SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1B2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NYR_A_THRA1004_0
(THREONYL-TRNA
SYNTHETASE 1)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		8 / 10 MET A 444
CYH A 446
ARG A 475
ASP A 495
HIS A 497
TYR A 573
GLN A 595
HIS A 623
 1B2  A 802 (-2.6A)
ZN  A 801 ( 2.3A)
1B2  A 802 (-2.5A)
1B2  A 802 (-3.6A)
ZN  A 801 ( 3.3A)
None
1B2  A 802 (-3.3A)
ZN  A 801 ( 3.1A)
 0.29A 1nyrA-4hwtA:
49.3		 1nyrA-4hwtA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NYR_B_THRB2004_0
(THREONYL-TRNA
SYNTHETASE 1)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		8 / 10 MET A 444
CYH A 446
ARG A 475
ASP A 495
HIS A 497
TYR A 573
GLN A 595
HIS A 623
 1B2  A 802 (-2.6A)
ZN  A 801 ( 2.3A)
1B2  A 802 (-2.5A)
1B2  A 802 (-3.6A)
ZN  A 801 ( 3.3A)
None
1B2  A 802 (-3.3A)
ZN  A 801 ( 3.1A)
 0.71A 1nyrB-4hwtA:
47.9		 1nyrB-4hwtA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 LEU A 596
ILE A 509
CYH A 512
PHE A 515
ASP A 495
 None
None
None
None
1B2  A 802 (-3.6A)
 1.22A 3ko0A-4hwtA:
1.2
3ko0B-4hwtA:
1.2
3ko0C-4hwtA:
1.1
3ko0D-4hwtA:
1.1		 3ko0A-4hwtA:
14.49
3ko0B-4hwtA:
14.49
3ko0C-4hwtA:
14.49
3ko0D-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 ASP A 495
LEU A 596
ILE A 509
CYH A 512
PHE A 515
 1B2  A 802 (-3.6A)
None
None
None
None
 1.24A 3ko0A-4hwtA:
1.2
3ko0B-4hwtA:
1.2
3ko0C-4hwtA:
1.1
3ko0D-4hwtA:
1.1		 3ko0A-4hwtA:
14.49
3ko0B-4hwtA:
14.49
3ko0C-4hwtA:
14.49
3ko0D-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 LEU A 596
ILE A 509
CYH A 512
PHE A 515
ASP A 495
 None
None
None
None
1B2  A 802 (-3.6A)
 1.24A 3ko0C-4hwtA:
1.1
3ko0D-4hwtA:
1.1
3ko0E-4hwtA:
1.1
3ko0F-4hwtA:
0.9		 3ko0C-4hwtA:
14.49
3ko0D-4hwtA:
14.49
3ko0E-4hwtA:
14.49
3ko0F-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 ASP A 495
LEU A 596
ILE A 509
CYH A 512
PHE A 515
 1B2  A 802 (-3.6A)
None
None
None
None
 1.20A 3ko0C-4hwtA:
1.1
3ko0D-4hwtA:
1.1
3ko0E-4hwtA:
1.1
3ko0F-4hwtA:
0.9		 3ko0C-4hwtA:
14.49
3ko0D-4hwtA:
14.49
3ko0E-4hwtA:
14.49
3ko0F-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 LEU A 596
ILE A 509
CYH A 512
PHE A 515
ASP A 495
 None
None
None
None
1B2  A 802 (-3.6A)
 1.26A 3ko0E-4hwtA:
1.1
3ko0F-4hwtA:
0.9
3ko0G-4hwtA:
0.8
3ko0H-4hwtA:
1.0		 3ko0E-4hwtA:
14.49
3ko0F-4hwtA:
14.49
3ko0G-4hwtA:
14.49
3ko0H-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 LEU A 596
ILE A 509
CYH A 512
PHE A 515
ASP A 495
 None
None
None
None
1B2  A 802 (-3.6A)
 1.24A 3ko0G-4hwtA:
0.8
3ko0H-4hwtA:
1.0
3ko0I-4hwtA:
1.1
3ko0J-4hwtA:
1.1		 3ko0G-4hwtA:
14.49
3ko0H-4hwtA:
14.49
3ko0I-4hwtA:
14.49
3ko0J-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 ASP A 495
LEU A 596
ILE A 509
CYH A 512
PHE A 515
 1B2  A 802 (-3.6A)
None
None
None
None
 1.27A 3ko0G-4hwtA:
0.8
3ko0H-4hwtA:
1.0
3ko0I-4hwtA:
1.1
3ko0J-4hwtA:
1.1		 3ko0G-4hwtA:
14.49
3ko0H-4hwtA:
14.49
3ko0I-4hwtA:
14.49
