS A 273
GLU A 288
ILE A 314
THR A 316
PHE A 318
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
 0.81A 3ue4A-2hk5A:
29.8		 3ue4A-2hk5A:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 251
ALA A 271
LYS A 273
VAL A 301
ILE A 314
THR A 316
PHE A 318
MET A 319
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.51A 3ue4A-2hk5A:
29.8		 3ue4A-2hk5A:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 251
VAL A 259
ALA A 271
GLU A 288
MET A 292
ILE A 314
THR A 316
PHE A 318
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
 0.73A 3ue4B-2hk5A:
30.6		 3ue4B-2hk5A:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 251
VAL A 259
ALA A 271
MET A 292
VAL A 301
ILE A 314
THR A 316
PHE A 318
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.55A 3ue4B-2hk5A:
30.6		 3ue4B-2hk5A:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 251
VAL A 259
ALA A 271
LYS A 273
MET A 319
GLY A 322
ASP A 326
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.5A)
None
1BM  A 499 (-4.4A)
 0.76A 3ug2A-2hk5A:
27.5		 3ug2A-2hk5A:
33.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 LEU A 251
ALA A 271
MET A 319
GLY A 322
LEU A 371
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.54A 3zbfA-2hk5A:
26.1		 3zbfA-2hk5A:
38.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 ALA A 271
LYS A 273
GLU A 288
THR A 316
HIS A 362
ARG A 363
LEU A 371
ALA A 381
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.2A)
None
None
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 1.01A 3zosA-2hk5A:
29.6		 3zosA-2hk5A:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 251
ALA A 271
LYS A 273
GLU A 288
THR A 316
HIS A 362
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.96A 3zosA-2hk5A:
29.6		 3zosA-2hk5A:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 251
ALA A 271
LYS A 273
GLU A 288
THR A 316
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 1.01A 3zosA-2hk5A:
29.6		 3zosA-2hk5A:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 ALA A 271
LYS A 273
GLU A 288
THR A 316
HIS A 362
ARG A 363
LEU A 371
ALA A 381
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.2A)
None
None
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 1.04A 3zosB-2hk5A:
23.5		 3zosB-2hk5A:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
VAL A 301
PHE A 318
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.94A 4ag8A-2hk5A:
30.6		 4ag8A-2hk5A:
39.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 11 LEU A 251
ALA A 271
VAL A 301
PHE A 318
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.63A 4agdA-2hk5A:
29.9		 4agdA-2hk5A:
35.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 9 LEU A 251
VAL A 259
ALA A 271
MET A 319
GLY A 322
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.55A 4anqA-2hk5A:
24.9		 4anqA-2hk5A:
37.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 9 LEU A 251
VAL A 259
ALA A 271
MET A 319
GLY A 322
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.56A 4ansA-2hk5A:
24.9		 4ansA-2hk5A:
37.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
PHE A 318
GLY A 322
HIS A 362
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
None
 0.98A 4asdA-2hk5A:
30.3		 4asdA-2hk5A:
35.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 271
MET A 292
THR A 316
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.85A 4bkjA-2hk5A:
29.3		 4bkjA-2hk5A:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 271
MET A 292
THR A 316
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.83A 4bkjB-2hk5A:
29.3		 4bkjB-2hk5A:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 VAL A 259
ALA A 271
GLU A 288
MET A 292
THR A 316
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
 1.06A 4bkjB-2hk5A:
29.3		 4bkjB-2hk5A:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 VAL A 259
ALA A 271
MET A 292
THR A 316
ALA A 381
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 1.00A 4bkjB-2hk5A:
29.3		 4bkjB-2hk5A:
35.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 ALA A 271
LYS A 273
GLU A 288
ILE A 314
THR A 316
HIS A 362
LEU A 371
ALA A 381
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.78A 4c8bA-2hk5A:
26.4		 4c8bA-2hk5A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 ALA A 271
LYS A 273
ILE A 314
THR A 316
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.66A 4c8bA-2hk5A:
