SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1AL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		4 / 6 GLY A 212
MET A 323
ILE A 210
VAL A 211
 None
1AL  A 502 ( 4.7A)
None
None
 1.11A 3kvvA-4pxdA:
10.0		 3kvvA-4pxdA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		4 / 6 GLY A 212
MET A 323
ILE A 210
VAL A 211
 None
1AL  A 502 ( 4.7A)
None
None
 1.08A 3kvvC-4pxdA:
9.7		 3kvvC-4pxdA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		4 / 6 GLY A 212
MET A 323
ILE A 210
VAL A 211
 None
1AL  A 502 ( 4.7A)
None
None
 1.15A 3kvvE-4pxdA:
10.0		 3kvvE-4pxdA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		4 / 6 GLY A 212
MET A 323
ILE A 210
VAL A 211
 None
1AL  A 502 ( 4.7A)
None
None
 1.13A 3kvvF-4pxdA:
9.5		 3kvvF-4pxdA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		3 / 3 ARG A 215
ASP A 359
GLN A  40
 1AL  A 502 (-3.9A)
None
None
 0.84A 3lcvB-4pxdA:
undetectable		 3lcvB-4pxdA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		3 / 3 GLU A 192
PHE A 373
GLN A 193
 None
None
1AL  A 502 ( 3.2A)
 1.02A 3r55A-4pxdA:
undetectable		 3r55A-4pxdA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		5 / 12 GLY A  93
HIS A 190
GLN A  40
ASP A  57
VAL A 121
 None
1AL  A 502 (-4.3A)
None
None
None
 1.39A 6bxlA-4pxdA:
undetectable		 6bxlA-4pxdA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4pxd ALLANTOATE
AMIDOHYDROLASE
(Escherichia
coli) 		5 / 12 LEU A 189
GLY A  96
GLN A 193
VAL A  85
ASP A  83
 None
None
1AL  A 502 ( 3.2A)
None
None
 1.39A 6bxnB-4pxdA:
undetectable		 6bxnB-4pxdA:
22.27