3ko0J-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 ASP A 495
LEU A 596
ILE A 509
CYH A 512
PHE A 515
 1B2  A 802 (-3.6A)
None
None
None
None
 1.21A 3ko0A-4hwtA:
1.1
3ko0B-4hwtA:
1.2
3ko0I-4hwtA:
1.1
3ko0J-4hwtA:
1.0		 3ko0A-4hwtA:
14.49
3ko0B-4hwtA:
14.49
3ko0I-4hwtA:
14.49
3ko0J-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 LEU A 596
ILE A 509
CYH A 512
PHE A 515
ASP A 495
 None
None
None
None
1B2  A 802 (-3.6A)
 1.23A 3ko0K-4hwtA:
0.9
3ko0L-4hwtA:
1.0
3ko0M-4hwtA:
1.1
3ko0N-4hwtA:
1.1		 3ko0K-4hwtA:
14.49
3ko0L-4hwtA:
14.49
3ko0M-4hwtA:
14.49
3ko0N-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 LEU A 596
ILE A 509
CYH A 512
PHE A 515
ASP A 495
 None
None
None
None
1B2  A 802 (-3.6A)
 1.22A 3ko0M-4hwtA:
1.1
3ko0N-4hwtA:
1.1
3ko0O-4hwtA:
1.0
3ko0P-4hwtA:
0.8		 3ko0M-4hwtA:
14.49
3ko0N-4hwtA:
14.49
3ko0O-4hwtA:
14.49
3ko0P-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 ASP A 495
LEU A 596
ILE A 509
CYH A 512
PHE A 515
 1B2  A 802 (-3.6A)
None
None
None
None
 1.24A 3ko0K-4hwtA:
0.9
3ko0L-4hwtA:
1.1
3ko0M-4hwtA:
1.1
3ko0N-4hwtA:
1.1		 3ko0K-4hwtA:
14.49
3ko0L-4hwtA:
14.49
3ko0M-4hwtA:
14.49
3ko0N-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 LEU A 596
ILE A 509
CYH A 512
PHE A 515
ASP A 495
 None
None
None
None
1B2  A 802 (-3.6A)
 1.23A 3ko0O-4hwtA:
1.0
3ko0P-4hwtA:
0.9
3ko0Q-4hwtA:
undetectable
3ko0R-4hwtA:
1.1		 3ko0O-4hwtA:
14.49
3ko0P-4hwtA:
14.49
3ko0Q-4hwtA:
14.49
3ko0R-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 ASP A 495
LEU A 596
ILE A 509
CYH A 512
PHE A 515
 1B2  A 802 (-3.6A)
None
None
None
None
 1.18A 3ko0M-4hwtA:
1.1
3ko0N-4hwtA:
1.1
3ko0O-4hwtA:
1.0
3ko0P-4hwtA:
0.9		 3ko0M-4hwtA:
14.49
3ko0N-4hwtA:
14.49
3ko0O-4hwtA:
14.49
3ko0P-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 10 ASP A 495
LEU A 596
ILE A 509
CYH A 512
PHE A 515
 1B2  A 802 (-3.6A)
None
None
None
None
 1.23A 3ko0O-4hwtA:
1.0
3ko0P-4hwtA:
0.9
3ko0Q-4hwtA:
0.2
3ko0R-4hwtA:
1.1		 3ko0O-4hwtA:
14.49
3ko0P-4hwtA:
14.49
3ko0Q-4hwtA:
14.49
3ko0R-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 ASP A 495
LEU A 596
ILE A 509
CYH A 512
PHE A 515
 1B2  A 802 (-3.6A)
None
None
None
None
 1.22A 3ko0Q-4hwtA:
undetectable
3ko0R-4hwtA:
1.1
3ko0S-4hwtA:
1.0
3ko0T-4hwtA:
1.1		 3ko0Q-4hwtA:
14.49
3ko0R-4hwtA:
14.49
3ko0S-4hwtA:
14.49
3ko0T-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 8 ARG A 475
PHE A 491
THR A 593
ARG A 632
 1B2  A 802 (-2.5A)
None
1B2  A 802 ( 4.1A)
None
 0.69A 4k87A-4hwtA:
26.0		 4k87A-4hwtA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 PHE A 559
GLU A 564
ASN A 530
ASP A 578
ILE A 577
 None
None
None
1B2  A 802 (-3.7A)
None
 1.14A 4u8yB-4hwtA:
undetectable		 4u8yB-4hwtA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 PHE A 559
GLU A 564
ASN A 530
ASP A 578
ILE A 577
 None
None
None
1B2  A 802 (-3.7A)
None
 1.10A 4u95B-4hwtA:
undetectable		 4u95B-4hwtA:
17.95