26.4		 4c8bA-2hk5A:
25.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 11 LEU A 251
GLY A 252
VAL A 259
ALA A 271
GLY A 322
SER A 323
LEU A 371
 1BM  A 499 ( 3.7A)
None
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.5A)
None
1BM  A 499 (-4.4A)
 0.49A 4ckiA-2hk5A:
30.3		 4ckiA-2hk5A:
40.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 10 LEU A 251
GLY A 252
GLY A 254
VAL A 259
ALA A 271
SER A 323
LEU A 371
 1BM  A 499 ( 3.7A)
None
None
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-4.4A)
 0.55A 4ckjA-2hk5A:
29.0		 4ckjA-2hk5A:
39.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 VAL A 259
ALA A 271
GLU A 288
MET A 292
VAL A 301
THR A 316
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 1.02A 4csvA-2hk5A:
28.0		 4csvA-2hk5A:
58.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 251
VAL A 259
ALA A 271
THR A 316
MET A 319
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.35A 4hjoA-2hk5A:
29.9		 4hjoA-2hk5A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 10 ALA A 271
VAL A 301
PHE A 318
GLY A 322
LEU A 371
 1BM  A 499 (-3.6A)
None
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.35A 4ks8A-2hk5A:
19.4		 4ks8A-2hk5A:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 7 VAL A 259
ALA A 271
MET A 319
LEU A 371
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-4.4A)
 0.82A 4l9iA-2hk5A:
10.2		 4l9iA-2hk5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 8 VAL A 259
ALA A 271
LYS A 273
MET A 319
LEU A 371
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-4.4A)
 0.79A 4l9iB-2hk5A:
20.1		 4l9iB-2hk5A:
20.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLY A 322
LEU A 371
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.64A 4mkcA-2hk5A:
24.3		 4mkcA-2hk5A:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		11 / 12 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
GLY A 322
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.69A 4mxoA-2hk5A:
29.9		 4mxoA-2hk5A:
67.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		11 / 12 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
VAL A 301
ILE A 314
THR A 316
GLY A 322
LEU A 371
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.74A 4mxoB-2hk5A:
29.8		 4mxoB-2hk5A:
67.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 251
ALA A 271
LYS A 273
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.66A 4mxxA-2hk5A:
29.5		 4mxxA-2hk5A:
66.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 251
VAL A 259
ALA A 271
LYS A 273
VAL A 301
THR A 316
MET A 319
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.61A 4mxxB-2hk5A:
27.1		 4mxxB-2hk5A:
66.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
VAL A 301
ILE A 314
GLY A 322
LEU A 371
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.64A 4mxyA-2hk5A:
28.4		 4mxyA-2hk5A:
66.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 251
VAL A 259
ALA A 271
GLU A 288
VAL A 301
GLY A 322
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.62A 4mxyB-2hk5A:
28.6		 4mxyB-2hk5A:
66.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
VAL A 301
ILE A 314
GLY A 322
LEU A 371
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.64A 4mxzA-2hk5A:
28.4		 4mxzA-2hk5A:
66.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 251
VAL A 259
ALA A 271
GLU A 288
VAL A 301
GLY A 322
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.62A 4mxzB-2hk5A:
28.6		 4mxzB-2hk5A:
66.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 251
VAL A 259
LYS A 273
VAL A 301
THR A 316
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.75A 4otwA-2hk5A:
24.7		 4otwA-2hk5A:
31.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 LYS A 273
VAL A 301
THR A 316
GLY A 322
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.90A 4otwA-2hk5A:
24.7		 4otwA-2hk5A:
31.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 8 PHE A 487
SER A 425
GLU A 288
ASP A 382
 None
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
 1.40A 4qb9D-2hk5A:
undetectable		 4qb9D-2hk5A:
19.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 271
GLU A 288
MET A 292
ARG A 363
ALA A 381
ASP A 382
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 1.37A 4qrcA-2hk5A:
31.2		 4qrcA-2hk5A:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
THR A 316
LEU A 371
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.89A 4r7iA-2hk5A:
24.9		 4r7iA-2hk5A:
36.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 12 ALA A 271
LYS A 273
ILE A 314
THR A 316
SER A 323
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
None
 0.57A 4rzvA-2hk5A:
26.3		 4rzvA-2hk5A:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 12 ALA A 271
LYS A 273
THR A 316
SER A 323
PHE A 383
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
None
 0.93A 4rzvA-2hk5A:
26.3		 4rzvA-2hk5A:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 12 VAL A 259
ALA A 271
LYS A 273
THR A 316
PHE A 383
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
 0.77A 4rzvB-2hk5A:
25.9		 4rzvB-2hk5A:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 12 VAL A 259
ALA A 271
LYS A 273
THR A 316
SER A 323
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
 0.63A 4rzvB-2hk5A:
25.9		 4rzvB-2hk5A:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 251
VAL A 259
ALA A 271
LYS A 273
PHE A 318
MET A 319
GLY A 322
ASN A 369
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-4.1A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.80A 4twpA-2hk5A:
31.7		 4twpA-2hk5A:
48.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		10 / 12 VAL A 259
ALA A 271
LYS A 273
PHE A 318
MET A 319
GLY A 322
ASN A 369
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-4.1A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.77A 4twpA-2hk5A:
31.7		 4twpA-2hk5A:
48.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		11 / 12 LEU A 251
VAL A 259
ALA A 271
LYS A 273
PHE A 318
MET A 319
GLY A 322
ASN A 369
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-4.1A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.81A 4twpB-2hk5A:
31.6		 4twpB-2hk5A:
48.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 271
GLU A 288
MET A 292
HIS A 362
LEU A 371
ALA A 381
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.75A 4tyjA-2hk5A:
26.1		 4tyjA-2hk5A:
41.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 271
LYS A 273
THR A 316
GLY A 322
HIS A 362
LEU A 371
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
None
1BM  A 499 (-4.4A)
 0.60A 4u0iA-2hk5A:
31.3		 4u0iA-2hk5A:
38.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 271
LYS A 273
THR A 316
GLY A 322
LEU A 371
ASP A 382
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.66A 4u0iA-2hk5A:
31.3		 4u0iA-2hk5A:
38.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 11 LEU A 251
VAL A 259
ALA A 271
MET A 319
GLY A 322
ASN A 369
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.50A 4u5jA-2hk5A:
30.2		 4u5jA-2hk5A:
67.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 9 LEU A 251
VAL A 259
ALA A 271
MET A 319
GLY A 322
LEU A 371
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.49A 4u5jB-2hk5A:
29.7		 4u5jB-2hk5A:
67.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 VAL A 259
ALA A 271
GLU A 288
HIS A 362
ALA A 381
GLY A 384
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
None
1BM  A 499 ( 3.7A)
None
 1.33A 4v04A-2hk5A:
24.4		 4v04A-2hk5A:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 8 LYS A 273
MET A 292
ARG A 363
LEU A 371
ILE A 380
 1BM  A 499 (-3.8A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-4.4A)
None
 1.34A 4v04A-2hk5A:
24.4		 4v04A-2hk5A:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 10 LEU A 251
VAL A 259
LYS A 273
MET A 292
LEU A 371
ILE A 380
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.8A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-4.4A)
None
 0.94A 4v04B-2hk5A:
24.7		 4v04B-2hk5A:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 11 ALA A 271
LYS A 273
THR A 316
MET A 319
GLY A 322
ASN A 369
LEU A 371
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
 1.10A 4wa9A-2hk5A:
31.9		 4wa9A-2hk5A:
46.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 11 LEU A 251
ALA A 271
THR A 316
MET A 319
GLY A 322
ASN A 369
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.45A 4wa9A-2hk5A:
31.9		 4wa9A-2hk5A:
46.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 VAL A 259
ALA A 271
LYS A 273
THR A 316
PHE A 318
MET A 319
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.79A 4wa9B-2hk5A:
35.2		 4wa9B-2hk5A:
46.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 VAL A 259
ALA A 271
THR A 316
PHE A 318
MET A 319
GLY A 322
ASN A 369
LEU A 371
ALA A 381
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.69A 4wa9B-2hk5A:
35.2		 4wa9B-2hk5A:
46.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 6 LEU A 251
ALA A 271
MET A 319
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-4.4A)
 0.59A 4wboC-2hk5A:
24.1		 4wboC-2hk5A:
19.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 251
ALA A 271
LYS A 273
GLU A 288
MET A 292
THR A 316
GLY A 322
ASP A 326
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
None
1BM  A 499 (-4.4A)
 0.63A 4wkqA-2hk5A:
33.3		 4wkqA-2hk5A:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		11 / 12 LEU A 251
VAL A 259
ALA A 271
LYS A 273
MET A 292
VAL A 301
ILE A 314
THR A 316
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.63A 4xeyA-2hk5A:
29.4		 4xeyA-2hk5A:
36.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		11 / 12 LEU A 251
VAL A 259
ALA A 271
MET A 292
VAL A 301
ILE A 314
THR A 316
PHE A 318
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.57A 4xeyA-2hk5A:
29.4		 4xeyA-2hk5A:
36.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 ALA A 271
LYS A 273
MET A 292
VAL A 301
ILE A 314
THR A 316
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.63A 4xeyB-2hk5A:
29.9		 4xeyB-2hk5A:
36.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		11 / 12 LEU A 251
VAL A 259
ALA A 271
MET A 292
VAL A 301
ILE A 314
THR A 316
PHE A 318
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.56A 4xeyB-2hk5A:
29.9		 4xeyB-2hk5A:
36.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 251
ALA A 271
GLU A 288
MET A 292
VAL A 301
THR A 316
MET A 319
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.49A 4xliA-2hk5A:
31.5		 4xliA-2hk5A:
48.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 251
ALA A 271
LYS A 273
GLU A 288
MET A 292
VAL A 301
THR A 316
MET A 319
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.67A 4xliA-2hk5A:
31.5		 4xliA-2hk5A:
48.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		11 / 12 LEU A 251
ALA A 271
LYS A 273
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.49A 4xliB-2hk5A:
30.4		 4xliB-2hk5A:
48.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 8 LEU A 251
GLY A 252
VAL A 259
ALA A 271
MET A 319
GLY A 322
 1BM  A 499 ( 3.7A)
None
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-3.5A)
 0.43A 4zauA-2hk5A:
33.7		 4zauA-2hk5A:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 9 LEU A 251
VAL A 259
ALA A 271
MET A 319
GLY A 322
LEU A 371
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.52A 5aaaA-2hk5A:
24.1		 5aaaA-2hk5A:
37.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 10 LEU A 251
VAL A 259
ALA A 271
LYS A 273
MET A 319
GLY A 322
LEU A 371
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.71A 5aabA-2hk5A:
31.9		 5aabA-2hk5A:
37.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 10 LEU A 251
VAL A 259
ALA A 271
LYS A 273
MET A 319
GLY A 322
LEU A 371
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.77A 5aacA-2hk5A:
31.7		 5aacA-2hk5A:
36.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 251
GLY A 252
ALA A 271
PHE A 318
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
None
1BM  A 499 (-3.6A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.83A 5ajqA-2hk5A:
23.3		 5ajqA-2hk5A:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 251
GLY A 252
PHE A 318
GLY A 322
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 3.7A)
None
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.99A 5ajqA-2hk5A:
23.3		 5ajqA-2hk5A:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 10 ALA A 271
PHE A 318
GLY A 322
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 (-3.6A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.73A 5ajqB-2hk5A:
24.0		 5ajqB-2hk5A:
26.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
THR A 316
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.86A 5bvwA-2hk5A:
30.2		 5bvwA-2hk5A:
34.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 12 VAL A 259
ALA A 271
LYS A 273
THR A 316
PHE A 383
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
 0.87A 5cswB-2hk5A:
26.5		 5cswB-2hk5A:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 LEU A 251
VAL A 259
ALA A 271
THR A 316
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.36A 5h2uA-2hk5A:
24.5		 5h2uA-2hk5A:
45.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 251
VAL A 259
ALA A 271
ILE A 314
THR A 316
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.44A 5h2uB-2hk5A:
24.5		 5h2uB-2hk5A:
45.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 LEU A 251
ALA A 271
ILE A 314
THR A 316
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.49A 5h2uC-2hk5A:
24.5		 5h2uC-2hk5A:
45.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 251
VAL A 259
ALA A 271
ILE A 314
THR A 316
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.42A 5h2uD-2hk5A:
24.7		 5h2uD-2hk5A:
45.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 12 VAL A 259
ALA A 271
ILE A 314
THR A 316
ASP A 326
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
None
 0.59A 5hesA-2hk5A:
25.7		 5hesA-2hk5A:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 259
ALA A 271
LYS A 273
ILE A 314
THR A 316
ASP A 326
PHE A 383
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
None
None
 0.79A 5hesB-2hk5A:
25.8		 5hesB-2hk5A:
26.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 12 VAL A 259
ALA A 271
LYS A 273
ILE A 314
THR A 316
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
 0.58A 5hieA-2hk5A:
25.5		 5hieA-2hk5A:
30.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 12 VAL A 259
ALA A 271
LYS A 273
ILE A 314
THR A 316
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
 0.58A 5hieB-2hk5A:
25.5		 5hieB-2hk5A:
30.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 12 VAL A 259
ALA A 271
LYS A 273
ILE A 314
THR A 316
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
 0.57A 5hieD-2hk5A:
25.7		 5hieD-2hk5A:
30.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 ALA A 271
LYS A 273
GLU A 288
ILE A 314
THR A 316
GLY A 322
LEU A 371
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.72A 5i9xA-2hk5A:
33.3		 5i9xA-2hk5A:
41.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 ALA A 271
LYS A 273
GLU A 288
MET A 292
THR A 316
GLY A 322
LEU A 371
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.49A 5i9yA-2hk5A:
25.2		 5i9yA-2hk5A:
41.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 7 GLY A 252
GLY A 254
GLY A 257
VAL A 259
 None
None
None
1BM  A 499 ( 4.8A)
 0.24A 5izjB-2hk5A:
17.5		 5izjB-2hk5A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 7 GLY A 252
GLY A 254
VAL A 259
LYS A 273
 None
None
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.8A)
 0.46A 5izjA-2hk5A:
18.9		 5izjA-2hk5A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 7 GLY A 252
GLY A 254
VAL A 259
LYS A 273
 None
None
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.8A)
 0.39A 5j5xA-2hk5A:
17.8		 5j5xA-2hk5A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 10 LEU A 251
VAL A 259
GLU A 288
ILE A 314
PHE A 318
MET A 319
GLY A 322
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.9A)
1BM  A 499 (-4.1A)
None
1BM  A 499 (-3.5A)
 1.05A 5mo4A-2hk5A:
26.8		 5mo4A-2hk5A:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 10 LEU A 251
VAL A 259
LYS A 273
GLU A 288
ILE A 314
PHE A 318
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.9A)
1BM  A 499 (-4.1A)
 0.77A 5mo4A-2hk5A:
26.8		 5mo4A-2hk5A:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 271
LEU A 300
VAL A 301
HIS A 362
LEU A 371
ALA A 381
 1BM  A 499 (-3.6A)
None
None
None
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.53A 5mo4A-2hk5A:
26.7		 5mo4A-2hk5A:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 ALA A 271
VAL A 291
MET A 292
LEU A 300
VAL A 301
LEU A 371
ALA A 381
 1BM  A 499 (-3.6A)
None
1BM  A 499 ( 3.8A)
None
None
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.75A 5mo4A-2hk5A:
26.7		 5mo4A-2hk5A:
29.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 259
ALA A 271
ILE A 314
THR A 316
GLY A 322
LEU A 371
PHE A 383
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
None
 0.90A 5p9iA-2hk5A:
24.7		 5p9iA-2hk5A:
40.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 271
MET A 292
VAL A 301
PHE A 318
GLY A 322
LEU A 371
 1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.72A 5te0A-2hk5A:
18.5		 5te0A-2hk5A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 LEU A 251
ALA A 271
LYS A 273
GLU A 288
VAL A 301
THR A 316
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.2A)
 0.62A 5vcvA-2hk5A:
25.7		 5vcvA-2hk5A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
THR A 316
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.2A)
 0.46A 5vcyA-2hk5A:
25.1		 5vcyA-2hk5A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 12 LEU A 251
GLY A 252
VAL A 259
ALA A 271
ALA A 381
 1BM  A 499 ( 3.7A)
None
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.7A)
 0.37A 5xv7A-2hk5A:
23.6		 5xv7A-2hk5A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 12 LEU A 251
GLY A 252
VAL A 259
GLY A 322
ALA A 381
 1BM  A 499 ( 3.7A)
None
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.5A)
1BM  A 499 ( 3.7A)
 0.54A 5xv7A-2hk5A:
23.6		 5xv7A-2hk5A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 12 VAL A 259
ALA A 271
GLY A 322
ASP A 326
LEU A 371
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.5A)
None
1BM  A 499 (-4.4A)
 0.49A 5yu9D-2hk5A:
23.7		 5yu9D-2hk5A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 251
VAL A 259
ALA A 271
GLU A 288
MET A 292
GLY A 322
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.5A)
1BM  A 499 ( 3.7A)
 1.05A 5zv2A-2hk5A:
25.2		 5zv2A-2hk5A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		6 / 12 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
 0.73A 5zv2B-2hk5A:
25.0		 5zv2B-2hk5A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
THR A 316
MET A 319
GLY A 322
LEU A 371
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.81A 6bsdA-2hk5A:
30.0		 6bsdA-2hk5A:
16.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 VAL A 259
ALA A 271
LYS A 273
GLU A 288
ILE A 314
THR A 316
MET A 319
GLY A 322
LEU A 371
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.58A 6fnmA-2hk5A:
27.2		 6fnmA-2hk5A:
40.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 VAL A 259
ALA A 271
LYS A 273
MET A 292
ILE A 314
THR A 316
MET A 319
GLY A 322
LEU A 371
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.77A 6fnmA-2hk5A:
27.2		 6fnmA-2hk5A:
40.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		10 / 12 VAL A 259
ALA A 271
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 1.01A 6hd4A-2hk5A:
26.5		 6hd4A-2hk5A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
 0.62A 6hd4A-2hk5A:
26.5		 6hd4A-2hk5A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		4 / 5 VAL A 291
PHE A 318
MET A 319
GLY A 322
 None
1BM  A 499 (-4.1A)
None
1BM  A 499 (-3.5A)
 0.70A 6hd4A-2hk5A:
26.5		 6hd4A-2hk5A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		10 / 12 VAL A 259
ALA A 271
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 1.01A 6hd4B-2hk5A:
26.5		 6hd4B-2hk5A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
 0.64A 6hd4B-2hk5A:
26.5		 6hd4B-2hk5A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 6 LEU A 251
VAL A 291
PHE A 318
MET A 319
GLY A 322
 1BM  A 499 ( 3.7A)
None
1BM  A 499 (-4.1A)
None
1BM  A 499 (-3.5A)
 0.95A 6hd4B-2hk5A:
26.5		 6hd4B-2hk5A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		11 / 12 VAL A 259
ALA A 271
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
PHE A 318
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.99A 6hd6A-2hk5A:
31.7		 6hd6A-2hk5A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
PHE A 318
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
 0.59A 6hd6A-2hk5A:
31.7		 6hd6A-2hk5A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 251
VAL A 259
ALA A 271
GLU A 288
MET A 292
VAL A 301
THR A 316
PHE A 318
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
 0.93A 6hd6B-2hk5A:
31.5		 6hd6B-2hk5A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
VAL A 301
THR A 316
PHE A 318
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
 0.65A 6hd6B-2hk5A:
31.5		 6hd6B-2hk5A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 251
VAL A 259
ALA A 271
MET A 292
VAL A 301
THR A 316
PHE A 318
LEU A 371
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.99A 6hd6B-2hk5A:
31.5		 6hd6B-2hk5A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 7 VAL A 291
ILE A 314
MET A 319
GLY A 322
ALA A 381
 None
1BM  A 499 (-3.9A)
None
1BM  A 499 (-3.5A)
1BM  A 499 ( 3.7A)
 0.68A 6hd6B-2hk5A:
31.5		 6hd6B-2hk5A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens) 		5 / 7 VAL A 291
MET A 319
GLY A 322
ARG A 363
ALA A 381
 None
None
1BM  A 499 (-3.5A)
None
1BM  A 499 ( 3.7A)
 0.92A 6hd6B-2hk5A:
31.5		 6hd6B-2hk5A:
18.05